Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.
Identifieur interne : 001200 ( PubMed/Corpus ); précédent : 001199; suivant : 001201Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.
Auteurs : Javed Ahmad ; Sohail Akhter ; Md Rizwanullah ; Mohammad Ahmed Khan ; Lucie Pigeon ; Richard T. Addo ; Nigel H. Greig ; Patrick Midoux ; Chantal Pichon ; Mohammad Amjad KamalSource :
- Current Alzheimer research [ 1875-5828 ] ; 2017.
Abstract
Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.
DOI: 10.2174/1567205014666170508121031
PubMed: 28482786
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.</title><author><name sortKey="Ahmad, Javed" sort="Ahmad, Javed" uniqKey="Ahmad J" first="Javed" last="Ahmad">Javed Ahmad</name><affiliation><nlm:affiliation>Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP- 229010. India.</nlm:affiliation></affiliation></author><author><name sortKey="Akhter, Sohail" sort="Akhter, Sohail" uniqKey="Akhter S" first="Sohail" last="Akhter">Sohail Akhter</name><affiliation><nlm:affiliation>LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire Region, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rizwanullah, Md" sort="Rizwanullah, Md" uniqKey="Rizwanullah M" first="Md" last="Rizwanullah">Md Rizwanullah</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation></affiliation></author><author><name sortKey="Khan, Mohammad Ahmed" sort="Khan, Mohammad Ahmed" uniqKey="Khan M" first="Mohammad Ahmed" last="Khan">Mohammad Ahmed Khan</name><affiliation><nlm:affiliation>Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation></affiliation></author><author><name sortKey="Pigeon, Lucie" sort="Pigeon, Lucie" uniqKey="Pigeon L" first="Lucie" last="Pigeon">Lucie Pigeon</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Addo, Richard T" sort="Addo, Richard T" uniqKey="Addo R" first="Richard T" last="Addo">Richard T. Addo</name><affiliation><nlm:affiliation>Union University, School of Pharmacy Room 149 Providence Hall, 1050 Union University Drive, Jackson, TN 38305. United States.</nlm:affiliation></affiliation></author><author><name sortKey="Greig, Nigel H" sort="Greig, Nigel H" uniqKey="Greig N" first="Nigel H" last="Greig">Nigel H. Greig</name><affiliation><nlm:affiliation>Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224. United States.</nlm:affiliation></affiliation></author><author><name sortKey="Midoux, Patrick" sort="Midoux, Patrick" uniqKey="Midoux P" first="Patrick" last="Midoux">Patrick Midoux</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pichon, Chantal" sort="Pichon, Chantal" uniqKey="Pichon C" first="Chantal" last="Pichon">Chantal Pichon</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kamal, Mohammad Amjad" sort="Kamal, Mohammad Amjad" uniqKey="Kamal M" first="Mohammad Amjad" last="Kamal">Mohammad Amjad Kamal</name><affiliation><nlm:affiliation>Novel Global Community Educational Foundation. Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28482786</idno><idno type="pmid">28482786</idno><idno type="doi">10.2174/1567205014666170508121031</idno><idno type="wicri:Area/PubMed/Corpus">001200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001200</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.</title><author><name sortKey="Ahmad, Javed" sort="Ahmad, Javed" uniqKey="Ahmad J" first="Javed" last="Ahmad">Javed Ahmad</name><affiliation><nlm:affiliation>Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP- 229010. India.</nlm:affiliation></affiliation></author><author><name sortKey="Akhter, Sohail" sort="Akhter, Sohail" uniqKey="Akhter S" first="Sohail" last="Akhter">Sohail Akhter</name><affiliation><nlm:affiliation>LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire Region, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rizwanullah, Md" sort="Rizwanullah, Md" uniqKey="Rizwanullah M" first="Md" last="Rizwanullah">Md Rizwanullah</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation></affiliation></author><author><name sortKey="Khan, Mohammad Ahmed" sort="Khan, Mohammad Ahmed" uniqKey="Khan M" first="Mohammad Ahmed" last="Khan">Mohammad Ahmed Khan</name><affiliation><nlm:affiliation>Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</nlm:affiliation></affiliation></author><author><name sortKey="Pigeon, Lucie" sort="Pigeon, Lucie" uniqKey="Pigeon L" first="Lucie" last="Pigeon">Lucie Pigeon</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Addo, Richard T" sort="Addo, Richard T" uniqKey="Addo R" first="Richard T" last="Addo">Richard T. Addo</name><affiliation><nlm:affiliation>Union University, School of Pharmacy Room 149 Providence Hall, 1050 Union University Drive, Jackson, TN 38305. United States.</nlm:affiliation></affiliation></author><author><name sortKey="Greig, Nigel H" sort="Greig, Nigel H" uniqKey="Greig N" first="Nigel H" last="Greig">Nigel H. Greig</name><affiliation><nlm:affiliation>Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224. United States.