Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Identifieur interne : 001740 ( Pmc/Curation ); précédent : 001739; suivant : 001741Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Auteurs : Annegien Broeks ; Marjanka K. Schmidt ; Mark E. Sherman [États-Unis] ; Fergus J. Couch [États-Unis] ; John L. Hopper ; Gillian S. Dite ; Carmel Apicella ; Letitia D. Smith [Australie] ; Fleur Hammet [Australie] ; Melissa C. Southey [Australie] ; Laura J. Van Veer ; Renate De Groot ; Vincent T. H. B. M. Smit ; Peter A. Fasching [États-Unis] ; Matthias W. Beckmann ; Sebastian Jud ; Arif B. Ekici [Allemagne] ; Arndt Hartmann ; Alexander Hein ; Ruediger Schulz-Wendtland [Allemagne] ; Barbara Burwinkel ; Frederik Marme ; Andreas Schneeweiss ; Hans-Peter Sinn [Allemagne] ; Christof Sohn ; Sandrine Tchatchou ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Henrik Flyger [Danemark] ; David D. Rsted [Danemark] ; Diljit Kaur-Knudsen [Danemark] ; Roger L. Milne ; Jose I. Arias Pérez ; Pilar Zamora [Espagne] ; Primitiva Menéndez Rodríguez [Espagne] ; Javier Benítez [Espagne] ; Hiltrud Brauch [Allemagne] ; Christina Justenhoven [Allemagne] ; Yon-Dschun Ko [Allemagne] ; Ute Hamann [Allemagne] ; Hans-Peter Fischer [Allemagne] ; Thomas Brüning [Allemagne] ; Beate Pesch [Allemagne] ; Jenny Chang-Claude [Allemagne] ; Shan Wang-Gohrke [Allemagne] ; Michael Bremer [Allemagne] ; Johann H. Karstens [Allemagne] ; Peter Hillemanns [Allemagne] ; Thilo Dörk [Allemagne] ; Heli A. Nevanlinna ; Tuomas Heikkinen ; P Ivi Heikkil ; Carl Blomqvist [Finlande] ; Kristiina Aittom Ki ; Kirsimari Aaltonen [Finlande] ; Annika Lindblom ; Sara Margolin ; Arto Mannermaa [Finlande] ; Veli-Matti Kosma [Finlande] ; Jaana M. Kauppinen [Finlande] ; Vesa Kataja [Finlande] ; P Ivi Auvinen ; Matti Eskelinen [Finlande] ; Ylermi Soini [Finlande] ; Georgia Chenevix-Trench [Australie] ; Amanda B. Spurdle [Australie] ; Jonathan Beesley [Australie] ; Xiaoqing Chen [Australie] ; Helene Holland [Australie] ; Diether Lambrechts [Belgique] ; Bart Claes [Belgique] ; Thijs Vandorpe [Belgique] ; Patrick Neven [Belgique] ; Hans Wildiers [Belgique] ; Dieter Flesch-Janys [Allemagne] ; Rebecca Hein [Allemagne] ; Thomas Löning [Allemagne] ; Matthew Kosel [États-Unis] ; Zachary S. Fredericksen [États-Unis] ; Xianshu Wang [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [Australie] ; Gianluca Severi [Australie] ; Catriona Mclean [Australie] ; Christopher A. Haiman [États-Unis] ; Brian E. Henderson [États-Unis] ; Loic Le Marchand [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Grethe Grenaker Aln S [Norvège] ; Vessela Kristensen [Norvège] ; Anne-Lise B Rresen-Dale [Norvège] ; David J. Hunter [États-Unis] ; Susan E. Hankinson [États-Unis] ; Irene L. Andrulis [Canada] ; Anna Marie Mulligan [Canada] ; Frances P. O'Malley [Canada] ; Peter Devilee ; Petra E. A. Huijts ; Rob A. E. M. Tollenaar [Pays-Bas] ; Christi J. Van Asperen ; Caroline S. Seynaeve [Pays-Bas] ; Stephen J. Chanock [États-Unis] ; Jolanta Lissowska [Pologne] ; Louise Brinton [États-Unis] ; Beata Peplonska [Pologne] ; Jonine Figueroa [États-Unis] ; Xiaohong R. Yang [États-Unis] ; Maartje J. Hooning ; Antoinette Hollestelle ; Rogier A. Oldenburg ; Agnes Jager ; Mieke Kriege ; Bahar Ozturk ; Geert J. L. H. Van Leenders ; Per Hall [Suède] ; Kamila Czene [Suède] ; Keith Humphreys [Suède] ; Jianjun Liu [Singapour] ; Angela Cox ; Daniel Connley ; Helen E. Cramp ; Simon S. Cross ; Sabapathy P. Balasubramanian [Royaume-Uni] ; Malcolm W. R. Reed [Royaume-Uni] ; Alison M. Dunning ; Douglas F. Easton [Royaume-Uni] ; Manjeet K. Humphreys [Royaume-Uni] ; Carlos Caldas ; Fiona Blows ; Kristy Driver ; Elena Provenzano ; Jan Lubinski [Pologne] ; Anna Jakubowska [Pologne] ; Tomasz Huzarski [Pologne] ; Tomasz Byrski [Pologne] ; Cezary Cybulski [Pologne] ; Bohdan Gorski [Pologne] ; Jacek Gronwald [Pologne] ; Paul Brennan [France] ; Suleeporn Sangrajrang [Thaïlande] ; Valerie Gaborieau [France] ; Chen-Yang Shen [Taïwan] ; Chia-Ni Hsiung [Taïwan] ; Jyh-Cherng Yu ; Shou-Tung Chen [Taïwan] ; Giu-Cheng Hsu [Taïwan] ; Ming-Feng Hou [Taïwan] ; Chiun-Sheng Huang [Taïwan] ; Hoda Anton-Culver [États-Unis] ; Argyrios Ziogas [États-Unis] ; Paul D. P. Pharoah [Royaume-Uni] ; Montserrat Garcia-Closas [États-Unis, Royaume-Uni]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2011.
