Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.
Identifieur interne : 000374 ( PubMed/Corpus ); précédent : 000373; suivant : 000375Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.
Auteurs : Philipp Schuetz ; Yannick Wirz ; Ramon Sager ; Mirjam Christ-Crain ; Daiana Stolz ; Michael Tamm ; Lila Bouadma ; Charles E. Luyt ; Michel Wolff ; Jean Chastre ; Florence Tubach ; Kristina B. Kristoffersen ; Olaf Burkhardt ; Tobias Welte ; Stefan Schroeder ; Vandack Nobre ; Long Wei ; Heiner C. Bucher ; Djillali Annane ; Konrad Reinhart ; Ann R. Falsey ; Angela Branche ; Pierre Damas ; Maarten Nijsten ; Dylan W. De Lange ; Rodrigo O. Deliberato ; Carolina F. Oliveira ; Vera Maravi Stojkovi ; Alessia Verduri ; Bianca Beghé ; Bin Cao ; Yahya Shehabi ; Jens-Ulrik S. Jensen ; Caspar Corti ; Jos A H. Van Oers ; Albertus Beishuizen ; Armand R J. Girbes ; Evelien De Jong ; Matthias Briel ; Beat MuellerSource :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2017.
Abstract
In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings.
DOI: 10.1016/S1473-3099(17)30592-3
PubMed: 29037960
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.</title><author><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland. Electronic address: schuetzph@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sager, Ramon" sort="Sager, Ramon" uniqKey="Sager R" first="Ramon" last="Sager">Ramon Sager</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Christ Crain, Mirjam" sort="Christ Crain, Mirjam" uniqKey="Christ Crain M" first="Mirjam" last="Christ-Crain">Mirjam Christ-Crain</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Luyt, Charles E" sort="Luyt, Charles E" uniqKey="Luyt C" first="Charles E" last="Luyt">Charles E. Luyt</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><affiliation><nlm:affiliation>Département de Biostatistique, Santé publique et Information médicale, AP-HP, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kristoffersen, Kristina B" sort="Kristoffersen, Kristina B" uniqKey="Kristoffersen K" first="Kristina B" last="Kristoffersen">Kristina B. Kristoffersen</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Burkhardt, Olaf" sort="Burkhardt, Olaf" uniqKey="Burkhardt O" first="Olaf" last="Burkhardt">Olaf Burkhardt</name><affiliation><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schroeder, Stefan" sort="Schroeder, Stefan" uniqKey="Schroeder S" first="Stefan" last="Schroeder">Stefan Schroeder</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name><affiliation><nlm:affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Long" sort="Wei, Long" uniqKey="Wei L" first="Long" last="Wei">Long Wei</name><affiliation><nlm:affiliation>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bucher, Heiner C" sort="Bucher, Heiner C" uniqKey="Bucher H" first="Heiner C" last="Bucher">Heiner C. Bucher</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation><nlm:affiliation>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name><affiliation><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name><affiliation><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name><affiliation><nlm:affiliation>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Nijsten, Maarten" sort="Nijsten, Maarten" uniqKey="Nijsten M" first="Maarten" last="Nijsten">Maarten Nijsten</name><affiliation><nlm:affiliation>University Medical Centre, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Lange, Dylan W" sort="De Lange, Dylan W" uniqKey="De Lange D" first="Dylan W" last="De Lange">Dylan W. De Lange</name><affiliation><nlm:affiliation>University Medical Center Utrecht and University of Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><affiliation><nlm:affiliation>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira, Carolina F" sort="Oliveira, Carolina F" uniqKey="Oliveira C" first="Carolina F" last="Oliveira">Carolina F. Oliveira</name><affiliation><nlm:affiliation>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Maravi Stojkovi, Vera" sort="Maravi Stojkovi, Vera" uniqKey="Maravi Stojkovi V" first="Vera" last="Maravi Stojkovi">Vera Maravi Stojkovi</name><affiliation><nlm:affiliation>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name><affiliation><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><affiliation><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation><nlm:affiliation>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation><nlm:affiliation>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name><affiliation><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Corti, Caspar" sort="Corti, Caspar" uniqKey="Corti C" first="Caspar" last="Corti">Caspar Corti</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Van Oers, Jos A H" sort="Van Oers, Jos A H" uniqKey="Van Oers J" first="Jos A H" last="Van Oers">Jos A H. Van Oers</name><affiliation><nlm:affiliation>Elisabeth Tweesteden Hospital, Tilburg, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><affiliation><nlm:affiliation>Medisch Spectrum Twente, Enschede, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Girbes, Armand R J" sort="Girbes, Armand R J" uniqKey="Girbes A" first="Armand R J" last="Girbes">Armand R J. Girbes</name><affiliation><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Evelien" sort="De Jong, Evelien" uniqKey="De Jong E" first="Evelien" last="De Jong">Evelien De Jong</name><affiliation><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Briel, Matthias" sort="Briel, Matthias" uniqKey="Briel M" first="Matthias" last="Briel">Matthias Briel</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29037960</idno><idno type="pmid">29037960</idno><idno type="doi">10.1016/S1473-3099(17)30592-3</idno><idno type="wicri:Area/PubMed/Corpus">000374</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000374</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.