Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women.
Identifieur interne : 003293 ( PubMed/Curation ); précédent : 003292; suivant : 003294Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women.
Auteurs : Myrto Barrdahl ; Federico Canzian [Allemagne] ; Amit D. Joshi [États-Unis] ; Ruth C. Travis [Royaume-Uni] ; Jenny Chang-Claude ; Paul L. Auer [États-Unis] ; Susan M. Gapstur [États-Unis] ; Mia Gaudet [États-Unis] ; W Ryan Diver [États-Unis] ; Brian E. Henderson [États-Unis] ; Christopher A. Haiman [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; Loïc Le Marchand [États-Unis] ; Christine D. Berg [États-Unis] ; Stephen J. Chanock [États-Unis] ; Robert N. Hoover [États-Unis] ; Anja Rudolph ; Regina G. Ziegler [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [Australie] ; Gianluca Severi [Australie] ; Susan E. Hankinson [États-Unis] ; Sara Lindström [États-Unis] ; Walter Willet [États-Unis] ; David J. Hunter [États-Unis] ; Julie E. Buring [États-Unis] ; I-Min Lee [États-Unis] ; Shumin Zhang [États-Unis] ; Laure Dossus [France] ; David G. Cox [France] ; Kay-Tee Khaw [Royaume-Uni] ; Eiliv Lund [Norvège] ; Alessio Naccarati [Italie] ; Petra H. Peeters [Pays-Bas] ; J Ram N Quir S [Espagne] ; Elio Riboli [Royaume-Uni] ; Malin Sund [Suède] ; Dimitrios Trichopoulos [Grèce] ; Ross L. Prentice [États-Unis] ; Peter Kraft [États-Unis] ; Rudolf Kaaks ; Daniele Campa [Allemagne]Source :
- Human molecular genetics [ 1460-2083 ] ; 2014.
Descripteurs français
- KwdFr :
- Allèles, Cartographie chromosomique, Femelle, Génotype, Humains, Interaction entre gènes et environnement, Marqueurs biologiques tumoraux, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Risque, Tumeurs du sein (épidémiologie), Tumeurs du sein (étiologie), Étude d'association pangénomique, Études cas-témoins.
- MESH :
- épidémiologie : Tumeurs du sein.
- étiologie : Tumeurs du sein.
- Allèles, Cartographie chromosomique, Femelle, Génotype, Humains, Interaction entre gènes et environnement, Marqueurs biologiques tumoraux, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Risque, Étude d'association pangénomique, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- chemical : Biomarkers, Tumor.
- epidemiology : Breast Neoplasms.
- etiology : Breast Neoplasms.
- Alleles, Case-Control Studies, Chromosome Mapping, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, Risk.
Abstract
We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (Pinteraction = 8.84 × 10(-4)) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC.
DOI: 10.1093/hmg/ddu223
PubMed: 24895409
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Myrto Barrdahl<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
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Le document en format XML
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<author><name sortKey="Willet, Walter" sort="Willet, Walter" uniqKey="Willet W" first="Walter" last="Willet">Walter Willet</name>
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<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
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<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
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<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E" last="Buring">Julie E. Buring</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
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<author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
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<author><name sortKey="Zhang, Shumin" sort="Zhang, Shumin" uniqKey="Zhang S" first="Shumin" last="Zhang">Shumin Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
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<author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif F-94805, France Paris South University, Villejuif F-94807, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif F-94805, France Paris South University, Villejuif F-94807</wicri:regionArea>
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<author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G" last="Cox">David G. Cox</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK Université de Lyon, Université Lyon 1, ISPB, Lyon F-69007, France INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69008, France Centre Léon Bérard, Lyon F-69008, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ, UK Université de Lyon, Université Lyon 1, ISPB, Lyon F-69007, France INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69008, France Centre Léon Bérard, Lyon F-69008</wicri:regionArea>
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<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP</wicri:regionArea>
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<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Community Medicine, University of Tromsø, Tromsø N-9037, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Community Medicine, University of Tromsø, Tromsø N-9037</wicri:regionArea>
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<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular and Genetic Epidemiology Unit, Human Genetics Foundation Torino, Torino I-10126, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Molecular and Genetic Epidemiology Unit, Human Genetics Foundation Torino, Torino I-10126</wicri:regionArea>
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<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3584 CS, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ, UK Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3584 CS</wicri:regionArea>
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<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J Ram N" last="Quir S">J Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:affiliation>Public Health Directorate, Asturias ES-CP33006, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Directorate, Asturias ES-CP33006</wicri:regionArea>
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<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ</wicri:regionArea>
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<author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå S-90185, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå S-90185</wicri:regionArea>
