AustralieFrV1, PubMed, Checkpoint, bibRecord, 002323

Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.

Identifieur interne : 002323 ( PubMed/Checkpoint ); précédent : 002322; suivant : 002324

Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.

Auteurs : Christine Kowalczyk-Quintas [Suisse] ; Sonia Schuepbach-Mallepell [Suisse] ; Michele Vigolo [Suisse] ; Laure Willen [Suisse] ; Aubry Tardivel [Suisse] ; Cristian R. Smulski [Suisse] ; Timothy S. Zheng [États-Unis] ; Jennifer Gommerman [Canada] ; Henry Hess [Allemagne] ; Jacques-Eric Gottenberg [France] ; Fabienne Mackay ; Olivier Donzé [Suisse] ; Pascal Schneider [Suisse]

Source :

The Journal of biological chemistry [ 1083-351X ] ; 2016.

RBID : pubmed:27451394

Descripteurs français

KwdFr :
- Animaux, Anticorps (immunologie), Anticorps (pharmacologie), Déplétion lymphocytaire (), Facteur d'activation des lymphocytes B (antagonistes et inhibiteurs), Facteur d'activation des lymphocytes B (génétique), Facteur d'activation des lymphocytes B (immunologie), Hyperplasie, Immunoglobuline G (immunologie), Immunoglobuline G (pharmacologie), Lymphocytes B (anatomopathologie), Lymphocytes B (immunologie), Souris, Souris knockout, Survie cellulaire ().
MESH :
- anatomopathologie : Lymphocytes B.
- antagonistes et inhibiteurs : Facteur d'activation des lymphocytes B.
- génétique : Facteur d'activation des lymphocytes B.
- immunologie : Anticorps, Facteur d'activation des lymphocytes B, Immunoglobuline G, Lymphocytes B.
- pharmacologie : Anticorps, Immunoglobuline G.
- Animaux, Déplétion lymphocytaire, Hyperplasie, Souris, Souris knockout, Survie cellulaire.

English descriptors

KwdEn :
- Animals, Antibodies (immunology), Antibodies (pharmacology), B-Cell Activating Factor (antagonists & inhibitors), B-Cell Activating Factor (genetics), B-Cell Activating Factor (immunology), B-Lymphocytes (immunology), B-Lymphocytes (pathology), Cell Survival (drug effects), Hyperplasia, Immunoglobulin G (immunology), Immunoglobulin G (pharmacology), Lymphocyte Depletion (methods), Mice, Mice, Knockout.
MESH :
- chemical , antagonists & inhibitors : B-Cell Activating Factor.
- chemical , genetics : B-Cell Activating Factor.
- chemical , immunology : Antibodies, B-Cell Activating Factor, Immunoglobulin G.
- chemical , pharmacology : Antibodies, Immunoglobulin G.
- drug effects : Cell Survival.
- immunology : B-Lymphocytes.
- methods : Lymphocyte Depletion.
- pathology : B-Lymphocytes.
- Animals, Hyperplasia, Mice, Mice, Knockout.

Abstract

B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.

DOI: 10.1074/jbc.M116.725929
PubMed: 27451394

Affiliations:

