A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Identifieur interne : 003851 ( PubMed/Checkpoint ); précédent : 003850; suivant : 003852A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.
Auteurs : Martina Sanderson-Smith [Australie] ; David M P. De Oliveira [Australie] ; Julien Guglielmini [France] ; David J. Mcmillan [Australie] ; Therese Vu [Belgique] ; Jessica K. Holien [Australie] ; Anna Henningham ; Andrew C. Steer [Australie] ; Debra E. Bessen ; James B. Dale ; Nigel Curtis [Australie] ; Bernard W. Beall [Géorgie (pays)] ; Mark J. Walker ; Michael W. Parker [Australie] ; Jonathan R. Carapetis ; Laurence Van Melderen [Belgique] ; Kadaba S. Sriprakash ; Pierre R. Smeesters [Belgique]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2014.
Descripteurs français
- KwdFr :
- Clonage moléculaire, Données de séquences moléculaires, Phylogénie, Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Protéines recombinantes, Régulation de l'expression des gènes bactériens, Streptococcus pyogenes (), Streptococcus pyogenes (physiologie), Séquence d'acides aminés, Vaccins antistreptococciques (immunologie).
- MESH :
- génétique : Protéines bactériennes.
- immunologie : Vaccins antistreptococciques.
- métabolisme : Protéines bactériennes.
- physiologie : Streptococcus pyogenes.
- Clonage moléculaire, Données de séquences moléculaires, Phylogénie, Protéines recombinantes, Régulation de l'expression des gènes bactériens, Streptococcus pyogenes, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins, Streptococcal Vaccines (immunology), Streptococcus pyogenes (classification), Streptococcus pyogenes (physiology).
- MESH :
- chemical , genetics : Bacterial Proteins.
- chemical , immunology : Streptococcal Vaccines.
- chemical , metabolism : Bacterial Proteins.
- classification : Streptococcus pyogenes.
- physiology : Streptococcus pyogenes.
- Amino Acid Sequence, Cloning, Molecular, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phylogeny, Recombinant Proteins.
Abstract
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
DOI: 10.1093/infdis/jiu260
PubMed: 24799598
Affiliations:
- Australie, Belgique, France, Géorgie (pays)
- Région de Bruxelles-Capitale, Victoria (État), Île-de-France
- Bruxelles, Melbourne, Paris
- Université de Melbourne, Université libre de Bruxelles
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pubmed:24799598Le document en format XML
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Steer</name><affiliation wicri:level="1"><nlm:affiliation>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne</wicri:regionArea><wicri:noRegion>Royal Children's Hospital Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</nlm:affiliation><wicri:noCountry code="subField">Valhalla</wicri:noCountry></affiliation></author><author><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name><affiliation><nlm:affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</nlm:affiliation><wicri:noCountry code="subField">Memphis</wicri:noCountry></affiliation></author><author><name sortKey="Curtis, Nigel" sort="Curtis, Nigel" uniqKey="Curtis N" first="Nigel" last="Curtis">Nigel Curtis</name><affiliation wicri:level="4"><nlm:affiliation>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Beall, Bernard W" sort="Beall, Bernard W" uniqKey="Beall B" first="Bernard W" last="Beall">Bernard W. Beall</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Mark J" sort="Walker, Mark J" uniqKey="Walker M" first="Mark J" last="Walker">Mark J. Walker</name><affiliation><nlm:affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</nlm:affiliation><wicri:noCountry code="subField">Brisbane</wicri:noCountry></affiliation></author><author><name sortKey="Parker, Michael W" sort="Parker, Michael W" uniqKey="Parker M" first="Michael W" last="Parker">Michael W. 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Carapetis</name><affiliation><nlm:affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</nlm:affiliation><wicri:noCountry code="subField">Perth</wicri:noCountry></affiliation></author><author><name sortKey="Van Melderen, Laurence" sort="Van Melderen, Laurence" uniqKey="Van Melderen L" first="Laurence" last="Van Melderen">Laurence Van Melderen</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name><affiliation><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</nlm:affiliation><wicri:noCountry code="subField">Brisbane</wicri:noCountry></affiliation></author><author><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</nlm:affiliation><orgName type="university">Université libre de Bruxelles</orgName><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24799598</idno><idno type="pmid">24799598</idno><idno type="doi">10.1093/infdis/jiu260</idno><idno type="wicri:Area/PubMed/Corpus">003406</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003406</idno><idno type="wicri:Area/PubMed/Curation">003294</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003294</idno><idno type="wicri:Area/PubMed/Checkpoint">003294</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003294</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.</title><author><name sortKey="Sanderson Smith, Martina" sort="Sanderson Smith, Martina" uniqKey="Sanderson Smith M" first="Martina" last="Sanderson-Smith">Martina Sanderson-Smith</name><affiliation wicri:level="1"><nlm:affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong</wicri:regionArea><wicri:noRegion>University of Wollongong</wicri:noRegion></affiliation></author><author><name sortKey="De Oliveira, David M P" sort="De Oliveira, David M P" uniqKey="De Oliveira D" first="David M P" last="De Oliveira">David M P. De Oliveira</name><affiliation wicri:level="1"><nlm:affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong</wicri:regionArea><wicri:noRegion>University of Wollongong</wicri:noRegion></affiliation></author><author><name sortKey="Guglielmini, Julien" sort="Guglielmini, Julien" uniqKey="Guglielmini J" first="Julien" last="Guglielmini">Julien Guglielmini</name><affiliation wicri:level="3"><nlm:affiliation>Microbial Evolutionary Genomics, Département Génomes et Génétique, Institut Pasteur CNRS, UMR3525, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Microbial Evolutionary Genomics, Département Génomes et Génétique, Institut Pasteur CNRS, UMR3525, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mcmillan, David J" sort="Mcmillan, David J" uniqKey="Mcmillan D" first="David J" last="Mcmillan">David J. Mcmillan</name><affiliation wicri:level="1"><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs</wicri:regionArea><wicri:noRegion>Sippy Downs</wicri:noRegion></affiliation></author><author><name sortKey="Vu, Therese" sort="Vu, Therese" uniqKey="Vu T" first="Therese" last="Vu">Therese Vu</name><affiliation wicri:level="4"><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Holien, Jessica K" sort="Holien, Jessica K" uniqKey="Holien J" first="Jessica K" last="Holien">Jessica K. Holien</name><affiliation wicri:level="3"><nlm:affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><wicri:orgArea>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research</wicri:orgArea></affiliation></author><author><name sortKey="Henningham, Anna" sort="Henningham, Anna" uniqKey="Henningham A" first="Anna" last="Henningham">Anna Henningham</name><affiliation><nlm:affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</nlm:affiliation><wicri:noCountry code="subField">Brisbane</wicri:noCountry></affiliation></author><author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name><affiliation wicri:level="1"><nlm:affiliation>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne</wicri:regionArea><wicri:noRegion>Royal Children's Hospital Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</nlm:affiliation><wicri:noCountry code="subField">Valhalla</wicri:noCountry></affiliation></author><author><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name><affiliation><nlm:affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</nlm:affiliation><wicri:noCountry code="subField">Memphis</wicri:noCountry></affiliation></author><author><name sortKey="Curtis, Nigel" sort="Curtis, Nigel" uniqKey="Curtis N" first="Nigel" last="Curtis">Nigel Curtis</name><affiliation wicri:level="4"><nlm:affiliation>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Beall, Bernard W" sort="Beall, Bernard W" uniqKey="Beall B" first="Bernard W" last="Beall">Bernard W. Beall</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Mark J" sort="Walker, Mark J" uniqKey="Walker M" first="Mark J" last="Walker">Mark J. Walker</name><affiliation><nlm:affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</nlm:affiliation><wicri:noCountry code="subField">Brisbane</wicri:noCountry></affiliation></author><author><name sortKey="Parker, Michael W" sort="Parker, Michael W" uniqKey="Parker M" first="Michael W" last="Parker">Michael W. Parker</name><affiliation wicri:level="4"><nlm:affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.