Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Identifieur interne : 001969 ( PubMed/Corpus ); précédent : 001968; suivant : 001970Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Auteurs : Christine Kowalczyk-Quintas ; Sonia Schuepbach-Mallepell ; Michele Vigolo ; Laure Willen ; Aubry Tardivel ; Cristian R. Smulski ; Timothy S. Zheng ; Jennifer Gommerman ; Henry Hess ; Jacques-Eric Gottenberg ; Fabienne Mackay ; Olivier Donzé ; Pascal SchneiderSource :
- The Journal of biological chemistry [ 1083-351X ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antibodies (immunology), Antibodies (pharmacology), B-Cell Activating Factor (antagonists & inhibitors), B-Cell Activating Factor (genetics), B-Cell Activating Factor (immunology), B-Lymphocytes (immunology), B-Lymphocytes (pathology), Cell Survival (drug effects), Hyperplasia, Immunoglobulin G (immunology), Immunoglobulin G (pharmacology), Lymphocyte Depletion (methods), Mice, Mice, Knockout.
- MESH :
- chemical , antagonists & inhibitors : B-Cell Activating Factor.
- chemical , genetics : B-Cell Activating Factor.
- chemical , immunology : Antibodies, B-Cell Activating Factor, Immunoglobulin G.
- chemical , pharmacology : Antibodies, Immunoglobulin G.
- drug effects : Cell Survival.
- immunology : B-Lymphocytes.
- methods : Lymphocyte Depletion.
- pathology : B-Lymphocytes.
- Animals, Hyperplasia, Mice, Mice, Knockout.
Abstract
B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.
DOI: 10.1074/jbc.M116.725929
PubMed: 27451394
Links to Exploration step
pubmed:27451394Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.</title><author><name sortKey="Kowalczyk Quintas, Christine" sort="Kowalczyk Quintas, Christine" uniqKey="Kowalczyk Quintas C" first="Christine" last="Kowalczyk-Quintas">Christine Kowalczyk-Quintas</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Schuepbach Mallepell, Sonia" sort="Schuepbach Mallepell, Sonia" uniqKey="Schuepbach Mallepell S" first="Sonia" last="Schuepbach-Mallepell">Sonia Schuepbach-Mallepell</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Vigolo, Michele" sort="Vigolo, Michele" uniqKey="Vigolo M" first="Michele" last="Vigolo">Michele Vigolo</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Willen, Laure" sort="Willen, Laure" uniqKey="Willen L" first="Laure" last="Willen">Laure Willen</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tardivel, Aubry" sort="Tardivel, Aubry" uniqKey="Tardivel A" first="Aubry" last="Tardivel">Aubry Tardivel</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Smulski, Cristian R" sort="Smulski, Cristian R" uniqKey="Smulski C" first="Cristian R" last="Smulski">Cristian R. Smulski</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. 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Smulski</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Timothy S" sort="Zheng, Timothy S" uniqKey="Zheng T" first="Timothy S" last="Zheng">Timothy S. Zheng</name><affiliation><nlm:affiliation>Biogen, Cambridge, Massachusetts 02142.</nlm:affiliation></affiliation></author><author><name sortKey="Gommerman, Jennifer" sort="Gommerman, Jennifer" uniqKey="Gommerman J" first="Jennifer" last="Gommerman">Jennifer Gommerman</name><affiliation><nlm:affiliation>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hess, Henry" sort="Hess, Henry" uniqKey="Hess H" first="Henry" last="Hess">Henry Hess</name><affiliation><nlm:affiliation>Merck KGaA, D-64293 Darmstadt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:affiliation>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mackay, Fabienne" sort="Mackay, Fabienne" uniqKey="Mackay F" first="Fabienne" last="Mackay">Fabienne Mackay</name><affiliation><nlm:affiliation>Department of Immunology, Monash University, Melbourne 3004, Australia, and.</nlm:affiliation></affiliation></author><author><name sortKey="Donze, Olivier" sort="Donze, Olivier" uniqKey="Donze O" first="Olivier" last="Donzé">Olivier Donzé</name><affiliation><nlm:affiliation>Adipogen Life Sciences, CH-1066 Epalinges, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Schneider, Pascal" sort="Schneider, Pascal" uniqKey="Schneider P" first="Pascal" last="Schneider">Pascal Schneider</name><affiliation><nlm:affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland, pascal.schneider@unil.ch.