Abstract
Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER− tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (
Url:
DOI: 10.1093/hmg/ddr228
PubMed: 21596841
PubMed Central: 3140824
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Laura J. Van Veer<affiliation><nlm:aff id="af3"><addr-line>Department of Molecular Pathology</addr-line>
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Le document en format XML
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<author><name sortKey="Jud, Sebastian" sort="Jud, Sebastian" uniqKey="Jud S" first="Sebastian" last="Jud">Sebastian Jud</name>
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<author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name>
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<author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name>
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</affiliation>
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<author><name sortKey="Schulz Wendtland, Ruediger" sort="Schulz Wendtland, Ruediger" uniqKey="Schulz Wendtland R" first="Ruediger" last="Schulz-Wendtland">Ruediger Schulz-Wendtland</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Institute of Radiology</addr-line>
,<institution>University Breast Center</institution>
,<institution>University Hospital Erlangen</institution>
,<addr-line>Erlangen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Molecular Epidemiology</addr-line>
</nlm:aff>
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<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
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<author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinn, Hans Peter" sort="Sinn, Hans Peter" uniqKey="Sinn H" first="Hans-Peter" last="Sinn">Hans-Peter Sinn</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Department of Pathology</addr-line>
,<institution>University Hospital Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Molecular Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey=" Rsted, David D" sort=" Rsted, David D" uniqKey=" Rsted D" first="David D." last=" Rsted">David D. Rsted</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaur Knudsen, Diljit" sort="Kaur Knudsen, Diljit" uniqKey="Kaur Knudsen D" first="Diljit" last="Kaur-Knudsen">Diljit Kaur-Knudsen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Genetic & Molecular Epidemiology Group</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perez, Jose I Arias" sort="Perez, Jose I Arias" uniqKey="Perez J" first="Jose I. Arias" last="Pérez">Jose I. Arias Pérez</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Servicio Cirugía General</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zamora, Pilar" sort="Zamora, Pilar" uniqKey="Zamora P" first="Pilar" last="Zamora">Pilar Zamora</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Servicio de Oncología Médica</addr-line>
,<institution>Hospital La Paz</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Primitiva Menendez" sort="Rodriguez, Primitiva Menendez" uniqKey="Rodriguez P" first="Primitiva Menéndez" last="Rodríguez">Primitiva Menéndez Rodríguez</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Servicio de Anatomía Patológica</addr-line>
,<institution>Hospital Monte Naranco</institution>
,<addr-line>Oviedo</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Human Cancer Genetic Group</addr-line>
,<institution>Spanish National Cancer Research Centre (CNIO)</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>CIBERER</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>
,<addr-line>Stuttgart</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af28"><institution>University Tübingen</institution>
,<addr-line>Tübingen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>
,<addr-line>Stuttgart</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af28"><institution>University Tübingen</institution>
,<addr-line>Tübingen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Evangelische Kliniken Bonn gGmbH</institution>
,<addr-line>Johanniter Krankenhaus, Bonn</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="af32"><addr-line>Molecular Genetics of Breast Cancer</addr-line>
,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Hans Peter" sort="Fischer, Hans Peter" uniqKey="Fischer H" first="Hans-Peter" last="Fischer">Hans-Peter Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="af33"><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>
,<addr-line>Bonn</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><institution>Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>
,<addr-line>Bochum</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pesch, Beate" sort="Pesch, Beate" uniqKey="Pesch B" first="Beate" last="Pesch">Beate Pesch</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><institution>Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>
,<addr-line>Bochum</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Division of Cancer Epidemiology</addr-line>
,<institution>German Cancer Research Center</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Hannover Medical School</addr-line>
,<institution>Clinics of Radiation Oncology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Hannover Medical School</addr-line>
,<institution>Clinics of Radiation Oncology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><institution>Clinics of Obstetrics and Gynaecology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><institution>Clinics of Obstetrics and Gynaecology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli A" sort="Nevanlinna, Heli A" uniqKey="Nevanlinna H" first="Heli A." last="Nevanlinna">Heli A. Nevanlinna</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkil, P Ivi" sort="Heikkil, P Ivi" uniqKey="Heikkil P" first="P Ivi" last="Heikkil">P Ivi Heikkil</name>
<affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Pathology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Oncology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Genetics</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Oncology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation><nlm:aff id="af42"><addr-line>Department of Molecular Medicine and Surgery,</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation><nlm:aff wicri:cut=" and" id="af43"><addr-line>Department of Oncology and Pathology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kauppinen, Jaana M" sort="Kauppinen, Jaana M" uniqKey="Kauppinen J" first="Jaana M." last="Kauppinen">Jaana M. Kauppinen</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Oncology</addr-line>
,<institution>Vaasa Central Hospital</institution>
,<addr-line>Vaasa</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auvinen, P Ivi" sort="Auvinen, P Ivi" uniqKey="Auvinen P" first="P Ivi" last="Auvinen">P Ivi Auvinen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af48"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eskelinen, Matti" sort="Eskelinen, Matti" uniqKey="Eskelinen M" first="Matti" last="Eskelinen">Matti Eskelinen</name>
<affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Department of Surgery</addr-line>
,<institution>Kuopio University Hospital</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soini, Ylermi" sort="Soini, Ylermi" uniqKey="Soini Y" first="Ylermi" last="Soini">Ylermi Soini</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><institution>Vesalius Research Center</institution>
,<addr-line>KU Leuven and VIB, Leuven</addr-line>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Claes, Bart" sort="Claes, Bart" uniqKey="Claes B" first="Bart" last="Claes">Bart Claes</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><institution>Vesalius Research Center</institution>
,<addr-line>KU Leuven and VIB, Leuven</addr-line>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandorpe, Thijs" sort="Vandorpe, Thijs" uniqKey="Vandorpe T" first="Thijs" last="Vandorpe">Thijs Vandorpe</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>
,<institution>University Clinic Hamburg-Eppendorf</institution>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Division of Cancer Epidemiology</addr-line>
,<institution>German Cancer Research Center</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loning, Thomas" sort="Loning, Thomas" uniqKey="Loning T" first="Thomas" last="Löning">Thomas Löning</name>
<affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Albertinen Pathology Department, Hamburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Cancer Epidemiology Centre</addr-line>
,<institution>The Cancer Council Victoria</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Department of Anatomical Pathology</addr-line>
,<institution>Alfred Hospital</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Cancer Epidemiology Centre</addr-line>
,<institution>The Cancer Council Victoria</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Department of Anatomical Pathology</addr-line>
,<institution>Alfred Hospital</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Epidemiology Program</addr-line>
,<institution>Cancer Research Center, University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Epidemiology Program</addr-line>
,<institution>Cancer Research Center, University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Faculty of Medicine</addr-line>
<institution>(Faculty Division Ahus)</institution>
,<addr-line>UiO</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Faculty of Medicine</addr-line>
<institution>(Faculty Division Ahus)</institution>
,<addr-line>UiO</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Womens Hospital and Harvard Medical school</institution>
, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard school of public health</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Womens Hospital and Harvard Medical school</institution>
, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard school of public health</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="af65"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af66"><addr-line>Department of Molecular Genetics and</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marie Mulligan, Anna" sort="Marie Mulligan, Anna" uniqKey="Marie Mulligan A" first="Anna" last="Marie Mulligan">Anna Marie Mulligan</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af68"><addr-line>Keenan Research Centre</addr-line>
,<institution>Li Ka Shing Knowledge Institute of St Michael's Hospital</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="O Malley, Frances P" sort="O Malley, Frances P" uniqKey="O Malley F" first="Frances P." last="O'Malley">Frances P. O'Malley</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>The Department of Laboratory Medicine and the</addr-line>
<institution>Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital,</institution>
<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="af70"><addr-line>Department Human Genetics & Department of Pathology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huijts, Petra E A" sort="Huijts, Petra E A" uniqKey="Huijts P" first="Petra E. A." last="Huijts">Petra E. A. Huijts</name>
