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Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations

Identifieur interne : 000357 ( Pmc/Curation ); précédent : 000356; suivant : 000358

Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations

Auteurs : Neelam Mallick [Pakistan] ; Rafeeq Alam Khan [Pakistan]

Source :

RBID : PMC:4832900

Abstract

Objective:

Hyperlipidemia, extensively contributes in the progression of coronary heart diseases and atherosclerosis, but may be managed through alterations in the nutritional pattern. Several studies show that diet rich in polyphenols and antioxidants have antiatherogenic effects. Citrus sinensis and Citrus paradisi are widely known for health benefits and have found to produce antioxidant, anti-inflammatory, and hypolipidemic effects, hence current research was planned to determine the hypolipidemic effects of C. sinensis and C. paradisi in rats receiving diet rich in cholesterol.

Materials and Methods:

All rats were divided into 11 groups each comprising 10 animals: Normal control group and hyperlipidemic control. C. sinensis treated three groups, C. paradisi treated three groups, C. sinensis and C. paradisi combination treated two groups, and group treated atorvastatin. All rats in the respective groups were treated orally with sterile water, juices, and standard drug for 8 weeks and lipid profile was estimated at the end of dosing.

Results:

Cholesterol, triglycerides (TGs), and low-density lipoprotein (LDL) were decreased at all the three doses of C. sinensis and C. paradisi but rise in high-density lipoprotein (HDL) was only significant at 8 ml/kg, and 0.3 ml/kg, respectively. Animals received the combination doses of C. sinensis and C. paradisi also showed a highly significant fall in cholesterol, LDL, and TGs, however HDL level was significantly elevated by SPJ-2 combination.

Conclusion:

Results suggest that C. sinensis and C. paradisi possess antihyperlipidemic activity due to phytochemicals and other essential nutrients, hence may serve as cardioprotective by preventing thrombosis.