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</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Bureau of Epidemiologic Research, Academy of Athens, Athens 10679, Greece Hellenic Health Foundation, Athens 11527, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Bureau of Epidemiologic Research, Academy of Athens, Athens 10679, Greece Hellenic Health Foundation, Athens 11527</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Division of Cancer Epidemiology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and d.campa@dkfz.de.</nlm:affiliation>
<country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women.</title>
<author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Division of Cancer Epidemiology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation wicri:level="1"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg D-69120, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg D-69120</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D" last="Joshi">Amit D. Joshi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Division of Cancer Epidemiology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L" last="Auer">Paul L. Auer</name>
<affiliation wicri:level="1"><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA School of Public Health, University of Wisconsin, Milwaukee, WI 1240, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA School of Public Health, University of Wisconsin, Milwaukee, WI 1240</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia" sort="Gaudet, Mia" uniqKey="Gaudet M" first="Mia" last="Gaudet">Mia Gaudet</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Center, University of Hawaii, Honolulu, HI 96813</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D" last="Berg">Christine D. Berg</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Division of Cancer Epidemiology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia Faculty of Medicine, Monash University, Melbourne, VIC 3800</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E" last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01003-9304, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01003-9304</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willet, Walter" sort="Willet, Walter" uniqKey="Willet W" first="Walter" last="Willet">Walter Willet</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E" last="Buring">Julie E. Buring</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Shumin" sort="Zhang, Shumin" uniqKey="Zhang S" first="Shumin" last="Zhang">Shumin Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif F-94805, France Paris South University, Villejuif F-94807, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif F-94805, France Paris South University, Villejuif F-94807</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G" last="Cox">David G. Cox</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK Université de Lyon, Université Lyon 1, ISPB, Lyon F-69007, France INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69008, France Centre Léon Bérard, Lyon F-69008, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ, UK Université de Lyon, Université Lyon 1, ISPB, Lyon F-69007, France INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69008, France Centre Léon Bérard, Lyon F-69008</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Community Medicine, University of Tromsø, Tromsø N-9037, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Community Medicine, University of Tromsø, Tromsø N-9037</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular and Genetic Epidemiology Unit, Human Genetics Foundation Torino, Torino I-10126, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Molecular and Genetic Epidemiology Unit, Human Genetics Foundation Torino, Torino I-10126</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3584 CS, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ, UK Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3584 CS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J Ram N" last="Quir S">J Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:affiliation>Public Health Directorate, Asturias ES-CP33006, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Directorate, Asturias ES-CP33006</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London SW7 2AZ</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå S-90185, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå S-90185</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Bureau of Epidemiologic Research, Academy of Athens, Athens 10679, Greece Hellenic Health Foundation, Athens 11527, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Bureau of Epidemiologic Research, Academy of Athens, Athens 10679, Greece Hellenic Health Foundation, Athens 11527</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and.</nlm:affiliation>
<wicri:noCountry code="no comma">Division of Cancer Epidemiology and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and d.campa@dkfz.de.</nlm:affiliation>
<country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
</analytic>
<series><title level="j">Human molecular genetics</title>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Biomarkers, Tumor</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (etiology)</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term>
<term>Cartographie chromosomique</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Risque</term>
<term>Tumeurs du sein (épidémiologie)</term>
<term>Tumeurs du sein (étiologie)</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers, Tumor</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
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<term>Cartographie chromosomique</term>
<term>Femelle</term>
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<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Risque</term>
<term>Étude d'association pangénomique</term>
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<front><div type="abstract" xml:lang="en">We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (Pinteraction = 8.84 × 10(-4)) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>09</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>05</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>10</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2083</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>19</Issue>
<PubDate><Year>2014</Year>
<Month>Oct</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Human molecular genetics</Title>
