Vitamin D and cognitive function: A Mendelian randomisation study.
Identifieur interne : 000373 ( PubMed/Corpus ); précédent : 000372; suivant : 000374Vitamin D and cognitive function: A Mendelian randomisation study.
Auteurs : Jane Maddock ; Ang Zhou ; Alana Cavadino ; El Bieta Ku Ma ; Yanchun Bao ; Melissa C. Smart ; Kai-Uwe Saum ; Ben Schöttker ; Jorgen Engmann ; Marie Kj Rgaard ; Ville Karhunen ; Yiqiang Zhan ; Terho Lehtim Ki ; Suvi P. Rovio ; Liisa Byberg ; Jari Lahti ; Pedro Marques-Vidal ; Abhijit Sen ; Laura Perna ; Henrik Schirmer ; Archana Singh-Manoux ; Juha Auvinen ; Nina Hutri-K Hönen ; Mika K Hönen ; Lena Kilander ; Katri R Ikkönen ; H Kan Melhus ; Erik Ingelsson ; Idris Guessous ; Katja E. Petrovic ; Helena Schmidt ; Reinhold Schmidt ; Peter Vollenweider ; Lars Lind ; Johan G. Eriksson ; Karl Michaëlsson ; Olli T. Raitakari ; Sara H Gg ; Nancy L. Pedersen ; Karl-Heinz Herzig ; Marjo-Riitta J Rvelin ; Juha Veijola ; Mika Kivimaki ; Rolf Jorde ; Hermann Brenner ; Meena Kumari ; Chris Power ; David J. Llewellyn ; Elina HyppönenSource :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.
DOI: 10.1038/s41598-017-13189-3
PubMed: 29038561
Links to Exploration step
pubmed:29038561Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin D and cognitive function: A Mendelian randomisation study.</title><author><name sortKey="Maddock, Jane" sort="Maddock, Jane" uniqKey="Maddock J" first="Jane" last="Maddock">Jane Maddock</name><affiliation><nlm:affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Ang" sort="Zhou, Ang" uniqKey="Zhou A" first="Ang" last="Zhou">Ang Zhou</name><affiliation><nlm:affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ku Ma, El Bieta" sort="Ku Ma, El Bieta" uniqKey="Ku Ma E" first="El Bieta" last="Ku Ma">El Bieta Ku Ma</name><affiliation><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Smart, Melissa C" sort="Smart, Melissa C" uniqKey="Smart M" first="Melissa C" last="Smart">Melissa C. Smart</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Saum, Kai Uwe" sort="Saum, Kai Uwe" uniqKey="Saum K" first="Kai-Uwe" last="Saum">Kai-Uwe Saum</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schottker, Ben" sort="Schottker, Ben" uniqKey="Schottker B" first="Ben" last="Schöttker">Ben Schöttker</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Engmann, Jorgen" sort="Engmann, Jorgen" uniqKey="Engmann J" first="Jorgen" last="Engmann">Jorgen Engmann</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kj Rgaard, Marie" sort="Kj Rgaard, Marie" uniqKey="Kj Rgaard M" first="Marie" last="Kj Rgaard">Marie Kj Rgaard</name><affiliation><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Karhunen, Ville" sort="Karhunen, Ville" uniqKey="Karhunen V" first="Ville" last="Karhunen">Ville Karhunen</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Zhan, Yiqiang" sort="Zhan, Yiqiang" uniqKey="Zhan Y" first="Yiqiang" last="Zhan">Yiqiang Zhan</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Rovio, Suvi P" sort="Rovio, Suvi P" uniqKey="Rovio S" first="Suvi P" last="Rovio">Suvi P. Rovio</name><affiliation><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Byberg, Liisa" sort="Byberg, Liisa" uniqKey="Byberg L" first="Liisa" last="Byberg">Liisa Byberg</name><affiliation><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sen, Abhijit" sort="Sen, Abhijit" uniqKey="Sen A" first="Abhijit" last="Sen">Abhijit Sen</name><affiliation><nlm:affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Perna, Laura" sort="Perna, Laura" uniqKey="Perna L" first="Laura" last="Perna">Laura Perna</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schirmer, Henrik" sort="Schirmer, Henrik" uniqKey="Schirmer H" first="Henrik" last="Schirmer">Henrik Schirmer</name><affiliation><nlm:affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Auvinen, Juha" sort="Auvinen, Juha" uniqKey="Auvinen J" first="Juha" last="Auvinen">Juha Auvinen</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hutri K Honen, Nina" sort="Hutri K Honen, Nina" uniqKey="Hutri K Honen N" first="Nina" last="Hutri-K Hönen">Nina Hutri-K Hönen</name><affiliation><nlm:affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kilander, Lena" sort="Kilander, Lena" uniqKey="Kilander L" first="Lena" last="Kilander">Lena Kilander</name><affiliation><nlm:affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Melhus, H Kan" sort="Melhus, H Kan" uniqKey="Melhus H" first="H Kan" last="Melhus">H Kan Melhus</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation><nlm:affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Petrovic, Katja E" sort="Petrovic, Katja E" uniqKey="Petrovic K" first="Katja E" last="Petrovic">Katja E. Petrovic</name><affiliation><nlm:affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Veijola, Juha" sort="Veijola, Juha" uniqKey="Veijola J" first="Juha" last="Veijola">Juha Veijola</name><affiliation><nlm:affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jorde, Rolf" sort="Jorde, Rolf" uniqKey="Jorde R" first="Rolf" last="Jorde">Rolf Jorde</name><affiliation><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J" last="Llewellyn">David J. Llewellyn</name><affiliation><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29038561</idno><idno type="pmid">29038561</idno><idno type="doi">10.1038/s41598-017-13189-3</idno><idno type="wicri:Area/PubMed/Corpus">000373</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000373</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vitamin D and cognitive function: A Mendelian randomisation study.