Url:
DOI: 10.4103/0975-7406.171727
PubMed: 27134462
PubMed Central: 4832900

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PMC:4832900

Le document en format XML

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<title xml:lang="en">Antihyperlipidemic effects of
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<name sortKey="Mallick, Neelam" sort="Mallick, Neelam" uniqKey="Mallick N" first="Neelam" last="Mallick">Neelam Mallick</name>
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<name sortKey="Khan, Rafeeq Alam" sort="Khan, Rafeeq Alam" uniqKey="Khan R" first="Rafeeq Alam" last="Khan">Rafeeq Alam Khan</name>
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<title xml:lang="en" level="a" type="main">Antihyperlipidemic effects of
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<title>Objective:</title>
<p>Hyperlipidemia, extensively contributes in the progression of coronary heart diseases and atherosclerosis, but may be managed through alterations in the nutritional pattern. Several studies show that diet rich in polyphenols and antioxidants have antiatherogenic effects.
<italic>Citrus sinensis</italic>
and
<italic>Citrus paradisi</italic>
are widely known for health benefits and have found to produce antioxidant, anti-inflammatory, and hypolipidemic effects, hence current research was planned to determine the hypolipidemic effects of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
in rats receiving diet rich in cholesterol.</p>
</sec>
<sec id="st2">
<title>Materials and Methods:</title>
<p>All rats were divided into 11 groups each comprising 10 animals: Normal control group and hyperlipidemic control.
<italic>C. sinensis</italic>
treated three groups,
<italic>C. paradisi</italic>
treated three groups,
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
combination treated two groups, and group treated atorvastatin. All rats in the respective groups were treated orally with sterile water, juices, and standard drug for 8 weeks and lipid profile was estimated at the end of dosing.</p>
</sec>
<sec id="st3">
<title>Results:</title>
<p>Cholesterol, triglycerides (TGs), and low-density lipoprotein (LDL) were decreased at all the three doses of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
but rise in high-density lipoprotein (HDL) was only significant at 8 ml/kg, and 0.3 ml/kg, respectively. Animals received the combination doses of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
also showed a highly significant fall in cholesterol, LDL, and TGs, however HDL level was significantly elevated by SPJ-2 combination.</p>
</sec>
<sec id="st4">
<title>Conclusion:</title>
<p>Results suggest that
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
possess antihyperlipidemic activity due to phytochemicals and other essential nutrients, hence may serve as cardioprotective by preventing thrombosis.</p>
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<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Kanakavalli, K" uniqKey="Kanakavalli K">K Kanakavalli</name>
</author>
<author>
<name sortKey="Thillaivanan, S" uniqKey="Thillaivanan S">S Thillaivanan</name>
</author>
<author>
<name sortKey="Parthiban, P" uniqKey="Parthiban P">P Parthiban</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wald, Nj" uniqKey="Wald N">NJ Wald</name>
</author>
<author>
<name sortKey="Law, Mr" uniqKey="Law M">MR Law</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Byington, Rp" uniqKey="Byington R">RP Byington</name>
</author>
<author>
<name sortKey="Jukema, Jw" uniqKey="Jukema J">JW Jukema</name>
</author>
<author>
<name sortKey="Salonen, Jt" uniqKey="Salonen J">JT Salonen</name>
</author>
<author>
<name sortKey="Pitt, B" uniqKey="Pitt B">B Pitt</name>
</author>
<author>
<name sortKey="Bruschke, Av" uniqKey="Bruschke A">AV Bruschke</name>
