Combination treatment of lycopene and hesperidin protect experimentally induced ulcer in laboratory rats
Identifieur interne : 000356 ( Pmc/Curation ); précédent : 000355; suivant : 000357Combination treatment of lycopene and hesperidin protect experimentally induced ulcer in laboratory rats
Auteurs : Dilpesh Jain [Inde] ; Neha Katti [Inde]Source :
- Journal of Intercultural Ethnopharmacology [ 2146-8397 ] ; 2015.
Abstract
Lycopene, a carotenoid and hesperidin, a flavonoid are naturally occurring in vegetables and fruits. Synergistic effect of a combination of carotenoid and flavonoid has been reported due to its antioxidant activity. Therefore, the present study was aimed to evaluate the protective effect of this combination on pylorus ligation induced ulcers in rats.
Thirty Wistar albino rats were divided into five groups (
The sham operated rats showed a significant increase in pH, volume of gastric content and total acidity and ulcer index. The rats pretreated with lycopene and hesperidin showed significant improvement in the ulcer conditions. However, rats treated with a combination of lycopene and hesperidin showed more significant restoration of gastric function as compared to sham operated rats. Moreover, a significant difference was also noted in rats treated with a combination as compared to lycopene and hesperidin treatment alone.
Thus experimentally the combination was seen to treat ulcers by anti-secretory, neutralizing, cytoprotective and mainly due to its antioxidant property.
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DOI: 10.5455/jice.20150314061404
PubMed: 26401402
PubMed Central: 4566771
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combination treatment of lycopene and hesperidin protect experimentally induced ulcer in laboratory rats</title><author><name sortKey="Jain, Dilpesh" sort="Jain, Dilpesh" uniqKey="Jain D" first="Dilpesh" last="Jain">Dilpesh Jain</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra</wicri:regionArea></affiliation></author><author><name sortKey="Katti, Neha" sort="Katti, Neha" uniqKey="Katti N" first="Neha" last="Katti">Neha Katti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26401402</idno><idno type="pmc">4566771</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566771</idno><idno type="RBID">PMC:4566771</idno><idno type="doi">10.5455/jice.20150314061404</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000357</idno><idno type="wicri:Area/Pmc/Curation">000356</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combination treatment of lycopene and hesperidin protect experimentally induced ulcer in laboratory rats</title><author><name sortKey="Jain, Dilpesh" sort="Jain, Dilpesh" uniqKey="Jain D" first="Dilpesh" last="Jain">Dilpesh Jain</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra</wicri:regionArea></affiliation></author><author><name sortKey="Katti, Neha" sort="Katti, Neha" uniqKey="Katti N" first="Neha" last="Katti">Neha Katti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Intercultural Ethnopharmacology</title><idno type="eISSN">2146-8397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim:</title><p>Lycopene, a carotenoid and hesperidin, a flavonoid are naturally occurring in vegetables and fruits. Synergistic effect of a combination of carotenoid and flavonoid has been reported due to its antioxidant activity. Therefore, the present study was aimed to evaluate the protective effect of this combination on pylorus ligation induced ulcers in rats.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Thirty Wistar albino rats were divided into five groups (<italic>n</italic> = 6). Rats were fasted for 24 h before pylorus ligation. After 24 h of fasting the rats were treated with hesperidin (100 mg/kg) and lycopene (2 mg/kg) and their combination 1h prior to surgery. After an hour under ether anesthesia pylorus ligation was performed, after 5 h the animals were sacrificed, stomach was dissected, and gastric contents were collected and measured. Total acidity and pH of gastric content was estimated. Ulcer index was calculated, and <italic>macroscopic</italic> examination of the stomach was carried out.</p></sec><sec id="st3"><title>Results:</title><p>The sham operated rats showed a significant increase in pH, volume of gastric content and total acidity and ulcer index. The rats pretreated with lycopene and hesperidin showed significant improvement in the ulcer conditions. However, rats treated with a combination of lycopene and hesperidin showed more significant restoration of gastric function as compared to sham operated rats. Moreover, a significant difference was also noted in rats treated with a combination as compared to lycopene and hesperidin treatment alone.