Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.
Identifieur interne : 000372 ( PubMed/Corpus ); précédent : 000371; suivant : 000373Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.
Auteurs : Yan-Hu Liu ; Lu Wang ; Tao Xu ; Xiaomin Guo ; Yang Li ; Ting-Ting Yin ; He-Chuan Yang ; Hu Yang ; Adeniyi C. Adeola ; Oscar J Sanke ; Newton O Otecko ; Meng Wang ; Yaping Ma ; Olaogun S Charles ; Mikkel-Holger S Sinding ; Shyam Gopalakrishnan ; José Alfredo Samaniego ; Anders J. Hansen ; Carlos Fernandes ; Philippe Gaubert ; Jane Budd ; Philip M Dawuda ; Eli Knispel Rueness ; Lubin Jiang ; Weiwei Zhai ; M T P. Gilbert ; Min-Sheng Peng ; Xiaopeng Qi ; Guo-Dong Wang ; Ya-Ping ZhangSource :
- Molecular biology and evolution [ 1537-1719 ] ; 2017.
Abstract
Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.
DOI: 10.1093/molbev/msx258
PubMed: 29040727
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.</title><author><name sortKey="Liu, Yan Hu" sort="Liu, Yan Hu" uniqKey="Liu Y" first="Yan-Hu" last="Liu">Yan-Hu Liu</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiaomin" sort="Guo, Xiaomin" uniqKey="Guo X" first="Xiaomin" last="Guo">Xiaomin Guo</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yin, Ting Ting" sort="Yin, Ting Ting" uniqKey="Yin T" first="Ting-Ting" last="Yin">Ting-Ting Yin</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, He Chuan" sort="Yang, He Chuan" uniqKey="Yang H" first="He-Chuan" last="Yang">He-Chuan Yang</name><affiliation><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Hu" sort="Yang, Hu" uniqKey="Yang H" first="Hu" last="Yang">Hu Yang</name><affiliation><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation></affiliation></author><author><name sortKey="Adeola, Adeniyi C" sort="Adeola, Adeniyi C" uniqKey="Adeola A" first="Adeniyi C" last="Adeola">Adeniyi C. Adeola</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="J Sanke, Oscar" sort="J Sanke, Oscar" uniqKey="J Sanke O" first="Oscar" last="J Sanke">Oscar J Sanke</name><affiliation><nlm:affiliation>Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="O Otecko, Newton" sort="O Otecko, Newton" uniqKey="O Otecko N" first="Newton" last="O Otecko">Newton O Otecko</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Yaping" sort="Ma, Yaping" uniqKey="Ma Y" first="Yaping" last="Ma">Yaping Ma</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="S Charles, Olaogun" sort="S Charles, Olaogun" uniqKey="S Charles O" first="Olaogun" last="S Charles">Olaogun S Charles</name><affiliation><nlm:affiliation>Department of Veterinary Medicine, University of Ibadan, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="S Sinding, Mikkel Holger" sort="S Sinding, Mikkel Holger" uniqKey="S Sinding M" first="Mikkel-Holger" last="S Sinding">Mikkel-Holger S Sinding</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Gopalakrishnan, Shyam" sort="Gopalakrishnan, Shyam" uniqKey="Gopalakrishnan S" first="Shyam" last="Gopalakrishnan">Shyam Gopalakrishnan</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Samaniego, Jose Alfredo" sort="Samaniego, Jose Alfredo" uniqKey="Samaniego J" first="José Alfredo" last="Samaniego">José Alfredo Samaniego</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Anders J" sort="Hansen, Anders J" uniqKey="Hansen A" first="Anders J" last="Hansen">Anders J. Hansen</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandes, Carlos" sort="Fernandes, Carlos" uniqKey="Fernandes C" first="Carlos" last="Fernandes">Carlos Fernandes</name><affiliation><nlm:affiliation>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Gaubert, Philippe" sort="Gaubert, Philippe" uniqKey="Gaubert P" first="Philippe" last="Gaubert">Philippe Gaubert</name><affiliation><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05,France.</nlm:affiliation></affiliation></author><author><name sortKey="Budd, Jane" sort="Budd, Jane" uniqKey="Budd J" first="Jane" last="Budd">Jane Budd</name><affiliation><nlm:affiliation>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah, United Arab Emirates.