</author>
<author>
<name sortKey="Hoen, H" uniqKey="Hoen H">H Hoen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Delsing, Dj" uniqKey="Delsing D">DJ Delsing</name>
</author>
<author>
<name sortKey="Offerman, Eh" uniqKey="Offerman E">EH Offerman</name>
</author>
<author>
<name sortKey="Van Duyvenvoorde, W" uniqKey="Van Duyvenvoorde W">W van Duyvenvoorde</name>
</author>
<author>
<name sortKey="Van Der Boom, H" uniqKey="Van Der Boom H">H van Der Boom</name>
</author>
<author>
<name sortKey="De Wit, Ec" uniqKey="De Wit E">EC de Wit</name>
</author>
<author>
<name sortKey="Gijbels, Mj" uniqKey="Gijbels M">MJ Gijbels</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kim, Dh" uniqKey="Kim D">DH Kim</name>
</author>
<author>
<name sortKey="Jung, Ea" uniqKey="Jung E">EA Jung</name>
</author>
<author>
<name sortKey="Sohng, Is" uniqKey="Sohng I">IS Sohng</name>
</author>
<author>
<name sortKey="Han, Ja" uniqKey="Han J">JA Han</name>
</author>
<author>
<name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name>
</author>
<author>
<name sortKey="Han, Mj" uniqKey="Han M">MJ Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Higashimoto, M" uniqKey="Higashimoto M">M Higashimoto</name>
</author>
<author>
<name sortKey="Yamato, H" uniqKey="Yamato H">H Yamato</name>
</author>
<author>
<name sortKey="Kinouchi, T" uniqKey="Kinouchi T">T Kinouchi</name>
</author>
<author>
<name sortKey="Ohnishi, Y" uniqKey="Ohnishi Y">Y Ohnishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Le Marchand, L" uniqKey="Le Marchand L">L Le Marchand</name>
</author>
<author>
<name sortKey="Murphy, Sp" uniqKey="Murphy S">SP Murphy</name>
</author>
<author>
<name sortKey="Hankin, Jh" uniqKey="Hankin J">JH Hankin</name>
</author>
<author>
<name sortKey="Wilkens, Lr" uniqKey="Wilkens L">LR Wilkens</name>
</author>
<author>
<name sortKey="Kolonel, Ln" uniqKey="Kolonel L">LN Kolonel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tsai, Sh" uniqKey="Tsai S">SH Tsai</name>
</author>
<author>
<name sortKey="Lin Shiau, Sy" uniqKey="Lin Shiau S">SY Lin-Shiau</name>
</author>
<author>
<name sortKey="Lin, Jk" uniqKey="Lin J">JK Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Bok, Sh" uniqKey="Bok S">SH Bok</name>
</author>
<author>
<name sortKey="Shin, Yw" uniqKey="Shin Y">YW Shin</name>
</author>
<author>
<name sortKey="Bae, Kh" uniqKey="Bae K">KH Bae</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Shin, Yw" uniqKey="Shin Y">YW Shin</name>
</author>
<author>
<name sortKey="Bok, Sh" uniqKey="Bok S">SH Bok</name>
</author>
<author>
<name sortKey="Jeong, Ts" uniqKey="Jeong T">TS Jeong</name>
</author>
<author>
<name sortKey="Bae, Kh" uniqKey="Bae K">KH Bae</name>
</author>
<author>
<name sortKey="Jeoung, Nh" uniqKey="Jeoung N">NH Jeoung</name>
</author>
<author>
<name sortKey="Choi, Ms" uniqKey="Choi M">MS Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jeon, Sm" uniqKey="Jeon S">SM Jeon</name>
</author>
<author>
<name sortKey="Park, Yb" uniqKey="Park Y">YB Park</name>
</author>
<author>
<name sortKey="Choi, Ms" uniqKey="Choi M">MS Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mateljan, G" uniqKey="Mateljan G">G Mateljan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cerda, Jj" uniqKey="Cerda J">JJ Cerda</name>
</author>
<author>
<name sortKey="Robbins, Fl" uniqKey="Robbins F">FL Robbins</name>
</author>
<author>
<name sortKey="Burgin, Cw" uniqKey="Burgin C">CW Burgin</name>
</author>
<author>
<name sortKey="Baumgartner, Tg" uniqKey="Baumgartner T">TG Baumgartner</name>
</author>
<author>
<name sortKey="Rice, Rw" uniqKey="Rice R">RW Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Fujioka, K" uniqKey="Fujioka K">K Fujioka</name>
</author>
<author>
<name sortKey="Greenway, F" uniqKey="Greenway F">F Greenway</name>
</author>
<author>