<affiliation><nlm:aff wicri:cut=" and" id="af71"><addr-line>Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name>
<affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Surgical Oncology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af71"><addr-line>Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline S" sort="Seynaeve, Caroline S" uniqKey="Seynaeve C" first="Caroline S." last="Seynaeve">Caroline S. Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Department of Medical Oncology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Advanced Technology Center</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Gaithersburg, MD 20892-4605</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>
,<institution>Cancer Center and M. Sklodowska-Curie Institute of Oncology</institution>
,<addr-line>02-781 Warsaw</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD 20852-7234</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><institution>Nofer Institute of Occupational Medicine</institution>
,<addr-line>91-348 Lodz</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name>
<affiliation><nlm:aff wicri:cut=" and" id="af79"><addr-line>Department of Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ozturk, Bahar" sort="Ozturk, Bahar" uniqKey="Ozturk B" first="Bahar" last="Ozturk">Bahar Ozturk</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Leenders, Geert J L H" sort="Van Leenders, Geert J L H" uniqKey="Van Leenders G" first="Geert J. L. H." last="Van Leenders">Geert J. L. H. Van Leenders</name>
<affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>the Netherlands</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Human Genetics Laboratory</addr-line>
,<institution>Genome Institute of Singapore</institution>
,<country>Singapore</country>
,</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Connley, Daniel" sort="Connley, Daniel" uniqKey="Connley D" first="Daniel" last="Connley">Daniel Connley</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cramp, Helen E" sort="Cramp, Helen E" uniqKey="Cramp H" first="Helen E." last="Cramp">Helen E. Cramp</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation><nlm:aff wicri:cut=" and" id="af83"><addr-line>Academic Unit of Pathology, Department of Oncology</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Department of Oncology</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
<affiliation wicri:level="1"><nlm:aff id="af84"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology</addr-line>
,<institution>University of Sheffield Medical School</institution>
,<addr-line>Sheffield</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name>
<affiliation wicri:level="1"><nlm:aff id="af84"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology</addr-line>
,<institution>University of Sheffield Medical School</institution>
,<addr-line>Sheffield</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Provenzano, Elena" sort="Provenzano, Elena" uniqKey="Provenzano E" first="Elena" last="Provenzano">Elena Provenzano</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorski, Bohdan" sort="Gorski, Bohdan" uniqKey="Gorski B" first="Bohdan" last="Gorski">Bohdan Gorski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><institution>International agency for Research on Cancer</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation wicri:level="1"><nlm:aff id="af89"><institution>National Cancer Institute</institution>
,<addr-line>Bangkok</addr-line>
,<country>Thailand</country>
,</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><institution>International agency for Research on Cancer</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
<affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af91"><addr-line>Graduate Institute of Environmental Science</addr-line>
,<institution>China Medical University</institution>
,<addr-line>Taichung</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name>
<affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation><nlm:aff wicri:cut=" and" id="af92"><addr-line>Department of Surgery</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Shou Tung" sort="Chen, Shou Tung" uniqKey="Chen S" first="Shou-Tung" last="Chen">Shou-Tung Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af94"><addr-line>Department of Surgery</addr-line>
,<institution>Changhua Christian Hospital</institution>
,<addr-line>Changhua</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Giu Cheng" sort="Hsu, Giu Cheng" uniqKey="Hsu G" first="Giu-Cheng" last="Hsu">Giu-Cheng Hsu</name>
<affiliation wicri:level="1"><nlm:aff id="af93"><addr-line>Department of Radiology</addr-line>
,<institution>Tri-Service General Hospital</institution>
,<addr-line>Taipei</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Department of Surgery</addr-line>
,<institution>Kaohsiung Medical University Hospital</institution>
,<addr-line>Kaohsiung</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Chiun Sheng" sort="Huang, Chiun Sheng" uniqKey="Huang C" first="Chiun-Sheng" last="Huang">Chiun-Sheng Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Surgery</addr-line>
,<institution>National Taiwan University Hospital</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California at Irvine</institution>
,<addr-line>Irvine, CA 92697</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California at Irvine</institution>
,<addr-line>Irvine, CA 92697</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21596841</idno>
<idno type="pmc">3140824</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140824</idno>
<idno type="RBID">PMC:3140824</idno>
<idno type="doi">10.1093/hmg/ddr228</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001881</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001881</idno>
<idno type="wicri:Area/Pmc/Curation">001740</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001740</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium</title>
<author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Experimental Therapy</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Experimental Therapy</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af2"><addr-line>Department of Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sherman, Mark E" sort="Sherman, Mark E" uniqKey="Sherman M" first="Mark E." last="Sherman">Mark E. Sherman</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation><nlm:aff wicri:cut=" and" id="af7"><institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dite, Gillian S" sort="Dite, Gillian S" uniqKey="Dite G" first="Gillian S." last="Dite">Gillian S. Dite</name>
<affiliation><nlm:aff wicri:cut=" and" id="af7"><institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<affiliation><nlm:aff wicri:cut=" and" id="af7"><institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Letitia D" sort="Smith, Letitia D" uniqKey="Smith L" first="Letitia D." last="Smith">Letitia D. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>
,<institution>The University of Melbourne</institution>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hammet, Fleur" sort="Hammet, Fleur" uniqKey="Hammet F" first="Fleur" last="Hammet">Fleur Hammet</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>
,<institution>The University of Melbourne</institution>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>
,<institution>The University of Melbourne</institution>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Veer, Laura J" sort="Van Veer, Laura J" uniqKey="Van Veer L" first="Laura J." last="Van Veer">Laura J. Van Veer</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Experimental Therapy</addr-line>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Department of Molecular Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>the Netherlands</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Groot, Renate" sort="De Groot, Renate" uniqKey="De Groot R" first="Renate" last="De Groot">Renate De Groot</name>
<affiliation><nlm:aff id="af3"><addr-line>Department of Molecular Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>the Netherlands</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Smit, Vincent T H B M" sort="Smit, Vincent T H B M" uniqKey="Smit V" first="Vincent T. H. B. M." last="Smit">Vincent T. H. B. M. Smit</name>
<affiliation><nlm:aff id="af9"><addr-line>Department of Pathology</addr-line>
,<institution>Leiden University Medical Centre</institution>
,<addr-line>Leiden</addr-line>
,<country>the Netherlands</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Hematology and Oncology, David Geffen School of Medicine</addr-line>
,<institution>University of California at Los Angeles</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Gynecology and Obstetrics</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jud, Sebastian" sort="Jud, Sebastian" uniqKey="Jud S" first="Sebastian" last="Jud">Sebastian Jud</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Gynecology and Obstetrics</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Institute of Human Genetics</addr-line>
,<institution>Friedrich Alexander University Erlangen</institution>
,<addr-line>Nürnberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name>
<affiliation><nlm:aff id="af12"><addr-line>Institute of Pathology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hein, Alexander" sort="Hein, Alexander" uniqKey="Hein A" first="Alexander" last="Hein">Alexander Hein</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Gynecology and Obstetrics</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schulz Wendtland, Ruediger" sort="Schulz Wendtland, Ruediger" uniqKey="Schulz Wendtland R" first="Ruediger" last="Schulz-Wendtland">Ruediger Schulz-Wendtland</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Institute of Radiology</addr-line>
,<institution>University Breast Center</institution>
,<institution>University Hospital Erlangen</institution>
,<addr-line>Erlangen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Molecular Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sinn, Hans Peter" sort="Sinn, Hans Peter" uniqKey="Sinn H" first="Hans-Peter" last="Sinn">Hans-Peter Sinn</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Department of Pathology</addr-line>
,<institution>University Hospital Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name>
<affiliation><nlm:aff wicri:cut=" and" id="af15"><addr-line>Department of Gynecology and Obstetrics</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af17"><addr-line>Molecular Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey=" Rsted, David D" sort=" Rsted, David D" uniqKey=" Rsted D" first="David D." last=" Rsted">David D. Rsted</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaur Knudsen, Diljit" sort="Kaur Knudsen, Diljit" uniqKey="Kaur Knudsen D" first="Diljit" last="Kaur-Knudsen">Diljit Kaur-Knudsen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af19"><addr-line>Department of Clinical Biochemistry</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff wicri:cut=" and" id="af21"><addr-line>Genetic & Molecular Epidemiology Group</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perez, Jose I Arias" sort="Perez, Jose I Arias" uniqKey="Perez J" first="Jose I. Arias" last="Pérez">Jose I. Arias Pérez</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Servicio Cirugía General</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zamora, Pilar" sort="Zamora, Pilar" uniqKey="Zamora P" first="Pilar" last="Zamora">Pilar Zamora</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Servicio de Oncología Médica</addr-line>
