Genome-wide association study identifies new prostate cancer susceptibility loci
Identifieur interne : 001741 ( Pmc/Curation ); précédent : 001740; suivant : 001742Genome-wide association study identifies new prostate cancer susceptibility loci
Auteurs : Fredrick R. Schumacher [États-Unis] ; Sonja I. Berndt [États-Unis] ; Afshan Siddiq ; Kevin B. Jacobs [États-Unis] ; Zhaoming Wang [États-Unis] ; Sara Lindstrom ; Victoria L. Stevens [États-Unis] ; Constance Chen ; Alison M. Mondul [États-Unis] ; Ruth C. Travis ; Daniel O. Stram [États-Unis] ; Rosalind A. Eeles [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni] ; Graham Giles [Australie] ; John L. Hopper [Australie] ; David E. Neal [Royaume-Uni] ; Freddie C. Hamdy [Royaume-Uni] ; Jenny L. Donovan [Royaume-Uni] ; Kenneth Muir [Royaume-Uni] ; Ali Amin Al Olama ; Zsofia Kote-Jarai [Royaume-Uni] ; Michelle Guy [Royaume-Uni] ; Gianluca Severi [Australie] ; Henrik Grönberg [Suède] ; William B. Isaacs [États-Unis] ; Robert Karlsson [Suède] ; Fredrik Wiklund [Suède] ; Jianfeng Xu [États-Unis] ; Naomi E. Allen ; Gerald L. Andriole [États-Unis] ; Aurelio Barricarte [Espagne] ; Heiner Boeing [Allemagne] ; H. Bas Bueno-De-Mesquita [Pays-Bas] ; E. David Crawford [États-Unis] ; W. Ryan Diver [États-Unis] ; Carlos A. Gonzalez [Espagne] ; J. Michael Gaziano [États-Unis] ; Edward L. Giovannucci [États-Unis] ; Mattias Johansson [France, Suède] ; Loic Le Marchand [États-Unis] ; Jing Ma [États-Unis] ; Sabina Sieri [Italie] ; P R Stattin [Suède] ; Meir J. Stampfer [États-Unis] ; Anne Tjonneland [Danemark] ; Paolo Vineis [Royaume-Uni] ; Jarmo Virtamo [Finlande] ; Ulla Vogel [Danemark] ; Stephanie J. Weinstein [États-Unis] ; Meredith Yeager [États-Unis] ; Michael J. Thun [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Brian E. Henderson [États-Unis] ; Demetrius Albanes [États-Unis] ; Richard B. Hayes [États-Unis] ; Heather Spencer Feigelson [États-Unis] ; Elio Riboli ; David J. Hunter ; Stephen J. Chanock [États-Unis] ; Christopher A. Haiman [États-Unis] ; Peter KraftSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2011.
Abstract
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on
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DOI: 10.1093/hmg/ddr295
PubMed: 21743057
PubMed Central: 3168287
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Berndt</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M." last="Mondul">Alison M. Mondul</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation wicri:level="1"><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Victoria</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Nuffield Department of Surgical Sciences</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="af22"><institution>Health Sciences Research Institute, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Victoria</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="1"><nlm:aff id="af24"><institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlsson, Robert" sort="Karlsson, Robert" uniqKey="Karlsson R" first="Robert" last="Karlsson">Robert Karlsson</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>,<institution>Wake Forest University School of Medicine</institution>,<addr-line>Winston-Salem, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation wicri:level="1"><nlm:aff id="af27"><institution>Navarre Public Health Institute</institution>,<addr-line>Pamplona</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Department of Epidemiology</addr-line>,<institution>Deutsches Institut für Ernährungsforschung</institution>,<addr-line>Potsdam-Rehbrücke</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Urologic Oncology</addr-line>,<institution>University of Colorado</institution>,<addr-line>Aurora, CO</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Unit of Nutrition</addr-line>,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name><affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Division of Aging</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af34"><institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston 02115, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:aff id="af36"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>,<institution>Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><institution>Channing Laboratory</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation wicri:level="1"><nlm:aff id="af40"><institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>,<institution>Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston 02115, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><institution>Channing Laboratory</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation wicri:level="1"><nlm:aff id="af41"><institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="af42"><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogel, Ulla" sort="Vogel, Ulla" uniqKey="Vogel U" first="Ulla" last="Vogel">Ulla Vogel</name><affiliation wicri:level="1"><nlm:aff id="af43"><institution>National Research Centre for the Working Environment</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af44"><institution>National Food Institute, Technical University of Denmark</institution>,<addr-line>Soborg</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af45"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spencer Feigelson, Heather" sort="Spencer Feigelson, Heather" uniqKey="Spencer Feigelson H" first="Heather" last="Spencer Feigelson">Heather Spencer Feigelson</name><affiliation wicri:level="1"><nlm:aff id="af46"><institution>Institute for Health Research, Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21743057</idno><idno type="pmc">3168287</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168287</idno><idno type="RBID">PMC:3168287</idno><idno type="doi">10.1093/hmg/ddr295</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001882</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001882</idno><idno type="wicri:Area/Pmc/Curation">001741</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001741</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study identifies new prostate cancer susceptibility loci</title><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M." last="Mondul">Alison M. Mondul</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation wicri:level="1"><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Victoria</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Nuffield Department of Surgical Sciences</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="af22"><institution>Health Sciences Research Institute, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="1"><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Victoria</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="1"><nlm:aff id="af24"><institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlsson, Robert" sort="Karlsson, Robert" uniqKey="Karlsson R" first="Robert" last="Karlsson">Robert Karlsson</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>,<institution>Wake Forest University School of Medicine</institution>,<addr-line>Winston-Salem, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation wicri:level="1"><nlm:aff id="af27"><institution>Navarre Public Health Institute</institution>,<addr-line>Pamplona</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Department of Epidemiology</addr-line>,<institution>Deutsches Institut für Ernährungsforschung</institution>,<addr-line>Potsdam-Rehbrücke</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line>,<country>The Netherlands</country>,</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Urologic Oncology</addr-line>,<institution>University of Colorado</institution>,<addr-line>Aurora, CO</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Unit of Nutrition</addr-line>,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name><affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Division of Aging</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af34"><institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston 02115, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:aff id="af36"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>,<institution>Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><institution>Channing Laboratory</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation wicri:level="1"><nlm:aff id="af40"><institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>,<institution>Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country>,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston 02115, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af39"><institution>Channing Laboratory</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name><affiliation wicri:level="1"><nlm:aff id="af41"><institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="af42"><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vogel, Ulla" sort="Vogel, Ulla" uniqKey="Vogel U" first="Ulla" last="Vogel">Ulla Vogel</name><affiliation wicri:level="1"><nlm:aff id="af43"><institution>National Research Centre for the Working Environment</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af44"><institution>National Food Institute, Technical University of Denmark</institution>,<addr-line>Soborg</addr-line>,<country>Denmark</country>,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af45"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spencer Feigelson, Heather" sort="Spencer Feigelson, Heather" uniqKey="Spencer Feigelson H" first="Heather" last="Spencer Feigelson">Heather Spencer Feigelson</name><affiliation wicri:level="1"><nlm:aff id="af46"><institution>Institute for Health Research, Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on <italic>in silico</italic> replication of 4679 SNPs (Stage 1, <italic>P</italic> < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, <italic>P</italic>= 4.3 × 10<sup>−8</sup>). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, <italic>P</italic>= 8.6 × 10<sup>−9</sup>). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity <italic>P</italic>= 0.72 and <italic>P</italic>= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-id journal-id-type="hwp">hmg</journal-id><journal-title-group><journal-title>Human Molecular Genetics</journal-title></journal-title-group><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21743057</article-id><article-id pub-id-type="pmc">3168287</article-id><article-id pub-id-type="doi">10.1093/hmg/ddr295</article-id><article-id pub-id-type="publisher-id">ddr295</article-id><article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study identifies new prostate cancer susceptibility loci</article-title></title-group><contrib-group><contrib 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rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af7">7</xref><xref ref-type="aff" rid="af8">8</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="AN1">†</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Preventive Medicine</addr-line>,<institution>Keck School of Medicine, University of Southern California</institution>,<addr-line>Los Angeles, CA</addr-line>,<country>USA</country>,</aff><aff id="af2"><label>2</label><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda, MD</addr-line>,<country>USA</country>,</aff><aff id="af3"><label>3</label><addr-line>Department of Epidemiology and Biostatistics</addr-line> and</aff><aff id="af4"><label>4</label><institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country>,</aff><aff id="af5"><label>5</label><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>,<addr-line>Frederick, MD</addr-line>,<country>USA</country>,</aff><aff id="af6"><label>6</label><institution>Bioinformed Consulting Services</institution>,<addr-line>Gaithersburg, MD</addr-line>,<country>USA</country>,</aff><aff id="af7"><label>7</label><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>,</aff><aff id="af8"><label>8</label><addr-line>Department of Epidemiology</addr-line> and</aff><aff id="af9"><label>9</label><addr-line>Department of Nutrition</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston 02115, MA</addr-line>,<country>USA</country>,</aff><aff id="af10"><label>10</label><institution>Epidemiology Research Program, American Cancer Society</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country>,</aff><aff id="af11"><label>11</label><addr-line>Cancer Epidemiology Unit</addr-line>,</aff><aff id="af12"><label>12</label><addr-line>Nuffield Department of Clinical Medicine</addr-line> and</aff><aff id="af13"><label>13</label><addr-line>Nuffield Department of Surgical