HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Identifieur interne : 003198 ( PubMed/Corpus ); précédent : 003197; suivant : 003199HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Auteurs : Daniel I. Swerdlow ; David Preiss ; Karoline B. Kuchenbaecker ; Michael V. Holmes ; Jorgen E L. Engmann ; Tina Shah ; Reecha Sofat ; Stefan Stender ; Paul C D. Johnson ; Robert A. Scott ; Maarten Leusink ; Niek Verweij ; Stephen J. Sharp ; Yiran Guo ; Claudia Giambartolomei ; Christina Chung ; Anne Peasey ; Antoinette Amuzu ; Kawah Li ; Jutta Palmen ; Philip Howard ; Jackie A. Cooper ; Fotios Drenos ; Yun R. Li ; Gordon Lowe ; John Gallacher ; Marlene C W. Stewart ; Ioanna Tzoulaki ; Sarah G. Buxbaum ; Daphne L. Van Der A ; Nita G. Forouhi ; N Charlotte Onland-Moret ; Yvonne T. Van Der Schouw ; Renate B. Schnabel ; Jaroslav A. Hubacek ; Ruzena Kubinova ; Migle Baceviciene ; Abdonas Tamosiunas ; Andrzej Pajak ; Roman Topor-Madry ; Urszula Stepaniak ; Sofia Malyutina ; Damiano Baldassarre ; Bengt Sennblad ; Elena Tremoli ; Ulf De Faire ; Fabrizio Veglia ; Ian Ford ; J Wouter Jukema ; Rudi G J. Westendorp ; Gert Jan De Borst ; Pim A. De Jong ; Ale Algra ; Wilko Spiering ; Anke H. Maitland-Van Der Zee ; Olaf H. Klungel ; Anthonius De Boer ; Pieter A. Doevendans ; Charles B. Eaton ; Jennifer G. Robinson ; David Duggan ; John Kjekshus ; John R. Downs ; Antonio M. Gotto ; Anthony C. Keech ; Roberto Marchioli ; Gianni Tognoni ; Peter S. Sever ; Neil R. Poulter ; David D. Waters ; Terje R. Pedersen ; Pierre Amarenco ; Haruo Nakamura ; John J V. Mcmurray ; James D. Lewsey ; Daniel I. Chasman ; Paul M. Ridker ; Aldo P. Maggioni ; Luigi Tavazzi ; Kausik K. Ray ; Sreenivasa Rao Kondapally Seshasai ; Joann E. Manson ; Jackie F. Price ; Peter H. Whincup ; Richard W. Morris ; Debbie A. Lawlor ; George Davey Smith ; Yoav Ben-Shlomo ; Pamela J. Schreiner ; Myriam Fornage ; David S. Siscovick ; Mary Cushman ; Meena Kumari ; Nick J. Wareham ; W M Monique Verschuren ; Susan Redline ; Sanjay R. Patel ; John C. Whittaker ; Anders Hamsten ; Joseph A. Delaney ; Caroline Dale ; Tom R. Gaunt ; Andrew Wong ; Diana Kuh ; Rebecca Hardy ; Sekar Kathiresan ; Berta A. Castillo ; Pim Van Der Harst ; Eric J. Brunner ; Anne Tybjaerg-Hansen ; Michael G. Marmot ; Ronald M. Krauss ; Michael Tsai ; Josef Coresh ; Ronald C. Hoogeveen ; Bruce M. Psaty ; Leslie A. Lange ; Hakon Hakonarson ; Frank Dudbridge ; Steve E. Humphries ; Philippa J. Talmud ; Mika Kivim Ki ; Nicholas J. Timpson ; Claudia Langenberg ; Folkert W. Asselbergs ; Mikhail Voevoda ; Martin Bobak ; Hynek Pikhart ; James G. Wilson ; Alex P. Reiner ; Brendan J. Keating ; Aroon D. Hingorani ; Naveed SattarSource :
- Lancet (London, England) [ 1474-547X ] ; 2015.