<ISOAbbreviation>Hum. Mol. Genet.</ISOAbbreviation>
</Journal>
<ArticleTitle>Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women.</ArticleTitle>
<Pagination><MedlinePgn>5260-70</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/hmg/ddu223</ELocationID>
<Abstract><AbstractText>We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (Pinteraction = 8.84 × 10(-4)) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC.</AbstractText>
<CopyrightInformation>© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
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<ForeName>Myrto</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and.</Affiliation>
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<ForeName>Federico</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg D-69120, Germany.</Affiliation>
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<ForeName>Amit D</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</Affiliation>
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<ForeName>Ruth C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA School of Public Health, University of Wisconsin, Milwaukee, WI 1240, USA.</Affiliation>
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<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</Affiliation>
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<ForeName>Mia</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</Affiliation>
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<ForeName>W Ryan</ForeName>
<Initials>WR</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, American Cancer Society, Atlanta, GA 30303, USA.</Affiliation>
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<Initials>BE</Initials>
<AffiliationInfo><Affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</Affiliation>
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<ForeName>Christopher A</ForeName>
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<AffiliationInfo><Affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Fredrick R</ForeName>
<Initials>FR</Initials>
<AffiliationInfo><Affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.</Affiliation>
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<ForeName>Loïc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.</Affiliation>
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<ForeName>Christine D</ForeName>
<Initials>CD</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Chanock</LastName>
<ForeName>Stephen J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</Affiliation>
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<ForeName>Robert N</ForeName>
<Initials>RN</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</Affiliation>
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<ForeName>Anja</ForeName>
<Initials>A</Initials>
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<ForeName>Regina G</ForeName>
<Initials>RG</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.</Affiliation>
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<ForeName>Graham G</ForeName>
<Initials>GG</Initials>
<AffiliationInfo><Affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia.</Affiliation>
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<ForeName>Laura</ForeName>
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<AffiliationInfo><Affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia.</Affiliation>
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<ForeName>Gianluca</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cancer Epidemiology Centre Melbourne, Cancer Council Victoria, Carlton South, VIC 3004, Australia Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, VIC 3010, Australia.</Affiliation>
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<ForeName>Susan E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01003-9304, USA.</Affiliation>
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<ForeName>Walter</ForeName>
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<ForeName>Julie E</ForeName>
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<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.</Affiliation>
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<Initials>KT</Initials>
<AffiliationInfo><Affiliation>Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.</Affiliation>
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<ForeName>Eiliv</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Institute of Community Medicine, University of Tromsø, Tromsø N-9037, Norway.</Affiliation>
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<ForeName>Alessio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Molecular and Genetic Epidemiology Unit, Human Genetics Foundation Torino, Torino I-10126, Italy.</Affiliation>
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<ForeName>Petra H</ForeName>
<Initials>PH</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3584 CS, The Netherlands.</Affiliation>
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<ForeName>J Ramón</ForeName>
<Initials>JR</Initials>
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<ForeName>Elio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Imperial College London, London SW7 2AZ, UK.</Affiliation>
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<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå S-90185, Sweden.</Affiliation>
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<ForeName>Dimitrios</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Bureau of Epidemiologic Research, Academy of Athens, Athens 10679, Greece Hellenic Health Foundation, Athens 11527, Greece.</Affiliation>
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<Initials>RL</Initials>
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<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
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<Country>United Kingdom</Country>
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<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
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<Month>05</Month>
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<MedlineTA>Hum Mol Genet</MedlineTA>
<NlmUniqueID>9208958</NlmUniqueID>
<ISSNLinking>0964-6906</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
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