</title><author><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland. Electronic address: schuetzph@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sager, Ramon" sort="Sager, Ramon" uniqKey="Sager R" first="Ramon" last="Sager">Ramon Sager</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Christ Crain, Mirjam" sort="Christ Crain, Mirjam" uniqKey="Christ Crain M" first="Mirjam" last="Christ-Crain">Mirjam Christ-Crain</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Stolz, Daiana" sort="Stolz, Daiana" uniqKey="Stolz D" first="Daiana" last="Stolz">Daiana Stolz</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tamm, Michael" sort="Tamm, Michael" uniqKey="Tamm M" first="Michael" last="Tamm">Michael Tamm</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Bouadma, Lila" sort="Bouadma, Lila" uniqKey="Bouadma L" first="Lila" last="Bouadma">Lila Bouadma</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Luyt, Charles E" sort="Luyt, Charles E" uniqKey="Luyt C" first="Charles E" last="Luyt">Charles E. Luyt</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation><nlm:affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name><affiliation><nlm:affiliation>Département de Biostatistique, Santé publique et Information médicale, AP-HP, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kristoffersen, Kristina B" sort="Kristoffersen, Kristina B" uniqKey="Kristoffersen K" first="Kristina B" last="Kristoffersen">Kristina B. Kristoffersen</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Burkhardt, Olaf" sort="Burkhardt, Olaf" uniqKey="Burkhardt O" first="Olaf" last="Burkhardt">Olaf Burkhardt</name><affiliation><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schroeder, Stefan" sort="Schroeder, Stefan" uniqKey="Schroeder S" first="Stefan" last="Schroeder">Stefan Schroeder</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name><affiliation><nlm:affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Long" sort="Wei, Long" uniqKey="Wei L" first="Long" last="Wei">Long Wei</name><affiliation><nlm:affiliation>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bucher, Heiner C" sort="Bucher, Heiner C" uniqKey="Bucher H" first="Heiner C" last="Bucher">Heiner C. Bucher</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation><nlm:affiliation>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name><affiliation><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name><affiliation><nlm:affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name><affiliation><nlm:affiliation>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Nijsten, Maarten" sort="Nijsten, Maarten" uniqKey="Nijsten M" first="Maarten" last="Nijsten">Maarten Nijsten</name><affiliation><nlm:affiliation>University Medical Centre, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Lange, Dylan W" sort="De Lange, Dylan W" uniqKey="De Lange D" first="Dylan W" last="De Lange">Dylan W. De Lange</name><affiliation><nlm:affiliation>University Medical Center Utrecht and University of Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><affiliation><nlm:affiliation>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Oliveira, Carolina F" sort="Oliveira, Carolina F" uniqKey="Oliveira C" first="Carolina F" last="Oliveira">Carolina F. Oliveira</name><affiliation><nlm:affiliation>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Maravi Stojkovi, Vera" sort="Maravi Stojkovi, Vera" uniqKey="Maravi Stojkovi V" first="Vera" last="Maravi Stojkovi">Vera Maravi Stojkovi</name><affiliation><nlm:affiliation>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Verduri, Alessia" sort="Verduri, Alessia" uniqKey="Verduri A" first="Alessia" last="Verduri">Alessia Verduri</name><affiliation><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Beghe, Bianca" sort="Beghe, Bianca" uniqKey="Beghe B" first="Bianca" last="Beghé">Bianca Beghé</name><affiliation><nlm:affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation><nlm:affiliation>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation><nlm:affiliation>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name><affiliation><nlm:affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Corti, Caspar" sort="Corti, Caspar" uniqKey="Corti C" first="Caspar" last="Corti">Caspar Corti</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Van Oers, Jos A H" sort="Van Oers, Jos A H" uniqKey="Van Oers J" first="Jos A H" last="Van Oers">Jos A H. Van Oers</name><affiliation><nlm:affiliation>Elisabeth Tweesteden Hospital, Tilburg, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><affiliation><nlm:affiliation>Medisch Spectrum Twente, Enschede, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Girbes, Armand R J" sort="Girbes, Armand R J" uniqKey="Girbes A" first="Armand R J" last="Girbes">Armand R J. Girbes</name><affiliation><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Evelien" sort="De Jong, Evelien" uniqKey="De Jong E" first="Evelien" last="De Jong">Evelien De Jong</name><affiliation><nlm:affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Briel, Matthias" sort="Briel, Matthias" uniqKey="Briel M" first="Matthias" last="Briel">Matthias Briel</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><affiliation><nlm:affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29037960</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4457</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>13</Day></PubDate></JournalIssue><Title>The Lancet. Infectious diseases</Title><ISOAbbreviation>Lancet Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1473-3099(17)30592-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1473-3099(17)30592-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Based on a prespecified Cochrane protocol, we did a systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled individual patient data from trials in which patients with respiratory infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (procalcitonin-guided group) or control. The coprimary endpoints were 30-day mortality and setting-specific treatment failure. Secondary endpoints were antibiotic use, length of stay, and antibiotic side-effects.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">We identified 990 records from the literature search, of which 71 articles were assessed for eligibility after exclusion of 919 records. We collected data on 6708 patients from 26 eligible trials in 12 countries. Mortality at 30 days was significantly lower in procalcitonin-guided patients than in control patients (286 [9%] deaths in 3336 procalcitonin-guided patients vs 336 [10%] in 3372 controls; adjusted odds ratio [OR] 0·83 [95% CI 0·70 to 0·99], p=0·037). This mortality benefit was similar across subgroups by setting and type of infection (pinteractions>0·05), although mortality was very low in primary care and in patients with acute bronchitis. Procalcitonin guidance was also associated with a 2·4-day reduction in antibiotic exposure (5·7 vs 8·1 days [95% CI -2·71 to -2·15], p<0·0001) and a reduction in antibiotic-related side-effects (16% vs 22%, adjusted OR 0·68 [95% CI 0·57 to 0·82], p<0·0001).