English descriptors
- KwdEn :
- Aged, Body Mass Index, Body Weight (genetics), Cholesterol, HDL (metabolism), Cholesterol, LDL (metabolism), Diabetes Mellitus, Type 2 (genetics), Female, Genetic Testing, Humans, Hydroxymethylglutaryl CoA Reductases (genetics), Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects), Male, Middle Aged, Polymorphism, Single Nucleotide (genetics), Randomized Controlled Trials as Topic, Risk Factors.
- MESH :
- chemical , adverse effects : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemical , genetics : Hydroxymethylglutaryl CoA Reductases.
- chemical , metabolism : Cholesterol, HDL, Cholesterol, LDL.
- genetics : Body Weight, Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide.
- Aged, Body Mass Index, Female, Genetic Testing, Humans, Male, Middle Aged, Randomized Controlled Trials as Topic, Risk Factors.
Abstract
Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.
DOI: 10.1016/S0140-6736(14)61183-1
PubMed: 25262344
Links to Exploration step
pubmed:25262344Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.</title><author><name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK. Electronic address: d.swerdlow@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address: david.preiss@glasgow.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Engmann, Jorgen E L" sort="Engmann, Jorgen E L" uniqKey="Engmann J" first="Jorgen E L" last="Engmann">Jorgen E L. Engmann</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name><affiliation><nlm:affiliation>UCL Department of Medicine, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stender, Stefan" sort="Stender, Stefan" uniqKey="Stender S" first="Stefan" last="Stender">Stefan Stender</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C D" last="Johnson">Paul C D. Johnson</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J" last="Sharp">Stephen J. Sharp</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Yiran" sort="Guo, Yiran" uniqKey="Guo Y" first="Yiran" last="Guo">Yiran Guo</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giambartolomei, Claudia" sort="Giambartolomei, Claudia" uniqKey="Giambartolomei C" first="Claudia" last="Giambartolomei">Claudia Giambartolomei</name><affiliation><nlm:affiliation>UCL Genetics Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Christina" sort="Chung, Christina" uniqKey="Chung C" first="Christina" last="Chung">Christina Chung</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Peasey, Anne" sort="Peasey, Anne" uniqKey="Peasey A" first="Anne" last="Peasey">Anne Peasey</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amuzu, Antoinette" sort="Amuzu, Antoinette" uniqKey="Amuzu A" first="Antoinette" last="Amuzu">Antoinette Amuzu</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Kawah" sort="Li, Kawah" uniqKey="Li K" first="Kawah" last="Li">Kawah Li</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Palmen, Jutta" sort="Palmen, Jutta" uniqKey="Palmen J" first="Jutta" last="Palmen">Jutta Palmen</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Howard, Philip" sort="Howard, Philip" uniqKey="Howard P" first="Philip" last="Howard">Philip Howard</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Jackie A" sort="Cooper, Jackie A" uniqKey="Cooper J" first="Jackie A" last="Cooper">Jackie A. Cooper</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Drenos, Fotios" sort="Drenos, Fotios" uniqKey="Drenos F" first="Fotios" last="Drenos">Fotios Drenos</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:affiliation>Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, Marlene C W" sort="Stewart, Marlene C W" uniqKey="Stewart M" first="Marlene C W" last="Stewart">Marlene C W. Stewart</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Buxbaum, Sarah G" sort="Buxbaum, Sarah G" uniqKey="Buxbaum S" first="Sarah G" last="Buxbaum">Sarah G. Buxbaum</name><affiliation><nlm:affiliation>Jackson State University, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der A, Daphne L" sort="Van Der A, Daphne L" uniqKey="Van Der A D" first="Daphne L" last="Van Der A">Daphne L. Van Der A</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schnabel, Renate B" sort="Schnabel, Renate B" uniqKey="Schnabel R" first="Renate B" last="Schnabel">Renate B. Schnabel</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hubacek, Jaroslav A" sort="Hubacek, Jaroslav A" uniqKey="Hubacek J" first="Jaroslav A" last="Hubacek">Jaroslav A. Hubacek</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Baceviciene, Migle" sort="Baceviciene, Migle" uniqKey="Baceviciene M" first="Migle" last="Baceviciene">Migle Baceviciene</name><affiliation><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation><nlm:affiliation>Institute of Cardiology, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Pajak, Andrzej" sort="Pajak, Andrzej" uniqKey="Pajak A" first="Andrzej" last="Pajak">Andrzej Pajak</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Topor Madry, Roman" sort="Topor Madry, Roman" uniqKey="Topor Madry R" first="Roman" last="Topor-Madry">Roman Topor-Madry</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Stepaniak, Urszula" sort="Stepaniak, Urszula" uniqKey="Stepaniak U" first="Urszula" last="Stepaniak">Urszula Stepaniak</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation><nlm:affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name><affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name><affiliation><nlm:affiliation>Biostatistics Unit, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Borst, Gert Jan" sort="De Borst, Gert Jan" uniqKey="De Borst G" first="Gert Jan" last="De Borst">Gert Jan De Borst</name><affiliation><nlm:affiliation>Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Pim A" sort="De Jong, Pim A" uniqKey="De Jong P" first="Pim A" last="De Jong">Pim A. De Jong</name><affiliation><nlm:affiliation>Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Spiering, Wilko" sort="Spiering, Wilko" uniqKey="Spiering