Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
Identifieur interne : 003611 ( PubMed/Corpus ); précédent : 003610; suivant : 003612Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
Auteurs : Jeannette Simino ; Gang Shi ; Joshua C. Bis ; Daniel I. Chasman ; Georg B. Ehret ; Xiangjun Gu ; Xiuqing Guo ; Shih-Jen Hwang ; Eric Sijbrands ; Albert V. Smith ; Germaine C. Verwoert ; Jennifer L. Bragg-Gresham ; Gemma Cadby ; Peng Chen ; Ching-Yu Cheng ; Tanguy Corre ; Rudolf A. De Boer ; Anuj Goel ; Toby Johnson ; Chiea-Chuen Khor ; Carla Lluís-Ganella ; Jian'An Luan ; Leo-Pekka Lyytik Inen ; Ilja M. Nolte ; Xueling Sim ; Siim S Ber ; Peter J. Van Der Most ; Niek Verweij ; Jing Hua Zhao ; Najaf Amin ; Eric Boerwinkle ; Claude Bouchard ; Abbas Dehghan ; Gudny Eiriksdottir ; Roberto Elosua ; Oscar H. Franco ; Christian Gieger ; Tamara B. Harris ; Serge Hercberg ; Albert Hofman ; Alan L. James ; Andrew D. Johnson ; Mika K Hönen ; Kay-Tee Khaw ; Zoltan Kutalik ; Martin G. Larson ; Lenore J. Launer ; Guo Li ; Jianjun Liu ; Kiang Liu ; Alanna C. Morrison ; Gerjan Navis ; Rick Twee-Hee Ong ; George J. Papanicolau ; Brenda W. Penninx ; Bruce M. Psaty ; Leslie J. Raffel ; Olli T. Raitakari ; Kenneth Rice ; Fernando Rivadeneira ; Lynda M. Rose ; Serena Sanna ; Robert A. Scott ; David S. Siscovick ; Ronald P. Stolk ; Andre G. Uitterlinden ; Dhananjay Vaidya ; Melanie M. Van Der Klauw ; Ramachandran S. Vasan ; Eranga Nishanthie Vithana ; Uwe Völker ; Henry Völzke ; Hugh Watkins ; Terri L. Young ; Tin Aung ; Murielle Bochud ; Martin Farrall ; Catharina A. Hartman ; Maris Laan ; Edward G. Lakatta ; Terho Lehtim Ki ; Ruth J F. Loos ; Gavin Lucas ; Pierre Meneton ; Lyle J. Palmer ; Rainer Rettig ; Harold Snieder ; E Shyong Tai ; Yik-Ying Teo ; Pim Van Der Harst ; Nicholas J. Wareham ; Cisca Wijmenga ; Tien Yin Wong ; Myriam Fornage ; Vilmundur Gudnason ; Daniel Levy ; Walter Palmas ; Paul M. Ridker ; Jerome I. Rotter ; Cornelia M. Van Duijn ; Jacqueline C M. Witteman ; Aravinda Chakravarti ; Dabeeru C. RaoSource :
- American journal of human genetics [ 1537-6605 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- genetics : Blood Pressure.
- Adolescent, Adult, Age Factors, Aged, Cohort Studies, Humans, Middle Aged, Young Adult.
Abstract
Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. In a two-staged design using 99,241 individuals of European ancestry, we identified 20 genome-wide significant (p ≤ 5 × 10(-8)) loci by using joint tests of the SNP main effect and SNP-age interaction. Nine of the significant loci demonstrated nominal evidence of age-dependent effects on BP by tests of the interactions alone. Index SNPs in the EHBP1L1 (DBP and MAP), CASZ1 (SBP and MAP), and GOSR2 (PP) loci exhibited the largest age interactions, with opposite directions of effect in the young versus the old. The changes in the genetic effects over time were small but nonnegligible (up to 1.58 mm Hg over 60 years). The EHBP1L1 locus was discovered through gene-age interactions only in whites but had DBP main effects replicated (p = 8.3 × 10(-4)) in 8,682 Asians from Singapore, indicating potential interethnic heterogeneity. A secondary analysis revealed 22 loci with evidence of age-specific effects (e.g., only in 20 to 29-year-olds). Age can be used to select samples with larger genetic effect sizes and more homogenous phenotypes, which may increase statistical power. Age-dependent effects identified through novel statistical approaches can provide insight into the biology and temporal regulation underlying BP associations.