,<institution>Hospital La Paz</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Primitiva Menendez" sort="Rodriguez, Primitiva Menendez" uniqKey="Rodriguez P" first="Primitiva Menéndez" last="Rodríguez">Primitiva Menéndez Rodríguez</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Servicio de Anatomía Patológica</addr-line>
,<institution>Hospital Monte Naranco</institution>
,<addr-line>Oviedo</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Human Cancer Genetic Group</addr-line>
,<institution>Spanish National Cancer Research Centre (CNIO)</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>CIBERER</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>
,<addr-line>Stuttgart</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af28"><institution>University Tübingen</institution>
,<addr-line>Tübingen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>
,<addr-line>Stuttgart</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af28"><institution>University Tübingen</institution>
,<addr-line>Tübingen</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Evangelische Kliniken Bonn gGmbH</institution>
,<addr-line>Johanniter Krankenhaus, Bonn</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="af32"><addr-line>Molecular Genetics of Breast Cancer</addr-line>
,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Hans Peter" sort="Fischer, Hans Peter" uniqKey="Fischer H" first="Hans-Peter" last="Fischer">Hans-Peter Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="af33"><institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>
,<addr-line>Bonn</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><institution>Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>
,<addr-line>Bochum</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pesch, Beate" sort="Pesch, Beate" uniqKey="Pesch B" first="Beate" last="Pesch">Beate Pesch</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><institution>Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>
,<addr-line>Bochum</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Division of Cancer Epidemiology</addr-line>
,<institution>German Cancer Research Center</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Hannover Medical School</addr-line>
,<institution>Clinics of Radiation Oncology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karstens, Johann H" sort="Karstens, Johann H" uniqKey="Karstens J" first="Johann H." last="Karstens">Johann H. Karstens</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Hannover Medical School</addr-line>
,<institution>Clinics of Radiation Oncology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><institution>Clinics of Obstetrics and Gynaecology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><institution>Clinics of Obstetrics and Gynaecology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli A" sort="Nevanlinna, Heli A" uniqKey="Nevanlinna H" first="Heli A." last="Nevanlinna">Heli A. Nevanlinna</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heikkil, P Ivi" sort="Heikkil, P Ivi" uniqKey="Heikkil P" first="P Ivi" last="Heikkil">P Ivi Heikkil</name>
<affiliation><nlm:aff wicri:cut=" and" id="af40"><addr-line>Department of Pathology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Oncology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation><nlm:aff id="af39"><addr-line>Department of Clinical Genetics</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aaltonen, Kirsimari" sort="Aaltonen, Kirsimari" uniqKey="Aaltonen K" first="Kirsimari" last="Aaltonen">Kirsimari Aaltonen</name>
<affiliation><nlm:aff id="af38"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Oncology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation><nlm:aff id="af42"><addr-line>Department of Molecular Medicine and Surgery,</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation><nlm:aff wicri:cut=" and" id="af43"><addr-line>Department of Oncology and Pathology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kauppinen, Jaana M" sort="Kauppinen, Jaana M" uniqKey="Kauppinen J" first="Jaana M." last="Kauppinen">Jaana M. Kauppinen</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Oncology</addr-line>
,<institution>Vaasa Central Hospital</institution>
,<addr-line>Vaasa</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auvinen, P Ivi" sort="Auvinen, P Ivi" uniqKey="Auvinen P" first="P Ivi" last="Auvinen">P Ivi Auvinen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af48"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eskelinen, Matti" sort="Eskelinen, Matti" uniqKey="Eskelinen M" first="Matti" last="Eskelinen">Matti Eskelinen</name>
<affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Department of Surgery</addr-line>
,<institution>Kuopio University Hospital</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soini, Ylermi" sort="Soini, Ylermi" uniqKey="Soini Y" first="Ylermi" last="Soini">Ylermi Soini</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af46"><institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holland, Helene" sort="Holland, Helene" uniqKey="Holland H" first="Helene" last="Holland">Helene Holland</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><institution>Vesalius Research Center</institution>
,<addr-line>KU Leuven and VIB, Leuven</addr-line>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Claes, Bart" sort="Claes, Bart" uniqKey="Claes B" first="Bart" last="Claes">Bart Claes</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><institution>Vesalius Research Center</institution>
,<addr-line>KU Leuven and VIB, Leuven</addr-line>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandorpe, Thijs" sort="Vandorpe, Thijs" uniqKey="Vandorpe T" first="Thijs" last="Vandorpe">Thijs Vandorpe</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation wicri:level="1"><nlm:aff id="af54"><addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>
,<institution>University Clinic Hamburg-Eppendorf</institution>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Division of Cancer Epidemiology</addr-line>
,<institution>German Cancer Research Center</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loning, Thomas" sort="Loning, Thomas" uniqKey="Loning T" first="Thomas" last="Löning">Thomas Löning</name>
<affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Albertinen Pathology Department, Hamburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kosel, Matthew" sort="Kosel, Matthew" uniqKey="Kosel M" first="Matthew" last="Kosel">Matthew Kosel</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Zachary S" sort="Fredericksen, Zachary S" uniqKey="Fredericksen Z" first="Zachary S." last="Fredericksen">Zachary S. Fredericksen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name>
<affiliation><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Laboratory Medicine and Pathology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Cancer Epidemiology Centre</addr-line>
,<institution>The Cancer Council Victoria</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Department of Anatomical Pathology</addr-line>
,<institution>Alfred Hospital</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Cancer Epidemiology Centre</addr-line>
,<institution>The Cancer Council Victoria</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Department of Anatomical Pathology</addr-line>
,<institution>Alfred Hospital</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health and Primary Care</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health and Primary Care</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Epidemiology Program</addr-line>
,<institution>Cancer Research Center, University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Epidemiology Program</addr-line>
,<institution>Cancer Research Center, University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Faculty of Medicine</addr-line>
<institution>(Faculty Division Ahus)</institution>
,<addr-line>UiO</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Faculty of Medicine</addr-line>
<institution>(Faculty Division Ahus)</institution>
,<addr-line>UiO</addr-line>
,<country>Norway</country>
,</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Womens Hospital and Harvard Medical school</institution>
, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard school of public health</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Womens Hospital and Harvard Medical school</institution>
, Boston, MA, USA,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af64"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard school of public health</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="af65"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af66"><addr-line>Department of Molecular Genetics and</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marie Mulligan, Anna" sort="Marie Mulligan, Anna" uniqKey="Marie Mulligan A" first="Anna" last="Marie Mulligan">Anna Marie Mulligan</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af68"><addr-line>Keenan Research Centre</addr-line>
,<institution>Li Ka Shing Knowledge Institute of St Michael's Hospital</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="O Malley, Frances P" sort="O Malley, Frances P" uniqKey="O Malley F" first="Frances P." last="O'Malley">Frances P. O'Malley</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af67"><addr-line>Laboratory Medicine</addr-line>
<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>The Department of Laboratory Medicine and the</addr-line>
<institution>Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital,</institution>
<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation><nlm:aff id="af70"><addr-line>Department Human Genetics & Department of Pathology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huijts, Petra E A" sort="Huijts, Petra E A" uniqKey="Huijts P" first="Petra E. A." last="Huijts">Petra E. A. Huijts</name>
<affiliation><nlm:aff wicri:cut=" and" id="af71"><addr-line>Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name>
<affiliation wicri:level="1"><nlm:aff id="af72"><addr-line>Surgical Oncology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name>