Sciences</addr-line>,<institution>University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country>,</aff><aff id="af14"><label>14</label><institution>Oncogenetics Team, The Institute of Cancer Research</institution>,<addr-line>Sutton</addr-line>,<country>UK</country>,</aff><aff id="af15"><label>15</label><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>,</aff><aff id="af16"><label>16</label><addr-line>Department of Public Health</addr-line>,</aff><aff id="af17"><label>17</label><addr-line>Department of Primary Care and</addr-line>,</aff><aff id="af18"><label>18</label><addr-line>Department of Oncology</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country>,</aff><aff id="af19"><label>19</label><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>,<addr-line>Victoria</addr-line>,<country>Australia</country>,</aff><aff id="af20"><label>20</label><addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country>,</aff><aff id="af21"><label>21</label><addr-line>School of Social and Community Medicine</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country>,</aff><aff id="af22"><label>22</label><institution>Health Sciences Research Institute, University of Warwick</institution>,<addr-line>Coventry</addr-line>,<country>UK</country>,</aff><aff id="af23"><label>23</label><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>,<institution>Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country>,</aff><aff id="af24"><label>24</label><institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>,<addr-line>Baltimore, MD</addr-line>,<country>USA</country>,</aff><aff id="af25"><label>25</label><addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>,<institution>Wake Forest University School of Medicine</institution>,<addr-line>Winston-Salem, NC</addr-line>,<country>USA</country>,</aff><aff id="af26"><label>26</label><addr-line>Division of Urologic Surgery</addr-line>,<institution>Washington University School of Medicine</institution>,<addr-line>St Louis, MO</addr-line>,<country>USA</country>,</aff><aff id="af27"><label>27</label><institution>Navarre Public Health Institute</institution>,<addr-line>Pamplona</addr-line>,<country>Spain</country>,</aff><aff id="af28"><label>28</label><addr-line>Department of Epidemiology</addr-line>,<institution>Deutsches Institut für Ernährungsforschung</institution>,<addr-line>Potsdam-Rehbrücke</addr-line>,<country>Germany</country>,</aff><aff id="af29"><label>29</label><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line>,<country>The Netherlands</country>,</aff><aff id="af30"><label>30</label><addr-line>Urologic Oncology</addr-line>,<institution>University of Colorado</institution>,<addr-line>Aurora, CO</addr-line>,<country>USA</country>,</aff><aff id="af31"><label>31</label><addr-line>Unit of Nutrition</addr-line>,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country>,</aff><aff id="af32"><label>32</label><addr-line>Division of Aging</addr-line> and</aff><aff id="af33"><label>33</label><addr-line>Department of Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af34"><label>34</label><institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af35"><label>35</label><addr-line>Department of Medicine</addr-line>,<institution>Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af36"><label>36</label><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country>,</aff><aff id="af37"><label>37</label><addr-line>Department of Surgical and Perioperative Sciences</addr-line>,<institution>Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country>,</aff><aff id="af38"><label>38</label><addr-line>Cancer Research Center of Hawaii</addr-line>,<institution>University of Hawaii</institution>,<addr-line>Honolulu, HI</addr-line>,<country>USA</country>,</aff><aff id="af39"><label>39</label><institution>Channing Laboratory</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</aff><aff id="af40"><label>40</label><institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>Milan</addr-line>,<country>Italy</country>,</aff><aff id="af41"><label>41</label><institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af42"><label>42</label><addr-line>Department of Chronic Disease Prevention</addr-line>,<institution>National Institute for Health and Welfare</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country>,</aff><aff id="af43"><label>43</label><institution>National Research Centre for the Working Environment</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country>,</aff><aff id="af44"><label>44</label><institution>National Food Institute, Technical University of Denmark</institution>,<addr-line>Soborg</addr-line>,<country>Denmark</country>,</aff><aff id="af45"><label>45</label><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country> and</aff><aff id="af46"><label>46</label><institution>Institute for Health Research, Kaiser Permanente</institution>,<addr-line>Denver, CO</addr-line>,<country>USA</country></aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed at: Harvard School of Public Health, 665 Huntington Ave Boston MA 02115, USA. Tel: +<phone>1 6174324271</phone>; Fax: +<fax>1 6174321722</fax>; Email: <email>pkraft@hsph.harvard.edu</email></corresp><fn id="AN1"><label>†</label><p>These authors contributed equally.</p></fn></author-notes><pub-date pub-type="ppub"><day>1</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>8</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>20</volume><issue>19</issue><fpage>3867</fpage><lpage>3875</lpage><history><date date-type="received"><day>9</day><month>1</month><year>2011</year></date><date date-type="rev-recd"><day>18</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>27</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="ddr295.pdf"></self-uri><abstract><p>Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on <italic>in silico</italic> replication of 4679 SNPs (Stage 1, <italic>P</italic> < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, <italic>P</italic>= 4.3 × 10<sup>−8</sup>). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, <italic>P</italic>= 8.6 × 10<sup>−9</sup>). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity <italic>P</italic>= 0.72 and <italic>P</italic>= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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