Genome-wide association study identifies new prostate cancer susceptibility loci
Identifieur interne : 001882 ( Pmc/Corpus ); précédent : 001881; suivant : 001883Genome-wide association study identifies new prostate cancer susceptibility loci
Auteurs : Fredrick R. Schumacher ; Sonja I. Berndt ; Afshan Siddiq ; Kevin B. Jacobs ; Zhaoming Wang ; Sara Lindstrom ; Victoria L. Stevens ; Constance Chen ; Alison M. Mondul ; Ruth C. Travis ; Daniel O. Stram ; Rosalind A. Eeles ; Douglas F. Easton ; Graham Giles ; John L. Hopper ; David E. Neal ; Freddie C. Hamdy ; Jenny L. Donovan ; Kenneth Muir ; Ali Amin Al Olama ; Zsofia Kote-Jarai ; Michelle Guy ; Gianluca Severi ; Henrik Grönberg ; William B. Isaacs ; Robert Karlsson ; Fredrik Wiklund ; Jianfeng Xu ; Naomi E. Allen ; Gerald L. Andriole ; Aurelio Barricarte ; Heiner Boeing ; H. Bas Bueno-De-Mesquita ; E. David Crawford ; W. Ryan Diver ; Carlos A. Gonzalez ; J. Michael Gaziano ; Edward L. Giovannucci ; Mattias Johansson ; Loic Le Marchand ; Jing Ma ; Sabina Sieri ; P R Stattin ; Meir J. Stampfer ; Anne Tjonneland ; Paolo Vineis ; Jarmo Virtamo ; Ulla Vogel ; Stephanie J. Weinstein ; Meredith Yeager ; Michael J. Thun ; Laurence N. Kolonel ; Brian E. Henderson ; Demetrius Albanes ; Richard B. Hayes ; Heather Spencer Feigelson ; Elio Riboli ; David J. Hunter ; Stephen J. Chanock ; Christopher A. Haiman ; Peter KraftSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2011.
Abstract
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on
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DOI: 10.1093/hmg/ddr295
PubMed: 21743057
PubMed Central: 3168287
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PMC:3168287Le document en format XML
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<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
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<author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
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<author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name>
<affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>
,<addr-line>Frederick, MD</addr-line>
,<country>USA</country>
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</affiliation>
<affiliation><nlm:aff id="af6"><institution>Bioinformed Consulting Services</institution>
,<addr-line>Gaithersburg, MD</addr-line>
,<country>USA</country>
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<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
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<affiliation><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>
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<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name>
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<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
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<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
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<author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name>
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<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
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<author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M." last="Mondul">Alison M. Mondul</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
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<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>
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<affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line>
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<author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
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</author>
<author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
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</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>
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<affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>
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<affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>
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</affiliation>
<affiliation><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name>
<affiliation><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
,<addr-line>Victoria</addr-line>
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<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="af20"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>
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,<country>Australia</country>
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<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>
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,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name>
<affiliation><nlm:aff id="af13"><addr-line>Nuffield Department of Surgical Sciences</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name>
<affiliation><nlm:aff id="af21"><addr-line>School of Social and Community Medicine</addr-line>
,<institution>University of Bristol</institution>
,<addr-line>Bristol</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation><nlm:aff id="af22"><institution>Health Sciences Research Institute, University of Warwick</institution>
,<addr-line>Coventry</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name>
<affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>
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</affiliation>
<affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>
,</nlm:aff>
</affiliation>
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<author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
