A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Identifieur interne : 003294 ( PubMed/Curation ); précédent : 003293; suivant : 003295A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Auteurs : Martina Sanderson-Smith [Australie] ; David M P. De Oliveira [Australie] ; Julien Guglielmini [France] ; David J. Mcmillan [Australie] ; Therese Vu [Belgique] ; Jessica K. Holien [Australie] ; Anna Henningham ; Andrew C. Steer [Australie] ; Debra E. Bessen ; James B. Dale ; Nigel Curtis [Australie] ; Bernard W. Beall [Géorgie (pays)] ; Mark J. Walker ; Michael W. Parker [Australie] ; Jonathan R. Carapetis ; Laurence Van Melderen [Belgique] ; Kadaba S. Sriprakash ; Pierre R. Smeesters [Belgique]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2014.
Descripteurs français
- KwdFr :
- Clonage moléculaire, Données de séquences moléculaires, Phylogénie, Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Protéines recombinantes, Régulation de l'expression des gènes bactériens, Streptococcus pyogenes (), Streptococcus pyogenes (physiologie), Séquence d'acides aminés, Vaccins antistreptococciques (immunologie).
- MESH :
- génétique : Protéines bactériennes.
- immunologie : Vaccins antistreptococciques.
- métabolisme : Protéines bactériennes.
- physiologie : Streptococcus pyogenes.
- Clonage moléculaire, Données de séquences moléculaires, Phylogénie, Protéines recombinantes, Régulation de l'expression des gènes bactériens, Streptococcus pyogenes, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins, Streptococcal Vaccines (immunology), Streptococcus pyogenes (classification), Streptococcus pyogenes (physiology).
- MESH :
- chemical , genetics : Bacterial Proteins.
- chemical , immunology : Streptococcal Vaccines.
- chemical , metabolism : Bacterial Proteins.
- classification : Streptococcus pyogenes.
- physiology : Streptococcus pyogenes.
- Amino Acid Sequence, Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins.
Abstract
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
DOI: 10.1093/infdis/jiu260
PubMed: 24799598
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Anna Henningham<affiliation><nlm:affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</nlm:affiliation>
<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</nlm:affiliation>
<wicri:noCountry code="subField">Valhalla</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</nlm:affiliation>
<wicri:noCountry code="subField">Memphis</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</nlm:affiliation>
<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</nlm:affiliation>
<wicri:noCountry code="subField">Perth</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</nlm:affiliation>
<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
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Le document en format XML
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<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
</affiliation>
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<author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name>
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</affiliation>
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<author><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name>
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<wicri:noCountry code="subField">Valhalla</wicri:noCountry>
</affiliation>
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<author><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name>
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<wicri:noCountry code="subField">Memphis</wicri:noCountry>
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<author><name sortKey="Curtis, Nigel" sort="Curtis, Nigel" uniqKey="Curtis N" first="Nigel" last="Curtis">Nigel Curtis</name>
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<wicri:regionArea>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne</wicri:regionArea>
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<author><name sortKey="Beall, Bernard W" sort="Beall, Bernard W" uniqKey="Beall B" first="Bernard W" last="Beall">Bernard W. Beall</name>
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<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea>
</affiliation>
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<author><name sortKey="Walker, Mark J" sort="Walker, Mark J" uniqKey="Walker M" first="Mark J" last="Walker">Mark J. Walker</name>
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<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
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<author><name sortKey="Parker, Michael W" sort="Parker, Michael W" uniqKey="Parker M" first="Michael W" last="Parker">Michael W. Parker</name>
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<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
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<author><name sortKey="Carapetis, Jonathan R" sort="Carapetis, Jonathan R" uniqKey="Carapetis J" first="Jonathan R" last="Carapetis">Jonathan R. Carapetis</name>
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<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name>
<affiliation><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</nlm:affiliation>
<wicri:noCountry code="subField">Brisbane</wicri:noCountry>
</affiliation>
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<author><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name>
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<orgName type="university">Université libre de Bruxelles</orgName>
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<series><title level="j">The Journal of infectious diseases</title>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Cloning, Molecular</term>
<term>Gene Expression Regulation, Bacterial</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Recombinant Proteins</term>
<term>Streptococcal Vaccines (immunology)</term>
<term>Streptococcus pyogenes (classification)</term>
<term>Streptococcus pyogenes (physiology)</term>
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<term>Données de séquences moléculaires</term>
<term>Phylogénie</term>
<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Protéines recombinantes</term>
<term>Régulation de l'expression des gènes bactériens</term>
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<term>Streptococcus pyogenes (physiologie)</term>
<term>Séquence d'acides aminés</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Cloning, Molecular</term>
<term>Gene Expression Regulation, Bacterial</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Recombinant Proteins</term>
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<term>Données de séquences moléculaires</term>
<term>Phylogénie</term>
<term>Protéines recombinantes</term>
<term>Régulation de l'expression des gènes bactériens</term>
<term>Streptococcus pyogenes</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</div>
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<Month>09</Month>
<Day>27</Day>
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<DateCompleted><Year>2014</Year>
<Month>11</Month>
<Day>17</Day>
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<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
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<JournalIssue CitedMedium="Internet"><Volume>210</Volume>
<Issue>8</Issue>
<PubDate><Year>2014</Year>
<Month>Oct</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.</ArticleTitle>
<Pagination><MedlinePgn>1325-38</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiu260</ELocationID>
<Abstract><AbstractText>Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</AbstractText>
<CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sanderson-Smith</LastName>
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<ForeName>David M P</ForeName>
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<Author ValidYN="Y"><LastName>Guglielmini</LastName>
<ForeName>Julien</ForeName>
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<AffiliationInfo><Affiliation>Microbial Evolutionary Genomics, Département Génomes et Génétique, Institut Pasteur CNRS, UMR3525, Paris, France.</Affiliation>
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<AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, Australia.</Affiliation>
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<Initials>DE</Initials>
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<ForeName>James B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</Affiliation>
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<ForeName>Nigel</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Beall</LastName>
<ForeName>Bernard W</ForeName>
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<AffiliationInfo><Affiliation>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation>
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<Author ValidYN="Y"><LastName>Walker</LastName>
<ForeName>Mark J</ForeName>
<Initials>MJ</Initials>
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<Author ValidYN="Y"><LastName>Parker</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo><Affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carapetis</LastName>
<ForeName>Jonathan R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Van Melderen</LastName>
<ForeName>Laurence</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</Affiliation>
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<ForeName>Kadaba S</ForeName>
<Initials>KS</Initials>
<AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</Affiliation>
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<ForeName>Pierre R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</Affiliation>
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<Acronym>AI</Acronym>
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