W" first="Wilko" last="Spiering">Wilko Spiering</name><affiliation><nlm:affiliation>Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Klungel, Olaf H" sort="Klungel, Olaf H" uniqKey="Klungel O" first="Olaf H" last="Klungel">Olaf H. Klungel</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Anthonius" sort="De Boer, Anthonius" uniqKey="De Boer A" first="Anthonius" last="De Boer">Anthonius De Boer</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eaton, Charles B" sort="Eaton, Charles B" uniqKey="Eaton C" first="Charles B" last="Eaton">Charles B. Eaton</name><affiliation><nlm:affiliation>Memorial Hospital of Rhode Island, RI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Jennifer G" sort="Robinson, Jennifer G" uniqKey="Robinson J" first="Jennifer G" last="Robinson">Jennifer G. Robinson</name><affiliation><nlm:affiliation>University of Iowa, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:affiliation>Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kjekshus, John" sort="Kjekshus, John" uniqKey="Kjekshus J" first="John" last="Kjekshus">John Kjekshus</name><affiliation><nlm:affiliation>Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name><affiliation><nlm:affiliation>Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA; VERDICT, South Texas Veterans Health Care System, San Antonio, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name><affiliation><nlm:affiliation>Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name><affiliation><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name><affiliation><nlm:affiliation>Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tognoni, Gianni" sort="Tognoni, Gianni" uniqKey="Tognoni G" first="Gianni" last="Tognoni">Gianni Tognoni</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name><affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name><affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name><affiliation><nlm:affiliation>Department of Medicine, University of California, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name><affiliation><nlm:affiliation>Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name><affiliation><nlm:affiliation>Denis Diderot University, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nakamura, Haruo" sort="Nakamura, Haruo" uniqKey="Nakamura H" first="Haruo" last="Nakamura">Haruo Nakamura</name><affiliation><nlm:affiliation>Mitsukoshi Health and Welfare Foundation, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J V" last="Mcmurray">John J V. Mcmurray</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lewsey, James D" sort="Lewsey, James D" uniqKey="Lewsey J" first="James D" last="Lewsey">James D. Lewsey</name><affiliation><nlm:affiliation>Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name><affiliation><nlm:affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Seshasai, Sreenivasa Rao Kondapally" sort="Seshasai, Sreenivasa Rao Kondapally" uniqKey="Seshasai S" first="Sreenivasa Rao Kondapally" last="Seshasai">Sreenivasa Rao Kondapally Seshasai</name><affiliation><nlm:affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name><affiliation><nlm:affiliation>St George's University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name><affiliation><nlm:affiliation>UCL Department of Primary Care and Population Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schreiner, Pamela J" sort="Schreiner, Pamela J" uniqKey="Schreiner P" first="Pamela J" last="Schreiner">Pamela J. Schreiner</name><affiliation><nlm:affiliation>School of Public Health, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:affiliation>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><affiliation><nlm:affiliation>Departments of Medicine and Pathology, University of Vermont, Colchester, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation><nlm:affiliation>Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R" last="Patel">Sanjay R. Patel</name><affiliation><nlm:affiliation>Division of Sleep Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Whittaker, John C" sort="Whittaker, John C" uniqKey="Whittaker J" first="John C" last="Whittaker">John C. Whittaker</name><affiliation><nlm:affiliation>GlaxoSmithKline, Stevenage, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Delaney, Joseph A" sort="Delaney, Joseph A" uniqKey="Delaney J" first="Joseph A" last="Delaney">Joseph A. Delaney</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dale, Caroline" sort="Dale, Caroline" uniqKey="Dale C" first="Caroline" last="Dale">Caroline Dale</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hardy, Rebecca" sort="Hardy, Rebecca" uniqKey="Hardy R" first="Rebecca" last="Hardy">Rebecca Hardy</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:affiliation>Cardiology Division, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Castillo, Berta A" sort="Castillo, Berta A" uniqKey="Castillo B" first="Berta A" last="Castillo">Berta A. Castillo</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M" last="Krauss">Ronald M. Krauss</name><affiliation><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, CA USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsai, Michael" sort="Tsai, Michael" uniqKey="Tsai M" first="Michael" last="Tsai">Michael Tsai</name><affiliation><nlm:affiliation>University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hoogeveen, Ronald C" sort="Hoogeveen, Ronald C" uniqKey="Hoogeveen R" first="Ronald C" last="Hoogeveen">Ronald C. Hoogeveen</name><affiliation><nlm:affiliation>Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation><nlm:affiliation>Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name><affiliation><nlm:affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, James G" sort="Wilson, James G" uniqKey="Wilson J" first="James G" last="Wilson">James G. Wilson</name><affiliation><nlm:affiliation>Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. 