Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease.
Identifieur interne : 000835 ( Ncbi/Curation ); précédent : 000834; suivant : 000836Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease.
Auteurs : Christine Dalg Rd [Danemark] ; Flemming Nielsen ; Jason D. Morrow ; Henrik Enghusen-Poulsen ; Torbjörn Jonung ; Mogens H Rder ; Moniek P M. De MaatSource :
- The British journal of nutrition [ 1475-2662 ] ; 2009.
English descriptors
- KwdEn :
- Antioxidants (administration & dosage), Beverages, Biomarkers (blood), C-Reactive Protein (analysis), Citrus sinensis, Dietary Supplements, Female, Fibrinogen (analysis), Humans, Interleukin-6 (blood), Male, Middle Aged, Multivariate Analysis, Oxidative Stress, Peripheral Vascular Diseases (blood), Peripheral Vascular Diseases (diet therapy), Ribes, Statistics, Nonparametric, Vitamin E (administration & dosage), von Willebrand Factor (analysis).
- MESH :
- chemical , administration & dosage : Antioxidants, Vitamin E.
- chemical , analysis : C-Reactive Protein, Fibrinogen, von Willebrand Factor.
- chemical , blood : Biomarkers, Interleukin-6.
- blood : Peripheral Vascular Diseases.
- diet therapy : Peripheral Vascular Diseases.
- Beverages, Citrus sinensis, Dietary Supplements, Female, Humans, Male, Middle Aged, Multivariate Analysis, Oxidative Stress, Ribes, Statistics, Nonparametric.
Abstract
Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P<0.008 and P<0.002, respectively). No significant differences were measured for IL-6 and the endothelial activation markers von Willebrand factor, tissue-plasminogen activator and plasmin activator inhibitor-1. Vitamin E supplementation had no significant effects on the various markers. We observed no significant interaction between juice and vitamin E. In this study, orange and blackcurrant juice reduced markers of inflammation, but not markers of endothelial activation, in patients with peripheral arterial disease, relative to sugar drinks.
DOI: 10.1017/S0007114508995660
PubMed: 18507878
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000986
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000986
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000986
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000835
Links to Exploration step
pubmed:18507878Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease.</title>
<author><name sortKey="Dalg Rd, Christine" sort="Dalg Rd, Christine" uniqKey="Dalg Rd C" first="Christine" last="Dalg Rd">Christine Dalg Rd</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Unit of Biochemistry, Pharmacology and Genetics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. cdalgaard@health.sdu.dk</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Research Unit of Biochemistry, Pharmacology and Genetics, Institute of Clinical Research, University of Southern Denmark, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nielsen, Flemming" sort="Nielsen, Flemming" uniqKey="Nielsen F" first="Flemming" last="Nielsen">Flemming Nielsen</name>
</author>
<author><name sortKey="Morrow, Jason D" sort="Morrow, Jason D" uniqKey="Morrow J" first="Jason D" last="Morrow">Jason D. Morrow</name>
</author>
<author><name sortKey="Enghusen Poulsen, Henrik" sort="Enghusen Poulsen, Henrik" uniqKey="Enghusen Poulsen H" first="Henrik" last="Enghusen-Poulsen">Henrik Enghusen-Poulsen</name>
</author>
<author><name sortKey="Jonung, Torbjorn" sort="Jonung, Torbjorn" uniqKey="Jonung T" first="Torbjörn" last="Jonung">Torbjörn Jonung</name>
</author>
<author><name sortKey="H Rder, Mogens" sort="H Rder, Mogens" uniqKey="H Rder M" first="Mogens" last="H Rder">Mogens H Rder</name>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:18507878</idno>
<idno type="pmid">18507878</idno>
<idno type="doi">10.1017/S0007114508995660</idno>
<idno type="wicri:Area/PubMed/Corpus">000986</idno>
<idno type="wicri:Area/PubMed/Curation">000986</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000986</idno>
<idno type="wicri:Area/Ncbi/Merge">000835</idno>
<idno type="wicri:Area/Ncbi/Curation">000835</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease.</title>
<author><name sortKey="Dalg Rd, Christine" sort="Dalg Rd, Christine" uniqKey="Dalg Rd C" first="Christine" last="Dalg Rd">Christine Dalg Rd</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Unit of Biochemistry, Pharmacology and Genetics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. cdalgaard@health.sdu.dk</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Research Unit of Biochemistry, Pharmacology and Genetics, Institute of Clinical Research, University of Southern Denmark, Odense</wicri:regionArea>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nielsen, Flemming" sort="Nielsen, Flemming" uniqKey="Nielsen F" first="Flemming" last="Nielsen">Flemming Nielsen</name>
</author>
<author><name sortKey="Morrow, Jason D" sort="Morrow, Jason D" uniqKey="Morrow J" first="Jason D" last="Morrow">Jason D. Morrow</name>
</author>
<author><name sortKey="Enghusen Poulsen, Henrik" sort="Enghusen Poulsen, Henrik" uniqKey="Enghusen Poulsen H" first="Henrik" last="Enghusen-Poulsen">Henrik Enghusen-Poulsen</name>
</author>
<author><name sortKey="Jonung, Torbjorn" sort="Jonung, Torbjorn" uniqKey="Jonung T" first="Torbjörn" last="Jonung">Torbjörn Jonung</name>
</author>
<author><name sortKey="H Rder, Mogens" sort="H Rder, Mogens" uniqKey="H Rder M" first="Mogens" last="H Rder">Mogens H Rder</name>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name>
</author>
</analytic>
<series><title level="j">The British journal of nutrition</title>
<idno type="eISSN">1475-2662</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (administration & dosage)</term>
<term>Beverages</term>
<term>Biomarkers (blood)</term>
<term>C-Reactive Protein (analysis)</term>
<term>Citrus sinensis</term>
<term>Dietary Supplements</term>
<term>Female</term>
<term>Fibrinogen (analysis)</term>
<term>Humans</term>
<term>Interleukin-6 (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Oxidative Stress</term>
<term>Peripheral Vascular Diseases (blood)</term>
<term>Peripheral Vascular Diseases (diet therapy)</term>
<term>Ribes</term>
<term>Statistics, Nonparametric</term>
<term>Vitamin E (administration & dosage)</term>
<term>von Willebrand Factor (analysis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term>
<term>Vitamin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term>
<term>Fibrinogen</term>
<term>von Willebrand Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Peripheral Vascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Peripheral Vascular Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Beverages</term>
<term>Citrus sinensis</term>
<term>Dietary Supplements</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Oxidative Stress</term>
<term>Ribes</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P<0.008 and P<0.002, respectively). No significant differences were measured for IL-6 and the endothelial activation markers von Willebrand factor, tissue-plasminogen activator and plasmin activator inhibitor-1. Vitamin E supplementation had no significant effects on the various markers. We observed no significant interaction between juice and vitamin E. In this study, orange and blackcurrant juice reduced markers of inflammation, but not markers of endothelial activation, in patients with peripheral arterial disease, relative to sugar drinks.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000835 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000835 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:18507878 |texte= Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:18507878" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a OrangerV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |