Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study.
Identifieur interne : 002322 ( PubMed/Checkpoint ); précédent : 002321; suivant : 002323Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study.
Auteurs : Phillip J. Tully ; Stephanie Debette ; Jean-François Dartigues ; Catherine Helmer ; Sylvaine Artero ; Christophe Tzourio [France]Source :
- Stroke [ 1524-4628 ] ; 2016.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (), Accident vasculaire cérébral (épidémiologie), Antagonistes bêta-adrénergiques (effets indésirables), Antagonistes des récepteurs aux angiotensines (effets indésirables), Antihypertenseurs (effets indésirables), Femelle, France (épidémiologie), Humains, Hypertension artérielle (traitement médicamenteux), Hypertension artérielle (épidémiologie), Incidence, Mâle, Pression sanguine (), Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
- MESH :
- effets indésirables : Antagonistes bêta-adrénergiques, Antagonistes des récepteurs aux angiotensines, Antihypertenseurs.
- traitement médicamenteux : Hypertension artérielle.
- épidémiologie : Accident vasculaire cérébral, France, Hypertension artérielle.
- Accident vasculaire cérébral, Femelle, Humains, Incidence, Mâle, Pression sanguine, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
English descriptors
- KwdEn :
- Adrenergic beta-Antagonists (adverse effects), Aged, Aged, 80 and over, Angiotensin Receptor Antagonists (adverse effects), Antihypertensive Agents (adverse effects), Blood Pressure (drug effects), Cohort Studies, Female, France (epidemiology), Humans, Hypertension (drug therapy), Hypertension (epidemiology), Incidence, Male, Risk, Stroke (chemically induced), Stroke (epidemiology).
- MESH :
- chemical , adverse effects : Adrenergic beta-Antagonists, Angiotensin Receptor Antagonists, Antihypertensive Agents.
- chemically induced : Stroke.
- drug effects : Blood Pressure.
- drug therapy : Hypertension.
- epidemiology : France, Hypertension, Stroke.
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Incidence, Male, Risk.
Abstract
The aim was to determine the association between antihypertensive drug class and incident stroke controlling for long-term blood pressure (BP) variability (BPV) in people aged ≥65 years.
DOI: 10.1161/STROKEAHA.115.012321
PubMed: 27012741
Affiliations:
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pubmed:27012741Le document en format XML
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Tully</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.). christophe.tzourio@u-bordeaux.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27012741</idno><idno type="pmid">27012741</idno><idno type="doi">10.1161/STROKEAHA.115.012321</idno><idno type="wicri:Area/PubMed/Corpus">001F39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F39</idno><idno type="wicri:Area/PubMed/Curation">001F15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F15</idno><idno type="wicri:Area/PubMed/Checkpoint">001F15</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study.</title><author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</nlm:affiliation><wicri:noCountry code="subField">C.T.).</wicri:noCountry></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.). christophe.tzourio@u-bordeaux.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><series><title level="j">Stroke</title><idno type="eISSN">1524-4628</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Antagonists (adverse effects)</term><term>Aged</term><term>Aged, 80 and over</term><term>Angiotensin Receptor Antagonists (adverse effects)</term><term>Antihypertensive Agents (adverse effects)</term><term>Blood Pressure (drug effects)</term><term>Cohort Studies</term><term>Female</term><term>France (epidemiology)</term><term>Humans</term><term>Hypertension (drug therapy)</term><term>Hypertension (epidemiology)</term><term>Incidence</term><term>Male</term><term>Risk</term><term>Stroke (chemically induced)</term><term>Stroke (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term><term>Accident vasculaire cérébral (épidémiologie)</term><term>Antagonistes bêta-adrénergiques (effets indésirables)</term><term>Antagonistes des récepteurs aux angiotensines (effets indésirables)</term><term>Antihypertenseurs (effets indésirables)</term><term>Femelle</term><term>France (épidémiologie)</term><term>Humains</term><term>Hypertension artérielle (traitement médicamenteux)</term><term>Hypertension artérielle (épidémiologie)</term><term>Incidence</term><term>Mâle</term><term>Pression sanguine ()</term><term>Risque</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adrenergic beta-Antagonists</term><term>Angiotensin Receptor Antagonists</term><term>Antihypertensive Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antagonistes bêta-adrénergiques</term><term>Antagonistes des récepteurs aux angiotensines</term><term>Antihypertenseurs</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>France</term><term>Hypertension</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypertension artérielle</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>France</term><term>Hypertension artérielle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Risk</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Pression sanguine</term><term>Risque</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim was to determine the association between antihypertensive drug class and incident stroke controlling for long-term blood pressure (BP) variability (BPV) in people aged ≥65 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27012741</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>26</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4628</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Stroke</Title><ISOAbbreviation>Stroke</ISOAbbreviation></Journal><ArticleTitle>Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study.</ArticleTitle><Pagination><MedlinePgn>1194-200</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.115.012321</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The aim was to determine the association between antihypertensive drug class and incident stroke controlling for long-term blood pressure (BP) variability (BPV) in people aged ≥65 years.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The sample included 5951 participants (median age 74 years, 60% women) taking at least 1 drug for hypertension (3727/5951) or with systolic BP >140 mm Hg or diastolic BP >90 mm Hg. Participants were evaluated for incident fatal and nonfatal stroke to 12 years follow-up. BPV was calculated with the coefficient of variation method and regressed against 9 antihypertensive drug classes (BPVreg). Hazard models were used to determine hazard ratios for incident stroke risk attributable to drug class, adjusted for BP, BPVreg, covariates, and delayed entry bias.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were 273 incident strokes over a median of 9.1 years (interquartile range 6.4-10.4). Stroke risk was generally not reduced by BP-lowering drugs. Angiotensin receptor blockers (hazard ratio 1.56; 95% confidence interval 1.06-2.28; P=0.02) and β-blockers (hazard ratio 1.41; 95% confidence interval 1.03-1.92; P=0.03) were associated with an increased total stroke risk. Angiotensin receptor blockers and β-blockers were also associated with ischemic strokes after adjustment for systolic BPV. Diastolic BPV was associated with stroke risk in analyses stratified by systolic BP 140 to 160 mm Hg (per 0.10 increase in coefficient of variation, hazard ratio 1.59; 95% confidence interval 1.05-2.40; P=0.03).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The angiotensin receptor blocker and β-blocker drug classes were associated with incident stroke and ischemic stroke in older adults. BPV was generally not associated with incident stroke.</AbstractText><CopyrightInformation>© 2016 American Heart Association, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tully</LastName><ForeName>Phillip J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debette</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dartigues</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmer</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Artero</LastName><ForeName>Sylvaine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the University of Bordeaux, Department of Neuroepidemiology, Bordeaux, France (P.J.T., S.D., C.T.); Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia (P.J.T.); Department of Neurology, Bordeaux University Hospital, Bordeaux, France (S.D.); Department of Neurology, Framingham Heart Study, Boston University School of medicine, MA (S.D.); Department of Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France (J.-F.D., C.H.); INSERM U1061, La Colombière Hospital, University of Montpellier UM1, Montpellier, France (S.A.); and INSERM, Department of Neuroepidemiology, UMR897, F-33000 Bordeaux, France (P.J.T., C.T.). christophe.tzourio@u-bordeaux.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Stroke</MedlineTA><NlmUniqueID>0235266</NlmUniqueID><ISSNLinking>0039-2499</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000319">Adrenergic beta-Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057911">Angiotensin Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000959">Antihypertensive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000319" MajorTopicYN="N">Adrenergic beta-Antagonists</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057911" MajorTopicYN="N">Angiotensin Receptor Antagonists</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000959" MajorTopicYN="N">Antihypertensive Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006973" MajorTopicYN="N">Hypertension</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">antihypertensive</Keyword><Keyword MajorTopicYN="Y">blood pressure variability</Keyword><Keyword MajorTopicYN="Y">hypertension</Keyword><Keyword MajorTopicYN="Y">ischemic</Keyword><Keyword MajorTopicYN="Y">stroke</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27012741</ArticleId><ArticleId IdType="pii">STROKEAHA.115.012321</ArticleId><ArticleId IdType="doi">10.1161/STROKEAHA.115.012321</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name></noCountry><country name="France"><noRegion><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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