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Swerdlow</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK. Electronic address: d.swerdlow@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address: david.preiss@glasgow.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Engmann, Jorgen E L" sort="Engmann, Jorgen E L" uniqKey="Engmann J" first="Jorgen E L" last="Engmann">Jorgen E L. Engmann</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name><affiliation><nlm:affiliation>UCL Department of Medicine, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stender, Stefan" sort="Stender, Stefan" uniqKey="Stender S" first="Stefan" last="Stender">Stefan Stender</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C D" last="Johnson">Paul C D. Johnson</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J" last="Sharp">Stephen J. Sharp</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Yiran" sort="Guo, Yiran" uniqKey="Guo Y" first="Yiran" last="Guo">Yiran Guo</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giambartolomei, Claudia" sort="Giambartolomei, Claudia" uniqKey="Giambartolomei C" first="Claudia" last="Giambartolomei">Claudia Giambartolomei</name><affiliation><nlm:affiliation>UCL Genetics Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Christina" sort="Chung, Christina" uniqKey="Chung C" first="Christina" last="Chung">Christina Chung</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Peasey, Anne" sort="Peasey, Anne" uniqKey="Peasey A" first="Anne" last="Peasey">Anne Peasey</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amuzu, Antoinette" sort="Amuzu, Antoinette" uniqKey="Amuzu A" first="Antoinette" last="Amuzu">Antoinette Amuzu</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Kawah" sort="Li, Kawah" uniqKey="Li K" first="Kawah" last="Li">Kawah Li</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Palmen, Jutta" sort="Palmen, Jutta" uniqKey="Palmen J" first="Jutta" last="Palmen">Jutta Palmen</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Howard, Philip" sort="Howard, Philip" uniqKey="Howard P" first="Philip" last="Howard">Philip Howard</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Jackie A" sort="Cooper, Jackie A" uniqKey="Cooper J" first="Jackie A" last="Cooper">Jackie A. Cooper</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Drenos, Fotios" sort="Drenos, Fotios" uniqKey="Drenos F" first="Fotios" last="Drenos">Fotios Drenos</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:affiliation>Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, Marlene C W" sort="Stewart, Marlene C W" uniqKey="Stewart M" first="Marlene C W" last="Stewart">Marlene C W. Stewart</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Buxbaum, Sarah G" sort="Buxbaum, Sarah G" uniqKey="Buxbaum S" first="Sarah G" last="Buxbaum">Sarah G. Buxbaum</name><affiliation><nlm:affiliation>Jackson State University, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der A, Daphne L" sort="Van Der A, Daphne L" uniqKey="Van Der A D" first="Daphne L" last="Van Der A">Daphne L. Van Der A</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schnabel, Renate B" sort="Schnabel, Renate B" uniqKey="Schnabel R" first="Renate B" last="Schnabel">Renate B. Schnabel</name><affiliation><nlm:affiliation>University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hubacek, Jaroslav A" sort="Hubacek, Jaroslav A" uniqKey="Hubacek J" first="Jaroslav A" last="Hubacek">Jaroslav A. Hubacek</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Baceviciene, Migle" sort="Baceviciene, Migle" uniqKey="Baceviciene M" first="Migle" last="Baceviciene">Migle Baceviciene</name><affiliation><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation><nlm:affiliation>Institute of Cardiology, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Pajak, Andrzej" sort="Pajak, Andrzej" uniqKey="Pajak A" first="Andrzej" last="Pajak">Andrzej Pajak</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Topor Madry, Roman" sort="Topor Madry, Roman" uniqKey="Topor Madry R" first="Roman" last="Topor-Madry">Roman Topor-Madry</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Stepaniak, Urszula" sort="Stepaniak, Urszula" uniqKey="Stepaniak U" first="Urszula" last="Stepaniak">Urszula Stepaniak</name><affiliation><nlm:affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation><nlm:affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name><affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name><affiliation><nlm:affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name><affiliation><nlm:affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name><affiliation><nlm:affiliation>Biostatistics Unit, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Borst, Gert Jan" sort="De Borst, Gert Jan" uniqKey="De Borst G" first="Gert Jan" last="De Borst">Gert Jan De Borst</name><affiliation><nlm:affiliation>Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Pim A" sort="De Jong, Pim A" uniqKey="De Jong P" first="Pim A" last="De Jong">Pim A. De Jong</name><affiliation><nlm:affiliation>Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Spiering, Wilko" sort="Spiering, Wilko" uniqKey="Spiering W" first="Wilko" last="Spiering">Wilko Spiering</name><affiliation><nlm:affiliation>Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Klungel, Olaf H" sort="Klungel, Olaf H" uniqKey="Klungel O" first="Olaf H" last="Klungel">Olaf H. Klungel</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Anthonius" sort="De Boer, Anthonius" uniqKey="De Boer A" first="Anthonius" last="De Boer">Anthonius De Boer</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eaton, Charles B" sort="Eaton, Charles B" uniqKey="Eaton C" first="Charles B" last="Eaton">Charles B. Eaton</name><affiliation><nlm:affiliation>Memorial Hospital of Rhode Island, RI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Jennifer G" sort="Robinson, Jennifer G" uniqKey="Robinson J" first="Jennifer G" last="Robinson">Jennifer G. Robinson</name><affiliation><nlm:affiliation>University of