</title><author><name sortKey="Maddock, Jane" sort="Maddock, Jane" uniqKey="Maddock J" first="Jane" last="Maddock">Jane Maddock</name><affiliation><nlm:affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Ang" sort="Zhou, Ang" uniqKey="Zhou A" first="Ang" last="Zhou">Ang Zhou</name><affiliation><nlm:affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ku Ma, El Bieta" sort="Ku Ma, El Bieta" uniqKey="Ku Ma E" first="El Bieta" last="Ku Ma">El Bieta Ku Ma</name><affiliation><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Smart, Melissa C" sort="Smart, Melissa C" uniqKey="Smart M" first="Melissa C" last="Smart">Melissa C. Smart</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Saum, Kai Uwe" sort="Saum, Kai Uwe" uniqKey="Saum K" first="Kai-Uwe" last="Saum">Kai-Uwe Saum</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schottker, Ben" sort="Schottker, Ben" uniqKey="Schottker B" first="Ben" last="Schöttker">Ben Schöttker</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Engmann, Jorgen" sort="Engmann, Jorgen" uniqKey="Engmann J" first="Jorgen" last="Engmann">Jorgen Engmann</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kj Rgaard, Marie" sort="Kj Rgaard, Marie" uniqKey="Kj Rgaard M" first="Marie" last="Kj Rgaard">Marie Kj Rgaard</name><affiliation><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Karhunen, Ville" sort="Karhunen, Ville" uniqKey="Karhunen V" first="Ville" last="Karhunen">Ville Karhunen</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Zhan, Yiqiang" sort="Zhan, Yiqiang" uniqKey="Zhan Y" first="Yiqiang" last="Zhan">Yiqiang Zhan</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Rovio, Suvi P" sort="Rovio, Suvi P" uniqKey="Rovio S" first="Suvi P" last="Rovio">Suvi P. Rovio</name><affiliation><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Byberg, Liisa" sort="Byberg, Liisa" uniqKey="Byberg L" first="Liisa" last="Byberg">Liisa Byberg</name><affiliation><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sen, Abhijit" sort="Sen, Abhijit" uniqKey="Sen A" first="Abhijit" last="Sen">Abhijit Sen</name><affiliation><nlm:affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Perna, Laura" sort="Perna, Laura" uniqKey="Perna L" first="Laura" last="Perna">Laura Perna</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schirmer, Henrik" sort="Schirmer, Henrik" uniqKey="Schirmer H" first="Henrik" last="Schirmer">Henrik Schirmer</name><affiliation><nlm:affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Auvinen, Juha" sort="Auvinen, Juha" uniqKey="Auvinen J" first="Juha" last="Auvinen">Juha Auvinen</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hutri K Honen, Nina" sort="Hutri K Honen, Nina" uniqKey="Hutri K Honen N" first="Nina" last="Hutri-K Hönen">Nina Hutri-K Hönen</name><affiliation><nlm:affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kilander, Lena" sort="Kilander, Lena" uniqKey="Kilander L" first="Lena" last="Kilander">Lena Kilander</name><affiliation><nlm:affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Melhus, H Kan" sort="Melhus, H Kan" uniqKey="Melhus H" first="H Kan" last="Melhus">H Kan Melhus</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation><nlm:affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Petrovic, Katja E" sort="Petrovic, Katja E" uniqKey="Petrovic K" first="Katja E" last="Petrovic">Katja E. Petrovic</name><affiliation><nlm:affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation><nlm:affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Veijola, Juha" sort="Veijola, Juha" uniqKey="Veijola J" first="Juha" last="Veijola">Juha Veijola</name><affiliation><nlm:affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jorde, Rolf" sort="Jorde, Rolf" uniqKey="Jorde R" first="Rolf" last="Jorde">Rolf Jorde</name><affiliation><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J" last="Llewellyn">David J. Llewellyn</name><affiliation><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">29038561</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>16</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Vitamin D and cognitive function: A Mendelian randomisation study.</ArticleTitle><Pagination><MedlinePgn>13230</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-017-13189-3</ELocationID><Abstract><AbstractText>The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maddock</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. jane.maddock@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Ang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavadino</LastName><ForeName>Alana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuźma</LastName><ForeName>Elżbieta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Exeter Medical School, Exeter, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Yanchun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smart</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saum</LastName><ForeName>Kai-Uwe</ForeName><Initials>KU</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schöttker</LastName><ForeName>Ben</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Health Care and Social Sciences, FOM University, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engmann</LastName><ForeName>Jorgen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kjærgaard</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Endocrinology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karhunen</LastName><ForeName>Ville</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Yiqiang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehtimäki</LastName><ForeName>Terho</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rovio</LastName><ForeName>Suvi P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byberg</LastName><ForeName>Liisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>Jari</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4548-8500</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sen</LastName><ForeName>Abhijit</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perna</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schirmer</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh-Manoux</LastName><ForeName>Archana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1018, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auvinen</LastName><ForeName>Juha</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutri-Kähönen</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kähönen</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kilander</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räikkönen</LastName><ForeName>Katri</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melhus</LastName><ForeName>Håkan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingelsson</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guessous</LastName><ForeName>Idris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrovic</LastName><ForeName>Katja