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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Engineered Biosynthesis of Natural Products in Heterologous Hosts</title><author><name sortKey="Luo, Yunzi" sort="Luo, Yunzi" uniqKey="Luo Y" first="Yunzi" last="Luo">Yunzi Luo</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff></affiliation></author><author><name sortKey="Li, Bing Zhi" sort="Li, Bing Zhi" uniqKey="Li B" first="Bing-Zhi" last="Li">Bing-Zhi Li</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Liu, Duo" sort="Liu, Duo" uniqKey="Liu D" first="Duo" last="Liu">Duo Liu</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zeng, Bo Xuan" sort="Zeng, Bo Xuan" uniqKey="Zeng B" first="Bo-Xuan" last="Zeng">Bo-Xuan Zeng</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Huimin" sort="Zhao, Huimin" uniqKey="Zhao H" first="Huimin" last="Zhao">Huimin Zhao</name><affiliation><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff></affiliation></author><author><name sortKey="Yuan, Ying Jin" sort="Yuan, Ying Jin" uniqKey="Yuan Y" first="Ying-Jin" last="Yuan">Ying-Jin Yuan</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25960127</idno><idno type="pmc">4510016</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510016</idno><idno type="RBID">PMC:4510016</idno><idno type="doi">10.1039/c5cs00025d</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000D53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Engineered Biosynthesis of Natural Products in Heterologous Hosts</title><author><name sortKey="Luo, Yunzi" sort="Luo, Yunzi" uniqKey="Luo Y" first="Yunzi" last="Luo">Yunzi Luo</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff></affiliation></author><author><name sortKey="Li, Bing Zhi" sort="Li, Bing Zhi" uniqKey="Li B" first="Bing-Zhi" last="Li">Bing-Zhi Li</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Liu, Duo" sort="Liu, Duo" uniqKey="Liu D" first="Duo" last="Liu">Duo Liu</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Jia, Bin" sort="Jia, Bin" uniqKey="Jia B" first="Bin" last="Jia">Bin Jia</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zeng, Bo Xuan" sort="Zeng, Bo Xuan" uniqKey="Zeng B" first="Bo-Xuan" last="Zeng">Bo-Xuan Zeng</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Huimin" sort="Zhao, Huimin" uniqKey="Zhao H" first="Huimin" last="Zhao">Huimin Zhao</name><affiliation><nlm:aff id="A3">Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</nlm:aff></affiliation></author><author><name sortKey="Yuan, Ying Jin" sort="Yuan, Ying Jin" uniqKey="Yuan Y" first="Ying-Jin" last="Yuan">Ying-Jin Yuan</name><affiliation><nlm:aff id="A1">Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</nlm:aff></affiliation></author></analytic><series><title level="j">Chemical Society reviews</title><idno type="ISSN">0306-0012</idno><idno type="eISSN">1460-4744</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0335405</journal-id><journal-id journal-id-type="pubmed-jr-id">29764</journal-id><journal-id journal-id-type="nlm-ta">Chem Soc Rev</journal-id><journal-id journal-id-type="iso-abbrev">Chem Soc Rev</journal-id><journal-title-group><journal-title>Chemical Society reviews</journal-title></journal-title-group><issn pub-type="ppub">0306-0012</issn><issn pub-type="epub">1460-4744</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25960127</article-id><article-id pub-id-type="pmc">4510016</article-id><article-id pub-id-type="doi">10.1039/c5cs00025d</article-id><article-id pub-id-type="manuscript">NIHMS689761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Engineered Biosynthesis of Natural Products in Heterologous Hosts</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Yunzi</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="author-notes" rid="FN2">#</xref><xref ref-type="author-notes" rid="FN1">+</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Bing-Zhi</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="author-notes" rid="FN1">+</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Duo</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="author-notes" rid="FN1">+</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Jia</surname><given-names>Bin</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Zeng</surname><given-names>Bo-Xuan</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Huimin</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Ying-Jin</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, PR China</aff><aff id="A2"><label>b</label>SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China</aff><aff id="A3"><label>c</label>Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author: Y-J Yuan, <email>yjyuan@tju.edu.cn</email>; Fax: +86-22-27403888</corresp><fn fn-type="equal" id="FN1"><label>+</label><p id="P1">Equal contribution</p></fn><fn fn-type="present-address" id="FN2"><label>#</label><p id="P2">Current address: State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China. Renmin South Road 3, NO.17, Chengdu, Sichuan, 610041, P R China.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>7</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>8</month><year>2016</year></pub-date><volume>44</volume><issue>15</issue><fpage>5265</fpage><lpage>5290</lpage><pmc-comment>elocation-id from pubmed: 10.1039/c5cs00025d</pmc-comment>
<abstract><p id="P3">Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.</p></abstract><kwd-group><kwd>synthetic biology</kwd><kwd>chassis</kwd><kwd>heterologous biosynthesis</kwd><kwd>natural products</kwd><kwd>terpenoids</kwd><kwd>alkaloids</kwd><kwd>flavonoids</kwd><kwd>polyketides</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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