Iowa, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:affiliation>Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kjekshus, John" sort="Kjekshus, John" uniqKey="Kjekshus J" first="John" last="Kjekshus">John Kjekshus</name><affiliation><nlm:affiliation>Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name><affiliation><nlm:affiliation>Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA; VERDICT, South Texas Veterans Health Care System, San Antonio, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name><affiliation><nlm:affiliation>Weill Cornell Medical College, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name><affiliation><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name><affiliation><nlm:affiliation>Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tognoni, Gianni" sort="Tognoni, Gianni" uniqKey="Tognoni G" first="Gianni" last="Tognoni">Gianni Tognoni</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name><affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name><affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name><affiliation><nlm:affiliation>Department of Medicine, University of California, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name><affiliation><nlm:affiliation>Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name><affiliation><nlm:affiliation>Denis Diderot University, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nakamura, Haruo" sort="Nakamura, Haruo" uniqKey="Nakamura H" first="Haruo" last="Nakamura">Haruo Nakamura</name><affiliation><nlm:affiliation>Mitsukoshi Health and Welfare Foundation, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J V" last="Mcmurray">John J V. Mcmurray</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lewsey, James D" sort="Lewsey, James D" uniqKey="Lewsey J" first="James D" last="Lewsey">James D. Lewsey</name><affiliation><nlm:affiliation>Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation><nlm:affiliation>ANMCO Research Center, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name><affiliation><nlm:affiliation>Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name><affiliation><nlm:affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Seshasai, Sreenivasa Rao Kondapally" sort="Seshasai, Sreenivasa Rao Kondapally" uniqKey="Seshasai S" first="Sreenivasa Rao Kondapally" last="Seshasai">Sreenivasa Rao Kondapally Seshasai</name><affiliation><nlm:affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name><affiliation><nlm:affiliation>St George's University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name><affiliation><nlm:affiliation>UCL Department of Primary Care and Population Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schreiner, Pamela J" sort="Schreiner, Pamela J" uniqKey="Schreiner P" first="Pamela J" last="Schreiner">Pamela J. Schreiner</name><affiliation><nlm:affiliation>School of Public Health, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><nlm:affiliation>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><affiliation><nlm:affiliation>Departments of Medicine and Pathology, University of Vermont, Colchester, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation><nlm:affiliation>Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R" last="Patel">Sanjay R. Patel</name><affiliation><nlm:affiliation>Division of Sleep Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Whittaker, John C" sort="Whittaker, John C" uniqKey="Whittaker J" first="John C" last="Whittaker">John C. Whittaker</name><affiliation><nlm:affiliation>GlaxoSmithKline, Stevenage, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Delaney, Joseph A" sort="Delaney, Joseph A" uniqKey="Delaney J" first="Joseph A" last="Delaney">Joseph A. Delaney</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dale, Caroline" sort="Dale, Caroline" uniqKey="Dale C" first="Caroline" last="Dale">Caroline Dale</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hardy, Rebecca" sort="Hardy, Rebecca" uniqKey="Hardy R" first="Rebecca" last="Hardy">Rebecca Hardy</name><affiliation><nlm:affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name><affiliation><nlm:affiliation>Cardiology Division, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Castillo, Berta A" sort="Castillo, Berta A" uniqKey="Castillo B" first="Berta A" last="Castillo">Berta A. Castillo</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name><affiliation><nlm:affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M" last="Krauss">Ronald M. Krauss</name><affiliation><nlm:affiliation>Children's Hospital Oakland Research Institute, Oakland, CA USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tsai, Michael" sort="Tsai, Michael" uniqKey="Tsai M" first="Michael" last="Tsai">Michael Tsai</name><affiliation><nlm:affiliation>University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hoogeveen, Ronald C" sort="Hoogeveen, Ronald C" uniqKey="Hoogeveen R" first="Ronald C" last="Hoogeveen">Ronald C. Hoogeveen</name><affiliation><nlm:affiliation>Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation><nlm:affiliation>Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name><affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name><affiliation><nlm:affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation><nlm:affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, James G" sort="Wilson, James G" uniqKey="Wilson J" first="James G" last="Wilson">James G. Wilson</name><affiliation><nlm:affiliation>Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Body Weight (genetics)</term><term>Cholesterol, HDL (metabolism)</term><term>Cholesterol, LDL (metabolism)</term><term>Diabetes Mellitus, Type 2 (genetics)</term><term>Female</term><term>Genetic Testing</term><term>Humans</term><term>Hydroxymethylglutaryl CoA Reductases (genetics)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hydroxymethylglutaryl CoA Reductases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Weight</term><term>Diabetes Mellitus, Type 2</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Female</term><term>Genetic Testing</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Randomized Controlled Trials as Topic</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25262344</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>24</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>385</Volume><Issue>9965</Issue><PubDate><Year>2015</Year><Month>Jan</Month><Day>24</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.