<name sortKey="Sheard, J" uniqKey="Sheard J">J Sheard</name>
</author>
<author>
<name sortKey="Ying, Y" uniqKey="Ying Y">Y Ying</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Giovannucci, E" uniqKey="Giovannucci E">E Giovannucci</name>
</author>
<author>
<name sortKey="Rimm, Eb" uniqKey="Rimm E">EB Rimm</name>
</author>
<author>
<name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author>
<name sortKey="Stampfer, Mj" uniqKey="Stampfer M">MJ Stampfer</name>
</author>
<author>
<name sortKey="Willett, Wc" uniqKey="Willett W">WC Willett</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Armando, C" uniqKey="Armando C">C Armando</name>
</author>
<author>
<name sortKey="Maythe, S" uniqKey="Maythe S">S Maythe</name>
</author>
<author>
<name sortKey="Beatriz, Np" uniqKey="Beatriz N">NP Beatriz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gorinstein, S" uniqKey="Gorinstein S">S Gorinstein</name>
</author>
<author>
<name sortKey="Caspi, A" uniqKey="Caspi A">A Caspi</name>
</author>
<author>
<name sortKey="Libman, I" uniqKey="Libman I">I Libman</name>
</author>
<author>
<name sortKey="Lerner, Ht" uniqKey="Lerner H">HT Lerner</name>
</author>
<author>
<name sortKey="Huang, D" uniqKey="Huang D">D Huang</name>
</author>
<author>
<name sortKey="Leontowicz, H" uniqKey="Leontowicz H">H Leontowicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gao, K" uniqKey="Gao K">K Gao</name>
</author>
<author>
<name sortKey="Henning, Sm" uniqKey="Henning S">SM Henning</name>
</author>
<author>
<name sortKey="Niu, Y" uniqKey="Niu Y">Y Niu</name>
</author>
<author>
<name sortKey="Youssefian, Aa" uniqKey="Youssefian A">AA Youssefian</name>
</author>
<author>
<name sortKey="Seeram, Np" uniqKey="Seeram N">NP Seeram</name>
</author>
<author>
<name sortKey="Xu, A" uniqKey="Xu A">A Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Holzapfel, Np" uniqKey="Holzapfel N">NP Holzapfel</name>
</author>
<author>
<name sortKey="Holzapfel, Bm" uniqKey="Holzapfel B">BM Holzapfel</name>
</author>
<author>
<name sortKey="Champ, S" uniqKey="Champ S">S Champ</name>
</author>
<author>
<name sortKey="Feldthusen, J" uniqKey="Feldthusen J">J Feldthusen</name>
</author>
<author>
<name sortKey="Clements, J" uniqKey="Clements J">J Clements</name>
</author>
<author>
<name sortKey="Hutmacher, Dw" uniqKey="Hutmacher D">DW Hutmacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Brown, Nd" uniqKey="Brown N">ND Brown</name>
</author>
<author>
<name sortKey="Steven, F" uniqKey="Steven F">F Steven</name>
</author>
<author>
<name sortKey="Lori, G" uniqKey="Lori G">G Lori</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author>
<name sortKey="Heying, E" uniqKey="Heying E">E Heying</name>
</author>
<author>
<name sortKey="Tanumihardjo, Sa" uniqKey="Tanumihardjo S">SA Tanumihardjo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Peluso, Mr" uniqKey="Peluso M">MR Peluso</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chiba, H" uniqKey="Chiba H">H Chiba</name>
</author>
<author>
<name sortKey="Uehara, M" uniqKey="Uehara M">M Uehara</name>
</author>
<author>
<name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author>
<name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author>
<name sortKey="Masuyama, R" uniqKey="Masuyama R">R Masuyama</name>
</author>
<author>
<name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Graciela, Or" uniqKey="Graciela O">OR Graciela</name>
</author>
<author>
<name sortKey="Fredy, Y" uniqKey="Fredy Y">Y Fredy</name>
</author>
<author>
<name sortKey="Betzabe, Sf" uniqKey="Betzabe S">SF Betzabe</name>
</author>
<author>
<name sortKey="Lilibeth, C" uniqKey="Lilibeth C">C Lilibeth</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kurowska, Em" uniqKey="Kurowska E">EM Kurowska</name>
</author>
<author>
<name sortKey="Borradaile, Nm" uniqKey="Borradaile N">NM Borradaile</name>