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of biological chemistry</title><idno type="eISSN">1083-351X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies (immunology)</term><term>Antibodies (pharmacology)</term><term>B-Cell Activating Factor (antagonists & inhibitors)</term><term>B-Cell Activating Factor (genetics)</term><term>B-Cell Activating Factor (immunology)</term><term>B-Lymphocytes (immunology)</term><term>B-Lymphocytes (pathology)</term><term>Cell Survival (drug effects)</term><term>Hyperplasia</term><term>Immunoglobulin G (immunology)</term><term>Immunoglobulin G (pharmacology)</term><term>Lymphocyte Depletion (methods)</term><term>Mice</term><term>Mice, Knockout</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>B-Cell Activating Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>B-Cell Activating Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term><term>B-Cell Activating Factor</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphocyte Depletion</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>B-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hyperplasia</term><term>Mice</term><term>Mice, Knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27451394</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>17</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN><JournalIssue CitedMedium="Internet"><Volume>291</Volume><Issue>38</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>16</Day></PubDate></JournalIssue><Title>The Journal of biological chemistry</Title><ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation></Journal><ArticleTitle>Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.</ArticleTitle><Pagination><MedlinePgn>19826-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.M116.725929</ELocationID><Abstract><AbstractText>B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligand required for the generation and maintenance of B lymphocytes. In this study, the ability of different monoclonal antibodies to recognize, inhibit, or activate mouse BAFF was investigated. One of them, a mouse IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modulating ligand interactor, and B cell maturation antigen, at a stoichiometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to those observed in BAFF-deficient mice. This depletion could then be maintained with a chronic treatment. Sandy-2 and a previously described rat IgG1 antibody, 5A8, also formed a pair suitable for the sensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay. Interestingly, 5A8 and Sandy-5 displayed activities opposite to that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detection and functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depletion of BAFF in mice.</AbstractText><CopyrightInformation>© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kowalczyk-Quintas</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schuepbach-Mallepell</LastName><ForeName>Sonia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vigolo</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willen</LastName><ForeName>Laure</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tardivel</LastName><ForeName>Aubry</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smulski</LastName><ForeName>Cristian R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Timothy S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Biogen, Cambridge, Massachusetts 02142.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gommerman</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hess</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Merck KGaA, D-64293 Darmstadt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gottenberg</LastName><ForeName>Jacques-Eric</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>INSERM UMR S1109, University of Strasbourg, 67085 Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mackay</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Immunology, Monash University, Melbourne 3004, Australia, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donzé</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Adipogen Life Sciences, CH-1066 Epalinges, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0677-9409</Identifier><AffiliationInfo><Affiliation>From the Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland, pascal.schneider@unil.ch.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biol Chem</MedlineTA><NlmUniqueID>2985121R</NlmUniqueID><ISSNLinking>0021-9258</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000906">Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053264">B-Cell Activating Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C505720">Tnfsf13b protein, 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MajorTopicYN="N">Antibodies</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053264" MajorTopicYN="N">B-Cell Activating Factor</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006965" MajorTopicYN="N">Hyperplasia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008212" MajorTopicYN="N">Lymphocyte Depletion</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BAFF</Keyword><Keyword MajorTopicYN="N">antibody</Keyword><Keyword MajorTopicYN="N">cytokine</Keyword><Keyword MajorTopicYN="N">immunology</Keyword><Keyword MajorTopicYN="N">lymphocyte</Keyword><Keyword MajorTopicYN="N">receptor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27451394</ArticleId><ArticleId IdType="pii">M116.725929</ArticleId><ArticleId IdType="doi">10.1074/jbc.M116.725929</ArticleId><ArticleId IdType="pmc">PMC5025672</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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