A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Identifieur interne : 003406 ( PubMed/Corpus ); précédent : 003405; suivant : 003407A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Auteurs : Martina Sanderson-Smith ; David M P. De Oliveira ; Julien Guglielmini ; David J. Mcmillan ; Therese Vu ; Jessica K. Holien ; Anna Henningham ; Andrew C. Steer ; Debra E. Bessen ; James B. Dale ; Nigel Curtis ; Bernard W. Beall ; Mark J. Walker ; Michael W. Parker ; Jonathan R. Carapetis ; Laurence Van Melderen ; Kadaba S. Sriprakash ; Pierre R. SmeestersSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2014.
English descriptors
- KwdEn :
- Amino Acid Sequence, Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins, Streptococcal Vaccines (immunology), Streptococcus pyogenes (classification), Streptococcus pyogenes (physiology).
- MESH :
- chemical , genetics : Bacterial Proteins.
- chemical , immunology : Streptococcal Vaccines.
- chemical , metabolism : Bacterial Proteins.
- classification : Streptococcus pyogenes.
- physiology : Streptococcus pyogenes.
- Amino Acid Sequence, Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins.
Abstract
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
DOI: 10.1093/infdis/jiu260
PubMed: 24799598
Links to Exploration step
pubmed:24799598Le document en format XML
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<author><name sortKey="Vu, Therese" sort="Vu, Therese" uniqKey="Vu T" first="Therese" last="Vu">Therese Vu</name>
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<author><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name>
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<author><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name>
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<author><name sortKey="Curtis, Nigel" sort="Curtis, Nigel" uniqKey="Curtis N" first="Nigel" last="Curtis">Nigel Curtis</name>
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<author><name sortKey="Parker, Michael W" sort="Parker, Michael W" uniqKey="Parker M" first="Michael W" last="Parker">Michael W. Parker</name>
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</affiliation>
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<author><name sortKey="Carapetis, Jonathan R" sort="Carapetis, Jonathan R" uniqKey="Carapetis J" first="Jonathan R" last="Carapetis">Jonathan R. Carapetis</name>
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<author><name sortKey="Van Melderen, Laurence" sort="Van Melderen, Laurence" uniqKey="Van Melderen L" first="Laurence" last="Van Melderen">Laurence Van Melderen</name>
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</affiliation>
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<author><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name>
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</affiliation>
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<author><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name>
<affiliation><nlm:affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.</title>
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<author><name sortKey="Guglielmini, Julien" sort="Guglielmini, Julien" uniqKey="Guglielmini J" first="Julien" last="Guglielmini">Julien Guglielmini</name>
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</affiliation>
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<author><name sortKey="Vu, Therese" sort="Vu, Therese" uniqKey="Vu T" first="Therese" last="Vu">Therese Vu</name>
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<author><name sortKey="Henningham, Anna" sort="Henningham, Anna" uniqKey="Henningham A" first="Anna" last="Henningham">Anna Henningham</name>
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<author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name>
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</affiliation>
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<author><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name>
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</affiliation>
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<author><name sortKey="Beall, Bernard W" sort="Beall, Bernard W" uniqKey="Beall B" first="Bernard W" last="Beall">Bernard W. Beall</name>
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</affiliation>
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</affiliation>
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<author><name sortKey="Carapetis, Jonathan R" sort="Carapetis, Jonathan R" uniqKey="Carapetis J" first="Jonathan R" last="Carapetis">Jonathan R. Carapetis</name>
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</affiliation>
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<author><name sortKey="Van Melderen, Laurence" sort="Van Melderen, Laurence" uniqKey="Van Melderen L" first="Laurence" last="Van Melderen">Laurence Van Melderen</name>
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</affiliation>
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<author><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name>
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</affiliation>
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<author><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name>
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<series><title level="j">The Journal of infectious diseases</title>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Cloning, Molecular</term>
<term>Gene Expression Regulation, Bacterial</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Recombinant Proteins</term>
<term>Streptococcal Vaccines (immunology)</term>
<term>Streptococcus pyogenes (classification)</term>
<term>Streptococcus pyogenes (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Streptococcal Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Streptococcus pyogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Streptococcus pyogenes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Cloning, Molecular</term>
<term>Gene Expression Regulation, Bacterial</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
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<front><div type="abstract" xml:lang="en">Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</div>
</front>
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<Month>09</Month>
<Day>27</Day>
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<DateCompleted><Year>2014</Year>
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<Month>10</Month>
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<PubDate><Year>2014</Year>
<Month>Oct</Month>
<Day>15</Day>
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<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
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<ArticleTitle>A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.</ArticleTitle>
<Pagination><MedlinePgn>1325-38</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiu260</ELocationID>
<Abstract><AbstractText>Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</AbstractText>
<CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sanderson-Smith</LastName>
<ForeName>Martina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Oliveira</LastName>
<ForeName>David M P</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guglielmini</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Microbial Evolutionary Genomics, Département Génomes et Génétique, Institut Pasteur CNRS, UMR3525, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McMillan</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vu</LastName>
<ForeName>Therese</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holien</LastName>
<ForeName>Jessica K</ForeName>
<Initials>JK</Initials>
<AffiliationInfo><Affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Henningham</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steer</LastName>
<ForeName>Andrew C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bessen</LastName>
<ForeName>Debra E</ForeName>
<Initials>DE</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dale</LastName>
<ForeName>James B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Curtis</LastName>
<ForeName>Nigel</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beall</LastName>
<ForeName>Bernard W</ForeName>
<Initials>BW</Initials>
<AffiliationInfo><Affiliation>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walker</LastName>
<ForeName>Mark J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Parker</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo><Affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carapetis</LastName>
<ForeName>Jonathan R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Van Melderen</LastName>
<ForeName>Laurence</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sriprakash</LastName>
<ForeName>Kadaba S</ForeName>
<Initials>KS</Initials>
<AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smeesters</LastName>
<ForeName>Pierre R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</Affiliation>
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</Author>
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</Author>
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<Language>eng</Language>
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<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
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<Month>05</Month>
<Day>05</Day>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
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<ISSNLinking>0022-1899</ISSNLinking>
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</MeshHeading>
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<MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName>
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<MeshHeading><DescriptorName UI="D015964" MajorTopicYN="Y">Gene Expression Regulation, Bacterial</DescriptorName>
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</MeshHeading>
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<Keyword MajorTopicYN="N">epidemiology</Keyword>
<Keyword MajorTopicYN="N">fibrinogen</Keyword>
<Keyword MajorTopicYN="N">molecular typing</Keyword>
<Keyword MajorTopicYN="N">plasminogen</Keyword>
<Keyword MajorTopicYN="N">vaccine</Keyword>
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