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Le document en format XML

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<author><name sortKey="Mackay, Fabienne" sort="Mackay, Fabienne" uniqKey="Mackay F" first="Fabienne" last="Mackay">Fabienne Mackay</name>
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<author><name sortKey="Donze, Olivier" sort="Donze, Olivier" uniqKey="Donze O" first="Olivier" last="Donzé">Olivier Donzé</name>
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<term>B-Cell Activating Factor (genetics)</term>
<term>B-Cell Activating Factor (immunology)</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (pathology)</term>
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<term>Immunoglobulin G (immunology)</term>
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<term>Facteur d'activation des lymphocytes B (antagonistes et inhibiteurs)</term>
<term>Facteur d'activation des lymphocytes B (génétique)</term>
<term>Facteur d'activation des lymphocytes B (immunologie)</term>
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<term>Immunoglobuline G (pharmacologie)</term>
<term>Lymphocytes B (anatomopathologie)</term>
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<term>Facteur d'activation des lymphocytes B</term>
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<term>Immunoglobuline G</term>
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<front><div type="abstract" xml:lang="en">B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.</div>
</front>
</TEI>
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<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>291</Volume>
<Issue>38</Issue>
<PubDate><Year>2016</Year>
<Month>Sep</Month>
<Day>16</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of biological chemistry</Title>
<ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.</ArticleTitle>
<Pagination><MedlinePgn>19826-34</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.M116.725929</ELocationID>
<Abstract><AbstractText>B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.</AbstractText>
<CopyrightInformation>© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kowalczyk-Quintas</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
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<Author ValidYN="Y"><LastName>Schuepbach-Mallepell</LastName>
<ForeName>Sonia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Vigolo</LastName>
<ForeName>Michele</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Willen</LastName>
<ForeName>Laure</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Aubry</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
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<ForeName>Cristian R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Timothy S</ForeName>
<Initials>TS</Initials>
<AffiliationInfo><Affiliation>Biogen, Cambridge, Massachusetts 02142.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gommerman</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hess</LastName>
<ForeName>Henry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Merck KGaA, D-64293 Darmstadt, Germany.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Gottenberg</LastName>
<ForeName>Jacques-Eric</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mackay</LastName>
<ForeName>Fabienne</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Immunology, Monash University, Melbourne 3004, Australia, and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Donzé</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Adipogen Life Sciences, CH-1066 Epalinges, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schneider</LastName>
<ForeName>Pascal</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0677-9409</Identifier>
<AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland, pascal.schneider@unil.ch.</Affiliation>
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<Language>eng</Language>
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</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>22</Day>
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<MedlineTA>J Biol Chem</MedlineTA>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Blood. 2008 Feb 1;111(3):1004-12</RefSource>
<PMID Version="1">17942754</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2011 Sep 2;286(35):30769-79</RefSource>
<PMID Version="1">21730053</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2003 Aug 29;278(35):33127-33</RefSource>
<PMID Version="1">12796483</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2002 Feb 8;108(3):383-94</RefSource>
<PMID Version="1">11853672</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2004 Jan 15;172(2):812-22</RefSource>
<PMID Version="1">14707051</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2013 Sep 19;39(3):573-83</RefSource>
<PMID Version="1">24012421</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2008 Jan;58(1):61-72</RefSource>
<PMID Version="1">18163485</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Expert Opin Ther Targets. 2014 Apr;18(4):473-89</RefSource>
<PMID Version="1">24521424</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2000 Apr 27;404(6781):995-9</RefSource>
<PMID Version="1">10801128</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2001 May;14(5):573-82</RefSource>
<PMID Version="1">11371359</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Feb 25;280(8):7218-27</RefSource>
<PMID Version="1">15542592</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2005 May 2;201(9):1375-83</RefSource>
<PMID Version="1">15851487</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Methods Enzymol. 2014;545:103-25</RefSource>
<PMID Version="1">25065888</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2004 Jan 5;199(1):91-8</RefSource>
<PMID Version="1">14707116</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cytokine Growth Factor Rev. 2014 Apr;25(2):195-203</RefSource>
<PMID Version="1">24508088</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2011 Mar;41(3):787-97</RefSource>
<PMID Version="1">21287546</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2015 Nov;74(11):2006-15</RefSource>
<PMID Version="1">24951103</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15517-22</RefSource>
<PMID Version="1">18832171</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2003 May 1;423(6935):49-56</RefSource>
<PMID Version="1">12721620</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2009 Sep 15;61(9):1168-78</RefSource>
<PMID Version="1">19714604</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2012 Jul;64(7):2328-37</RefSource>
<PMID Version="1">22275291</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2015 Jun 26;290(26):16330-42</RefSource>
<PMID Version="1">25953898</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2001 Jul;2(7):638-43</RefSource>
<PMID Version="1">11429549</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2012 Oct 26;287(44):37434-46</RefSource>
<PMID Version="1">22961987</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2010 May;62(5):1457-68</RefSource>
<PMID Version="1">20131293</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2011 Oct;121(10):3991-4002</RefSource>
<PMID Version="1">21881212</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Methods Enzymol. 2000;322:325-45</RefSource>
<PMID Version="1">10914028</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2009 Jul;9(7):491-502</RefSource>
<PMID Version="1">19521398</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int Immunol. 1995 Jul;7(7):1093-106</RefSource>
<PMID Version="1">8527407</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2009 Oct 2;284(40):27567-76</RefSource>
<PMID Version="1">19657145</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053264" MajorTopicYN="N">B-Cell Activating Factor</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006965" MajorTopicYN="N">Hyperplasia</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008212" MajorTopicYN="N">Lymphocyte Depletion</DescriptorName>
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<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
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<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BAFF</Keyword>
<Keyword MajorTopicYN="N">antibody</Keyword>
<Keyword MajorTopicYN="N">cytokine</Keyword>
<Keyword MajorTopicYN="N">immunology</Keyword>
<Keyword MajorTopicYN="N">lymphocyte</Keyword>
<Keyword MajorTopicYN="N">receptor</Keyword>
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</MedlineCitation>
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<name sortKey="Schuepbach Mallepell, Sonia" sort="Schuepbach Mallepell, Sonia" uniqKey="Schuepbach Mallepell S" first="Sonia" last="Schuepbach-Mallepell">Sonia Schuepbach-Mallepell</name>
<name sortKey="Smulski, Cristian R" sort="Smulski, Cristian R" uniqKey="Smulski C" first="Cristian R" last="Smulski">Cristian R. Smulski</name>
<name sortKey="Tardivel, Aubry" sort="Tardivel, Aubry" uniqKey="Tardivel A" first="Aubry" last="Tardivel">Aubry Tardivel</name>
<name sortKey="Vigolo, Michele" sort="Vigolo, Michele" uniqKey="Vigolo M" first="Michele" last="Vigolo">Michele Vigolo</name>
<name sortKey="Willen, Laure" sort="Willen, Laure" uniqKey="Willen L" first="Laure" last="Willen">Laure Willen</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. Zheng</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Gommerman, Jennifer" sort="Gommerman, Jennifer" uniqKey="Gommerman J" first="Jennifer" last="Gommerman">Jennifer Gommerman</name>
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<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Hess, Henry" sort="Hess, Henry" uniqKey="Hess H" first="Henry" last="Hess">Henry Hess</name>
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<country name="France"><region name="Grand Est"><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.

Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.

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