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</affiliation>
</author>
<author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
,<addr-line>Victoria</addr-line>
,<country>Australia</country>
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</affiliation>
</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<affiliation><nlm:aff id="af24"><institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
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</author>
<author><name sortKey="Karlsson, Robert" sort="Karlsson, Robert" uniqKey="Karlsson R" first="Robert" last="Karlsson">Robert Karlsson</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name>
<affiliation><nlm:aff id="af25"><addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>
,<institution>Wake Forest University School of Medicine</institution>
,<addr-line>Winston-Salem, NC</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name>
<affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name>
<affiliation><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>St Louis, MO</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name>
<affiliation><nlm:aff id="af27"><institution>Navarre Public Health Institute</institution>
,<addr-line>Pamplona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name>
<affiliation><nlm:aff id="af28"><addr-line>Department of Epidemiology</addr-line>
,<institution>Deutsches Institut für Ernährungsforschung</institution>
,<addr-line>Potsdam-Rehbrücke</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name>
<affiliation><nlm:aff id="af29"><institution>National Institute for Public Health and the Environment (RIVM)</institution>
,<addr-line>Bilthoven</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name>
<affiliation><nlm:aff id="af30"><addr-line>Urologic Oncology</addr-line>
,<institution>University of Colorado</institution>
,<addr-line>Aurora, CO</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name>
<affiliation><nlm:aff id="af31"><addr-line>Unit of Nutrition</addr-line>
,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name>
<affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Division of Aging</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af34"><institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston 02115, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
<affiliation><nlm:aff id="af36"><institution>International Agency for Research on Cancer (IARC)</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>
,<institution>Urology and Andrology, Umeå University</institution>
,<addr-line>Umeå</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name>
<affiliation><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af39"><institution>Channing Laboratory</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name>
<affiliation><nlm:aff id="af40"><institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
<affiliation><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>
,<institution>Urology and Andrology, Umeå University</institution>
,<addr-line>Umeå</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston 02115, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af39"><institution>Channing Laboratory</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name>
<affiliation><nlm:aff id="af41"><institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation><nlm:aff id="af4"><institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation><nlm:aff id="af42"><addr-line>Department of Chronic Disease Prevention</addr-line>
,<institution>National Institute for Health and Welfare</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vogel, Ulla" sort="Vogel, Ulla" uniqKey="Vogel U" first="Ulla" last="Vogel">Ulla Vogel</name>
<affiliation><nlm:aff id="af43"><institution>National Research Centre for the Working Environment</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af44"><institution>National Food Institute, Technical University of Denmark</institution>
,<addr-line>Soborg</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name>
<affiliation><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>
,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spencer Feigelson, Heather" sort="Spencer Feigelson, Heather" uniqKey="Spencer Feigelson H" first="Heather" last="Spencer Feigelson">Heather Spencer Feigelson</name>
<affiliation><nlm:aff id="af46"><institution>Institute for Health Research, Kaiser Permanente</institution>
,<addr-line>Denver, CO</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21743057</idno>
<idno type="pmc">3168287</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168287</idno>
<idno type="RBID">PMC:3168287</idno>
<idno type="doi">10.1093/hmg/ddr295</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001882</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001882</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study identifies new prostate cancer susceptibility loci</title>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name>
<affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jacobs, Kevin B" sort="Jacobs, Kevin B" uniqKey="Jacobs K" first="Kevin B." last="Jacobs">Kevin B. Jacobs</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>
,<addr-line>Frederick, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af6"><institution>Bioinformed Consulting Services</institution>
,<addr-line>Gaithersburg, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af5"><institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>
,<addr-line>Frederick, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
<affiliation><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M." last="Mondul">Alison M. Mondul</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name>
<affiliation><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