</author>
<author>
<name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
<author>
<name sortKey="Carroll, Kk" uniqKey="Carroll K">KK Carroll</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Roza, Jm" uniqKey="Roza J">JM Roza</name>
</author>
<author>
<name sortKey="Xian Liu, Z" uniqKey="Xian Liu Z">Z Xian-Liu</name>
</author>
<author>
<name sortKey="Guthrie, N" uniqKey="Guthrie N">N Guthrie</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Buscemi, S" uniqKey="Buscemi S">S Buscemi</name>
</author>
<author>
<name sortKey="Rosafio, G" uniqKey="Rosafio G">G Rosafio</name>
</author>
<author>
<name sortKey="Arcoleo, G" uniqKey="Arcoleo G">G Arcoleo</name>
</author>
<author>
<name sortKey="Mattina, A" uniqKey="Mattina A">A Mattina</name>
</author>
<author>
<name sortKey="Canino, B" uniqKey="Canino B">B Canino</name>
</author>
<author>
<name sortKey="Montana, M" uniqKey="Montana M">M Montana</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name>
</author>
<author>
<name sortKey="Sia, Cl" uniqKey="Sia C">CL Sia</name>
</author>
<author>
<name sortKey="Upadhyay, M" uniqKey="Upadhyay M">M Upadhyay</name>
</author>
<author>
<name sortKey="Korzeniewski, K" uniqKey="Korzeniewski K">K Korzeniewski</name>
</author>
<author>
<name sortKey="Viswanathan, P" uniqKey="Viswanathan P">P Viswanathan</name>
</author>
<author>
<name sortKey="Abuaysheh, S" uniqKey="Abuaysheh S">S Abuaysheh</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sawalha, S" uniqKey="Sawalha S">S Sawalha</name>
</author>
<author>
<name sortKey="Arraez Roman, D" uniqKey="Arraez Roman D">D Arráez-Román</name>
</author>
<author>
<name sortKey="Segura Carretero, A" uniqKey="Segura Carretero A">A Segura-Carretero</name>
</author>
<author>
<name sortKey="Fernandez Gutierrez, A" uniqKey="Fernandez Gutierrez A">A Fernández-Gutiérrez</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Manach, C" uniqKey="Manach C">C Manach</name>
</author>
<author>
<name sortKey="Morand, C" uniqKey="Morand C">C Morand</name>
</author>
<author>
<name sortKey="Gil Izquierdo, A" uniqKey="Gil Izquierdo A">A Gil-Izquierdo</name>
</author>
<author>
<name sortKey="Bouteloup Demange, C" uniqKey="Bouteloup Demange C">C Bouteloup-Demange</name>
</author>
<author>
<name sortKey="Remesy, C" uniqKey="Remesy C">C Rémésy</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ha, Sk" uniqKey="Ha S">SK Ha</name>
</author>
<author>
<name sortKey="Park, Hy" uniqKey="Park H">HY Park</name>
</author>
<author>
<name sortKey="Eom, H" uniqKey="Eom H">H Eom</name>
</author>
<author>
<name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
<author>
<name sortKey="Choi, I" uniqKey="Choi I">I Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Funaguchi, N" uniqKey="Funaguchi N">N Funaguchi</name>
</author>
<author>
<name sortKey="Ohno, Y" uniqKey="Ohno Y">Y Ohno</name>
</author>
<author>
<name sortKey="La, Bl" uniqKey="La B">BL La</name>
</author>
<author>
<name sortKey="Asai, T" uniqKey="Asai T">T Asai</name>
</author>
<author>
<name sortKey="Yuhgetsu, H" uniqKey="Yuhgetsu H">H Yuhgetsu</name>
</author>
<author>
<name sortKey="Sawada, M" uniqKey="Sawada M">M Sawada</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rogerio, Ap" uniqKey="Rogerio A">AP Rogerio</name>
</author>
<author>
<name sortKey="Sa Nunes, A" uniqKey="Sa Nunes A">A Sá-Nunes</name>
</author>
<author>
<name sortKey="Faccioli, Lh" uniqKey="Faccioli L">LH Faccioli</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Council, Nr" uniqKey="Council N">NR Council</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sumbul, S" uniqKey="Sumbul S">S Sumbul</name>
</author>
<author>
<name sortKey="Ahmed, Si" uniqKey="Ahmed S">SI Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sanguino, E" uniqKey="Sanguino E">E Sanguino</name>
</author>
<author>
