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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Moro</italic> orange juice prevents fatty liver in mice</title><author><name sortKey="Salamone, Federico" sort="Salamone, Federico" uniqKey="Salamone F" first="Federico" last="Salamone">Federico Salamone</name></author><author><name sortKey="Li Volti, Giovanni" sort="Li Volti, Giovanni" uniqKey="Li Volti G" first="Giovanni" last="Li Volti">Giovanni Li Volti</name></author><author><name sortKey="Titta, Lucilla" sort="Titta, Lucilla" uniqKey="Titta L" first="Lucilla" last="Titta">Lucilla Titta</name></author><author><name sortKey="Puzzo, Lidia" sort="Puzzo, Lidia" uniqKey="Puzzo L" first="Lidia" last="Puzzo">Lidia Puzzo</name></author><author><name sortKey="Barbagallo, Ignazio" sort="Barbagallo, Ignazio" uniqKey="Barbagallo I" first="Ignazio" last="Barbagallo">Ignazio Barbagallo</name></author><author><name sortKey="La Delia, Francesco" sort="La Delia, Francesco" uniqKey="La Delia F" first="Francesco" last="La Delia">Francesco La Delia</name></author><author><name sortKey="Zelber Sagi, Shira" sort="Zelber Sagi, Shira" uniqKey="Zelber Sagi S" first="Shira" last="Zelber-Sagi">Shira Zelber-Sagi</name></author><author><name sortKey="Malaguarnera, Michele" sort="Malaguarnera, Michele" uniqKey="Malaguarnera M" first="Michele" last="Malaguarnera">Michele Malaguarnera</name></author><author><name sortKey="Pelicci, Pier Giuseppe" sort="Pelicci, Pier Giuseppe" uniqKey="Pelicci P" first="Pier Giuseppe" last="Pelicci">Pier Giuseppe Pelicci</name></author><author><name sortKey="Giorgio, Marco" sort="Giorgio, Marco" uniqKey="Giorgio M" first="Marco" last="Giorgio">Marco Giorgio</name></author><author><name sortKey="Galvano, Fabio" sort="Galvano, Fabio" uniqKey="Galvano F" first="Fabio" last="Galvano">Fabio Galvano</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22876038</idno><idno type="pmc">3413058</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413058</idno><idno type="RBID">PMC:3413058</idno><idno type="doi">10.3748/wjg.v18.i29.3862</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000D52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Moro</italic> orange juice prevents fatty liver in mice</title><author><name sortKey="Salamone, Federico" sort="Salamone, Federico" uniqKey="Salamone F" first="Federico" last="Salamone">Federico Salamone</name></author><author><name sortKey="Li Volti, Giovanni" sort="Li Volti, Giovanni" uniqKey="Li Volti G" first="Giovanni" last="Li Volti">Giovanni Li Volti</name></author><author><name sortKey="Titta, Lucilla" sort="Titta, Lucilla" uniqKey="Titta L" first="Lucilla" last="Titta">Lucilla Titta</name></author><author><name sortKey="Puzzo, Lidia" sort="Puzzo, Lidia" uniqKey="Puzzo L" first="Lidia" last="Puzzo">Lidia Puzzo</name></author><author><name sortKey="Barbagallo, Ignazio" sort="Barbagallo, Ignazio" uniqKey="Barbagallo I" first="Ignazio" last="Barbagallo">Ignazio Barbagallo</name></author><author><name sortKey="La Delia, Francesco" sort="La Delia, Francesco" uniqKey="La Delia F" first="Francesco" last="La Delia">Francesco La Delia</name></author><author><name sortKey="Zelber Sagi, Shira" sort="Zelber Sagi, Shira" uniqKey="Zelber Sagi S" first="Shira" last="Zelber-Sagi">Shira Zelber-Sagi</name></author><author><name sortKey="Malaguarnera, Michele" sort="Malaguarnera, Michele" uniqKey="Malaguarnera M" first="Michele" last="Malaguarnera">Michele Malaguarnera</name></author><author><name sortKey="Pelicci, Pier Giuseppe" sort="Pelicci, Pier Giuseppe" uniqKey="Pelicci P" first="Pier Giuseppe" last="Pelicci">Pier Giuseppe Pelicci</name></author><author><name sortKey="Giorgio, Marco" sort="Giorgio, Marco" uniqKey="Giorgio M" first="Marco" last="Giorgio">Marco Giorgio</name></author><author><name sortKey="Galvano, Fabio" sort="Galvano, Fabio" uniqKey="Galvano F" first="Fabio" last="Galvano">Fabio Galvano</name></author></analytic><series><title level="j">World Journal of Gastroenterology : WJG</title><idno type="ISSN">1007-9327</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>AIM: To establish if the juice of <italic>Moro</italic>, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity.</p><p>METHODS: Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or <italic>Moro</italic> juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed.</p><p>RESULTS: Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. <italic>Moro</italic> juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary <italic>Moro</italic> juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, <italic>Moro</italic> juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity.</p><p>CONCLUSION: <italic>Moro</italic> juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><publisher><publisher-name>Baishideng Publishing Group Co., Limited</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22876038</article-id><article-id pub-id-type="pmc">3413058</article-id><article-id pub-id-type="other">jWJG.v18.i29.pg3862</article-id><article-id pub-id-type="doi">10.3748/wjg.v18.i29.3862</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Article</subject></subj-group></article-categories><title-group><article-title><italic>Moro</italic> orange juice prevents fatty liver in mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Salamone</surname><given-names>Federico</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li Volti</surname><given-names>Giovanni</given-names></name></contrib><contrib contrib-type="author"><name><surname>Titta</surname><given-names>Lucilla</given-names></name></contrib><contrib contrib-type="author"><name><surname>Puzzo</surname><given-names>Lidia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Barbagallo</surname><given-names>Ignazio</given-names></name></contrib><contrib contrib-type="author"><name><surname>La Delia</surname><given-names>Francesco</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zelber-Sagi</surname><given-names>Shira</given-names></name></contrib><contrib contrib-type="author"><name><surname>Malaguarnera</surname><given-names>Michele</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pelicci</surname><given-names>Pier Giuseppe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Giorgio</surname><given-names>Marco</given-names></name></contrib><contrib contrib-type="author"><name><surname>Galvano</surname><given-names>Fabio</given-names></name></contrib><aff>Federico Salamone, Department of Internal Medicine, University of Catania, 95123 Catania, Italy</aff><aff>Giovanni Li Volti, Ignazio Barbagallo, Francesco La Delia, Michele Malaguarnera, Fabio Galvano, Department of Drug Sciences, University of Catania, 95125 Catania, Italy</aff><aff>Lucilla Titta, Pier Giuseppe Pelicci, Marco Giorgio, Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy</aff><aff>Lidia Puzzo, Department of Pathology, University of Catania, 95123 Catania, Italy</aff><aff>Shira Zelber-Sagi, Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel</aff></contrib-group><author-notes><fn><p>Author contributions: Salamone F designed the study, performed the experiments, analyzed the data and wrote the manuscript; Li Volti G performed the experiments, analyzed the data and critically reviewed the manuscript; Titta L designed the study, performed the experiments, analyzed the data and critically reviewed the manuscript; Puzzo L, Barbagallo I and La Delia F performed the experiments and analyzed the data; Zelber-Sagi S and Pelicci PG critically reviewed the manuscript; Malaguarnera M performed the experiments, analyzed the data and critically reviewed the manuscript; Giorgio M designed the study, performed the experiments, analyzed the data and critically reviewed the manuscript; Galvano F designed the study, analyzed the data and contributed to writing of the manuscript.</p><p>Correspondence to: Federico Salamone, MD, Department of Internal Medicine, University of Catania, Via Santa Sofia, 78, 95123 Catania, Italy. <email>federicosalamone@yahoo.it</email></p><p>Telephone: +39-320-6990366 Fax: +39-095-7384220</p></fn></author-notes><pub-date pub-type="ppub"><day>7</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>7</day><month>8</month><year>2012</year></pub-date><volume>18</volume><issue>29</issue><fpage>3862</fpage><lpage>3868</lpage><history><date date-type="received"><day>29</day><month>10</month><year>2011</year></date><date date-type="rev-recd"><day>16</day><month>2</month><year>2012</year></date><date date-type="accepted"><day>10</day><month>4</month><year>2012</year></date></history><permissions><copyright-statement>©2012 Baishideng Publishing Group Co., Limited. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p>AIM: To establish if the juice of <italic>Moro</italic>, an anthocyanin-rich orange, may improve liver damage in mice with diet-induced obesity.</p><p>METHODS: Eight-week-old mice were fed a high-fat diet (HFD) and were administrated water or <italic>Moro</italic> juice for 12 wk. Liver morphology, gene expression of lipid transcription factors, and metabolic enzymes were assessed.</p><p>RESULTS: Mice fed HFD displayed increased body weight, insulin resistance and dyslipidemia. <italic>Moro</italic> juice administration limited body weight gain, enhanced insulin sensitivity, and decreased serum triglycerides and total cholesterol. Mice fed HFD showed liver steatosis associated with ballooning. Dietary <italic>Moro</italic> juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase, a key enzyme of lipid oxidation. Consistently, <italic>Moro</italic> juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase, and restored liver glycerol-3-phosphate acyltransferase 1 activity.</p><p>CONCLUSION: <italic>Moro</italic> juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.</p></abstract><kwd-group><kwd>Liver steatosis</kwd><kwd>Anthocyanins</kwd><kwd>Lipogenesis</kwd><kwd>Lipid oxidation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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