</nlm:affiliation></affiliation></author><author><name sortKey="M Dawuda, Philip" sort="M Dawuda, Philip" uniqKey="M Dawuda P" first="Philip" last="M Dawuda">Philip M Dawuda</name><affiliation><nlm:affiliation>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Rueness, Eli Knispel" sort="Rueness, Eli Knispel" uniqKey="Rueness E" first="Eli Knispel" last="Rueness">Eli Knispel Rueness</name><affiliation><nlm:affiliation>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Lubin" sort="Jiang, Lubin" uniqKey="Jiang L" first="Lubin" last="Jiang">Lubin Jiang</name><affiliation><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhai, Weiwei" sort="Zhai, Weiwei" uniqKey="Zhai W" first="Weiwei" last="Zhai">Weiwei Zhai</name><affiliation><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gilbert, M T P" sort="Gilbert, M T P" uniqKey="Gilbert M" first="M T P" last="Gilbert">M T P. Gilbert</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Min Sheng" sort="Peng, Min Sheng" uniqKey="Peng M" first="Min-Sheng" last="Peng">Min-Sheng Peng</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Xiaopeng" sort="Qi, Xiaopeng" uniqKey="Qi X" first="Xiaopeng" last="Qi">Xiaopeng Qi</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ya Ping" sort="Zhang, Ya Ping" uniqKey="Zhang Y" first="Ya-Ping" last="Zhang">Ya-Ping Zhang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29040727</idno><idno type="pmid">29040727</idno><idno type="doi">10.1093/molbev/msx258</idno><idno type="wicri:Area/PubMed/Corpus">000372</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000372</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.</title><author><name sortKey="Liu, Yan Hu" sort="Liu, Yan Hu" uniqKey="Liu Y" first="Yan-Hu" last="Liu">Yan-Hu Liu</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiaomin" sort="Guo, Xiaomin" uniqKey="Guo X" first="Xiaomin" last="Guo">Xiaomin Guo</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yin, Ting Ting" sort="Yin, Ting Ting" uniqKey="Yin T" first="Ting-Ting" last="Yin">Ting-Ting Yin</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, He Chuan" sort="Yang, He Chuan" uniqKey="Yang H" first="He-Chuan" last="Yang">He-Chuan Yang</name><affiliation><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Hu" sort="Yang, Hu" uniqKey="Yang H" first="Hu" last="Yang">Hu Yang</name><affiliation><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation></affiliation></author><author><name sortKey="Adeola, Adeniyi C" sort="Adeola, Adeniyi C" uniqKey="Adeola A" first="Adeniyi C" last="Adeola">Adeniyi C. Adeola</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="J Sanke, Oscar" sort="J Sanke, Oscar" uniqKey="J Sanke O" first="Oscar" last="J Sanke">Oscar J Sanke</name><affiliation><nlm:affiliation>Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="O Otecko, Newton" sort="O Otecko, Newton" uniqKey="O Otecko N" first="Newton" last="O Otecko">Newton O Otecko</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Yaping" sort="Ma, Yaping" uniqKey="Ma Y" first="Yaping" last="Ma">Yaping Ma</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="S Charles, Olaogun" sort="S Charles, Olaogun" uniqKey="S Charles O" first="Olaogun" last="S Charles">Olaogun S Charles</name><affiliation><nlm:affiliation>Department of Veterinary Medicine, University of Ibadan, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="S Sinding, Mikkel Holger" sort="S Sinding, Mikkel Holger" uniqKey="S Sinding M" first="Mikkel-Holger" last="S Sinding">Mikkel-Holger S Sinding</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Gopalakrishnan, Shyam" sort="Gopalakrishnan, Shyam" uniqKey="Gopalakrishnan S" first="Shyam" last="Gopalakrishnan">Shyam Gopalakrishnan</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Samaniego, Jose Alfredo" sort="Samaniego, Jose Alfredo" uniqKey="Samaniego J" first="José Alfredo" last="Samaniego">José Alfredo Samaniego</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Anders J" sort="Hansen, Anders J" uniqKey="Hansen A" first="Anders J" last="Hansen">Anders J. Hansen</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandes, Carlos" sort="Fernandes, Carlos" uniqKey="Fernandes C" first="Carlos" last="Fernandes">Carlos Fernandes</name><affiliation><nlm:affiliation>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Gaubert, Philippe" sort="Gaubert, Philippe" uniqKey="Gaubert P" first="Philippe" last="Gaubert">Philippe Gaubert</name><affiliation><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05,France.</nlm:affiliation></affiliation></author><author><name sortKey="Budd, Jane" sort="Budd, Jane" uniqKey="Budd J" first="Jane" last="Budd">Jane Budd</name><affiliation><nlm:affiliation>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah, United Arab Emirates.