<name sortKey="Roglans, N" uniqKey="Roglans N">N Roglans</name>
</author>
<author>
<name sortKey="Alegret, M" uniqKey="Alegret M">M Alegret</name>
</author>
<author>
<name sortKey="Sanchez, Rm" uniqKey="Sanchez R">RM Sánchez</name>
</author>
<author>
<name sortKey="Vazquez Carrera, M" uniqKey="Vazquez Carrera M">M Vázquez-Carrera</name>
</author>
<author>
<name sortKey="Laguna, Jc" uniqKey="Laguna J">JC Laguna</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trinder, P" uniqKey="Trinder P">P Trinder</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Warnick, Gr" uniqKey="Warnick G">GR Warnick</name>
</author>
<author>
<name sortKey="Wood, Pd" uniqKey="Wood P">PD Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Friedewald, Wt" uniqKey="Friedewald W">WT Friedewald</name>
</author>
<author>
<name sortKey="Levy, Ri" uniqKey="Levy R">RI Levy</name>
</author>
<author>
<name sortKey="Fredrickson, Ds" uniqKey="Fredrickson D">DS Fredrickson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Brisson, Gj" uniqKey="Brisson G">GJ Brisson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Havsteen, B" uniqKey="Havsteen B">B Havsteen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Choi, Js" uniqKey="Choi J">JS Choi</name>
</author>
<author>
<name sortKey="Yokozawa, T" uniqKey="Yokozawa T">T Yokozawa</name>
</author>
<author>
<name sortKey="Oura, H" uniqKey="Oura H">H Oura</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kurowska, Em" uniqKey="Kurowska E">EM Kurowska</name>
</author>
<author>
<name sortKey="Spence, Jd" uniqKey="Spence J">JD Spence</name>
</author>
<author>
<name sortKey="Jordan, J" uniqKey="Jordan J">J Jordan</name>
</author>
<author>
<name sortKey="Wetmore, S" uniqKey="Wetmore S">S Wetmore</name>
</author>
<author>
<name sortKey="Freeman, Dj" uniqKey="Freeman D">DJ Freeman</name>
</author>
<author>
<name sortKey="Piche, La" uniqKey="Piche L">LA Piché</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Verlecar, Xn" uniqKey="Verlecar X">XN Verlecar</name>
</author>
<author>
<name sortKey="Jena, Kb" uniqKey="Jena K">KB Jena</name>
</author>
<author>
<name sortKey="Chainy, Gb" uniqKey="Chainy G">GB Chainy</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zulet, Ma" uniqKey="Zulet M">MA Zulet</name>
</author>
<author>
<name sortKey="Barber, A" uniqKey="Barber A">A Barber</name>
</author>
<author>
<name sortKey="Garcin, H" uniqKey="Garcin H">H Garcin</name>
</author>
<author>
<name sortKey="Higueret, P" uniqKey="Higueret P">P Higueret</name>
</author>
<author>
<name sortKey="Martinez, Ja" uniqKey="Martinez J">JA Martínez</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kanungo, Sk" uniqKey="Kanungo S">SK Kanungo</name>
</author>
<author>
<name sortKey="Panda, Ds" uniqKey="Panda D">DS Panda</name>
</author>
<author>
<name sortKey="Swain, Sr" uniqKey="Swain S">SR Swain</name>
</author>
<author>
<name sortKey="Barik, Bb" uniqKey="Barik B">BB Barik</name>
</author>
<author>
<name sortKey="Tripathi, Dk" uniqKey="Tripathi D">DK Tripathi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Patel, Dk" uniqKey="Patel D">DK Patel</name>
</author>
<author>
<name sortKey="Patel, Ka" uniqKey="Patel K">KA Patel</name>
</author>
<author>
<name sortKey="Patel, Uk" uniqKey="Patel U">UK Patel</name>
</author>
<author>
<name sortKey="Thounaoja, Mc" uniqKey="Thounaoja M">MC Thounaoja</name>
</author>
<author>
<name sortKey="Jadeja, Rn" uniqKey="Jadeja R">RN Jadeja</name>
</author>
<author>
<name sortKey="Ansarullah" uniqKey="Ansarullah">Ansarullah</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Matsuo, N" uniqKey="Matsuo N">N Matsuo</name>
</author>
<author>
<name sortKey="Osada, K" uniqKey="Osada K">K Osada</name>
</author>
<author>
<name sortKey="Kodama, T" uniqKey="Kodama T">T Kodama</name>
</author>
<author>
<name sortKey="Lim, Bo" uniqKey="Lim B">BO Lim</name>