,<addr-line>Victoria</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff id="af20"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Oncology</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name>
<affiliation><nlm:aff id="af13"><addr-line>Nuffield Department of Surgical Sciences</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name>
<affiliation><nlm:aff id="af21"><addr-line>School of Social and Community Medicine</addr-line>
,<institution>University of Bristol</institution>
,<addr-line>Bristol</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation><nlm:aff id="af22"><institution>Health Sciences Research Institute, University of Warwick</institution>
,<addr-line>Coventry</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name>
<affiliation><nlm:aff id="af15"><addr-line>Centre for Cancer Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af16"><addr-line>Department of Public Health</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af17"><addr-line>Department of Primary Care and</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name>
<affiliation><nlm:aff id="af14"><institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:aff id="af19"><institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
,<addr-line>Victoria</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<affiliation><nlm:aff id="af24"><institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Karlsson, Robert" sort="Karlsson, Robert" uniqKey="Karlsson R" first="Robert" last="Karlsson">Robert Karlsson</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation><nlm:aff id="af23"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name>
<affiliation><nlm:aff id="af25"><addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>
,<institution>Wake Forest University School of Medicine</institution>
,<addr-line>Winston-Salem, NC</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name>
<affiliation><nlm:aff id="af11"><addr-line>Cancer Epidemiology Unit</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af12"><addr-line>Nuffield Department of Clinical Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name>
<affiliation><nlm:aff id="af26"><addr-line>Division of Urologic Surgery</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>St Louis, MO</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name>
<affiliation><nlm:aff id="af27"><institution>Navarre Public Health Institute</institution>
,<addr-line>Pamplona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name>
<affiliation><nlm:aff id="af28"><addr-line>Department of Epidemiology</addr-line>
,<institution>Deutsches Institut für Ernährungsforschung</institution>
,<addr-line>Potsdam-Rehbrücke</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name>
<affiliation><nlm:aff id="af29"><institution>National Institute for Public Health and the Environment (RIVM)</institution>
,<addr-line>Bilthoven</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crawford, E David" sort="Crawford, E David" uniqKey="Crawford E" first="E. David" last="Crawford">E. David Crawford</name>
<affiliation><nlm:aff id="af30"><addr-line>Urologic Oncology</addr-line>
,<institution>University of Colorado</institution>
,<addr-line>Aurora, CO</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="Gonzalez">Carlos A. Gonzalez</name>
<affiliation><nlm:aff id="af31"><addr-line>Unit of Nutrition</addr-line>
,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J. Michael" last="Gaziano">J. Michael Gaziano</name>
<affiliation><nlm:aff wicri:cut=" and" id="af32"><addr-line>Division of Aging</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af34"><institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston 02115, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
<affiliation><nlm:aff id="af36"><institution>International Agency for Research on Cancer (IARC)</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>
,<institution>Urology and Andrology, Umeå University</institution>
,<addr-line>Umeå</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name>
<affiliation><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af39"><institution>Channing Laboratory</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name>
<affiliation><nlm:aff id="af40"><institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
<affiliation><nlm:aff id="af37"><addr-line>Department of Surgical and Perioperative Sciences</addr-line>
,<institution>Urology and Andrology, Umeå University</institution>
,<addr-line>Umeå</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af9"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston 02115, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af33"><addr-line>Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af35"><addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af39"><institution>Channing Laboratory</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tjonneland, Anne" sort="Tjonneland, Anne" uniqKey="Tjonneland A" first="Anne" last="Tjonneland">Anne Tjonneland</name>
<affiliation><nlm:aff id="af41"><institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation><nlm:aff id="af4"><institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation><nlm:aff id="af42"><addr-line>Department of Chronic Disease Prevention</addr-line>
,<institution>National Institute for Health and Welfare</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vogel, Ulla" sort="Vogel, Ulla" uniqKey="Vogel U" first="Ulla" last="Vogel">Ulla Vogel</name>
<affiliation><nlm:aff id="af43"><institution>National Research Centre for the Working Environment</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af44"><institution>National Food Institute, Technical University of Denmark</institution>
,<addr-line>Soborg</addr-line>
,<country>Denmark</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thun, Michael J" sort="Thun, Michael J" uniqKey="Thun M" first="Michael J." last="Thun">Michael J. Thun</name>
<affiliation><nlm:aff id="af10"><institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation><nlm:aff id="af38"><addr-line>Cancer Research Center of Hawaii</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B." last="Hayes">Richard B. Hayes</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af45"><addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>
,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spencer Feigelson, Heather" sort="Spencer Feigelson, Heather" uniqKey="Spencer Feigelson H" first="Heather" last="Spencer Feigelson">Heather Spencer Feigelson</name>
<affiliation><nlm:aff id="af46"><institution>Institute for Health Research, Kaiser Permanente</institution>
,<addr-line>Denver, CO</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation><nlm:aff wicri:cut=" and" id="af3"><addr-line>Department of Epidemiology and Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation><nlm:aff id="af2"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation><nlm:aff id="af7"><addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af8"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on <italic>in silico</italic>
replication of 4679 SNPs (Stage 1, <italic>P</italic>
< 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, <italic>P</italic>
= 4.3 × 10<sup>−8</sup>
). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, <italic>P</italic>
= 8.6 × 10<sup>−9</sup>
). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity <italic>P</italic>
= 0.72 and <italic>P</italic>
= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id>
<journal-id journal-id-type="publisher-id">hmg</journal-id>
<journal-id journal-id-type="hwp">hmg</journal-id>
<journal-title-group><journal-title>Human Molecular Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0964-6906</issn>
<issn pub-type="epub">1460-2083</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21743057</article-id>
<article-id pub-id-type="pmc">3168287</article-id>
<article-id pub-id-type="doi">10.1093/hmg/ddr295</article-id>
<article-id pub-id-type="publisher-id">ddr295</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Genome-wide association study identifies new prostate cancer susceptibility loci</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Schumacher</surname>
<given-names>Fredrick R.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Berndt</surname>
<given-names>Sonja I.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siddiq</surname>
<given-names>Afshan</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacobs</surname>
<given-names>Kevin B.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Zhaoming</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindstrom</surname>
<given-names>Sara</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stevens</surname>
<given-names>Victoria L.</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Constance</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mondul</surname>
<given-names>Alison M.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Travis</surname>
<given-names>Ruth C.</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stram</surname>
<given-names>Daniel O.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eeles</surname>
<given-names>Rosalind A.</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af16">16</xref>
<xref ref-type="aff" rid="af17">17</xref>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neal</surname>
<given-names>David E.</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamdy</surname>
<given-names>Freddie C.</given-names>
</name>
<xref ref-type="aff" rid="af13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Donovan</surname>
<given-names>Jenny L.</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muir</surname>
<given-names>Kenneth</given-names>
</name>
<xref ref-type="aff" rid="af22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al Olama</surname>
<given-names>Ali Amin</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af16">16</xref>
<xref ref-type="aff" rid="af17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kote-Jarai</surname>
<given-names>Zsofia</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guy</surname>
<given-names>Michelle</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grönberg</surname>
<given-names>Henrik</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Isaacs</surname>
<given-names>William B.</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karlsson</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wiklund</surname>
<given-names>Fredrik</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname>
<given-names>Jianfeng</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Allen</surname>
<given-names>Naomi E.</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andriole</surname>
<given-names>Gerald L.</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barricarte</surname>
<given-names>Aurelio</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boeing</surname>
<given-names>Heiner</given-names>
</name>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bas Bueno-de-Mesquita</surname>
<given-names>H.</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crawford</surname>
<given-names>E. David</given-names>
</name>
<xref ref-type="aff" rid="af30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diver</surname>
<given-names>W. Ryan</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gonzalez</surname>
<given-names>Carlos A.</given-names>
</name>
<xref ref-type="aff" rid="af31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gaziano</surname>
<given-names>J. Michael</given-names>
</name>
<xref ref-type="aff" rid="af32">32</xref>