</nlm:affiliation></affiliation></author><author><name sortKey="Midoux, Patrick" sort="Midoux, Patrick" uniqKey="Midoux P" first="Patrick" last="Midoux">Patrick Midoux</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pichon, Chantal" sort="Pichon, Chantal" uniqKey="Pichon C" first="Chantal" last="Pichon">Chantal Pichon</name><affiliation><nlm:affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kamal, Mohammad Amjad" sort="Kamal, Mohammad Amjad" uniqKey="Kamal M" first="Mohammad Amjad" last="Kamal">Mohammad Amjad Kamal</name><affiliation><nlm:affiliation>Novel Global Community Educational Foundation. Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Current Alzheimer research</title><idno type="eISSN">1875-5828</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28482786</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>09</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-5828</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>11</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Current Alzheimer research</Title><ISOAbbreviation>Curr Alzheimer Res</ISOAbbreviation></Journal><ArticleTitle>Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective.</ArticleTitle><Pagination><MedlinePgn>1164-1181</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2174/1567205014666170508121031</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alzheimer's disease (AD), a cognitive dysfunction/dementia state amongst the elders is characterized by irreversible neurodegeneration due to varied pathophysiology. Up till now, anti-AD drugs having different pharmacology have been developed and used in clinic. Yet, these medications are not curative and only lowering the AD associated symptoms. Improvement in treatment outcome required drug targeting across the blood-brain barrier (BBB) to the central nervous system (CNS) in optimal therapeutic concentration. Nanotechnology based diagnostic tools, drug carriers and theranostics offer highly sensitive molecular detection, effective drug targeting and their combination. Over the past decade, significant works have been done in this area and we have seen very remarkable outocome in AD therapy. Various nanoparticles from organic and inorganic nanomaterial category have successfully been investigated against AD.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This paper discussed the role of nanoparticles in early detection of AD, effective drug targeting to brain and theranostic (diagnosis and therapy) approaches in AD's management.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahmad</LastName><ForeName>Javed</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP- 229010. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akhter</LastName><ForeName>Sohail</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire Region, Orleans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rizwanullah</LastName><ForeName>Md</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Mohammad Ahmed</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pigeon</LastName><ForeName>Lucie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Addo</LastName><ForeName>Richard T</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Union University, School of Pharmacy Room 149 Providence Hall, 1050 Union University Drive, Jackson, TN 38305. United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greig</LastName><ForeName>Nigel H</ForeName><Initials>NH</Initials><AffiliationInfo><Affiliation>Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National, Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224. United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Midoux</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pichon</LastName><ForeName>Chantal</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Nucleic acids transfer by non viral methods, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamal</LastName><ForeName>Mohammad Amjad</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Novel Global Community Educational Foundation. Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Alzheimer Res</MedlineTA><NlmUniqueID>101208441</NlmUniqueID><ISSNLinking>1567-2050</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">blood brain barrier</Keyword><Keyword MajorTopicYN="N">diagnosis</Keyword><Keyword MajorTopicYN="N">nanomedicines</Keyword><Keyword MajorTopicYN="N">nanoparticles</Keyword><Keyword MajorTopicYN="N">theranostic</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>01</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>04</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28482786</ArticleId><ArticleId IdType="pii">CAR-EPUB-83332</ArticleId><ArticleId IdType="doi">10.2174/1567205014666170508121031</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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