Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.
Identifieur interne : 003197 ( PubMed/Corpus ); précédent : 003196; suivant : 003198Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.
Auteurs : A J Nore A ; W H A M. Mulders ; D. RobertsonSource :
- Journal of neurophysiology [ 1522-1598 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Acoustic Stimulation, Noise.
- methods : Electric Stimulation Therapy.
- physiology : Neurons.
- physiopathology : Inferior Colliculi, Tinnitus.
- therapy : Tinnitus.
- Action Potentials, Animals, Disease Models, Animal, Guinea Pigs.
Abstract
Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-induced central hyperactivity. This latter result further suggests that an approach consisting of reducing cochlear activity may provide a therapeutic avenue for tinnitus. In this context, extra-cochlear electric stimulation (ECES) may be a good candidate to modulate cochlear activity and suppress tinnitus. Indeed, it has been shown that a positive current applied at the round window reduces cochlear nerve activity and can suppress tinnitus reliably in tinnitus subjects. The present study investigates whether ECES with a positive current can abolish the noise-induced central hyperactivity, i.e., the putative tinnitus-related activity. Spontaneous and stimulus-evoked neural activity before, during and after ECES was assessed from single-unit recordings in the inferior colliculus of anesthetized guinea pigs. We found that ECES with positive current significantly decreases the spontaneous firing rate of neurons with high characteristic frequencies, whereas negative current produces the opposite effect. The effects of the ECES are absent or even reversed for neurons with low characteristic frequencies. Importantly, ECES with positive current had only a marginal effect on thresholds and tone-induced activity of collicular neurons, suggesting that the main action of positive current is to modulate the spontaneous firing. Overall, cochlear electrical stimulation may be a viable approach for suppressing some forms of (peripheral-dependent) tinnitus.
DOI: 10.1152/jn.00580.2014
PubMed: 25298390
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.</title><author><name sortKey="Nore A, A J" sort="Nore A, A J" uniqKey="Nore A A" first="A J" last="Nore A">A J Nore A</name><affiliation><nlm:affiliation>Laboratory of Adaptive and Integrative Neuroscience, CNRS, and Aix-Marseille Université, Fédération de Recherche 3C, Marseille, France; and arnaud.norena@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Mulders, W H A M" sort="Mulders, W H A M" uniqKey="Mulders W" first="W H A M" last="Mulders">W H A M. Mulders</name><affiliation><nlm:affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Robertson, D" sort="Robertson, D" uniqKey="Robertson D" first="D" last="Robertson">D. Robertson</name><affiliation><nlm:affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25298390</idno><idno type="pmid">25298390</idno><idno type="doi">10.1152/jn.00580.2014</idno><idno type="wicri:Area/PubMed/Corpus">003197</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003197</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.</title><author><name sortKey="Nore A, A J" sort="Nore A, A J" uniqKey="Nore A A" first="A J" last="Nore A">A J Nore A</name><affiliation><nlm:affiliation>Laboratory of Adaptive and Integrative Neuroscience, CNRS, and Aix-Marseille Université, Fédération de Recherche 3C, Marseille, France; and arnaud.norena@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Mulders, W H A M" sort="Mulders, W H A M" uniqKey="Mulders W" first="W H A M" last="Mulders">W H A M. Mulders</name><affiliation><nlm:affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Robertson, D" sort="Robertson, D" uniqKey="Robertson D" first="D" last="Robertson">D. Robertson</name><affiliation><nlm:affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of neurophysiology</title><idno type="eISSN">1522-1598</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (adverse effects)</term><term>Action Potentials</term><term>Animals</term><term>Disease Models, Animal</term><term>Electric Stimulation Therapy (methods)</term><term>Guinea Pigs</term><term>Inferior Colliculi (physiopathology)</term><term>Neurons (physiology)</term><term>Noise (adverse effects)</term><term>Tinnitus (physiopathology)</term><term>Tinnitus (therapy)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Acoustic Stimulation</term><term>Noise</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Inferior Colliculi</term><term>Tinnitus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Tinnitus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term><term>Animals</term><term>Disease Models, Animal</term><term>Guinea Pigs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-induced central hyperactivity. This latter result further suggests that an approach consisting of reducing cochlear activity may provide a therapeutic avenue for tinnitus. In this context, extra-cochlear electric stimulation (ECES) may be a good candidate to modulate cochlear activity and suppress tinnitus. Indeed, it has been shown that a positive current applied at the round window reduces cochlear nerve activity