Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers.
Identifieur interne : 000505 ( PubMed/Checkpoint ); précédent : 000504; suivant : 000506Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers.
Auteurs : Emanuela Napoleone [Italie] ; Antonella Cutrone ; Filomena Zurlo ; Augusto Di Castelnuovo ; Marco D'Imperio ; Lucia Giordano ; Amalia De Curtis ; Licia Iacoviello ; Domenico Rotilio ; Chiara Cerletti ; Giovanni De Gaetano ; Maria Benedetta Donati ; Roberto LorenzetSource :
- Thrombosis research [ 1879-2472 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Thromboplastin.
- drug effects : Blood Coagulation.
- physiology : Blood Coagulation.
- Adult, Beverages, Citrus sinensis, Cross-Over Studies, Fruit, Healthy Volunteers, Humans, Male, Risk Factors.
Abstract
Numerous epidemiological studies suggest that exposure to flavonoid-rich fruits has beneficial influence on risk factors for cardiovascular disease. We investigated whether intake of orange juice (OJ) could affect whole blood (WB) procoagulant activity.
DOI: 10.1016/j.thromres.2013.06.022
PubMed: 23859487
Affiliations:
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pubmed:23859487Le document en format XML
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<author><name sortKey="Napoleone, Emanuela" sort="Napoleone, Emanuela" uniqKey="Napoleone E" first="Emanuela" last="Napoleone">Emanuela Napoleone</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Laboratories, Catholic University, Campobasso, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Research Laboratories, Catholic University, Campobasso</wicri:regionArea>
<wicri:noRegion>Campobasso</wicri:noRegion>
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<author><name sortKey="Cutrone, Antonella" sort="Cutrone, Antonella" uniqKey="Cutrone A" first="Antonella" last="Cutrone">Antonella Cutrone</name>
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<author><name sortKey="Zurlo, Filomena" sort="Zurlo, Filomena" uniqKey="Zurlo F" first="Filomena" last="Zurlo">Filomena Zurlo</name>
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<author><name sortKey="Di Castelnuovo, Augusto" sort="Di Castelnuovo, Augusto" uniqKey="Di Castelnuovo A" first="Augusto" last="Di Castelnuovo">Augusto Di Castelnuovo</name>
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<author><name sortKey="D Imperio, Marco" sort="D Imperio, Marco" uniqKey="D Imperio M" first="Marco" last="D'Imperio">Marco D'Imperio</name>
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<author><name sortKey="Giordano, Lucia" sort="Giordano, Lucia" uniqKey="Giordano L" first="Lucia" last="Giordano">Lucia Giordano</name>
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<author><name sortKey="De Curtis, Amalia" sort="De Curtis, Amalia" uniqKey="De Curtis A" first="Amalia" last="De Curtis">Amalia De Curtis</name>
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<author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name>
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<author><name sortKey="Rotilio, Domenico" sort="Rotilio, Domenico" uniqKey="Rotilio D" first="Domenico" last="Rotilio">Domenico Rotilio</name>
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<author><name sortKey="Cerletti, Chiara" sort="Cerletti, Chiara" uniqKey="Cerletti C" first="Chiara" last="Cerletti">Chiara Cerletti</name>
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<author><name sortKey="De Gaetano, Giovanni" sort="De Gaetano, Giovanni" uniqKey="De Gaetano G" first="Giovanni" last="De Gaetano">Giovanni De Gaetano</name>
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<author><name sortKey="Donati, Maria Benedetta" sort="Donati, Maria Benedetta" uniqKey="Donati M" first="Maria Benedetta" last="Donati">Maria Benedetta Donati</name>
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<author><name sortKey="Lorenzet, Roberto" sort="Lorenzet, Roberto" uniqKey="Lorenzet R" first="Roberto" last="Lorenzet">Roberto Lorenzet</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers.</title>
<author><name sortKey="Napoleone, Emanuela" sort="Napoleone, Emanuela" uniqKey="Napoleone E" first="Emanuela" last="Napoleone">Emanuela Napoleone</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Laboratories, Catholic University, Campobasso, Italy.</nlm:affiliation>
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<wicri:noRegion>Campobasso</wicri:noRegion>
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<author><name sortKey="Cutrone, Antonella" sort="Cutrone, Antonella" uniqKey="Cutrone A" first="Antonella" last="Cutrone">Antonella Cutrone</name>
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<author><name sortKey="Zurlo, Filomena" sort="Zurlo, Filomena" uniqKey="Zurlo F" first="Filomena" last="Zurlo">Filomena Zurlo</name>
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<author><name sortKey="Di Castelnuovo, Augusto" sort="Di Castelnuovo, Augusto" uniqKey="Di Castelnuovo A" first="Augusto" last="Di Castelnuovo">Augusto Di Castelnuovo</name>
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<author><name sortKey="D Imperio, Marco" sort="D Imperio, Marco" uniqKey="D Imperio M" first="Marco" last="D'Imperio">Marco D'Imperio</name>
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<author><name sortKey="Giordano, Lucia" sort="Giordano, Lucia" uniqKey="Giordano L" first="Lucia" last="Giordano">Lucia Giordano</name>
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<author><name sortKey="De Curtis, Amalia" sort="De Curtis, Amalia" uniqKey="De Curtis A" first="Amalia" last="De Curtis">Amalia De Curtis</name>
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<author><name sortKey="Iacoviello, Licia" sort="Iacoviello, Licia" uniqKey="Iacoviello L" first="Licia" last="Iacoviello">Licia Iacoviello</name>
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<author><name sortKey="Rotilio, Domenico" sort="Rotilio, Domenico" uniqKey="Rotilio D" first="Domenico" last="Rotilio">Domenico Rotilio</name>
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<author><name sortKey="Cerletti, Chiara" sort="Cerletti, Chiara" uniqKey="Cerletti C" first="Chiara" last="Cerletti">Chiara Cerletti</name>
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<author><name sortKey="De Gaetano, Giovanni" sort="De Gaetano, Giovanni" uniqKey="De Gaetano G" first="Giovanni" last="De Gaetano">Giovanni De Gaetano</name>
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<author><name sortKey="Donati, Maria Benedetta" sort="Donati, Maria Benedetta" uniqKey="Donati M" first="Maria Benedetta" last="Donati">Maria Benedetta Donati</name>
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<author><name sortKey="Lorenzet, Roberto" sort="Lorenzet, Roberto" uniqKey="Lorenzet R" first="Roberto" last="Lorenzet">Roberto Lorenzet</name>
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<series><title level="j">Thrombosis research</title>
<idno type="eISSN">1879-2472</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Beverages</term>
<term>Blood Coagulation (drug effects)</term>
<term>Blood Coagulation (physiology)</term>
<term>Citrus sinensis</term>
<term>Cross-Over Studies</term>
<term>Fruit</term>
<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Male</term>
<term>Risk Factors</term>
<term>Thromboplastin (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Thromboplastin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Coagulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Coagulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Beverages</term>
<term>Citrus sinensis</term>
<term>Cross-Over Studies</term>
<term>Fruit</term>
<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Male</term>
<term>Risk Factors</term>
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<front><div type="abstract" xml:lang="en">Numerous epidemiological studies suggest that exposure to flavonoid-rich fruits has beneficial influence on risk factors for cardiovascular disease. We investigated whether intake of orange juice (OJ) could affect whole blood (WB) procoagulant activity.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23859487</PMID>
<DateCreated><Year>2013</Year>
<Month>9</Month>
<Day>9</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>06</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>9</Month>
<Day>9</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-2472</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>132</Volume>
<Issue>2</Issue>
<PubDate><Year>2013</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Thrombosis research</Title>
<ISOAbbreviation>Thromb. Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers.</ArticleTitle>
<Pagination><MedlinePgn>288-92</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.thromres.2013.06.022</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0049-3848(13)00273-9</ELocationID>
<Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Numerous epidemiological studies suggest that exposure to flavonoid-rich fruits has beneficial influence on risk factors for cardiovascular disease. We investigated whether intake of orange juice (OJ) could affect whole blood (WB) procoagulant activity.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">17 healthy subjects (aged 31 ± 1.5 SEM 10 males) were randomized to receive, according to a cross-over design, either red or blond OJ, enriched or free of anthocyanins, respectively. After one week run-in period on a controlled diet, the subjects were randomly allocated to receive either type of OJ for 4 weeks, with a 4-week wash-out period. Venous blood was collected on citrate before and at the end of each treatment period. WB was incubated with or without an inflammatory stimulus (tumor necrosis factor-α or bacterial endotoxin LPS). Procoagulant activity was evaluated by a one-stage clotting assay. Tissue factor (TF) and TF pathway inhibitor (TFPI) were measured in plasma by ELISA.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Intake of either type of OJ caused a prolongation of unstimulated and stimulated WB clotting times, without any difference between the two treatments. Intake of OJ did not modify TF levels. On the contrary, an increase in circulating TFPI antigen was detected following either treatment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Orange juice intake by healthy volunteers decreases procoagulant activity, possibly through mechanisms independent of its anthocyanin content.</AbstractText>
<CopyrightInformation>© 2013.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Napoleone</LastName>
<ForeName>Emanuela</ForeName>
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<AffiliationInfo><Affiliation>Research Laboratories, Catholic University, Campobasso, Italy.</Affiliation>
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<MeshHeading><DescriptorName UI="D001777" MajorTopicYN="N">Blood Coagulation</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Orange juice</Keyword>
<Keyword MajorTopicYN="N">Procoagulant activity</Keyword>
<Keyword MajorTopicYN="N">Tissue factor</Keyword>
<Keyword MajorTopicYN="N">Tissue factor pathway inhibitor</Keyword>
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