<affiliation><nlm:aff wicri:cut=" and" id="af71"><addr-line>Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline S" sort="Seynaeve, Caroline S" uniqKey="Seynaeve C" first="Caroline S." last="Seynaeve">Caroline S. Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Department of Medical Oncology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Advanced Technology Center</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Gaithersburg, MD 20892-4605</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Department of Cancer Epidemiology and Prevention</addr-line>
,<institution>Cancer Center and M. Sklodowska-Curie Institute of Oncology</institution>
,<addr-line>02-781 Warsaw</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD 20852-7234</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><institution>Nofer Institute of Occupational Medicine</institution>
,<addr-line>91-348 Lodz</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oldenburg, Rogier A" sort="Oldenburg, Rogier A" uniqKey="Oldenburg R" first="Rogier A." last="Oldenburg">Rogier A. Oldenburg</name>
<affiliation><nlm:aff wicri:cut=" and" id="af79"><addr-line>Department of Clinical Genetics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ozturk, Bahar" sort="Ozturk, Bahar" uniqKey="Ozturk B" first="Bahar" last="Ozturk">Bahar Ozturk</name>
<affiliation><nlm:aff id="af78"><addr-line>Department of Medical Oncology</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Leenders, Geert J L H" sort="Van Leenders, Geert J L H" uniqKey="Van Leenders G" first="Geert J. L. H." last="Van Leenders">Geert J. L. H. Van Leenders</name>
<affiliation><nlm:aff id="af80"><addr-line>Department of Pathology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>the Netherlands</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af81"><addr-line>Human Genetics Laboratory</addr-line>
,<institution>Genome Institute of Singapore</institution>
,<country>Singapore</country>
,</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Connley, Daniel" sort="Connley, Daniel" uniqKey="Connley D" first="Daniel" last="Connley">Daniel Connley</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cramp, Helen E" sort="Cramp, Helen E" uniqKey="Cramp H" first="Helen E." last="Cramp">Helen E. Cramp</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation><nlm:aff wicri:cut=" and" id="af83"><addr-line>Academic Unit of Pathology, Department of Oncology</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Department of Oncology</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Balasubramanian, Sabapathy P" sort="Balasubramanian, Sabapathy P" uniqKey="Balasubramanian S" first="Sabapathy P." last="Balasubramanian">Sabapathy P. Balasubramanian</name>
<affiliation wicri:level="1"><nlm:aff id="af84"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology</addr-line>
,<institution>University of Sheffield Medical School</institution>
,<addr-line>Sheffield</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name>
<affiliation wicri:level="1"><nlm:aff id="af84"><addr-line>Academic Unit of Surgical Oncology, Department of Oncology</addr-line>
,<institution>University of Sheffield Medical School</institution>
,<addr-line>Sheffield</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humphreys, Manjeet K" sort="Humphreys, Manjeet K" uniqKey="Humphreys M" first="Manjeet K." last="Humphreys">Manjeet K. Humphreys</name>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blows, Fiona" sort="Blows, Fiona" uniqKey="Blows F" first="Fiona" last="Blows">Fiona Blows</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Driver, Kristy" sort="Driver, Kristy" uniqKey="Driver K" first="Kristy" last="Driver">Kristy Driver</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Provenzano, Elena" sort="Provenzano, Elena" uniqKey="Provenzano E" first="Elena" last="Provenzano">Elena Provenzano</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorski, Bohdan" sort="Gorski, Bohdan" uniqKey="Gorski B" first="Bohdan" last="Gorski">Bohdan Gorski</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><institution>International agency for Research on Cancer</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sangrajrang, Suleeporn" sort="Sangrajrang, Suleeporn" uniqKey="Sangrajrang S" first="Suleeporn" last="Sangrajrang">Suleeporn Sangrajrang</name>
<affiliation wicri:level="1"><nlm:aff id="af89"><institution>National Cancer Institute</institution>
,<addr-line>Bangkok</addr-line>
,<country>Thailand</country>
,</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaborieau, Valerie" sort="Gaborieau, Valerie" uniqKey="Gaborieau V" first="Valerie" last="Gaborieau">Valerie Gaborieau</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><institution>International agency for Research on Cancer</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
<affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af91"><addr-line>Graduate Institute of Environmental Science</addr-line>
,<institution>China Medical University</institution>
,<addr-line>Taichung</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsiung, Chia Ni" sort="Hsiung, Chia Ni" uniqKey="Hsiung C" first="Chia-Ni" last="Hsiung">Chia-Ni Hsiung</name>
<affiliation wicri:level="1"><nlm:aff id="af90"><institution>Institute of Biomedical Sciences, Academia Sinica</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation><nlm:aff wicri:cut=" and" id="af92"><addr-line>Department of Surgery</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Shou Tung" sort="Chen, Shou Tung" uniqKey="Chen S" first="Shou-Tung" last="Chen">Shou-Tung Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af94"><addr-line>Department of Surgery</addr-line>
,<institution>Changhua Christian Hospital</institution>
,<addr-line>Changhua</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Giu Cheng" sort="Hsu, Giu Cheng" uniqKey="Hsu G" first="Giu-Cheng" last="Hsu">Giu-Cheng Hsu</name>
<affiliation wicri:level="1"><nlm:aff id="af93"><addr-line>Department of Radiology</addr-line>
,<institution>Tri-Service General Hospital</institution>
,<addr-line>Taipei</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hou, Ming Feng" sort="Hou, Ming Feng" uniqKey="Hou M" first="Ming-Feng" last="Hou">Ming-Feng Hou</name>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Department of Surgery</addr-line>
,<institution>Kaohsiung Medical University Hospital</institution>
,<addr-line>Kaohsiung</addr-line>
, Taiwan,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Academic Unit of Pathology</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Chiun Sheng" sort="Huang, Chiun Sheng" uniqKey="Huang C" first="Chiun-Sheng" last="Huang">Chiun-Sheng Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Surgery</addr-line>
,<institution>National Taiwan University Hospital</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California at Irvine</institution>
,<addr-line>Irvine, CA 92697</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of California at Irvine</institution>
,<addr-line>Irvine, CA 92697</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="af85"><addr-line>Department of Oncology</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af86"><addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER− tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (<italic>P</italic>
-heterogeneity = 6.1 × 10<sup>−18</sup>
), rs3803662 (16q12) (<italic>P</italic>
= 3.7 × 10<sup>−5</sup>
), rs13281615 (8q24) (<italic>P</italic>
= 0.002), rs13387042 (2q35) (<italic>P</italic>
= 0.006), rs4973768 (3p24) (<italic>P</italic>
= 0.003) and rs6504950 (17q23) (<italic>P</italic>
= 0.002)<italic>.</italic>
The two candidate loci, <italic>CASP8</italic>
(rs1045485, rs17468277) and <italic>TGFB1</italic>
(rs1982073), were most strongly related with the risk of PR negative tumors (<italic>P</italic>
= 5.1 × 10<sup>−6</sup>
and <italic>P</italic>
= 4.1 × 10<sup>−4</sup>
, respectively), as previously suggested. Four of the eight loci identified in GWAS were associated with triple negative tumors (<italic>P</italic>
≤ 0.016): rs3803662 (16q12), rs889312 (5q11), rs3817198 (11p15) and rs13387042 (2q35); however, only two of them (16q12 and 2q35) were associated with tumors with the core basal phenotype (<italic>P</italic>
≤ 0.002). These analyses are consistent with different biological origins of breast cancers, and indicate that tumor stratification might help in the identification and characterization of novel risk factors for breast cancer subtypes. This may eventually result in further improvements in prevention, early detection and treatment.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id>
<journal-id journal-id-type="publisher-id">hmg</journal-id>
<journal-id journal-id-type="hwp">hmg</journal-id>
<journal-title-group><journal-title>Human Molecular Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0964-6906</issn>
<issn pub-type="epub">1460-2083</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21596841</article-id>
<article-id pub-id-type="pmc">3140824</article-id>
<article-id pub-id-type="doi">10.1093/hmg/ddr228</article-id>
<article-id pub-id-type="publisher-id">ddr228</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Broeks</surname>
<given-names>Annegien</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Marjanka K.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sherman</surname>
<given-names>Mark E.</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>Fergus J.</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hopper</surname>
<given-names>John L.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dite</surname>
<given-names>Gillian S.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Apicella</surname>
<given-names>Carmel</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Letitia D.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hammet</surname>
<given-names>Fleur</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Southey</surname>
<given-names>Melissa C.</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van ’t Veer</surname>
<given-names>Laura J.</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Groot</surname>
<given-names>Renate</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smit</surname>
<given-names>Vincent T.H.B.M.</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fasching</surname>
<given-names>Peter A.</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beckmann</surname>
<given-names>Matthias W.</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jud</surname>
<given-names>Sebastian</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ekici</surname>
<given-names>Arif B.</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hartmann</surname>
<given-names>Arndt</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hein</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schulz-Wendtland</surname>
<given-names>Ruediger</given-names>
</name>
<xref ref-type="aff" rid="af13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burwinkel</surname>
<given-names>Barbara</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marme</surname>
<given-names>Frederik</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schneeweiss</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sinn</surname>
<given-names>Hans-Peter</given-names>
</name>
<xref ref-type="aff" rid="af16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sohn</surname>
