TOR Signaling Is Going through a Phase.
Identifieur interne : 000219 ( Main/Exploration ); précédent : 000218; suivant : 000220TOR Signaling Is Going through a Phase.
Auteurs : Manoel Prouteau [Suisse] ; Robbie Loewith [Suisse]Source :
- Cell metabolism [ 1932-7420 ] ; 2019.
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Abstract
Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.
DOI: 10.1016/j.cmet.2019.04.010
PubMed: 31067446
Affiliations:
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Electronic address: robbie.loewith@unige.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31067446</idno><idno type="pmid">31067446</idno><idno type="doi">10.1016/j.cmet.2019.04.010</idno><idno type="wicri:Area/Main/Corpus">000278</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000278</idno><idno type="wicri:Area/Main/Curation">000278</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000278</idno><idno type="wicri:Area/Main/Exploration">000278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">TOR Signaling Is Going through a Phase.</title><author><name sortKey="Prouteau, Manoel" sort="Prouteau, Manoel" uniqKey="Prouteau M" first="Manoel" last="Prouteau">Manoel Prouteau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Loewith, Robbie" sort="Loewith, Robbie" uniqKey="Loewith R" first="Robbie" last="Loewith">Robbie Loewith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland. Electronic address: robbie.loewith@unige.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author></analytic><series><title level="j">Cell metabolism</title><idno type="eISSN">1932-7420</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ataxin-2 (MeSH)</term><term>Carrier Proteins (MeSH)</term><term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Saccharomyces cerevisiae Proteins (MeSH)</term><term>Signal Transduction (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Ataxine-2 (MeSH)</term><term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term><term>Protéines de Saccharomyces cerevisiae (MeSH)</term><term>Protéines de transport (MeSH)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ataxin-2</term><term>Carrier Proteins</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Saccharomyces cerevisiae</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Ataxine-2</term><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines de transport</term><term>Saccharomyces cerevisiae</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">31067446</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1932-7420</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>05</Month><Day>07</Day></PubDate></JournalIssue><Title>Cell metabolism</Title><ISOAbbreviation>Cell Metab</ISOAbbreviation></Journal><ArticleTitle>TOR Signaling Is Going through a Phase.</ArticleTitle><Pagination><MedlinePgn>1019-1021</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1550-4131(19)30194-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmet.2019.04.010</ELocationID><Abstract><AbstractText>Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prouteau</LastName><ForeName>Manoel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loewith</LastName><ForeName>Robbie</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland. Electronic address: robbie.loewith@unige.ch.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016420">Comment</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Metab</MedlineTA><NlmUniqueID>101233170</NlmUniqueID><ISSNLinking>1550-4131</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000067698">Ataxin-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C116076">PBP1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentOn"><RefSource>Cell. 2019 Apr 18;177(3):697-710.e17</RefSource><PMID Version="1">30982600</PMID></CommentsCorrections><CommentsCorrections RefType="CommentOn"><RefSource>Cell. 2019 Apr 18;177(3):711-721.e8</RefSource><PMID Version="1">30982603</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000067698" MajorTopicYN="Y">Ataxin-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="Y">Saccharomyces cerevisiae Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31067446</ArticleId><ArticleId IdType="pii">S1550-4131(19)30194-9</ArticleId><ArticleId IdType="doi">10.1016/j.cmet.2019.04.010</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Genève</li></region><settlement><li>Genève</li></settlement><orgName><li>Université de Genève</li></orgName></list><tree><country name="Suisse"><region name="Canton de Genève"><name sortKey="Prouteau, Manoel" sort="Prouteau, Manoel" uniqKey="Prouteau M" first="Manoel" last="Prouteau">Manoel Prouteau</name></region><name sortKey="Loewith, Robbie" sort="Loewith, Robbie" uniqKey="Loewith R" first="Robbie" last="Loewith">Robbie Loewith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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