</ArticleTitle><Pagination><MedlinePgn>351-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(14)61183-1</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(14)61183-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes. Study-specific effect estimates per copy of each LDL-lowering allele were pooled by meta-analysis. These findings were compared with a meta-analysis of new-onset type 2 diabetes and bodyweight change data from randomised trials of statin drugs. The effects of statins in each randomised trial were assessed using meta-analysis.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Data were available for up to 223 463 individuals from 43 genetic studies. Each additional rs17238484-G allele was associated with a mean 0·06 mmol/L (95% CI 0·05-0·07) lower LDL cholesterol and higher body weight (0·30 kg, 0·18-0·43), waist circumference (0·32 cm, 0·16-0·47), plasma insulin concentration (1·62%, 0·53-2·72), and plasma glucose concentration (0·23%, 0·02-0·44). The rs12916 SNP had similar effects on LDL cholesterol, bodyweight, and waist circumference. The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00-1·05); the rs12916-T allele association was consistent (1·06, 1·03-1·09). In 129 170 individuals in randomised trials, statins lowered LDL cholesterol by 0·92 mmol/L (95% CI 0·18-1·67) at 1-year of follow-up, increased bodyweight by 0·24 kg (95% CI 0·10-0·38 in all trials; 0·33 kg, 95% CI 0·24-0·42 in placebo or standard care controlled trials and -0·15 kg, 95% CI -0·39 to 0·08 in intensive-dose vs moderate-dose trials) at a mean of 4·2 years (range 1·9-6·7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1·12, 95% CI 1·06-1·18 in all trials; 1·11, 95% CI 1·03-1·20 in placebo or standard care controlled trials and 1·12, 95% CI 1·04-1·22 in intensive-dose vs moderate dose trials).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">The funding sources are cited at the end of the paper.</AbstractText><CopyrightInformation>Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Swerdlow</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK. Electronic address: d.swerdlow@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preiss</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address: david.preiss@glasgow.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuchenbaecker</LastName><ForeName>Karoline B</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Michael V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engmann</LastName><ForeName>Jorgen E L</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Tina</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sofat</LastName><ForeName>Reecha</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>UCL Department of Medicine, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stender</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Paul C D</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leusink</LastName><ForeName>Maarten</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharp</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Yiran</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giambartolomei</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UCL Genetics Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peasey</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amuzu</LastName><ForeName>Antoinette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>KaWah</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmen</LastName><ForeName>Jutta</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Howard</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Jackie A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drenos</LastName><ForeName>Fotios</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yun R</ForeName><Initials>YR</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lowe</LastName><ForeName>Gordon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallacher</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>Marlene C W</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzoulaki</LastName><ForeName>Ioanna</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buxbaum</LastName><ForeName>Sarah G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Jackson State University, Jackson, MS, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der A</LastName><ForeName>Daphne L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forouhi</LastName><ForeName>Nita G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onland-Moret</LastName><ForeName>N Charlotte</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Schouw</LastName><ForeName>Yvonne T</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schnabel</LastName><ForeName>Renate B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hubacek</LastName><ForeName>Jaroslav A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubinova</LastName><ForeName>Ruzena</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Institute of Public Health, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baceviciene</LastName><ForeName>Migle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamosiunas</LastName><ForeName>Abdonas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cardiology, Kaunas, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pajak</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topor-Madry</LastName><ForeName>Roman</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stepaniak</LastName><ForeName>Urszula</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malyutina</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baldassarre</LastName><ForeName>Damiano</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sennblad</LastName><ForeName>Bengt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tremoli</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Faire</LastName><ForeName>Ulf</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veglia</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Biostatistics