<given-names>Christof</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tchatchou</surname>
<given-names>Sandrine</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bojesen</surname>
<given-names>Stig E.</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nordestgaard</surname>
<given-names>Børge G.</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flyger</surname>
<given-names>Henrik</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ørsted</surname>
<given-names>David D.</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaur-Knudsen</surname>
<given-names>Diljit</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Milne</surname>
<given-names>Roger L.</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pérez</surname>
<given-names>Jose I. Arias</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zamora</surname>
<given-names>Pilar</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rodríguez</surname>
<given-names>Primitiva Menéndez</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benítez</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="af22">22</xref>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brauch</surname>
<given-names>Hiltrud</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Justenhoven</surname>
<given-names>Christina</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
<xref ref-type="aff" rid="af28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ko</surname>
<given-names>Yon-Dschun</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author"><collab>The Genica Network</collab>
<xref ref-type="aff" rid="af30">30</xref>
<xref ref-type="aff" rid="af31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamann</surname>
<given-names>Ute</given-names>
</name>
<xref ref-type="aff" rid="af32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Hans-Peter</given-names>
</name>
<xref ref-type="aff" rid="af33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brüning</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pesch</surname>
<given-names>Beate</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang-Claude</surname>
<given-names>Jenny</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang-Gohrke</surname>
<given-names>Shan</given-names>
</name>
<xref ref-type="aff" rid="af35">35</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bremer</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="af36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karstens</surname>
<given-names>Johann H.</given-names>
</name>
<xref ref-type="aff" rid="af36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hillemanns</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dörk</surname>
<given-names>Thilo</given-names>
</name>
<xref ref-type="aff" rid="af37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nevanlinna</surname>
<given-names>Heli A.</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heikkinen</surname>
<given-names>Tuomas</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heikkilä</surname>
<given-names>Päivi</given-names>
</name>
<xref ref-type="aff" rid="af40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blomqvist</surname>
<given-names>Carl</given-names>
</name>
<xref ref-type="aff" rid="af41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aittomäki</surname>
<given-names>Kristiina</given-names>
</name>
<xref ref-type="aff" rid="af39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aaltonen</surname>
<given-names>Kirsimari</given-names>
</name>
<xref ref-type="aff" rid="af38">38</xref>
<xref ref-type="aff" rid="af41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindblom</surname>
<given-names>Annika</given-names>
</name>
<xref ref-type="aff" rid="af42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Margolin</surname>
<given-names>Sara</given-names>
</name>
<xref ref-type="aff" rid="af43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mannermaa</surname>
<given-names>Arto</given-names>
</name>
<xref ref-type="aff" rid="af45">45</xref>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kosma</surname>
<given-names>Veli-Matti</given-names>
</name>
<xref ref-type="aff" rid="af45">45</xref>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kauppinen</surname>
<given-names>Jaana M.</given-names>
</name>
<xref ref-type="aff" rid="af45">45</xref>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kataja</surname>
<given-names>Vesa</given-names>
</name>
<xref ref-type="aff" rid="af47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Auvinen</surname>
<given-names>Päivi</given-names>
</name>
<xref ref-type="aff" rid="af48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eskelinen</surname>
<given-names>Matti</given-names>
</name>
<xref ref-type="aff" rid="af49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soini</surname>
<given-names>Ylermi</given-names>
</name>
<xref ref-type="aff" rid="af45">45</xref>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spurdle</surname>
<given-names>Amanda B.</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beesley</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Xiaoqing</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Holland</surname>
<given-names>Helene</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><collab>kConFab</collab>
<xref ref-type="aff" rid="af51">51</xref>
</contrib>
<contrib contrib-type="author"><collab>AOCS</collab>
<xref ref-type="aff" rid="af50">50</xref>
<xref ref-type="aff" rid="af51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lambrechts</surname>
<given-names>Diether</given-names>
</name>
<xref ref-type="aff" rid="af52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Claes</surname>
<given-names>Bart</given-names>
</name>
<xref ref-type="aff" rid="af52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vandorpe</surname>
<given-names>Thijs</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neven</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wildiers</surname>
<given-names>Hans</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flesch-Janys</surname>
<given-names>Dieter</given-names>
</name>
<xref ref-type="aff" rid="af54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hein</surname>
<given-names>Rebecca</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Löning</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="af55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kosel</surname>
<given-names>Matthew</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Zachary S.</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Xianshu</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giles</surname>
<given-names>Graham G.</given-names>
</name>
<xref ref-type="aff" rid="af57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baglietto</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="af58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Severi</surname>
<given-names>Gianluca</given-names>
</name>
<xref ref-type="aff" rid="af57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McLean</surname>
<given-names>Catriona</given-names>
</name>
<xref ref-type="aff" rid="af58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haiman</surname>
<given-names>Christopher A.</given-names>
</name>
<xref ref-type="aff" rid="af59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Henderson</surname>
<given-names>Brian E.</given-names>
</name>
<xref ref-type="aff" rid="af59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Le Marchand</surname>
<given-names>Loic</given-names>
</name>
<xref ref-type="aff" rid="af60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kolonel</surname>
<given-names>Laurence N.</given-names>
</name>
<xref ref-type="aff" rid="af60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grenaker Alnæs</surname>
<given-names>Grethe</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kristensen</surname>
<given-names>Vessela</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
<xref ref-type="aff" rid="af62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Børresen-Dale</surname>
<given-names>Anne-Lise</given-names>
</name>
<xref ref-type="aff" rid="af61">61</xref>
<xref ref-type="aff" rid="af62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>David J.</given-names>
</name>
<xref ref-type="aff" rid="af63">63</xref>
<xref ref-type="aff" rid="af64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hankinson</surname>
<given-names>Susan E.</given-names>
</name>
<xref ref-type="aff" rid="af63">63</xref>
<xref ref-type="aff" rid="af64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Andrulis</surname>
<given-names>Irene L.</given-names>
</name>
<xref ref-type="aff" rid="af65">65</xref>
<xref ref-type="aff" rid="af66">66</xref>
<xref ref-type="aff" rid="af67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marie Mulligan</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="af67">67</xref>
<xref ref-type="aff" rid="af68">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>O'Malley</surname>
<given-names>Frances P.</given-names>
</name>
<xref ref-type="aff" rid="af67">67</xref>
<xref ref-type="aff" rid="af69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devilee</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af70">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huijts</surname>
<given-names>Petra E.A.</given-names>
</name>
<xref ref-type="aff" rid="af71">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tollenaar</surname>
<given-names>Rob A.E.M.</given-names>
</name>
<xref ref-type="aff" rid="af72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Asperen</surname>
<given-names>Christi J.</given-names>
</name>
<xref ref-type="aff" rid="af71">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seynaeve</surname>
<given-names>Caroline S.</given-names>
</name>
<xref ref-type="aff" rid="af73">73</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chanock</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="af74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lissowska</surname>
<given-names>Jolanta</given-names>
</name>
<xref ref-type="aff" rid="af75">75</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brinton</surname>
<given-names>Louise</given-names>
</name>
<xref ref-type="aff" rid="af76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peplonska</surname>
<given-names>Beata</given-names>
</name>
<xref ref-type="aff" rid="af77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Figueroa</surname>
<given-names>Jonine</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Xiaohong R.</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hooning</surname>
<given-names>Maartje J.</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hollestelle</surname>
<given-names>Antoinette</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oldenburg</surname>
<given-names>Rogier A.</given-names>
</name>
<xref ref-type="aff" rid="af79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jager</surname>
<given-names>Agnes</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kriege</surname>
