Heterologous vaccine effects.
Identifieur interne : 001D14 ( PubMed/Checkpoint ); précédent : 001D13; suivant : 001D15Heterologous vaccine effects.
Auteurs : Mitra Saadatian-Elahi [France] ; Peter Aaby [Guinée-Bissau] ; Frank Shann [Australie] ; Mihai G. Netea [Pays-Bas] ; Ofer Levy [États-Unis] ; Jacques Louis [France] ; Valentina Picot [France] ; Michael Greenberg [États-Unis] ; William Warren [États-Unis]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Vaccines, Attenuated, Vaccines, Inactivated.
- Congresses as Topic, France, Humans, Immunity, Heterologous, Immunity, Innate, Immunologic Memory.
Abstract
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.
DOI: 10.1016/j.vaccine.2016.06.020
PubMed: 27312214
Affiliations:
- Australie, France, Guinée-Bissau, Pays-Bas, États-Unis
- Auvergne-Rhône-Alpes, Californie, Floride, Gueldre, Massachusetts, Rhône-Alpes, Victoria (État)
- Lyon, Melbourne, Nimègue
- Université de Melbourne
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:27312214Le document en format XML
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<front><div type="abstract" xml:lang="en">The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</div>
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<Abstract><AbstractText>The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</AbstractText>
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</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Guinée-Bissau</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Floride</li>
<li>Gueldre</li>
<li>Massachusetts</li>
<li>Rhône-Alpes</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Lyon</li>
<li>Melbourne</li>
<li>Nimègue</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Saadatian Elahi, Mitra" sort="Saadatian Elahi, Mitra" uniqKey="Saadatian Elahi M" first="Mitra" last="Saadatian-Elahi">Mitra Saadatian-Elahi</name>
</region>
<name sortKey="Louis, Jacques" sort="Louis, Jacques" uniqKey="Louis J" first="Jacques" last="Louis">Jacques Louis</name>
<name sortKey="Picot, Valentina" sort="Picot, Valentina" uniqKey="Picot V" first="Valentina" last="Picot">Valentina Picot</name>
</country>
<country name="Guinée-Bissau"><noRegion><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name>
</noRegion>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Shann, Frank" sort="Shann, Frank" uniqKey="Shann F" first="Frank" last="Shann">Frank Shann</name>
</region>
</country>
<country name="Pays-Bas"><region name="Gueldre"><name sortKey="Netea, Mihai G" sort="Netea, Mihai G" uniqKey="Netea M" first="Mihai G" last="Netea">Mihai G. Netea</name>
</region>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name>
</region>
<name sortKey="Greenberg, Michael" sort="Greenberg, Michael" uniqKey="Greenberg M" first="Michael" last="Greenberg">Michael Greenberg</name>
<name sortKey="Warren, William" sort="Warren, William" uniqKey="Warren W" first="William" last="Warren">William Warren</name>
</country>
</tree>
</affiliations>
</record>
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