Blood orange juice inhibits fat accumulation in mice
Identifieur interne : 000252 ( PascalFrancis/Checkpoint ); précédent : 000251; suivant : 000253Blood orange juice inhibits fat accumulation in mice
Auteurs : L. Titta [Italie] ; M. Trinei [Italie] ; M. Stendardo [Italie] ; I. Berniakovich [Italie] ; K. Petroni [Italie] ; C. Tonelli [Italie] ; P. Riso [Italie] ; M. Porrini [Italie] ; S. Minucci [Italie] ; P. G. Pelicci [Italie] ; P. Rapisarda [Italie] ; G. Reforgiato Recupero [Italie] ; M. Giorgio [Italie]Source :
- International journal of obesity [ 0307-0565 ] ; 2010.
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- topic : Nutrition.
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Abstract
Objective: To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Methods: Obesity was induced in male C57/B16 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight and food intake were measured regularly over a 12-week period. The adipose pads were weighted and analyzed histologically; total RNA was also isolated for microarray analysis. Results: Dietary supplementation of Moro juice, but not Navelina juice significantly reduced body weight gain and fat accumulation regardless of the increased energy intake because of sugar content. Furthermore, mice drinking Moro juice were resistant to HFD-induced obesity with no alterations in food intake. Only the anthocyanin extract, but not the purified C3G, slightly affected fat accumulation. High-throughput gene expression analysis of fat tissues confirmed that Moro juice could entirely rescue the high fat-induced transcriptional reprogramming. Conclusion: Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Our findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation.
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Titta</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Trinei, M" sort="Trinei, M" uniqKey="Trinei M" first="M." last="Trinei">M. Trinei</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Congenia Srl</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stendardo, M" sort="Stendardo, M" uniqKey="Stendardo M" first="M." last="Stendardo">M. Stendardo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Berniakovich, I" sort="Berniakovich, I" uniqKey="Berniakovich I" first="I." last="Berniakovich">I. Berniakovich</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Petroni, K" sort="Petroni, K" uniqKey="Petroni K" first="K." last="Petroni">K. Petroni</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tonelli, C" sort="Tonelli, C" uniqKey="Tonelli C" first="C." last="Tonelli">C. Tonelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Riso, P" sort="Riso, P" uniqKey="Riso P" first="P." last="Riso">P. Riso</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Porrini, M" sort="Porrini, M" uniqKey="Porrini M" first="M." last="Porrini">M. Porrini</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Minucci, S" sort="Minucci, S" uniqKey="Minucci S" first="S." last="Minucci">S. Minucci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pelicci, P G" sort="Pelicci, P G" uniqKey="Pelicci P" first="P. G." last="Pelicci">P. G. Pelicci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rapisarda, P" sort="Rapisarda, P" uniqKey="Rapisarda P" first="P." last="Rapisarda">P. Rapisarda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</s1><s2>Acireale</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</wicri:noRegion></affiliation></author><author><name sortKey="Reforgiato Recupero, G" sort="Reforgiato Recupero, G" uniqKey="Reforgiato Recupero G" first="G." last="Reforgiato Recupero">G. Reforgiato Recupero</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</s1><s2>Acireale</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</wicri:noRegion></affiliation></author><author><name sortKey="Giorgio, M" sort="Giorgio, M" uniqKey="Giorgio M" first="M." last="Giorgio">M. Giorgio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0150578</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0150578 INIST</idno><idno type="RBID">Pascal:10-0150578</idno><idno type="wicri:Area/PascalFrancis/Corpus">000260</idno><idno type="wicri:Area/PascalFrancis/Curation">000740</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000252</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Blood orange juice inhibits fat accumulation in mice</title><author><name sortKey="Titta, L" sort="Titta, L" uniqKey="Titta L" first="L." last="Titta">L. Titta</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Trinei, M" sort="Trinei, M" uniqKey="Trinei M" first="M." last="Trinei">M. Trinei</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Congenia Srl</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Stendardo, M" sort="Stendardo, M" uniqKey="Stendardo M" first="M." last="Stendardo">M. Stendardo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Berniakovich, I" sort="Berniakovich, I" uniqKey="Berniakovich I" first="I." last="Berniakovich">I. Berniakovich</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Petroni, K" sort="Petroni, K" uniqKey="Petroni K" first="K." last="Petroni">K. Petroni</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tonelli, C" sort="Tonelli, C" uniqKey="Tonelli C" first="C." last="Tonelli">C. Tonelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Riso, P" sort="Riso, P" uniqKey="Riso P" first="P." last="Riso">P. Riso</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Porrini, M" sort="Porrini, M" uniqKey="Porrini