<given-names>Mieke</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ozturk</surname>
<given-names>Bahar</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Leenders</surname>
<given-names>Geert J.L.H.</given-names>
</name>
<xref ref-type="aff" rid="af80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Czene</surname>
<given-names>Kamila</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Humphreys</surname>
<given-names>Keith</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jianjun</given-names>
</name>
<xref ref-type="aff" rid="af81">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cox</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="af82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Connley</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="af82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cramp</surname>
<given-names>Helen E.</given-names>
</name>
<xref ref-type="aff" rid="af82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cross</surname>
<given-names>Simon S.</given-names>
</name>
<xref ref-type="aff" rid="af83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Balasubramanian</surname>
<given-names>Sabapathy P.</given-names>
</name>
<xref ref-type="aff" rid="af84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reed</surname>
<given-names>Malcolm W.R.</given-names>
</name>
<xref ref-type="aff" rid="af84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dunning</surname>
<given-names>Alison M.</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Easton</surname>
<given-names>Douglas F.</given-names>
</name>
<xref ref-type="aff" rid="af86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Humphreys</surname>
<given-names>Manjeet K.</given-names>
</name>
<xref ref-type="aff" rid="af86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caldas</surname>
<given-names>Carlos</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blows</surname>
<given-names>Fiona</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Driver</surname>
<given-names>Kristy</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Provenzano</surname>
<given-names>Elena</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jakubowska</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huzarski</surname>
<given-names>Tomasz</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Byrski</surname>
<given-names>Tomasz</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cybulski</surname>
<given-names>Cezary</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gorski</surname>
<given-names>Bohdan</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gronwald</surname>
<given-names>Jacek</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brennan</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="af88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sangrajrang</surname>
<given-names>Suleeporn</given-names>
</name>
<xref ref-type="aff" rid="af89">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gaborieau</surname>
<given-names>Valerie</given-names>
</name>
<xref ref-type="aff" rid="af88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shen</surname>
<given-names>Chen-Yang</given-names>
</name>
<xref ref-type="aff" rid="af90">90</xref>
<xref ref-type="aff" rid="af91">91</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hsiung</surname>
<given-names>Chia-Ni</given-names>
</name>
<xref ref-type="aff" rid="af90">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Jyh-Cherng</given-names>
</name>
<xref ref-type="aff" rid="af92">92</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Shou-Tung</given-names>
</name>
<xref ref-type="aff" rid="af94">94</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hsu</surname>
<given-names>Giu-Cheng</given-names>
</name>
<xref ref-type="aff" rid="af93">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hou</surname>
<given-names>Ming-Feng</given-names>
</name>
<xref ref-type="aff" rid="af95">95</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Chiun-Sheng</given-names>
</name>
<xref ref-type="aff" rid="af96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Anton-Culver</surname>
<given-names>Hoda</given-names>
</name>
<xref ref-type="aff" rid="af97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ziogas</surname>
<given-names>Argyrios</given-names>
</name>
<xref ref-type="aff" rid="af97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pharoah</surname>
<given-names>Paul D.P.</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
<xref ref-type="aff" rid="af86">86</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garcia-Closas</surname>
<given-names>Montserrat</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
<xref ref-type="aff" rid="af85">85</xref>
<xref ref-type="aff" rid="af86">86</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Experimental Therapy</addr-line>
,</aff>
<aff id="af2"><label>2</label>
<addr-line>Department of Epidemiology</addr-line>
and</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Molecular Pathology</addr-line>
,<institution>The Netherlands Cancer Institute</institution>
,<addr-line>Amsterdam</addr-line>
,<country>the Netherlands</country>
,</aff>
<aff id="af4"><label>4</label>
<addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af5"><label>5</label>
<addr-line>Department of Laboratory Medicine and Pathology</addr-line>
and</aff>
<aff id="af6"><label>6</label>
<addr-line>Department of Health Sciences Research</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>Rochester, MN</addr-line>
,<country>USA</country>
,</aff>
<aff id="af7"><label>7</label>
<institution>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology</institution>
and</aff>
<aff id="af8"><label>8</label>
<addr-line>Genetic Epidemiology Laboratory, Department of Pathology</addr-line>
,<institution>The University of Melbourne</institution>
,<country>Australia</country>
,</aff>
<aff id="af9"><label>9</label>
<addr-line>Department of Pathology</addr-line>
,<institution>Leiden University Medical Centre</institution>
,<addr-line>Leiden</addr-line>
,<country>the Netherlands</country>
,</aff>
<aff id="af10"><label>10</label>
<addr-line>Division of Hematology and Oncology, David Geffen School of Medicine</addr-line>
,<institution>University of California at Los Angeles</institution>
,<addr-line>Los Angeles, CA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af11"><label>11</label>
<addr-line>Department of Gynecology and Obstetrics</addr-line>
,</aff>
<aff id="af12"><label>12</label>
<addr-line>Institute of Pathology</addr-line>
,</aff>
<aff id="af13"><label>13</label>
<addr-line>Institute of Radiology</addr-line>
,<institution>University Breast Center</institution>
,<institution>University Hospital Erlangen</institution>
,<addr-line>Erlangen</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af14"><label>14</label>
<addr-line>Institute of Human Genetics</addr-line>
,<institution>Friedrich Alexander University Erlangen</institution>
,<addr-line>Nürnberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af15"><label>15</label>
<addr-line>Department of Gynecology and Obstetrics</addr-line>
and</aff>
<aff id="af16"><label>16</label>
<addr-line>Department of Pathology</addr-line>
,<institution>University Hospital Heidelberg</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af17"><label>17</label>
<addr-line>Molecular Epidemiology</addr-line>
and</aff>
<aff id="af18"><label>18</label>
<addr-line>Division of Cancer Epidemiology</addr-line>
,<institution>German Cancer Research Center</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af19"><label>19</label>
<addr-line>Department of Clinical Biochemistry</addr-line>
and</aff>
<aff id="af20"><label>20</label>
<addr-line>Department of Breast Surgery</addr-line>
,<institution>Herlev University Hospital</institution>
,<institution>University of Copenhagen</institution>
, Copenhagen,<country>Denmark</country>
,</aff>
<aff id="af21"><label>21</label>
<addr-line>Genetic & Molecular Epidemiology Group</addr-line>
and</aff>
<aff id="af22"><label>22</label>
<addr-line>Human Cancer Genetic Group</addr-line>
,<institution>Spanish National Cancer Research Centre (CNIO)</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af23"><label>23</label>
<addr-line>Servicio Cirugía General</addr-line>
and</aff>
<aff id="af24"><label>24</label>
<addr-line>Servicio de Anatomía Patológica</addr-line>
,<institution>Hospital Monte Naranco</institution>
,<addr-line>Oviedo</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af25"><label>25</label>
<addr-line>Servicio de Oncología Médica</addr-line>
,<institution>Hospital La Paz</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af26"><label>26</label>
<institution>CIBERER</institution>
,<addr-line>Madrid</addr-line>
,<country>Spain</country>
,</aff>
<aff id="af27"><label>27</label>
<institution>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology</institution>
,<addr-line>Stuttgart</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af28"><label>28</label>
<institution>University Tübingen</institution>
,<addr-line>Tübingen</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af29"><label>29</label>
<addr-line>Department of Internal Medicine</addr-line>
,<institution>Evangelische Kliniken Bonn gGmbH</institution>
,<addr-line>Johanniter Krankenhaus, Bonn</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af30"><label>30</label>
<addr-line>Institute of Pathology</addr-line>
,<institution>Medical Faculty of the University of Bonn</institution>
,<country>Germany</country>
,</aff>
<aff id="af31"><label>31</label>
<addr-line>BGFA - Research Institute of Occupational Medicine of the German Social Accident Insurance</addr-line>
,<institution>Ruhr University Bochum</institution>
,<country>Germany</country>
,</aff>
<aff id="af32"><label>32</label>
<addr-line>Molecular Genetics of Breast Cancer</addr-line>
,<institution>Deutsches Krebsforschungszentrum (DKFZ)</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af33"><label>33</label>
<institution>Institute of Pathology, Medical Faculty of the University of Bonn</institution>
,<addr-line>Bonn</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af34"><label>34</label>
<institution>Institute of Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)</institution>
,<addr-line>Bochum</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af35"><label>35</label>
<addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>University of Ulm</institution>
,<addr-line>Ulm</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af36"><label>36</label>
<addr-line>Hannover Medical School</addr-line>
,<institution>Clinics of Radiation Oncology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af37"><label>37</label>
<institution>Clinics of Obstetrics and Gynaecology</institution>
,<addr-line>Hannover</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af38"><label>38</label>
<addr-line>Department of Obstetrics and Gynecology</addr-line>
,</aff>
<aff id="af39"><label>39</label>
<addr-line>Department of Clinical Genetics</addr-line>
,</aff>
<aff id="af40"><label>40</label>