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in patients with acute respiratory infections thus has the potential to improve antibiotic management with positive effects on clinical outcomes and on the current threat of increasing antibiotic multiresistance.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">National Institute for Health Research.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schuetz</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland. Electronic address: schuetzph@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wirz</LastName><ForeName>Yannick</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sager</LastName><ForeName>Ramon</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christ-Crain</LastName><ForeName>Mirjam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stolz</LastName><ForeName>Daiana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamm</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouadma</LastName><ForeName>Lila</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luyt</LastName><ForeName>Charles E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolff</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chastre</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Université Paris 6-Pierre-et-Marie-Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tubach</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de Biostatistique, Santé publique et Information médicale, AP-HP, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kristoffersen</LastName><ForeName>Kristina B</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burkhardt</LastName><ForeName>Olaf</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welte</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover, Member of the German Center of Lung Research, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schroeder</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, Krankenhaus Dueren, Dueren, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nobre</LastName><ForeName>Vandack</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Long</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal and Geriatric Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bucher</LastName><ForeName>Heiner C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Annane</LastName><ForeName>Djillali</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Critical Care Department, Hôpital Raymond Poincaré, AP-HP, Faculty of Health Science Simone Veil, UVSQ-University Paris Saclay, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reinhart</LastName><ForeName>Konrad</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falsey</LastName><ForeName>Ann R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Branche</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Rochester, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Damas</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nijsten</LastName><ForeName>Maarten</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Medical Centre, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lange</LastName><ForeName>Dylan W</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>University Medical Center Utrecht and University of Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deliberato</LastName><ForeName>Rodrigo O</ForeName><Initials>RO</Initials><AffiliationInfo><Affiliation>Critical Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliveira</LastName><ForeName>Carolina F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maravić-Stojković</LastName><ForeName>Vera</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Immunology Laboratory, Dedinje Cardiovascular Institute, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verduri</LastName><ForeName>Alessia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beghé</LastName><ForeName>Bianca</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Section of Respiratory Medicine, Department of Medical and Surgical Sciences, University Polyclinic of Modena, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Center for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shehabi</LastName><ForeName>Yahya</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Critical Care and Peri-operative Medicine, Monash Health, Melbourne, VIC, Australia; School of Clinical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Jens-Ulrik S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases and Rheumatology, Finsencentret, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corti</LastName><ForeName>Caspar</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Oers</LastName><ForeName>Jos A H</ForeName><Initials>JAH</Initials><AffiliationInfo><Affiliation>Elisabeth Tweesteden Hospital, Tilburg, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beishuizen</LastName><ForeName>Albertus</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medisch Spectrum Twente, Enschede, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girbes</LastName><ForeName>Armand R J</ForeName><Initials>ARJ</Initials><AffiliationInfo><Affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>Evelien</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>VUmc University Medical Center, Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briel</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Basel, Basel, Switzerland; Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Beat</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical University Department, Kantonsspital Aarau, Aarau, Switzerland; Faculty of Medicine, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lancet Infect Dis</MedlineTA><NlmUniqueID>101130150</NlmUniqueID><ISSNLinking>1473-3099</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>09</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29037960</ArticleId><ArticleId IdType="pii">S1473-3099(17)30592-3</ArticleId><ArticleId IdType="doi">10.1016/S1473-3099(17)30592-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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