Unit, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jukema</LastName><ForeName>J Wouter</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westendorp</LastName><ForeName>Rudi G J</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Borst</LastName><ForeName>Gert Jan</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>Pim A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Algra</LastName><ForeName>Ale</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spiering</LastName><ForeName>Wilko</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maitland-van der Zee</LastName><ForeName>Anke H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klungel</LastName><ForeName>Olaf H</ForeName><Initials>OH</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Boer</LastName><ForeName>Anthonius</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doevendans</LastName><ForeName>Pieter A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eaton</LastName><ForeName>Charles B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Memorial Hospital of Rhode Island, RI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Jennifer G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>University of Iowa, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duggan</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Translational Genomics Research Institute, Phoenix, AZ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>DIAGRAM Consortium</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>MAGIC Consortium</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>InterAct Consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Kjekshus</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Downs</LastName><ForeName>John R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA; VERDICT, South Texas Veterans Health Care System, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gotto</LastName><ForeName>Antonio M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Weill Cornell Medical College, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keech</LastName><ForeName>Anthony C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marchioli</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tognoni</LastName><ForeName>Gianni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sever</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poulter</LastName><ForeName>Neil R</ForeName><Initials>NR</Initials><AffiliationInfo><Affiliation>International Centre for Circulatory Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waters</LastName><ForeName>David D</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Terje R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amarenco</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Denis Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Haruo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Mitsukoshi Health and Welfare Foundation, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMurray</LastName><ForeName>John J V</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewsey</LastName><ForeName>James D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maggioni</LastName><ForeName>Aldo P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>ANMCO Research Center, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavazzi</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ray</LastName><ForeName>Kausik K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seshasai</LastName><ForeName>Sreenivasa Rao Kondapally</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Cardiac and Cell Sciences Research Institute, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manson</LastName><ForeName>JoAnn E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>Jackie F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whincup</LastName><ForeName>Peter H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>St George's University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Richard W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>UCL Department of Primary Care and Population Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawlor</LastName><ForeName>Debbie A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>George Davey</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schreiner</LastName><ForeName>Pamela J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>School of Public Health, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fornage</LastName><ForeName>Myriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siscovick</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cushman</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Departments of Medicine and Pathology, University of Vermont, Colchester, VT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nick J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verschuren</LastName><ForeName>W M Monique</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>National Institute for Public Health and the Environment, Bilthoven, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Redline</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Sanjay R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Division of Sleep Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whittaker</LastName><ForeName>John C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline, Stevenage, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamsten</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delaney</LastName><ForeName>Joseph