[Anti-injure effect of extract from orange (EOP) peel on germ cells of male mice].
Identifieur interne : 000088 ( Ncbi/Curation ); précédent : 000087; suivant : 000089[Anti-injure effect of extract from orange (EOP) peel on germ cells of male mice].
Auteurs : Q. Liu ; Q. Jiao ; T. LiuSource :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [ 1001-4454 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Plant Extracts.
- chemical , antagonists & inhibitors : Cyclophosphamide.
- abnormalities : Spermatozoa.
- chemistry : Citrus sinensis.
- drug effects : Spermatids, Spermatozoa.
- chemical , pharmacology : Plant Extracts.
- Animals, Male, Mice, Micronucleus Tests.
Abstract
In present study, the anti-injure effect of EOP, on incidence of sperm abnormality and meiotic micronuclei of early spermatids in mice induced by cyclophosphamide was investigated. The results indicated that EOP itself was not a mutagen, but significantly inhibited increase of the rate of micronuclei and the sperm abnormality by CP. The rates of sperm abnormality and meiotic micronuclei of early spermatide of EOP before CP using group were lower obviously than those of CP could before EOP using group (P < 0.01). The results suggested that the CP could permeate blood-testis barrier into germ cells of male mice and induced mutation on genetic material.
PubMed: 12567978
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Q. Liu<affiliation><nlm:affiliation>Department of Biological Science and Technology, Nanjiang University, Nanjing 210093.</nlm:affiliation>
<wicri:noCountry code="subField">Nanjing 210093</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Liu, Q" sort="Liu, Q" uniqKey="Liu Q" first="Q" last="Liu">Q. Liu</name>
<affiliation><nlm:affiliation>Department of Biological Science and Technology, Nanjiang University, Nanjing 210093.</nlm:affiliation>
<wicri:noCountry code="subField">Nanjing 210093</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jiao, Q" sort="Jiao, Q" uniqKey="Jiao Q" first="Q" last="Jiao">Q. Jiao</name>
</author>
<author><name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
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<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1998">1998</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Anti-injure effect of extract from orange (EOP) peel on germ cells of male mice].</title>
<author><name sortKey="Liu, Q" sort="Liu, Q" uniqKey="Liu Q" first="Q" last="Liu">Q. Liu</name>
<affiliation><nlm:affiliation>Department of Biological Science and Technology, Nanjiang University, Nanjing 210093.</nlm:affiliation>
<wicri:noCountry code="subField">Nanjing 210093</wicri:noCountry>
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<author><name sortKey="Jiao, Q" sort="Jiao, Q" uniqKey="Jiao Q" first="Q" last="Jiao">Q. Jiao</name>
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<author><name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
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<series><title level="j">Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials</title>
<idno type="ISSN">1001-4454</idno>
<imprint><date when="1998" type="published">1998</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Citrus sinensis (chemistry)</term>
<term>Cyclophosphamide (antagonists & inhibitors)</term>
<term>Male</term>
<term>Mice</term>
<term>Micronucleus Tests</term>
<term>Plant Extracts (administration & dosage)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Spermatids (drug effects)</term>
<term>Spermatozoa (abnormalities)</term>
<term>Spermatozoa (drug effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cyclophosphamide</term>
</keywords>
<keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Spermatozoa</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Spermatids</term>
<term>Spermatozoa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Mice</term>
<term>Micronucleus Tests</term>
</keywords>
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<front><div type="abstract" xml:lang="en">In present study, the anti-injure effect of EOP, on incidence of sperm abnormality and meiotic micronuclei of early spermatids in mice induced by cyclophosphamide was investigated. The results indicated that EOP itself was not a mutagen, but significantly inhibited increase of the rate of micronuclei and the sperm abnormality by CP. The rates of sperm abnormality and meiotic micronuclei of early spermatide of EOP before CP using group were lower obviously than those of CP could before EOP using group (P < 0.01). The results suggested that the CP could permeate blood-testis barrier into germ cells of male mice and induced mutation on genetic material.</div>
</front>
</TEI>
</record>
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