DOI: 10.1016/j.ajhg.2014.05.010
PubMed: 24954895
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pubmed:24954895Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.</title><author><name sortKey="Simino, Jeannette" sort="Simino, Jeannette" uniqKey="Simino J" first="Jeannette" last="Simino">Jeannette Simino</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jeannette@wubios.wustl.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Gang" sort="Shi, Gang" uniqKey="Shi G" first="Gang" last="Shi">Gang Shi</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva 1211, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation><nlm:affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sijbrands, Eric" sort="Sijbrands, Eric" uniqKey="Sijbrands E" first="Eric" last="Sijbrands">Eric Sijbrands</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Verwoert, Germaine C" sort="Verwoert, Germaine C" uniqKey="Verwoert G" first="Germaine C" last="Verwoert">Germaine C. Verwoert</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L" last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:affiliation>Centre for Genetic Origins of Health and Disease, University of Western Australia, Nedlands, WA 6009, Australia; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Peng" sort="Chen, Peng" uniqKey="Chen P" first="Peng" last="Chen">Peng Chen</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:affiliation>Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Paediatrics, National University Health System, Singapore 119074, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Lluis Ganella, Carla" sort="Lluis Ganella, Carla" uniqKey="Lluis Ganella C" first="Carla" last="Lluís-Ganella">Carla Lluís-Ganella</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sim, Xueling" sort="Sim, Xueling" uniqKey="Sim X" first="Xueling" last="Sim">Xueling Sim</name><affiliation><nlm:affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Centre for Molecular Epidemiology, National University of Singapore, Singapore 119260, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="S Ber, Siim" sort="S Ber, Siim" uniqKey="S Ber S" first="Siim" last="S Ber">Siim S Ber</name><affiliation><nlm:affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J" last="Van Der Most">Peter J. Van Der Most</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:affiliation>Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Elosua, Roberto" sort="Elosua, Roberto" uniqKey="Elosua R" first="Roberto" last="Elosua">Roberto Elosua</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain; Epidemiology and Public Health Network (CIBERESP), 08036 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:affiliation>U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 93000 Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:affiliation>Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33521, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Larson, Martin G" sort="Larson, Martin G" uniqKey="Larson M" first="Martin G" last="Larson">Martin G. Larson</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Ong, Rick Twee Hee" sort="Ong, Rick Twee Hee" uniqKey="Ong R" first="Rick Twee-Hee" last="Ong">Rick Twee-Hee Ong</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Papanicolau, George J" sort="Papanicolau, George J" uniqKey="Papanicolau G" first="George J" last="Papanicolau">George J. Papanicolau</name><affiliation><nlm:affiliation>Division of Cardiovascular Sciences, National Heart, Lung, & Blood Institute, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:affiliation>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands; Department of Psychiatry, Leiden University Medical Centre, 2333 ZD Leiden, the Netherlands; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J" last="Raffel">Leslie J. Raffel</name><affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Pacific Theatres, Los Angeles, CA 90048, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Rice, Kenneth" sort="Rice, Kenneth" uniqKey="Rice K" first="Kenneth" last="Rice">Kenneth Rice</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vaidya, Dhananjay" sort="Vaidya, Dhananjay" uniqKey="Vaidya D" first="Dhananjay" last="Vaidya">Dhananjay Vaidya</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University, Baltimore, MD 21202, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:affiliation>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vithana, Eranga Nishanthie" sort="Vithana, Eranga Nishanthie" uniqKey="Vithana E" first="Eranga Nishanthie" last="Vithana">Eranga Nishanthie Vithana</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Neuroscience and Behavioural Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17487 Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University of Greifswald, 17487 Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA; Division of Neuroscience, Duke-National University of Singapore, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:affiliation>Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A" last="Hartman">Catharina A. Hartman</name><affiliation><nlm:affiliation>Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name><affiliation><nlm:affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G" last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:affiliation>Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Bethesda, MD 21224, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lucas, Gavin" sort="Lucas, Gavin" uniqKey="Lucas G" first="Gavin" last="Lucas">Gavin Lucas</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:affiliation>U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris 75006, France.