Heterologous vaccine effects.
Identifieur interne : 001B83 ( PubMed/Corpus ); précédent : 001B82; suivant : 001B84Heterologous vaccine effects.
Auteurs : Mitra Saadatian-Elahi ; Peter Aaby ; Frank Shann ; Mihai G. Netea ; Ofer Levy ; Jacques Louis ; Valentina Picot ; Michael Greenberg ; William WarrenSource :
- Vaccine [ 1873-2518 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Vaccines, Attenuated, Vaccines, Inactivated.
- Congresses as Topic, France, Humans, Immunity, Heterologous, Immunity, Innate, Immunologic Memory.
Abstract
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.
DOI: 10.1016/j.vaccine.2016.06.020
PubMed: 27312214
Links to Exploration step
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Electronic address: mitra.elahi@chu-lyon.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name><affiliation><nlm:affiliation>Bandim Health Project, INDEPTH Network, CP861 Bissau, Guinea-Bissau.</nlm:affiliation></affiliation></author><author><name sortKey="Shann, Frank" sort="Shann, Frank" uniqKey="Shann F" first="Frank" last="Shann">Frank Shann</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Melbourne, Victoria 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Netea, Mihai G" sort="Netea, Mihai G" uniqKey="Netea M" first="Mihai G" last="Netea">Mihai G. Netea</name><affiliation><nlm:affiliation>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name><affiliation><nlm:affiliation>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Louis, Jacques" sort="Louis, Jacques" uniqKey="Louis J" first="Jacques" last="Louis">Jacques Louis</name><affiliation><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Picot, Valentina" sort="Picot, Valentina" uniqKey="Picot V" first="Valentina" last="Picot">Valentina Picot</name><affiliation><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Greenberg, Michael" sort="Greenberg, Michael" uniqKey="Greenberg M" first="Michael" last="Greenberg">Michael Greenberg</name><affiliation><nlm:affiliation>Sanofi Pasteur, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Warren, William" sort="Warren, William" uniqKey="Warren W" first="William" last="Warren">William Warren</name><affiliation><nlm:affiliation>Sanofi Pasteur, Orlando, FL 32826, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27312214</idno><idno type="pmid">27312214</idno><idno type="doi">10.1016/j.vaccine.2016.06.020</idno><idno type="wicri:Area/PubMed/Corpus">001B83</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Heterologous vaccine effects.</title><author><name sortKey="Saadatian Elahi, Mitra" sort="Saadatian Elahi, Mitra" uniqKey="Saadatian Elahi M" first="Mitra" last="Saadatian-Elahi">Mitra Saadatian-Elahi</name><affiliation><nlm:affiliation>Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon cedex 03, France. Electronic address: mitra.elahi@chu-lyon.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name><affiliation><nlm:affiliation>Bandim Health Project, INDEPTH Network, CP861 Bissau, Guinea-Bissau.</nlm:affiliation></affiliation></author><author><name sortKey="Shann, Frank" sort="Shann, Frank" uniqKey="Shann F" first="Frank" last="Shann">Frank Shann</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Melbourne, Victoria 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Netea, Mihai G" sort="Netea, Mihai G" uniqKey="Netea M" first="Mihai G" last="Netea">Mihai G. Netea</name><affiliation><nlm:affiliation>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name><affiliation><nlm:affiliation>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Louis, Jacques" sort="Louis, Jacques" uniqKey="Louis J" first="Jacques" last="Louis">Jacques Louis</name><affiliation><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Picot, Valentina" sort="Picot, Valentina" uniqKey="Picot V" first="Valentina" last="Picot">Valentina Picot</name><affiliation><nlm:affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Greenberg, Michael" sort="Greenberg, Michael" uniqKey="Greenberg M" first="Michael" last="Greenberg">Michael Greenberg</name><affiliation><nlm:affiliation>Sanofi Pasteur, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Warren, William" sort="Warren, William" uniqKey="Warren W" first="William" last="Warren">William Warren</name><affiliation><nlm:affiliation>Sanofi Pasteur, Orlando, FL 32826, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Congresses as Topic</term><term>France</term><term>Humans</term><term>Immunity, Heterologous</term><term>Immunity, Innate</term><term>Immunologic Memory</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Inactivated (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Congresses as Topic</term><term>France</term><term>Humans</term><term>Immunity, Heterologous</term><term>Immunity, Innate</term><term>Immunologic Memory</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27312214</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>11</Day></DateCreated><DateCompleted><Year>2017</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>34</Issue><PubDate><Year>2016</Year><Month>Jul</Month><Day>25</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Heterologous vaccine effects.</ArticleTitle><Pagination><MedlinePgn>3923-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2016.06.020</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(16)30433-9</ELocationID><Abstract><AbstractText>The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference "Off-target effects of vaccination" held in Annecy-France (June 8-10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, epidemiology, bioinformatics, public health and regulatory science to address fundamental questions of immunological mechanisms, as well as translational questions about vaccines NSEs. NSE observations were examined using case-studies on live attenuated vaccines and non-live vaccines followed by discussion of studies of possible biological mechanisms. Some possible pathways forward in the study of vaccines NSE were identified and discussed by the expert group.</AbstractText><CopyrightInformation>Copyright © 2016.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saadatian-Elahi</LastName><ForeName>Mitra</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon cedex 03, France. Electronic address: mitra.elahi@chu-lyon.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aaby</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Bandim Health Project, INDEPTH Network, CP861 Bissau, Guinea-Bissau.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shann</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Melbourne, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Netea</LastName><ForeName>Mihai G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Ofer</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Precision Vaccines Program, Boston Children's Hospital & Havard Medical School, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Picot</LastName><ForeName>Valentina</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greenberg</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sanofi Pasteur, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warren</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Sanofi Pasteur, Orlando, FL 32826, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003226" MajorTopicYN="N">Congresses as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" 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