A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dale</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaunt</LastName><ForeName>Tom R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuh</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kathiresan</LastName><ForeName>Sekar</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cardiology Division, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castillo</LastName><ForeName>Berta A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunner</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tybjaerg-Hansen</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marmot</LastName><ForeName>Michael G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krauss</LastName><ForeName>Ronald M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Children's Hospital Oakland Research Institute, Oakland, CA USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coresh</LastName><ForeName>Josef</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoogeveen</LastName><ForeName>Ronald C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psaty</LastName><ForeName>Bruce M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Leslie A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hakonarson</LastName><ForeName>Hakon</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dudbridge</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humphries</LastName><ForeName>Steve E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talmud</LastName><ForeName>Philippa J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimäki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Timpson</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langenberg</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asselbergs</LastName><ForeName>Folkert W</ForeName><Initials>FW</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voevoda</LastName><ForeName>Mikhail</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bobak</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pikhart</LastName><ForeName>Hynek</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>UCL Research Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>James G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Alex P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keating</LastName><ForeName>Brendan J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hingorani</LastName><ForeName>Aroon D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sattar</LastName><ForeName>Naveed</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>1R01 AG23522-01</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RG/13/2/30098</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/08/008/25291</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/13/66/30442</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL036310</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UP_A100_1003</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006215/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G19/35</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12013/3</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0100222</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>K013351</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12019/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G8802774</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0902037</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 AG034454</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0500877</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>FS/07/011</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>064947/Z/01/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P20 MD006899</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG023522</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20MD006899</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G1000616</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12013/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0701830</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG 08/008</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HL036310</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182913</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>81081/Z/06/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0802432</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006584/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12015/5</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/07/133/24260</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U19 HL065797</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12013/5</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0601647</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>AG034454</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12013/8</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0600705</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>081081/Z/06/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/07/008/23674</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/10/12/28456</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008076">Cholesterol, HDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.-</RegistryNumber><NameOfSubstance UI="C553220">HMGCR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.-</RegistryNumber><NameOfSubstance UI="D006903">Hydroxymethylglutaryl CoA 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RefType="CommentIn"><RefSource>Lancet. 2015 Jan 24;385(9965):310-2</RefSource><PMID Version="1">25262342</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2015 May 16;385(9981):1946</RefSource><PMID Version="1">26090640</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008076" MajorTopicYN="N">Cholesterol, HDL</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008078" MajorTopicYN="N">Cholesterol, LDL</DescriptorName><QualifierName UI="Q000378" 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