</nlm:affiliation></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:affiliation>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:affiliation>Institute of Physiology, University of Greifswald, 17495 Karlsburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E Shyong" last="Tai">E Shyong Tai</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Medicine, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Singapore; Genome Institute of Singapore, A(∗)STAR, Singapore 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, 3501 DG Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:affiliation>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Palmas, Walter" sort="Palmas, Walter" uniqKey="Palmas W" first="Walter" last="Palmas">Walter Palmas</name><affiliation><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands; Netherland Genomics Initiative, Centre for Medical Systems Biology, 2300 RC Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Dabeeru C" sort="Rao, Dabeeru C" uniqKey="Rao D" first="Dabeeru C" last="Rao">Dabeeru C. Rao</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24954895</idno><idno type="pmid">24954895</idno><idno type="doi">10.1016/j.ajhg.2014.05.010</idno><idno type="wicri:Area/PubMed/Corpus">003611</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003611</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.</title><author><name sortKey="Simino, Jeannette" sort="Simino, Jeannette" uniqKey="Simino J" first="Jeannette" last="Simino">Jeannette Simino</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jeannette@wubios.wustl.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Gang" sort="Shi, Gang" uniqKey="Shi G" first="Gang" last="Shi">Gang Shi</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ehret, Georg B" sort="Ehret, Georg B" uniqKey="Ehret G" first="Georg B" last="Ehret">Georg B. Ehret</name><affiliation><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva 1211, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Xiangjun" sort="Gu, Xiangjun" uniqKey="Gu X" first="Xiangjun" last="Gu">Xiangjun Gu</name><affiliation><nlm:affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sijbrands, Eric" sort="Sijbrands, Eric" uniqKey="Sijbrands E" first="Eric" last="Sijbrands">Eric Sijbrands</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Verwoert, Germaine C" sort="Verwoert, Germaine C" uniqKey="Verwoert G" first="Germaine C" last="Verwoert">Germaine C. Verwoert</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L" last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation><nlm:affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cadby, Gemma" sort="Cadby, Gemma" uniqKey="Cadby G" first="Gemma" last="Cadby">Gemma Cadby</name><affiliation><nlm:affiliation>Centre for Genetic Origins of Health and Disease, University of Western Australia, Nedlands, WA 6009, Australia; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Peng" sort="Chen, Peng" uniqKey="Chen P" first="Peng" last="Chen">Peng Chen</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:affiliation>Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Paediatrics, National University Health System, Singapore 119074, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Lluis Ganella, Carla" sort="Lluis Ganella, Carla" uniqKey="Lluis Ganella C" first="Carla" last="Lluís-Ganella">Carla Lluís-Ganella</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sim, Xueling" sort="Sim, Xueling" uniqKey="Sim X" first="Xueling" last="Sim">Xueling Sim</name><affiliation><nlm:affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Centre for Molecular Epidemiology, National University of Singapore, Singapore 119260, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="S Ber, Siim" sort="S Ber, Siim" uniqKey="S Ber S" first="Siim" last="S Ber">Siim S Ber</name><affiliation><nlm:affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J" last="Van Der Most">Peter J. Van Der Most</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchard, Claude" sort="Bouchard, Claude" uniqKey="Bouchard C" first="Claude" last="Bouchard">Claude Bouchard</name><affiliation><nlm:affiliation>Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Elosua, Roberto" sort="Elosua, Roberto" uniqKey="Elosua R" first="Roberto" last="Elosua">Roberto Elosua</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain; Epidemiology and Public Health Network (CIBERESP), 08036 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:affiliation>U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 93000 Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="James, Alan L" sort="James, Alan L" uniqKey="James A" first="Alan L" last="James">Alan L. James</name><affiliation><nlm:affiliation>Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33521, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation><nlm:affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Larson, Martin G" sort="Larson, Martin G" uniqKey="Larson M" first="Martin G" last="Larson">Martin G. Larson</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name><affiliation><nlm:affiliation>Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Ong, Rick Twee Hee" sort="Ong, Rick Twee Hee" uniqKey="Ong R" first="Rick Twee-Hee" last="Ong">Rick Twee-Hee Ong</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Papanicolau, George J" sort="Papanicolau, George J" uniqKey="Papanicolau G" first="George J" last="Papanicolau">George J. Papanicolau</name><affiliation><nlm:affiliation>Division of Cardiovascular Sciences, National Heart, Lung, & Blood Institute, NIH, Bethesda, MD 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:affiliation>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands; Department of Psychiatry, Leiden University Medical Centre, 2333 ZD Leiden, the Netherlands; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J" last="Raffel">Leslie J. Raffel</name><affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Pacific Theatres, Los Angeles, CA 90048, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Rice, Kenneth" sort="Rice, Kenneth" uniqKey="Rice K" first="Kenneth" last="Rice">Kenneth Rice</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vaidya, Dhananjay" sort="Vaidya, Dhananjay" uniqKey="Vaidya D" first="Dhananjay" last="Vaidya">Dhananjay Vaidya</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University, Baltimore, MD 21202, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:affiliation>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vithana, Eranga Nishanthie" sort="Vithana, Eranga Nishanthie" uniqKey="Vithana E" first="Eranga Nishanthie" last="Vithana">Eranga Nishanthie Vithana</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Neuroscience and Behavioural Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17487 Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University of Greifswald, 17487 Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA; Division of Neuroscience, Duke-National University of Singapore, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation><nlm:affiliation>Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010 Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartman, Catharina A" sort="Hartman, Catharina A" uniqKey="Hartman C" first="Catharina A" last="Hartman">Catharina A. Hartman</name><affiliation><nlm:affiliation>Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Laan, Maris" sort="Laan, Maris" uniqKey="Laan M" first="Maris" last="Laan">Maris Laan</name><affiliation><nlm:affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Lakatta, Edward G" sort="Lakatta, Edward G" uniqKey="Lakatta E" first="Edward G" last="Lakatta">Edward G. Lakatta</name><affiliation><nlm:affiliation>Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Bethesda, MD 21224, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lucas, Gavin" sort="Lucas, Gavin" uniqKey="Lucas G" first="Gavin" last="Lucas">Gavin Lucas</name><affiliation><nlm:affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name><affiliation><nlm:affiliation>U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris 75006, France.</nlm:affiliation></affiliation></author><author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J" last="Palmer">Lyle J. Palmer</name><affiliation><nlm:affiliation>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation><nlm:affiliation>Institute of Physiology, University of Greifswald, 17495 Karlsburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E Shyong" last="Tai">E Shyong Tai</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Medicine, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Singapore; Genome Institute of Singapore, A(∗)STAR, Singapore 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, 3501 DG Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation><nlm:affiliation>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation><nlm:affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Palmas, Walter" sort="Palmas, Walter" uniqKey="Palmas W" first="Walter" last="Palmas">Walter Palmas</name><affiliation><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands; Netherland Genomics Initiative, Centre for Medical Systems Biology, 2300 RC Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name><affiliation><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Dabeeru C" sort="Rao, Dabeeru C" uniqKey="Rao D" first="Dabeeru C" last="Rao">Dabeeru C. Rao</name><affiliation><nlm:affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of human genetics</title><idno type="eISSN">1537-6605</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Blood Pressure (genetics)</term><term>Cohort Studies</term><term>Humans</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Cohort Studies</term><term>Humans</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. In a two-staged design using 99,241 individuals of European ancestry, we identified 20 genome-wide significant (p ≤ 5 × 10(-8)) loci by using joint tests of the SNP main effect and SNP-age interaction. Nine of the significant loci demonstrated nominal evidence of age-dependent effects on BP by tests of the interactions alone. Index SNPs in the EHBP1L1 (DBP and MAP), CASZ1 (SBP and MAP), and GOSR2 (PP) loci exhibited the largest age interactions, with opposite directions of effect in the young versus the old. The changes in the genetic effects over time were small but nonnegligible (up to 1.58 mm Hg over 60 years). The EHBP1L1 locus was discovered through gene-age interactions only in whites but had DBP main effects replicated (p = 8.3 × 10(-4)) in 8,682 Asians from Singapore, indicating potential interethnic heterogeneity. A secondary analysis revealed 22 loci with evidence of age-specific effects (e.g., only in 20 to 29-year-olds). Age can be used to select samples with larger genetic effect sizes and more homogenous phenotypes, which may increase statistical power. Age-dependent effects identified through novel statistical approaches can provide insight into the biology and temporal regulation underlying BP associations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24954895</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>05</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6605</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Jul</Month><Day>03</Day></PubDate></JournalIssue><Title>American journal of human genetics</Title><ISOAbbreviation>Am. J. Hum. Genet.</ISOAbbreviation></Journal><ArticleTitle>Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.</ArticleTitle><Pagination><MedlinePgn>24-38</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ajhg.2014.05.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0002-9297(14)00230-4</ELocationID><Abstract><AbstractText>Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. In a two-staged design using 99,241 individuals of European ancestry, we identified 20 genome-wide significant (p ≤ 5 × 10(-8)) loci by using joint tests of the SNP main effect and SNP-age interaction. Nine of the significant loci demonstrated nominal evidence of age-dependent effects on BP by tests of the interactions alone. Index SNPs in the EHBP1L1 (DBP and MAP), CASZ1 (SBP and MAP), and GOSR2 (PP) loci exhibited the largest age interactions, with opposite directions of effect in the young versus the old. The changes in the genetic effects over time were small but nonnegligible (up to 1.58 mm Hg over 60 years). The EHBP1L1 locus was discovered through gene-age interactions only in whites but had DBP main effects replicated (p = 8.3 × 10(-4)) in 8,682 Asians from Singapore, indicating potential interethnic heterogeneity. A secondary analysis revealed 22 loci with evidence of age-specific effects (e.g., only in 20 to 29-year-olds). Age can be used to select samples with larger genetic effect sizes and more homogenous phenotypes, which may increase statistical power. Age-dependent effects identified through novel statistical approaches can provide insight into the biology and temporal regulation underlying BP associations.</AbstractText><CopyrightInformation>Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simino</LastName><ForeName>Jeannette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jeannette@wubios.wustl.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bis</LastName><ForeName>Joshua C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ehret</LastName><ForeName>Georg B</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Geneva 1211, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Xiangjun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xiuqing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Shih-Jen</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sijbrands</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Albert V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verwoert</LastName><ForeName>Germaine C</ForeName><Initials>GC</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bragg-Gresham</LastName><ForeName>Jennifer L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cadby</LastName><ForeName>Gemma</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre for Genetic Origins of Health and Disease, University of Western Australia, Nedlands, WA 6009, Australia; Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Ching-Yu</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corre</LastName><ForeName>Tanguy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Boer</LastName><ForeName>Rudolf A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goel</LastName><ForeName>Anuj</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Toby</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khor</LastName><ForeName>Chiea-Chuen</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Paediatrics, National University Health System, Singapore 119074, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LifeLines Cohort Study</CollectiveName></Author><Author ValidYN="Y"><LastName>Lluís-Ganella</LastName><ForeName>Carla</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luan</LastName><ForeName>Jian'an</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyytikäinen</LastName><ForeName>Leo-Pekka</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolte</LastName><ForeName>Ilja M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sim</LastName><ForeName>Xueling</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Centre for Molecular Epidemiology, National University of Singapore, Singapore 119260, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sõber</LastName><ForeName>Siim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Most</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jing Hua</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Najaf</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boerwinkle</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchard</LastName><ForeName>Claude</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehghan</LastName><ForeName>Abbas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eiriksdottir</LastName><ForeName>Gudny</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elosua</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain; Epidemiology and Public Health Network (CIBERESP), 08036 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco</LastName><ForeName>Oscar H</ForeName><Initials>OH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gieger</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Tamara B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hercberg</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la Recherche Agronomique, Université Paris 13, 93000 Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Alan L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kähönen</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33521, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kutalik</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larson</LastName><ForeName>Martin G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Launer</LastName><ForeName>Lenore J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Guo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jianjun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Kiang</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Alanna C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navis</LastName><ForeName>Gerjan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ong</LastName><ForeName>Rick Twee-Hee</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papanicolau</LastName><ForeName>George J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Sciences, National Heart, Lung, & Blood Institute, NIH, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Penninx</LastName><ForeName>Brenda W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands; Department of Psychiatry, Leiden University Medical Centre, 2333 ZD Leiden, the Netherlands; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psaty</LastName><ForeName>Bruce M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raffel</LastName><ForeName>Leslie J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Pacific Theatres, Los Angeles, CA 