<xref ref-type="aff" rid="af34">34</xref>
<xref ref-type="aff" rid="af35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giovannucci</surname>
<given-names>Edward L.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
<xref ref-type="aff" rid="af9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Johansson</surname>
<given-names>Mattias</given-names>
</name>
<xref ref-type="aff" rid="af36">36</xref>
<xref ref-type="aff" rid="af37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Le Marchand</surname>
<given-names>Loic</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Jing</given-names>
</name>
<xref ref-type="aff" rid="af33">33</xref>
<xref ref-type="aff" rid="af35">35</xref>
<xref ref-type="aff" rid="af39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sieri</surname>
<given-names>Sabina</given-names>
</name>
<xref ref-type="aff" rid="af40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stattin</surname>
<given-names>Pär</given-names>
</name>
<xref ref-type="aff" rid="af37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stampfer</surname>
<given-names>Meir J.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
<xref ref-type="aff" rid="af9">9</xref>
<xref ref-type="aff" rid="af33">33</xref>
<xref ref-type="aff" rid="af35">35</xref>
<xref ref-type="aff" rid="af39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tjonneland</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="af41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vineis</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Virtamo</surname>
<given-names>Jarmo</given-names>
</name>
<xref ref-type="aff" rid="af42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vogel</surname>
<given-names>Ulla</given-names>
</name>
<xref ref-type="aff" rid="af43">43</xref>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weinstein</surname>
<given-names>Stephanie J.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yeager</surname>
<given-names>Meredith</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thun</surname>
<given-names>Michael J.</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kolonel</surname>
<given-names>Laurence N.</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Henderson</surname>
<given-names>Brian E.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Albanes</surname>
<given-names>Demetrius</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayes</surname>
<given-names>Richard B.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spencer Feigelson</surname>
<given-names>Heather</given-names>
</name>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Riboli</surname>
<given-names>Elio</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>David J.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chanock</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kraft</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
<xref ref-type="aff" rid="af8">8</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Preventive Medicine</addr-line>
,<institution>Keck School of Medicine, University of Southern California</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af2"><label>2</label>
<addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Epidemiology and Biostatistics</addr-line>
and</aff>
<aff id="af4"><label>4</label>
<institution>MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
,</aff>
<aff id="af5"><label>5</label>
<institution>Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick</institution>
,<addr-line>Frederick, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af6"><label>6</label>
<institution>Bioinformed Consulting Services</institution>
,<addr-line>Gaithersburg, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af7"><label>7</label>
<addr-line>Program in Molecular and Genetic Epidemiology</addr-line>
,</aff>
<aff id="af8"><label>8</label>
<addr-line>Department of Epidemiology</addr-line>
and</aff>
<aff id="af9"><label>9</label>
<addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston 02115, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af10"><label>10</label>
<institution>Epidemiology Research Program, American Cancer Society</institution>
,<addr-line>Atlanta, GA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af11"><label>11</label>
<addr-line>Cancer Epidemiology Unit</addr-line>
,</aff>
<aff id="af12"><label>12</label>
<addr-line>Nuffield Department of Clinical Medicine</addr-line>
and</aff>
<aff id="af13"><label>13</label>
<addr-line>Nuffield Department of Surgical Sciences</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford</addr-line>
,<country>UK</country>
,</aff>
<aff id="af14"><label>14</label>
<institution>Oncogenetics Team, The Institute of Cancer Research</institution>
,<addr-line>Sutton</addr-line>
,<country>UK</country>
,</aff>
<aff id="af15"><label>15</label>
<addr-line>Centre for Cancer Genetic Epidemiology</addr-line>
,</aff>
<aff id="af16"><label>16</label>
<addr-line>Department of Public Health</addr-line>
,</aff>
<aff id="af17"><label>17</label>
<addr-line>Department of Primary Care and</addr-line>
,</aff>
<aff id="af18"><label>18</label>
<addr-line>Department of Oncology</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</aff>
<aff id="af19"><label>19</label>
<institution>Cancer Epidemiology Centre, Cancer Council Victoria</institution>
,<addr-line>Victoria</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af20"><label>20</label>
<addr-line>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af21"><label>21</label>
<addr-line>School of Social and Community Medicine</addr-line>
,<institution>University of Bristol</institution>
,<addr-line>Bristol</addr-line>
,<country>UK</country>
,</aff>
<aff id="af22"><label>22</label>
<institution>Health Sciences Research Institute, University of Warwick</institution>