and can suppress tinnitus reliably in tinnitus subjects. The present study investigates whether ECES with a positive current can abolish the noise-induced central hyperactivity, i.e., the putative tinnitus-related activity. Spontaneous and stimulus-evoked neural activity before, during and after ECES was assessed from single-unit recordings in the inferior colliculus of anesthetized guinea pigs. We found that ECES with positive current significantly decreases the spontaneous firing rate of neurons with high characteristic frequencies, whereas negative current produces the opposite effect. The effects of the ECES are absent or even reversed for neurons with low characteristic frequencies. Importantly, ECES with positive current had only a marginal effect on thresholds and tone-induced activity of collicular neurons, suggesting that the main action of positive current is to modulate the spontaneous firing. Overall, cochlear electrical stimulation may be a viable approach for suppressing some forms of (peripheral-dependent) tinnitus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25298390</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>02</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>01</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1598</ISSN><JournalIssue CitedMedium="Internet"><Volume>113</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of neurophysiology</Title><ISOAbbreviation>J. Neurophysiol.</ISOAbbreviation></Journal><ArticleTitle>Suppression of putative tinnitus-related activity by extra-cochlear electrical stimulation.</ArticleTitle><Pagination><MedlinePgn>132-43</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/jn.00580.2014</ELocationID><Abstract><AbstractText>Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-induced central hyperactivity. This latter result further suggests that an approach consisting of reducing cochlear activity may provide a therapeutic avenue for tinnitus. In this context, extra-cochlear electric stimulation (ECES) may be a good candidate to modulate cochlear activity and suppress tinnitus. Indeed, it has been shown that a positive current applied at the round window reduces cochlear nerve activity and can suppress tinnitus reliably in tinnitus subjects. The present study investigates whether ECES with a positive current can abolish the noise-induced central hyperactivity, i.e., the putative tinnitus-related activity. Spontaneous and stimulus-evoked neural activity before, during and after ECES was assessed from single-unit recordings in the inferior colliculus of anesthetized guinea pigs. We found that ECES with positive current significantly decreases the spontaneous firing rate of neurons with high characteristic frequencies, whereas negative current produces the opposite effect. The effects of the ECES are absent or even reversed for neurons with low characteristic frequencies. Importantly, ECES with positive current had only a marginal effect on thresholds and tone-induced activity of collicular neurons, suggesting that the main action of positive current is to modulate the spontaneous firing. Overall, cochlear electrical stimulation may be a viable approach for suppressing some forms of (peripheral-dependent) tinnitus.</AbstractText><CopyrightInformation>Copyright © 2015 the American Physiological Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Noreña</LastName><ForeName>A J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Laboratory of Adaptive and Integrative Neuroscience, CNRS, and Aix-Marseille Université, Fédération de Recherche 3C, Marseille, France; and arnaud.norena@univ-amu.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulders</LastName><ForeName>W H A M</ForeName><Initials>WH</Initials><AffiliationInfo><Affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robertson</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The University of Western Australia, Crawley, Western Australia, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurophysiol</MedlineTA><NlmUniqueID>0375404</NlmUniqueID><ISSNLinking>0022-3077</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000161" MajorTopicYN="N">Acoustic Stimulation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000200" MajorTopicYN="N">Action Potentials</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006168" MajorTopicYN="N">Guinea Pigs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007245" MajorTopicYN="N">Inferior Colliculi</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009622" MajorTopicYN="N">Noise</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014012" MajorTopicYN="N">Tinnitus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">auditory perception</Keyword><Keyword MajorTopicYN="N">cochlear nerve</Keyword><Keyword MajorTopicYN="N">hearing loss</Keyword><Keyword MajorTopicYN="N">noise trauma</Keyword><Keyword MajorTopicYN="N">plasticity</Keyword><Keyword MajorTopicYN="N">spontaneous activity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25298390</ArticleId><ArticleId IdType="pii">jn.00580.2014</ArticleId><ArticleId IdType="doi">10.1152/jn.00580.2014</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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