90048, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raitakari</LastName><ForeName>Olli T</ForeName><Initials>OT</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rice</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivadeneira</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Lynda M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanna</LastName><ForeName>Serena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siscovick</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stolk</LastName><ForeName>Ronald P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>Andre G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaidya</LastName><ForeName>Dhananjay</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medicine, Johns Hopkins University, Baltimore, MD 21202, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Klauw</LastName><ForeName>Melanie M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vasan</LastName><ForeName>Ramachandran S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vithana</LastName><ForeName>Eranga Nishanthie</ForeName><Initials>EN</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore; Neuroscience and Behavioural Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völker</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17487 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völzke</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University of Greifswald, 17487 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watkins</LastName><ForeName>Hugh</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Terri L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA; Division of Neuroscience, Duke-National University of Singapore, Singapore 169857, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aung</LastName><ForeName>Tin</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bochud</LastName><ForeName>Murielle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010 Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrall</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartman</LastName><ForeName>Catharina A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Interdisciplinary Center for Pathology of Emotions, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laan</LastName><ForeName>Maris</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lakatta</LastName><ForeName>Edward G</ForeName><Initials>EG</Initials><AffiliationInfo><Affiliation>Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Bethesda, MD 21224, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehtimäki</LastName><ForeName>Terho</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 30101, Finland; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33101, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loos</LastName><ForeName>Ruth J F</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lucas</LastName><ForeName>Gavin</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meneton</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris 75006, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmer</LastName><ForeName>Lyle J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rettig</LastName><ForeName>Rainer</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Physiology, University of Greifswald, 17495 Karlsburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snieder</LastName><ForeName>Harold</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tai</LastName><ForeName>E Shyong</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Department of Medicine, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teo</LastName><ForeName>Yik-Ying</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore; Saw Swee Hock School of Public Health, National University Health System, Singapore 117597, Singapore; Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117543, Singapore; Genome Institute of Singapore, A(∗)STAR, Singapore 138672, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, 3501 DG Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wijmenga</LastName><ForeName>Cisca</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tien Yin</ForeName><Initials>TY</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Department of Ophthalmology, National University Health System, Singapore 119228, Singapore; Singapore Eye Research Institute, Singapore 168751, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fornage</LastName><ForeName>Myriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77225, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>Vilmundur</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Boston University School of Medicine, Boston, MA 02118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmas</LastName><ForeName>Walter</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rotter</LastName><ForeName>Jerome I</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Duijn</LastName><ForeName>Cornelia M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands; Netherland Genomics Inititiative, Netherlands Center for Healthy Aging, The Hague 2509, the Netherlands; Netherland Genomics Initiative, Centre for Medical Systems Biology, 2300 RC Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witteman</LastName><ForeName>Jacqueline C M</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chakravarti</LastName><ForeName>Aravinda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Dabeeru C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1000143</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>UL1 TR000124</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL105756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P30 DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>14136</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0401527</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0701863</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Hum 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