Heterologous vaccine effects.
Identifieur interne : 001B59 ( PubMed/Curation ); précédent : 001B58; suivant : 001B60Heterologous vaccine effects.
Auteurs : Mitra Saadatian-Elahi [France] ; Peter Aaby [Guinée-Bissau] ; Frank Shann [Australie] ; Mihai G. Netea [Pays-Bas] ; Ofer Levy [États-Unis] ; Jacques Louis [France] ; Valentina Picot [France] ; Michael Greenberg [États-Unis] ; William Warren [États-Unis]Source :
- Vaccine [ 1873-2518 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Vaccines, Attenuated, Vaccines, Inactivated.
- Congresses as Topic, France, Humans, Immunity, Heterologous, Immunity, Innate, Immunologic Memory.
Abstract
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.
DOI: 10.1016/j.vaccine.2016.06.020
PubMed: 27312214
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Electronic address: mitra.elahi@chu-lyon.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon cedex 03</wicri:regionArea></affiliation></author><author><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name><affiliation wicri:level="1"><nlm:affiliation>Bandim Health Project, INDEPTH Network, CP861 Bissau, Guinea-Bissau.</nlm:affiliation><country xml:lang="fr">Guinée-Bissau</country><wicri:regionArea>Bandim Health Project, INDEPTH Network, CP861 Bissau</wicri:regionArea></affiliation></author><author><name sortKey="Shann, Frank" sort="Shann, Frank" uniqKey="Shann F" first="Frank" last="Shann">Frank Shann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Melbourne, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pediatrics, University of Melbourne, Victoria 3052</wicri:regionArea></affiliation></author><author><name sortKey="Netea, Mihai G" sort="Netea, Mihai G" uniqKey="Netea M" first="Mihai G" last="Netea">Mihai G. Netea</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name><affiliation wicri:level="1"><nlm:affiliation>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115</wicri:regionArea></affiliation></author><author><name sortKey="Louis, Jacques" sort="Louis, Jacques" uniqKey="Louis J" first="Jacques" last="Louis">Jacques Louis</name><affiliation wicri:level="1"><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Picot, Valentina" sort="Picot, Valentina" uniqKey="Picot V" first="Valentina" last="Picot">Valentina Picot</name><affiliation wicri:level="1"><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Greenberg, Michael" sort="Greenberg, Michael" uniqKey="Greenberg M" first="Michael" last="Greenberg">Michael Greenberg</name><affiliation wicri:level="1"><nlm:affiliation>Sanofi Pasteur, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi Pasteur, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Warren, William" sort="Warren, William" uniqKey="Warren W" first="William" last="Warren">William Warren</name><affiliation wicri:level="1"><nlm:affiliation>Sanofi Pasteur, Orlando, FL 32826, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi Pasteur, Orlando, FL 32826</wicri:regionArea></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Congresses as Topic</term><term>France</term><term>Humans</term><term>Immunity, Heterologous</term><term>Immunity, Innate</term><term>Immunologic Memory</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Inactivated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Congrès comme sujet</term><term>France</term><term>Humains</term><term>Immunité hétérologue</term><term>Immunité innée</term><term>Mémoire immunologique</term><term>Vaccins atténués (immunologie)</term><term>Vaccins inactivés (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins atténués</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Congresses as Topic</term><term>France</term><term>Humans</term><term>Immunity, Heterologous</term><term>Immunity, Innate</term><term>Immunologic Memory</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Congrès comme sujet</term><term>France</term><term>Humains</term><term>Immunité hétérologue</term><term>Immunité innée</term><term>Mémoire immunologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27312214</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>11</Day></DateCreated><DateCompleted><Year>2017</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>34</Issue><PubDate><Year>2016</Year><Month>Jul</Month><Day>25</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Heterologous vaccine effects.</ArticleTitle><Pagination><MedlinePgn>3923-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2016.06.020</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(16)30433-9</ELocationID><Abstract><AbstractText>The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</AbstractText><CopyrightInformation>Copyright © 2016.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saadatian-Elahi</LastName><ForeName>Mitra</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon cedex 03, France. Electronic address: mitra.elahi@chu-lyon.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aaby</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Bandim Health Project, INDEPTH Network, CP861 Bissau, Guinea-Bissau.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shann</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Melbourne, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Netea</LastName><ForeName>Mihai G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Ofer</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Picot</LastName><ForeName>Valentina</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greenberg</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sanofi Pasteur, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warren</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Sanofi Pasteur, Orlando, FL 32826, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003226" MajorTopicYN="N">Congresses as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064789" MajorTopicYN="Y">Immunity, Heterologous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="N">Immunologic Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015164" MajorTopicYN="N">Vaccines, Inactivated</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Conference report</Keyword><Keyword MajorTopicYN="N">Heterologous effect</Keyword><Keyword MajorTopicYN="N">Non-antigen-specific effects</Keyword><Keyword MajorTopicYN="N">Off-target effects</Keyword><Keyword MajorTopicYN="N">Vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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