E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Reinhold</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Johan G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Center, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michaëlsson</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raitakari</LastName><ForeName>Olli T</ForeName><Initials>OT</Initials><AffiliationInfo><Affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hägg</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Nancy L</ForeName><Initials>NL</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herzig</LastName><ForeName>Karl-Heinz</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biocenter Oulu, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Järvelin</LastName><ForeName>Marjo-Riitta</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veijola</LastName><ForeName>Juha</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University Hospital of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimaki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4699-5627</Identifier><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinicum, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jorde</LastName><ForeName>Rolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Endocrinology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Power</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llewellyn</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>University of Exeter Medical School, Exeter, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyppönen</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, Adelaide, Australia. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL135313</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4135-7</RefSource><PMID Version="1">11929987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr Health Aging. 2009 Nov;13(9):760-7</RefSource><PMID Version="1">19812865</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2007 Jul 19;357(3):266-81</RefSource><PMID Version="1">17634462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Nutr. 2014 Mar 14;111(5):904-14</RefSource><PMID Version="1">24135155</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2011;26(3):477-84</RefSource><PMID Version="1">21694461</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ageing Res Rev. 2013 Sep;12(4):1013-23</RefSource><PMID Version="1">23727408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2016 Dec 13;87(24):2567-2574</RefSource><PMID Version="1">27856775</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2012 Dec;60(12):2197-205</RefSource><PMID Version="1">23176129</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2012 Apr;60(4):793-5</RefSource><PMID Version="1">22494292</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Sep 25;79(13):1397-405</RefSource><PMID Version="1">23008220</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Intern Med. 2015 Jan;277(1):45-57</RefSource><PMID Version="1">24995480</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Endocrinol Metab. 2002 Apr;13(3):100-5</RefSource><PMID Version="1">11893522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Audiol Neurootol. 2008;13(4):219-30</RefSource><PMID Version="1">18259074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Geriatr. 2017 Jan 13;17 (1):16</RefSource><PMID Version="1">28086755</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7</RefSource><PMID Version="1">19500727</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(11):e25966</RefSource><PMID Version="1">22073146</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2013;37(1):147-71</RefSource><PMID Version="1">23948884</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Osteoporos Int. 2008 Nov;19(11):1621-8</RefSource><PMID Version="1">18421544</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dement Geriatr Cogn Disord. 2012;33(5):297-305</RefSource><PMID Version="1">22759681</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2013 Jan;9(1):63-75.e2</RefSource><PMID Version="1">23305823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2010 Jul 1;19(13):2739-45</RefSource><PMID Version="1">20418485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(5):e37465</RefSource><PMID Version="1">22629401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2009 Oct;16(10):1083-9</RefSource><PMID Version="1">19659751</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2008 Apr 15;27(8):1133-63</RefSource><PMID Version="1">17886233</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Nephrol Hypertens. 2011 Jul;20(4):331-6</RefSource><PMID Version="1">21654390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Aging Neurosci. 2014 Apr 15;6:72</RefSource><PMID Version="1">24782767</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Bull. 2004 Jul 30;64(1):25-9</RefSource><PMID Version="1">15275953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2014 Apr 01;348:g1903</RefSource><PMID Version="1">24690623</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2003 Jun 5;343(2):139-43</RefSource><PMID Version="1">12759183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2013 Jun;61(6):1049-50</RefSource><PMID Version="1">23772744</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 Jul 17;376(9736):180-8</RefSource><PMID Version="1">20541252</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2005 Feb 28;157(2):299-308</RefSource><PMID Version="1">15639181</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29038561</ArticleId><ArticleId IdType="doi">10.1038/s41598-017-13189-3</ArticleId><ArticleId IdType="pii">10.1038/s41598-017-13189-3</ArticleId><ArticleId IdType="pmc">PMC5643555</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000373 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000373 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:29038561
|texte= Vitamin D and cognitive function: A Mendelian randomisation study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:29038561" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |