Expression of E-cadherin and catenins on testis tumor.
Identifieur interne : 004822 ( Main/Corpus ); précédent : 004821; suivant : 004823Expression of E-cadherin and catenins on testis tumor.
Auteurs : T. Saito ; A. Katagiri ; R. Watanabe ; T. Tanikawa ; T. Kawasaki ; Y. Tomita ; K. TakahashiSource :
- Urologia internationalis [ 0042-1138 ] ; 2000.
English descriptors
- KwdEn :
- Adult (MeSH), Blotting, Western (MeSH), Cadherins (metabolism), Cytoskeletal Proteins (metabolism), Germinoma (metabolism), Humans (MeSH), Immunoenzyme Techniques (MeSH), Male (MeSH), Seminoma (metabolism), Testicular Neoplasms (metabolism), Trans-Activators (MeSH), alpha Catenin (MeSH), beta Catenin (MeSH).
- MESH :
- chemical , metabolism : Cadherins, Cytoskeletal Proteins.
- metabolism : Germinoma, Seminoma, Testicular Neoplasms.
- Adult, Blotting, Western, Humans, Immunoenzyme Techniques, Male, Trans-Activators, alpha Catenin, beta Catenin.
Abstract
E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.
DOI: 10.1159/000064859
PubMed: 11054031
Links to Exploration step
pubmed:11054031Le document en format XML
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<author><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T" last="Saito">T. Saito</name>
<affiliation><nlm:affiliation>Department of Urology, Niigata Cancer Center Hospital, Niigata, Japan. saitoshi@poplar.ocn.ne.jp</nlm:affiliation>
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<author><name sortKey="Katagiri, A" sort="Katagiri, A" uniqKey="Katagiri A" first="A" last="Katagiri">A. Katagiri</name>
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<author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name>
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<author><name sortKey="Tanikawa, T" sort="Tanikawa, T" uniqKey="Tanikawa T" first="T" last="Tanikawa">T. Tanikawa</name>
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<author><name sortKey="Kawasaki, T" sort="Kawasaki, T" uniqKey="Kawasaki T" first="T" last="Kawasaki">T. Kawasaki</name>
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<author><name sortKey="Tomita, Y" sort="Tomita, Y" uniqKey="Tomita Y" first="Y" last="Tomita">Y. Tomita</name>
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<author><name sortKey="Takahashi, K" sort="Takahashi, K" uniqKey="Takahashi K" first="K" last="Takahashi">K. Takahashi</name>
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<series><title level="j">Urologia internationalis</title>
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<term>Blotting, Western (MeSH)</term>
<term>Cadherins (metabolism)</term>
<term>Cytoskeletal Proteins (metabolism)</term>
<term>Germinoma (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Immunoenzyme Techniques (MeSH)</term>
<term>Male (MeSH)</term>
<term>Seminoma (metabolism)</term>
<term>Testicular Neoplasms (metabolism)</term>
<term>Trans-Activators (MeSH)</term>
<term>alpha Catenin (MeSH)</term>
<term>beta Catenin (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadherins</term>
<term>Cytoskeletal Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Germinoma</term>
<term>Seminoma</term>
<term>Testicular Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Blotting, Western</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Male</term>
<term>Trans-Activators</term>
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<front><div type="abstract" xml:lang="en">E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.</div>
</front>
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<Title>Urologia internationalis</Title>
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<ArticleTitle>Expression of E-cadherin and catenins on testis tumor.</ArticleTitle>
<Pagination><MedlinePgn>140-3</MedlinePgn>
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<Abstract><AbstractText>E-cadherin (ECD) is a homophilic Ca(2+)-dependent adhesion molecule associated with cell-to-cell interactions and normal growth. Recent reports have suggested that decrease or loss of ECD facilitates tumor progression and/or metastasis. ECD functions in a complex called an adherens junction, which includes several other proteins including alpha- and beta-catenin. In the present study, fresh-frozen sections from 32 testis cancers, 16 seminomas and 16 non-seminomatous germ cell tumors (NSGCT), were examined immunohistochemically. E-cadherin was not expressed on normal germ cells, but expressed on 3 (18.8%) of 16 seminomas and 10 (62.5%) of 16 NSGCTs, mainly on the epithelial component of teratoma cells. alpha-Catenin was detected on 0 (0%) of 13 seminomas and 4 (25%) of 16 NSGCTs. beta-Catenin was detected on 10 (71.4%) of 14 seminomas and 13 (81.2%) of 16 NSGCTs. ECD was detected significantly more frequently on NSGCTs than on seminomas. Immunoblot analysis confirmed the expression of ECD and beta-catenin in NSGCTs. Expression of ECD and catenins may reflect the degree of differentiation and provide some information on the character of the tumor.</AbstractText>
<CopyrightInformation>Copyright 2000 S. Karger AG, Basel</CopyrightInformation>
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