</author>
<author>
<name sortKey="Nakao, A" uniqKey="Nakao A">A Nakao</name>
</author>
<author>
<name sortKey="Yamada, K" uniqKey="Yamada K">K Yamada</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilcox, Lj" uniqKey="Wilcox L">LJ Wilcox</name>
</author>
<author>
<name sortKey="Borradaile, Nm" uniqKey="Borradaile N">NM Borradaile</name>
</author>
<author>
<name sortKey="Kurowska, E" uniqKey="Kurowska E">E Kurowska</name>
</author>
<author>
<name sortKey="Telford, De" uniqKey="Telford D">DE Telford</name>
</author>
<author>
<name sortKey="Huff, Mw" uniqKey="Huff M">MW Huff</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilcox, Lj" uniqKey="Wilcox L">LJ Wilcox</name>
</author>
<author>
<name sortKey="Borradaile, Nm" uniqKey="Borradaile N">NM Borradaile</name>
</author>
<author>
<name sortKey="Huff, Mw" uniqKey="Huff M">MW Huff</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lansky, Ep" uniqKey="Lansky E">EP Lansky</name>
</author>
<author>
<name sortKey="Newman, Ra" uniqKey="Newman R">RA Newman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Uelmen, Pj" uniqKey="Uelmen P">PJ Uelmen</name>
</author>
<author>
<name sortKey="Oka, K" uniqKey="Oka K">K Oka</name>
</author>
<author>
<name sortKey="Sullivan, M" uniqKey="Sullivan M">M Sullivan</name>
</author>
<author>
<name sortKey="Chang, Cc" uniqKey="Chang C">CC Chang</name>
</author>
<author>
<name sortKey="Chang, Ty" uniqKey="Chang T">TY Chang</name>
</author>
<author>
<name sortKey="Chan, L" uniqKey="Chan L">L Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Grogan, Wm" uniqKey="Grogan W">WM Grogan</name>
</author>
<author>
<name sortKey="Bailey, Ml" uniqKey="Bailey M">ML Bailey</name>
</author>
<author>
<name sortKey="Heuman, Dm" uniqKey="Heuman D">DM Heuman</name>
</author>
<author>
<name sortKey="Vlahcevic, Zr" uniqKey="Vlahcevic Z">ZR Vlahcevic</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mortensen, A" uniqKey="Mortensen A">A Mortensen</name>
</author>
<author>
<name sortKey="Breinholt, V" uniqKey="Breinholt V">V Breinholt</name>
</author>
<author>
<name sortKey="Dalsgaard, T" uniqKey="Dalsgaard T">T Dalsgaard</name>
</author>
<author>
<name sortKey="Frandsen, H" uniqKey="Frandsen H">H Frandsen</name>
</author>
<author>
<name sortKey="Lauridsen, St" uniqKey="Lauridsen S">ST Lauridsen</name>
</author>
<author>
<name sortKey="Laigaard, J" uniqKey="Laigaard J">J Laigaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Nielsen, Lb" uniqKey="Nielsen L">LB Nielsen</name>
</author>
<author>
<name sortKey="Stender, S" uniqKey="Stender S">S Stender</name>
</author>
<author>
<name sortKey="Kjeldsen, K" uniqKey="Kjeldsen K">K Kjeldsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zeiher, Am" uniqKey="Zeiher A">AM Zeiher</name>
</author>
<author>
<name sortKey="Drexler, H" uniqKey="Drexler H">H Drexler</name>
</author>
<author>
<name sortKey="Saurbier, B" uniqKey="Saurbier B">B Saurbier</name>
</author>
<author>
<name sortKey="Just, H" uniqKey="Just H">H Just</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Quyyumi, A" uniqKey="Quyyumi A">A Quyyumi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Anoosh, E" uniqKey="Anoosh E">E Anoosh</name>
</author>
<author>
<name sortKey="Mojtaba, E" uniqKey="Mojtaba E">E Mojtaba</name>
</author>
<author>
<name sortKey="Fatemeh, S" uniqKey="Fatemeh S">S Fatemeh</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Pharm Bioallied Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">J Pharm Bioallied Sci</journal-id>
<journal-id journal-id-type="publisher-id">JPBS</journal-id>
<journal-title-group>
<journal-title>Journal of Pharmacy & Bioallied Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">0976-4879</issn>
<issn pub-type="epub">0975-7406</issn>
<publisher>
<publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">27134462</article-id>