M" first="M." last="Porrini">M. Porrini</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Minucci, S" sort="Minucci, S" uniqKey="Minucci S" first="S." last="Minucci">S. Minucci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pelicci, P G" sort="Pelicci, P G" uniqKey="Pelicci P" first="P. G." last="Pelicci">P. G. Pelicci</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rapisarda, P" sort="Rapisarda, P" uniqKey="Rapisarda P" first="P." last="Rapisarda">P. Rapisarda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</s1><s2>Acireale</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</wicri:noRegion></affiliation></author><author><name sortKey="Reforgiato Recupero, G" sort="Reforgiato Recupero, G" uniqKey="Reforgiato Recupero G" first="G." last="Reforgiato Recupero">G. Reforgiato Recupero</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</s1><s2>Acireale</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</wicri:noRegion></affiliation></author><author><name sortKey="Giorgio, M" sort="Giorgio, M" uniqKey="Giorgio M" first="M." last="Giorgio">M. Giorgio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of obesity</title><title level="j" type="abbreviated">Int. j. obes.</title><idno type="ISSN">0307-0565</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of obesity</title><title level="j" type="abbreviated">Int. j. obes.</title><idno type="ISSN">0307-0565</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accumulation</term><term>Animal</term><term>Anthocyanin</term><term>Anti-obesity agent</term><term>Blood</term><term>Fat</term><term>Inhibitor</term><term>Metabolic diseases</term><term>Mouse</term><term>Nutrition</term><term>Nutritional status</term><term>Obesity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Sang</term><term>Inhibiteur</term><term>Matière grasse</term><term>Accumulation</term><term>Animal</term><term>Souris</term><term>Anti-obésité</term><term>Anthocyane</term><term>Maladie métabolique</term><term>Nutrition</term><term>Obésité</term><term>Etat nutritionnel</term><term>Chrysanthémine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Nutrition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Methods: Obesity was induced in male C57/B16 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight and food intake were measured regularly over a 12-week period. The adipose pads were weighted and analyzed histologically; total RNA was also isolated for microarray analysis. Results: Dietary supplementation of Moro juice, but not Navelina juice significantly reduced body weight gain and fat accumulation regardless of the increased energy intake because of sugar content. Furthermore, mice drinking Moro juice were resistant to HFD-induced obesity with no alterations in food intake. Only the anthocyanin extract, but not the purified C3G, slightly affected fat accumulation. High-throughput gene expression analysis of fat tissues confirmed that Moro juice could entirely rescue the high fat-induced transcriptional reprogramming. Conclusion: Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Our findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0307-0565</s0></fA01><fA02 i1="01"><s0>IJOBDP</s0></fA02><fA03 i2="1"><s0>Int. j. obes.</s0></fA03><fA05><s2>34</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Blood orange juice inhibits fat accumulation in mice</s1></fA08><fA11 i1="01" i2="1"><s1>TITTA (L.)</s1></fA11><fA11 i1="02" i2="1"><s1>TRINEI (M.)</s1></fA11><fA11 i1="03" i2="1"><s1>STENDARDO (M.)</s1></fA11><fA11 i1="04" i2="1"><s1>BERNIAKOVICH (I.)</s1></fA11><fA11 i1="05" i2="1"><s1>PETRONI (K.)</s1></fA11><fA11 i1="06" i2="1"><s1>TONELLI (C.)</s1></fA11><fA11 i1="07" i2="1"><s1>RISO (P.)</s1></fA11><fA11 i1="08" i2="1"><s1>PORRINI (M.)</s1></fA11><fA11 i1="09" i2="1"><s1>MINUCCI (S.)</s1></fA11><fA11 i1="10" i2="1"><s1>PELICCI (P. G.)</s1></fA11><fA11 i1="11" i2="1"><s1>RAPISARDA (P.)</s1></fA11><fA11 i1="12" i2="1"><s1>REFORGIATO RECUPERO (G.)</s1></fA11><fA11 i1="13" i2="1"><s1>GIORGIO (M.)</s1></fA11><fA14 i1="01"><s1>Department of Experimental Oncology, European Institute of Oncology (IEO)</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Food Science and Microbiology (DISTAM), Division of Human Nutrition University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Congenia Srl</s1><s2>Milan</s2><s3>ITA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Biomolecular Sciences and Biotechnology, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="05"><s1>Research Center for Citric culture and Mediterranean Crops (CRA-ACM)</s1><s2>Acireale</s2><s3>ITA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA20><s1>578-588</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18243</s2><s5>354000181622720190</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0150578</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>International journal of obesity</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective: To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD). Methods: Obesity was induced in male C57/B16 mice by feeding a HFD. Moro and Navelina juices were provided instead of water. The effect of an anthocyanin-enriched extract from Moro oranges or purified cyanidin-3-glucoside (C3G) was also analyzed. Body weight and food intake were measured regularly over a 12-week period. The adipose pads were weighted and analyzed histologically; total RNA was also isolated for microarray analysis. Results: Dietary supplementation of Moro juice, but not Navelina juice significantly reduced body weight gain and fat accumulation regardless of the increased energy intake because of sugar content. Furthermore, mice drinking Moro juice were resistant to HFD-induced obesity with no alterations in food intake. Only the anthocyanin extract, but not the purified C3G, slightly affected fat accumulation. High-throughput gene expression analysis of fat tissues confirmed that Moro juice could entirely rescue the high fat-induced transcriptional reprogramming. Conclusion: Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content. Our findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation.</s0></fC01><fC02 i1="01" i2="X"><s0>002B22B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Sang</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Blood</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sangre</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Inhibiteur</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Inhibitor</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Inhibidor</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Matière grasse</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Fat</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Materia grasa</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Accumulation</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Accumulation</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Acumulación</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Animal</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Animal</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Animal</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Souris</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Mouse</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Ratón</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Anti-obésité</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Anti-obesity agent</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Anti-obesidad</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Anthocyane</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Anthocyanin</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Antocianina</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Maladie métabolique</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Metabolic diseases</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Metabolismo patología</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Nutrition</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Nutrition</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Nutrición</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Obésité</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Obesity</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Obesidad</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Etat nutritionnel</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Nutritional status</s0><s5>25</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Estado nutricional</s0><s5>25</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Chrysanthémine</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Trouble de la nutrition</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Nutrition disorder</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Trastorno nutricíon</s0><s5>37</s5></fC07><fN21><s1>095</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Titta, L" sort="Titta, L" uniqKey="Titta L" first="L." last="Titta">L. Titta</name></region><name sortKey="Berniakovich, I" sort="Berniakovich, I" uniqKey="Berniakovich I" first="I." last="Berniakovich">I. Berniakovich</name><name sortKey="Giorgio, M" sort="Giorgio, M" uniqKey="Giorgio M" first="M." last="Giorgio">M. Giorgio</name><name sortKey="Minucci, S" sort="Minucci, S" uniqKey="Minucci S" first="S." last="Minucci">S. Minucci</name><name sortKey="Minucci, S" sort="Minucci, S" uniqKey="Minucci S" first="S." last="Minucci">S. Minucci</name><name sortKey="Pelicci, P G" sort="Pelicci, P G" uniqKey="Pelicci P" first="P. G." last="Pelicci">P. G. Pelicci</name><name sortKey="Pelicci, P G" sort="Pelicci, P G" uniqKey="Pelicci P" first="P. G." last="Pelicci">P. G. Pelicci</name><name sortKey="Petroni, K" sort="Petroni, K" uniqKey="Petroni K" first="K." last="Petroni">K. Petroni</name><name sortKey="Porrini, M" sort="Porrini, M" uniqKey="Porrini M" first="M." last="Porrini">M. Porrini</name><name sortKey="Rapisarda, P" sort="Rapisarda, P" uniqKey="Rapisarda P" first="P." last="Rapisarda">P. Rapisarda</name><name sortKey="Reforgiato Recupero, G" sort="Reforgiato Recupero, G" uniqKey="Reforgiato Recupero G" first="G." last="Reforgiato Recupero">G. Reforgiato Recupero</name><name sortKey="Riso, P" sort="Riso, P" uniqKey="Riso P" first="P." last="Riso">P. Riso</name><name sortKey="Stendardo, M" sort="Stendardo, M" uniqKey="Stendardo M" first="M." last="Stendardo">M. Stendardo</name><name sortKey="Titta, L" sort="Titta, L" uniqKey="Titta L" first="L." last="Titta">L. Titta</name><name sortKey="Tonelli, C" sort="Tonelli, C" uniqKey="Tonelli C" first="C." last="Tonelli">C. Tonelli</name><name sortKey="Trinei, M" sort="Trinei, M" uniqKey="Trinei M" first="M." last="Trinei">M. Trinei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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