Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.
Identifieur interne : 001189 ( PubMed/Curation ); précédent : 001188; suivant : 001190Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.
Auteurs : Javed Ahmad ; Sohail Akhter [France] ; Md Rizwanullah ; Mohammad Ahmed Khan ; Lucie Pigeon [France] ; Richard T. Addo [États-Unis] ; Nigel H. Greig [États-Unis] ; Patrick Midoux [France] ; Chantal Pichon [France] ; Mohammad Amjad KamalSource :
- Current Alzheimer research [ 1875-5828 ] ; 2017.
Abstract
Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.
DOI: 10.2174/1567205014666170508121031
PubMed: 28482786
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Javed Ahmad<affiliation><nlm:affiliation>Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP- 229010. India.</nlm:affiliation>
<wicri:noCountry code="subField">UP- 229010</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation>
<wicri:noCountry code="subField">New Delhi-110062</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation>
<wicri:noCountry code="subField">New Delhi-110062</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Novel Global Community Educational Foundation. Australia.</nlm:affiliation>
<wicri:noCountry code="no comma">Novel Global Community Educational Foundation. Australia.</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en">Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.</div>
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<Title>Current Alzheimer research</Title>
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<ArticleTitle>Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This paper discussed the role of nanoparticles in early detection of AD, effective drug targeting to brain and theranostic (diagnosis and therapy) approaches in AD's management.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahmad</LastName>
<ForeName>Javed</ForeName>
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<ForeName>Nigel H</ForeName>
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<Author ValidYN="Y"><LastName>Kamal</LastName>
<ForeName>Mohammad Amjad</ForeName>
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<Keyword MajorTopicYN="N">blood brain barrier</Keyword>
<Keyword MajorTopicYN="N">diagnosis</Keyword>
<Keyword MajorTopicYN="N">nanomedicines</Keyword>
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