<article-id pub-id-type="pmc">4832900</article-id>
<article-id pub-id-type="publisher-id">JPBS-8-112</article-id>
<article-id pub-id-type="doi">10.4103/0975-7406.171727</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Antihyperlipidemic effects of
<italic>Citrus sinensis</italic>
,
<italic>Citrus paradisi</italic>
, and their combinations</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Mallick</surname>
<given-names>Neelam</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Khan</surname>
<given-names>Rafeeq Alam</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan</aff>
<author-notes>
<corresp id="cor1">
<bold>Address for correspondence:</bold>
Prof. Rafeeq Alam Khan, E-mail:
<email xlink:href="rkhan1959@gmail.com">rkhan1959@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<season>Apr-Jun</season>
<year>2016</year>
</pub-date>
<volume>8</volume>
<issue>2</issue>
<fpage>112</fpage>
<lpage>118</lpage>
<history>
<date date-type="received">
<day>16</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="rev-recd">
<day>06</day>
<month>8</month>
<year>2015</year>
</date>
<date date-type="accepted">
<day>09</day>
<month>8</month>
<year>2015</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright: © Journal of Pharmacy and Bioallied Sciences</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0">
<license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p>
</license>
</permissions>
<abstract>
<sec id="st1">
<title>Objective:</title>
<p>Hyperlipidemia, extensively contributes in the progression of coronary heart diseases and atherosclerosis, but may be managed through alterations in the nutritional pattern. Several studies show that diet rich in polyphenols and antioxidants have antiatherogenic effects.
<italic>Citrus sinensis</italic>
and
<italic>Citrus paradisi</italic>
are widely known for health benefits and have found to produce antioxidant, anti-inflammatory, and hypolipidemic effects, hence current research was planned to determine the hypolipidemic effects of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
in rats receiving diet rich in cholesterol.</p>
</sec>
<sec id="st2">
<title>Materials and Methods:</title>
<p>All rats were divided into 11 groups each comprising 10 animals: Normal control group and hyperlipidemic control.
<italic>C. sinensis</italic>
treated three groups,
<italic>C. paradisi</italic>
treated three groups,
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
combination treated two groups, and group treated atorvastatin. All rats in the respective groups were treated orally with sterile water, juices, and standard drug for 8 weeks and lipid profile was estimated at the end of dosing.</p>
</sec>
<sec id="st3">
<title>Results:</title>
<p>Cholesterol, triglycerides (TGs), and low-density lipoprotein (LDL) were decreased at all the three doses of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
but rise in high-density lipoprotein (HDL) was only significant at 8 ml/kg, and 0.3 ml/kg, respectively. Animals received the combination doses of
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
also showed a highly significant fall in cholesterol, LDL, and TGs, however HDL level was significantly elevated by SPJ-2 combination.</p>
</sec>
<sec id="st4">
<title>Conclusion:</title>
<p>Results suggest that
<italic>C. sinensis</italic>
and
<italic>C. paradisi</italic>
possess antihyperlipidemic activity due to phytochemicals and other essential nutrients, hence may serve as cardioprotective by preventing thrombosis.</p>
</sec>
</abstract>
<kwd-group>
<title>KEY WORDS</title>
<kwd>Grapefruit</kwd>
<kwd>hyperlipidemia</kwd>
<kwd>hypocholesterolemic</kwd>
<kwd>orange</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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