,<addr-line>Coventry</addr-line>
,<country>UK</country>
,</aff>
<aff id="af23"><label>23</label>
<addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institutet</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af24"><label>24</label>
<institution>The Brady Urological Institute, Johns Hopkins Medical Institutions</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af25"><label>25</label>
<addr-line>Centers for Cancer Genomics and Center for Human Genomics</addr-line>
,<institution>Wake Forest University School of Medicine</institution>
,<addr-line>Winston-Salem, NC</addr-line>
,<country>USA</country>
,</aff>
<aff id="af26"><label>26</label>
<addr-line>Division of Urologic Surgery</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>St Louis, MO</addr-line>
,<country>USA</country>
,</aff>
<aff id="af27"><label>27</label>
<institution>Navarre Public Health Institute</institution>
,<addr-line>Pamplona</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af28"><label>28</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>Deutsches Institut für Ernährungsforschung</institution>
,<addr-line>Potsdam-Rehbrücke</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af29"><label>29</label>
<institution>National Institute for Public Health and the Environment (RIVM)</institution>
,<addr-line>Bilthoven</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af30"><label>30</label>
<addr-line>Urologic Oncology</addr-line>
,<institution>University of Colorado</institution>
,<addr-line>Aurora, CO</addr-line>
,<country>USA</country>
,</aff>
<aff id="af31"><label>31</label>
<addr-line>Unit of Nutrition</addr-line>
,<institution>Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL-RETICC RD06/0020), L'Hospitalet de Llobregat</institution>
,<addr-line>Barcelona</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af32"><label>32</label>
<addr-line>Division of Aging</addr-line>
and</aff>
<aff id="af33"><label>33</label>
<addr-line>Department of Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af34"><label>34</label>
<institution>Massachusetts Veterans Epidemiology Research and Information Center/VA Cooperative Studies Programs, VA Boston Healthcare System</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af35"><label>35</label>
<addr-line>Department of Medicine</addr-line>
,<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af36"><label>36</label>
<institution>International Agency for Research on Cancer (IARC)</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</aff>
<aff id="af37"><label>37</label>
<addr-line>Department of Surgical and Perioperative Sciences</addr-line>
,<institution>Urology and Andrology, Umeå University</institution>
,<addr-line>Umeå</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af38"><label>38</label>
<addr-line>Cancer Research Center of Hawaii</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI</addr-line>
,<country>USA</country>
,</aff>
<aff id="af39"><label>39</label>
<institution>Channing Laboratory</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af40"><label>40</label>
<institution>Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>
,<addr-line>Milan</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af41"><label>41</label>
<institution>Institute of Cancer Epidemiology, Danish Cancer Society</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af42"><label>42</label>
<addr-line>Department of Chronic Disease Prevention</addr-line>
,<institution>National Institute for Health and Welfare</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af43"><label>43</label>
<institution>National Research Centre for the Working Environment</institution>
,<addr-line>Copenhagen</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af44"><label>44</label>
<institution>National Food Institute, Technical University of Denmark</institution>
,<addr-line>Soborg</addr-line>
,<country>Denmark</country>
,</aff>
<aff id="af45"><label>45</label>
<addr-line>Division of Epidemiology, Department of Environmental Medicine</addr-line>
,<institution>New York University Langone Medical Center, NYU Cancer Institute</institution>
,<addr-line>New York, NY</addr-line>
,<country>USA</country>
and</aff>
<aff id="af46"><label>46</label>
<institution>Institute for Health Research, Kaiser Permanente</institution>
,<addr-line>Denver, CO</addr-line>
,<country>USA</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
To whom correspondence should be addressed at: Harvard School of Public Health, 665 Huntington Ave Boston MA 02115, USA. Tel: +<phone>1 6174324271</phone>
; Fax: +<fax>1 6174321722</fax>
; Email: <email>pkraft@hsph.harvard.edu</email>
</corresp>
<fn id="AN1"><label>†</label>
<p>These authors contributed equally.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>8</day>
<month>7</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2012</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>20</volume>
<issue>19</issue>
<fpage>3867</fpage>
<lpage>3875</lpage>
<history><date date-type="received"><day>9</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><day>18</day>
<month>6</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>27</day>
<month>6</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="ddr295.pdf"></self-uri>
<abstract><p>Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on <italic>in silico</italic>
replication of 4679 SNPs (Stage 1, <italic>P</italic>
< 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, <italic>P</italic>
= 4.3 × 10<sup>−8</sup>
). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, <italic>P</italic>
= 8.6 × 10<sup>−9</sup>
). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity <italic>P</italic>
= 0.72 and <italic>P</italic>
= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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