</nlm:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Carapetis, Jonathan R" sort="Carapetis, Jonathan R" uniqKey="Carapetis J" first="Jonathan R" last="Carapetis">Jonathan R. Carapetis</name><affiliation><nlm:affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</nlm:affiliation><wicri:noCountry code="subField">Perth</wicri:noCountry></affiliation></author><author><name sortKey="Van Melderen, Laurence" sort="Van Melderen, Laurence" uniqKey="Van Melderen L" first="Laurence" last="Van Melderen">Laurence Van Melderen</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name><affiliation><nlm:affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</nlm:affiliation><wicri:noCountry code="subField">Brisbane</wicri:noCountry></affiliation></author><author><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</nlm:affiliation><orgName type="university">Université libre de Bruxelles</orgName><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Bacterial Proteins (genetics)</term><term>Bacterial Proteins (metabolism)</term><term>Cloning, Molecular</term><term>Gene Expression Regulation, Bacterial</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Recombinant Proteins</term><term>Streptococcal Vaccines (immunology)</term><term>Streptococcus pyogenes (classification)</term><term>Streptococcus pyogenes (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Phylogénie</term><term>Protéines bactériennes (génétique)</term><term>Protéines bactériennes (métabolisme)</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes bactériens</term><term>Streptococcus pyogenes ()</term><term>Streptococcus pyogenes (physiologie)</term><term>Séquence d'acides aminés</term><term>Vaccins antistreptococciques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Streptococcal Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Streptococcus pyogenes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antistreptococciques</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines bactériennes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Streptococcus pyogenes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Streptococcus pyogenes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Cloning, Molecular</term><term>Gene Expression Regulation, Bacterial</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Phylogénie</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes bactériens</term><term>Streptococcus pyogenes</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24799598</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>210</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.</ArticleTitle><Pagination><MedlinePgn>1325-38</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiu260</ELocationID><Abstract><AbstractText>Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sanderson-Smith</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Oliveira</LastName><ForeName>David M P</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guglielmini</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Microbial Evolutionary Genomics, Département Génomes et Génétique, Institut Pasteur CNRS, UMR3525, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMillan</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Inflammation and Healing Research Cluster, School of Health and Sports Sciences, University of the Sunshine Coast, Sippy Downs, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vu</LastName><ForeName>Therese</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holien</LastName><ForeName>Jessica K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henningham</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steer</LastName><ForeName>Andrew C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Murdoch Children Research Institute Centre for International Child Health, The University of Melbourne Department of General Medicine, Royal Children's Hospital Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bessen</LastName><ForeName>Debra E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dale</LastName><ForeName>James B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Medicine, The University of Tennessee Health Science Center Department of Veterans Affairs Medical Center, and Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtis</LastName><ForeName>Nigel</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Murdoch Children Research Institute Infectious Diseases Unit, Royal Children's Hospital Melbourne Department of Paediatrics, The University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beall</LastName><ForeName>Bernard W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parker</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Melbourne Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carapetis</LastName><ForeName>Jonathan R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Melderen</LastName><ForeName>Laurence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sriprakash</LastName><ForeName>Kadaba S</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, Brisbane.