</nlm:affiliation></affiliation></author><author><name sortKey="M Dawuda, Philip" sort="M Dawuda, Philip" uniqKey="M Dawuda P" first="Philip" last="M Dawuda">Philip M Dawuda</name><affiliation><nlm:affiliation>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Rueness, Eli Knispel" sort="Rueness, Eli Knispel" uniqKey="Rueness E" first="Eli Knispel" last="Rueness">Eli Knispel Rueness</name><affiliation><nlm:affiliation>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Lubin" sort="Jiang, Lubin" uniqKey="Jiang L" first="Lubin" last="Jiang">Lubin Jiang</name><affiliation><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhai, Weiwei" sort="Zhai, Weiwei" uniqKey="Zhai W" first="Weiwei" last="Zhai">Weiwei Zhai</name><affiliation><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gilbert, M T P" sort="Gilbert, M T P" uniqKey="Gilbert M" first="M T P" last="Gilbert">M T P. Gilbert</name><affiliation><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Min Sheng" sort="Peng, Min Sheng" uniqKey="Peng M" first="Min-Sheng" last="Peng">Min-Sheng Peng</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Xiaopeng" sort="Qi, Xiaopeng" uniqKey="Qi X" first="Xiaopeng" last="Qi">Xiaopeng Qi</name><affiliation><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ya Ping" sort="Zhang, Ya Ping" uniqKey="Zhang Y" first="Ya-Ping" last="Zhang">Ya-Ping Zhang</name><affiliation><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular biology and evolution</title><idno type="eISSN">1537-1719</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29040727</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-1719</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>10</Day></PubDate></JournalIssue><Title>Molecular biology and evolution</Title><ISOAbbreviation>Mol. Biol. Evol.</ISOAbbreviation></Journal><ArticleTitle>Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1093/molbev/msx258</ELocationID><Abstract><AbstractText>Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yan-Hu</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xiaomin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Ting-Ting</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>He-Chuan</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adeola</LastName><ForeName>Adeniyi C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>J Sanke</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O Otecko</LastName><ForeName>Newton</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Yaping</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>S Charles</LastName><ForeName>Olaogun</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medicine, University of Ibadan, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>S Sinding</LastName><ForeName>Mikkel-Holger</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Natural History Museum, University of Oslo, PO Box 1172 Blindern, N-0318 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gopalakrishnan</LastName><ForeName>Shyam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samaniego</LastName><ForeName>José Alfredo</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Anders J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandes</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaubert</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05,France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Budd</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>M Dawuda</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rueness</LastName><ForeName>Eli Knispel</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Lubin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhai</LastName><ForeName>Weiwei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilbert</LastName><ForeName>M T P</ForeName><Initials>MTP</Initials><AffiliationInfo><Affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Trace and Environmental DNA Laboratory, Department of Environment and Agriculture, Curtin University, Perth, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NTNU University Museum, N-7491 Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Min-Sheng</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qi</LastName><ForeName>Xiaopeng</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Guo-Dong</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Ya-Ping</ForeName><Initials>YP</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Biol Evol</MedlineTA><NlmUniqueID>8501455</NlmUniqueID><ISSNLinking>0737-4038</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">African dogs</Keyword><Keyword MajorTopicYN="N">adaptive evolution</Keyword><Keyword MajorTopicYN="N">anti-parasite</Keyword><Keyword MajorTopicYN="N">demographic history</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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