</p></sec><sec id="st4"><title>Conclusion:</title><p>Thus experimentally the combination was seen to treat ulcers by anti-secretory, neutralizing, cytoprotective and mainly due to its antioxidant property.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Goel, Rk" uniqKey="Goel R">RK Goel</name></author><author><name sortKey="Bhattacharya, Sk" uniqKey="Bhattacharya S">SK Bhattacharya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Kuipers, Ej" uniqKey="Kuipers E">EJ Kuipers</name></author><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-serag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cara, K" uniqKey="Cara K">K 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Intercult Ethnopharmacol</journal-id><journal-id journal-id-type="iso-abbrev">J Intercult Ethnopharmacol</journal-id><journal-id journal-id-type="publisher-id">JIE</journal-id><journal-title-group><journal-title>Journal of Intercultural Ethnopharmacology</journal-title></journal-title-group><issn pub-type="epub">2146-8397</issn><publisher><publisher-name>SAGEYA</publisher-name><publisher-loc>Turkey</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26401402</article-id><article-id pub-id-type="pmc">4566771</article-id><article-id pub-id-type="publisher-id">JIE-4-143</article-id><article-id pub-id-type="doi">10.5455/jice.20150314061404</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Combination treatment of lycopene and hesperidin protect experimentally induced ulcer in laboratory rats</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jain</surname><given-names>Dilpesh</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Katti</surname><given-names>Neha</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1">Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dilpesh Jain, Department of Pharmacology, Post-Graduation Research Center, Sinhgad College of Pharmacy, S. NO. 44/1, Off Sinhgad Road, Vadgaon, Pune - 411 041, Maharashtra, India. Mobile: +91 9423614296, E-mail: <email xlink:href="dilpeshjain@yahoo.com">dilpeshjain@yahoo.com</email></corresp></author-notes><pub-date pub-type="collection"><season>Apr-Jun</season><year>2015</year></pub-date><pub-date pub-type="epub"><day>16</day><month>3</month><year>2015</year></pub-date><volume>4</volume><issue>2</issue><fpage>143</fpage><lpage>146</lpage><history><date date-type="received"><day>17</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>16</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>Copyright: © SAGEYA</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Aim:</title><p>Lycopene, a carotenoid and hesperidin, a flavonoid are naturally occurring in vegetables and fruits. Synergistic effect of a combination of carotenoid and flavonoid has been reported due to its antioxidant activity. Therefore, the present study was aimed to evaluate the protective effect of this combination on pylorus ligation induced ulcers in rats.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Thirty Wistar albino rats were divided into five groups (<italic>n</italic> = 6). Rats were fasted for 24 h before pylorus ligation. After 24 h of fasting the rats were treated with hesperidin (100 mg/kg) and lycopene (2 mg/kg) and their combination 1h prior to surgery. After an hour under ether anesthesia pylorus ligation was performed, after 5 h the animals were sacrificed, stomach was dissected, and gastric contents were collected and measured. Total acidity and pH of gastric content was estimated. Ulcer index was calculated, and <italic>macroscopic</italic> examination of the stomach was carried out.</p></sec><sec id="st3"><title>Results:</title><p>The sham operated rats showed a significant increase in pH, volume of gastric content and total acidity and ulcer index. The rats pretreated with lycopene and hesperidin showed significant improvement in the ulcer conditions. However, rats treated with a combination of lycopene and hesperidin showed more significant restoration of gastric function as compared to sham operated rats. Moreover, a significant difference was also noted in rats treated with a combination as compared to lycopene and hesperidin treatment alone.</p></sec><sec id="st4"><title>Conclusion:</title><p>Thus experimentally the combination was seen to treat ulcers by anti-secretory, neutralizing, cytoprotective and mainly due to its antioxidant property.</p></sec></abstract><kwd-group><title>KEY WORDS</title><kwd>Hesperidin</kwd><kwd>lycopene</kwd><kwd>pylorus ligation</kwd><kwd>ulcer index</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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