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smeesters</LastName><ForeName>Pierre R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Gosselies, Belgium Murdoch Children Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>M Protein Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI010085</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D022541">Streptococcal Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015964" MajorTopicYN="Y">Gene Expression Regulation, Bacterial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D022541" MajorTopicYN="N">Streptococcal Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013297" MajorTopicYN="N">Streptococcus pyogenes</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">IgA</Keyword><Keyword MajorTopicYN="N">IgG</Keyword><Keyword MajorTopicYN="N">M protein</Keyword><Keyword MajorTopicYN="N">Streptococcus pyogenes</Keyword><Keyword MajorTopicYN="N">epidemiology</Keyword><Keyword MajorTopicYN="N">fibrinogen</Keyword><Keyword MajorTopicYN="N">molecular typing</Keyword><Keyword MajorTopicYN="N">plasminogen</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Batzloff</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Towers</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goossens</LastName><ForeName>Herman</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Malhotra-Kumar</LastName><ForeName>Surhbi</ForeName><Initials>S</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Tanz</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24799598</ArticleId><ArticleId IdType="pii">jiu260</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiu260</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Géorgie (pays)</li></country><region><li>Région de Bruxelles-Capitale</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Melbourne</li><li>Université libre de Bruxelles</li></orgName></list><tree><noCountry><name sortKey="Bessen, Debra E" sort="Bessen, Debra E" uniqKey="Bessen D" first="Debra E" last="Bessen">Debra E. Bessen</name><name sortKey="Carapetis, Jonathan R" sort="Carapetis, Jonathan R" uniqKey="Carapetis J" first="Jonathan R" last="Carapetis">Jonathan R. Carapetis</name><name sortKey="Dale, James B" sort="Dale, James B" uniqKey="Dale J" first="James B" last="Dale">James B. Dale</name><name sortKey="Henningham, Anna" sort="Henningham, Anna" uniqKey="Henningham A" first="Anna" last="Henningham">Anna Henningham</name><name sortKey="Sriprakash, Kadaba S" sort="Sriprakash, Kadaba S" uniqKey="Sriprakash K" first="Kadaba S" last="Sriprakash">Kadaba S. Sriprakash</name><name sortKey="Walker, Mark J" sort="Walker, Mark J" uniqKey="Walker M" first="Mark J" last="Walker">Mark J. Walker</name></noCountry><country name="Australie"><noRegion><name sortKey="Sanderson Smith, Martina" sort="Sanderson Smith, Martina" uniqKey="Sanderson Smith M" first="Martina" last="Sanderson-Smith">Martina Sanderson-Smith</name></noRegion><name sortKey="Curtis, Nigel" sort="Curtis, Nigel" uniqKey="Curtis N" first="Nigel" last="Curtis">Nigel Curtis</name><name sortKey="De Oliveira, David M P" sort="De Oliveira, David M P" uniqKey="De Oliveira D" first="David M P" last="De Oliveira">David M P. De Oliveira</name><name sortKey="Holien, Jessica K" sort="Holien, Jessica K" uniqKey="Holien J" first="Jessica K" last="Holien">Jessica K. Holien</name><name sortKey="Mcmillan, David J" sort="Mcmillan, David J" uniqKey="Mcmillan D" first="David J" last="Mcmillan">David J. Mcmillan</name><name sortKey="Parker, Michael W" sort="Parker, Michael W" uniqKey="Parker M" first="Michael W" last="Parker">Michael W. Parker</name><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C" last="Steer">Andrew C. Steer</name></country><country name="France"><region name="Île-de-France"><name sortKey="Guglielmini, Julien" sort="Guglielmini, Julien" uniqKey="Guglielmini J" first="Julien" last="Guglielmini">Julien Guglielmini</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Vu, Therese" sort="Vu, Therese" uniqKey="Vu T" first="Therese" last="Vu">Therese Vu</name></region><name sortKey="Smeesters, Pierre R" sort="Smeesters, Pierre R" uniqKey="Smeesters P" first="Pierre R" last="Smeesters">Pierre R. Smeesters</name><name sortKey="Van Melderen, Laurence" sort="Van Melderen, Laurence" uniqKey="Van Melderen L" first="Laurence" last="Van Melderen">Laurence Van Melderen</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Beall, Bernard W" sort="Beall, Bernard W" uniqKey="Beall B" first="Bernard W" last="Beall">Bernard W. Beall</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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