Expression of E-cadherin and catenins on testis tumor.
Identifieur interne : 004809 ( Main/Exploration ); précédent : 004808; suivant : 004810Expression of E-cadherin and catenins on testis tumor.
Auteurs : T. Saito [Japon] ; A. Katagiri ; R. Watanabe ; T. Tanikawa ; T. Kawasaki ; Y. Tomita ; K. TakahashiSource :
- Urologia internationalis [ 0042-1138 ] ; 2000.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Cadhérines (métabolisme), Germinome (métabolisme), Humains (MeSH), Mâle (MeSH), Protéines du cytosquelette (métabolisme), Séminome (métabolisme), Technique de Western (MeSH), Techniques immunoenzymatiques (MeSH), Transactivateurs (MeSH), Tumeurs du testicule (métabolisme), alpha-Caténine (MeSH), bêta-Caténine (MeSH).
- MESH :
English descriptors
- KwdEn :
- Adult (MeSH), Blotting, Western (MeSH), Cadherins (metabolism), Cytoskeletal Proteins (metabolism), Germinoma (metabolism), Humans (MeSH), Immunoenzyme Techniques (MeSH), Male (MeSH), Seminoma (metabolism), Testicular Neoplasms (metabolism), Trans-Activators (MeSH), alpha Catenin (MeSH), beta Catenin (MeSH).
- MESH :
- chemical , metabolism : Cadherins, Cytoskeletal Proteins.
- metabolism : Germinoma, Seminoma, Testicular Neoplasms.
- Adult, Blotting, Western, Humans, Immunoenzyme Techniques, Male, Trans-Activators, alpha Catenin, beta Catenin.
Abstract
E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.
DOI: 10.1159/000064859
PubMed: 11054031
Affiliations:
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Le document en format XML
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Tanikawa</name></author><author><name sortKey="Kawasaki, T" sort="Kawasaki, T" uniqKey="Kawasaki T" first="T" last="Kawasaki">T. Kawasaki</name></author><author><name sortKey="Tomita, Y" sort="Tomita, Y" uniqKey="Tomita Y" first="Y" last="Tomita">Y. Tomita</name></author><author><name sortKey="Takahashi, K" sort="Takahashi, K" uniqKey="Takahashi K" first="K" last="Takahashi">K. 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Saito</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Niigata Cancer Center Hospital, Niigata, Japan. saitoshi@poplar.ocn.ne.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Urology, Niigata Cancer Center Hospital, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Katagiri, A" sort="Katagiri, A" uniqKey="Katagiri A" first="A" last="Katagiri">A. Katagiri</name></author><author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name></author><author><name sortKey="Tanikawa, T" sort="Tanikawa, T" uniqKey="Tanikawa T" first="T" last="Tanikawa">T. Tanikawa</name></author><author><name sortKey="Kawasaki, T" sort="Kawasaki, T" uniqKey="Kawasaki T" first="T" last="Kawasaki">T. Kawasaki</name></author><author><name sortKey="Tomita, Y" sort="Tomita, Y" uniqKey="Tomita Y" first="Y" last="Tomita">Y. Tomita</name></author><author><name sortKey="Takahashi, K" sort="Takahashi, K" uniqKey="Takahashi K" first="K" last="Takahashi">K. Takahashi</name></author></analytic><series><title level="j">Urologia internationalis</title><idno type="ISSN">0042-1138</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Blotting, Western (MeSH)</term><term>Cadherins (metabolism)</term><term>Cytoskeletal Proteins (metabolism)</term><term>Germinoma (metabolism)</term><term>Humans (MeSH)</term><term>Immunoenzyme Techniques (MeSH)</term><term>Male (MeSH)</term><term>Seminoma (metabolism)</term><term>Testicular Neoplasms (metabolism)</term><term>Trans-Activators (MeSH)</term><term>alpha Catenin (MeSH)</term><term>beta Catenin (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Cadhérines (métabolisme)</term><term>Germinome (métabolisme)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Protéines du cytosquelette (métabolisme)</term><term>Séminome (métabolisme)</term><term>Technique de Western (MeSH)</term><term>Techniques immunoenzymatiques (MeSH)</term><term>Transactivateurs (MeSH)</term><term>Tumeurs du testicule (métabolisme)</term><term>alpha-Caténine (MeSH)</term><term>bêta-Caténine (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadherins</term><term>Cytoskeletal Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Germinoma</term><term>Seminoma</term><term>Testicular Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cadhérines</term><term>Germinome</term><term>Protéines du cytosquelette</term><term>Séminome</term><term>Tumeurs du testicule</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Blotting, Western</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Trans-Activators</term><term>alpha Catenin</term><term>beta Catenin</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Humains</term><term>Mâle</term><term>Technique de Western</term><term>Techniques immunoenzymatiques</term><term>Transactivateurs</term><term>alpha-Caténine</term><term>bêta-Caténine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11054031</PMID><DateCompleted><Year>2000</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0042-1138</ISSN><JournalIssue CitedMedium="Print"><Volume>65</Volume><Issue>3</Issue><PubDate><Year>2000</Year></PubDate></JournalIssue><Title>Urologia internationalis</Title><ISOAbbreviation>Urol Int</ISOAbbreviation></Journal><ArticleTitle>Expression of E-cadherin and catenins on testis tumor.</ArticleTitle><Pagination><MedlinePgn>140-3</MedlinePgn></Pagination><Abstract><AbstractText>E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.</AbstractText><CopyrightInformation>Copyright 2000 S. Karger AG, Basel</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saito</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Urology, Niigata Cancer Center Hospital, Niigata, Japan. saitoshi@poplar.ocn.ne.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katagiri</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Tanikawa</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kawasaki</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tomita</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Takahashi</LastName><ForeName>K</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Urol Int</MedlineTA><NlmUniqueID>0417373</NlmUniqueID><ISSNLinking>0042-1138</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495273">CTNNA1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495270">CTNNB1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015820">Cadherins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003598">Cytoskeletal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015534">Trans-Activators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051178">alpha Catenin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051176">beta Catenin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015820" MajorTopicYN="N">Cadherins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003598" MajorTopicYN="N">Cytoskeletal Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018237" MajorTopicYN="N">Germinoma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018239" MajorTopicYN="N">Seminoma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013736" MajorTopicYN="N">Testicular Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015534" MajorTopicYN="Y">Trans-Activators</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051178" MajorTopicYN="N">alpha Catenin</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051176" MajorTopicYN="N">beta Catenin</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>10</Month><Day>29</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>2</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>10</Month><Day>29</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11054031</ArticleId><ArticleId IdType="pii">64859</ArticleId><ArticleId IdType="doi">10.1159/000064859</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Katagiri, A" sort="Katagiri, A" uniqKey="Katagiri A" first="A" last="Katagiri">A. Katagiri</name><name sortKey="Kawasaki, T" sort="Kawasaki, T" uniqKey="Kawasaki T" first="T" last="Kawasaki">T. Kawasaki</name><name sortKey="Takahashi, K" sort="Takahashi, K" uniqKey="Takahashi K" first="K" last="Takahashi">K. Takahashi</name><name sortKey="Tanikawa, T" sort="Tanikawa, T" uniqKey="Tanikawa T" first="T" last="Tanikawa">T. Tanikawa</name><name sortKey="Tomita, Y" sort="Tomita, Y" uniqKey="Tomita Y" first="Y" last="Tomita">Y. Tomita</name><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name></noCountry><country name="Japon"><noRegion><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T" last="Saito">T. Saito</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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