<addr-line>Department of Pathology</addr-line>
and</aff>
<aff id="af41"><label>41</label>
<addr-line>Department of Oncology</addr-line>
,<institution>Helsinki University Central Hospital</institution>
,<addr-line>Helsinki</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af42"><label>42</label>
<addr-line>Department of Molecular Medicine and Surgery,</addr-line>
</aff>
<aff id="af43"><label>43</label>
<addr-line>Department of Oncology and Pathology</addr-line>
and</aff>
<aff id="af44"><label>44</label>
<addr-line>Department of Medical Epidemiology and Biostatistics</addr-line>
,<institution>Karolinska Institute</institution>
,<addr-line>Stockholm</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af45"><label>45</label>
<addr-line>Department of Pathology</addr-line>
,<institution>Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital</institution>
, Kuopio,<country>Finland</country>
,</aff>
<aff id="af46"><label>46</label>
<institution>Biocenter Kuopio</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af47"><label>47</label>
<addr-line>Department of Oncology</addr-line>
,<institution>Vaasa Central Hospital</institution>
,<addr-line>Vaasa</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af48"><label>48</label>
<addr-line>Department of Oncology</addr-line>
and</aff>
<aff id="af49"><label>49</label>
<addr-line>Department of Surgery</addr-line>
,<institution>Kuopio University Hospital</institution>
,<addr-line>Kuopio</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af50"><label>50</label>
<institution>Queensland Institute of Medical Research</institution>
,<addr-line>Brisbane</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af51"><label>51</label>
<institution>Peter MacCallum Cancer Centre</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af52"><label>52</label>
<institution>Vesalius Research Center</institution>
,<addr-line>KU Leuven and VIB, Leuven</addr-line>
,<country>Belgium</country>
,</aff>
<aff id="af53"><label>53</label>
<addr-line>Multidisciplinary Breast Center</addr-line>
,<institution>University Hospitals Leuven</institution>
,<country>Belgium</country>
,</aff>
<aff id="af54"><label>54</label>
<addr-line>Institute for Medical Biometrics and Epidemiology</addr-line>
,<institution>University Clinic Hamburg-Eppendorf</institution>
,<country>Germany</country>
,</aff>
<aff id="af55"><label>55</label>
<addr-line>Albertinen Pathology Department, Hamburg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af56"><label>56</label>
<addr-line>Department of Pathology</addr-line>
,<institution>University Hospital</institution>
,<addr-line>Heidelberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af57"><label>57</label>
<addr-line>Cancer Epidemiology Centre</addr-line>
,<institution>The Cancer Council Victoria</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af58"><label>58</label>
<addr-line>Department of Anatomical Pathology</addr-line>
,<institution>Alfred Hospital</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af59"><label>59</label>
<addr-line>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
, USA,</aff>
<aff id="af60"><label>60</label>
<addr-line>Epidemiology Program</addr-line>
,<institution>Cancer Research Center, University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
,</aff>
<aff id="af61"><label>61</label>
<addr-line>Department of Genetics</addr-line>
,<institution>Institute for Cancer Research, Oslo University Hospital</institution>
,<addr-line>Radiumhospitalet, Montebello 0310, Oslo</addr-line>
,<country>Norway</country>
,</aff>
<aff id="af62"><label>62</label>
<addr-line>Faculty of Medicine</addr-line>
<institution>(Faculty Division Ahus)</institution>
,<addr-line>UiO</addr-line>
,<country>Norway</country>
,</aff>
<aff id="af63"><label>63</label>
<addr-line>Channing Laboratory, Department of Medicine</addr-line>
,<institution>Brigham and Womens Hospital and Harvard Medical school</institution>
, Boston, MA, USA,</aff>
<aff id="af64"><label>64</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard school of public health</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
,</aff>
<aff id="af65"><label>65</label>
<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
,<addr-line>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af66"><label>66</label>
<addr-line>Department of Molecular Genetics and</addr-line>
</aff>
<aff id="af67"><label>67</label>
<addr-line>Laboratory Medicine</addr-line>
and<addr-line>Pathobiology</addr-line>
,<institution>University of Toronto</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af68"><label>68</label>
<addr-line>Keenan Research Centre</addr-line>
,<institution>Li Ka Shing Knowledge Institute of St Michael's Hospital</institution>
,<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
,</aff>
<aff id="af69"><label>69</label>
<addr-line>The Department of Laboratory Medicine and the</addr-line>
<institution>Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital,</institution>
<addr-line>Toronto, Ontario</addr-line>
,<country>Canada</country>
</aff>
<aff id="af70"><label>70</label>
<addr-line>Department Human Genetics & Department of Pathology</addr-line>
,</aff>
<aff id="af71"><label>71</label>
<addr-line>Clinical Genetics</addr-line>
and</aff>
<aff id="af72"><label>72</label>
<addr-line>Surgical Oncology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af73"><label>73</label>
<addr-line>Department of Medical Oncology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af74"><label>74</label>
<addr-line>Advanced Technology Center</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Gaithersburg, MD 20892-4605</addr-line>
,<country>USA</country>
,</aff>
<aff id="af75"><label>75</label>
<addr-line>Department of Cancer Epidemiology and Prevention</addr-line>
,<institution>Cancer Center and M. Sklodowska-Curie Institute of Oncology</institution>
,<addr-line>02-781 Warsaw</addr-line>
,<country>Poland</country>
,</aff>
<aff id="af76"><label>76</label>
<addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Rockville, MD 20852-7234</addr-line>
,<country>USA</country>
,</aff>
<aff id="af77"><label>77</label>
<institution>Nofer Institute of Occupational Medicine</institution>
,<addr-line>91-348 Lodz</addr-line>
,<country>Poland</country>
,</aff>
<aff id="af78"><label>78</label>
<addr-line>Department of Medical Oncology</addr-line>
,</aff>
<aff id="af79"><label>79</label>
<addr-line>Department of Clinical Genetics</addr-line>
and</aff>
<aff id="af80"><label>80</label>
<addr-line>Department of Pathology</addr-line>
,<institution>Rotterdam Family Cancer Clinic, Erasmus University Medical Center</institution>
,<addr-line>Rotterdam</addr-line>
,<country>the Netherlands</country>
,</aff>
<aff id="af81"><label>81</label>
<addr-line>Human Genetics Laboratory</addr-line>
,<institution>Genome Institute of Singapore</institution>
,<country>Singapore</country>
,</aff>
<aff id="af82"><label>82</label>
<addr-line>Department of Oncology, Institute for Cancer Studies</addr-line>
,</aff>
<aff id="af83"><label>83</label>
<addr-line>Academic Unit of Pathology, Department of Oncology</addr-line>
and</aff>
<aff id="af84"><label>84</label>
<addr-line>Academic Unit of Surgical Oncology, Department of Oncology</addr-line>
,<institution>University of Sheffield Medical School</institution>
,<addr-line>Sheffield</addr-line>
,<country>UK</country>
,</aff>
<aff id="af85"><label>85</label>
<addr-line>Department of Oncology</addr-line>
and</aff>
<aff id="af86"><label>86</label>
<addr-line>Department of Public Health and Primary Care</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge</addr-line>
,<country>UK</country>
,</aff>
<aff id="af87"><label>87</label>
<addr-line>Department of Genetics and Pathology</addr-line>
,<institution>International Hereditary Cancer Center, Pomeranian Medical University</institution>
,<addr-line>Szczecin</addr-line>
,<country>Poland</country>
,</aff>
<aff id="af88"><label>88</label>
<institution>International agency for Research on Cancer</institution>
,<addr-line>Lyon</addr-line>
,<country>France</country>
,</aff>
<aff id="af89"><label>89</label>
<institution>National Cancer Institute</institution>
,<addr-line>Bangkok</addr-line>
,<country>Thailand</country>
,</aff>
<aff id="af90"><label>90</label>
<institution>Institute of Biomedical Sciences, Academia Sinica</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</aff>
<aff id="af91"><label>91</label>
<addr-line>Graduate Institute of Environmental Science</addr-line>
,<institution>China Medical University</institution>
,<addr-line>Taichung</addr-line>
,<country>Taiwan</country>
,</aff>
<aff id="af92"><label>92</label>
<addr-line>Department of Surgery</addr-line>
and</aff>
<aff id="af93"><label>93</label>
<addr-line>Department of Radiology</addr-line>
,<institution>Tri-Service General Hospital</institution>
,<addr-line>Taipei</addr-line>
, Taiwan,</aff>
<aff id="af94"><label>94</label>
<addr-line>Department of Surgery</addr-line>
,<institution>Changhua Christian Hospital</institution>
,<addr-line>Changhua</addr-line>
, Taiwan,</aff>
<aff id="af95"><label>95</label>
<addr-line>Department of Surgery</addr-line>
,<institution>Kaohsiung Medical University Hospital</institution>
,<addr-line>Kaohsiung</addr-line>
, Taiwan,</aff>
<aff id="af96"><label>96</label>
<addr-line>Department of Surgery</addr-line>
,<institution>National Taiwan University Hospital</institution>
,<addr-line>Taipei</addr-line>
,<country>Taiwan</country>
,</aff>
<aff id="af97"><label>97</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>University of California at Irvine</institution>
,<addr-line>Irvine, CA 92697</addr-line>
,<country>USA</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
To whom correspondence should be addressed at: Division of Experimental Therapy C2, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Tel: +31 205122037; Fax: +31 205122035; Email: <email>a.broeks@nki.nl</email>
</corresp>
<fn id="AN1"><label>†</label>
<p>The authors wish it to be known that, in their opinion, the first four authors should be regarded as joint First Authors and together with the last two as the writing group.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>19</day>
<month>5</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>8</month>
<year>2012</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>20</volume>
<issue>16</issue>
<fpage>3289</fpage>
<lpage>3303</lpage>
<history><date date-type="received"><day>17</day>
<month>12</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>10</day>
<month>5</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>16</day>
<month>5</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="ddr228.pdf"></self-uri>
<abstract><p>Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER− tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (<italic>P</italic>
-heterogeneity = 6.1 × 10<sup>−18</sup>
), rs3803662 (16q12) (<italic>P</italic>
= 3.7 × 10<sup>−5</sup>
), rs13281615 (8q24) (<italic>P</italic>
= 0.002), rs13387042 (2q35) (<italic>P</italic>
= 0.006), rs4973768 (3p24) (<italic>P</italic>
= 0.003) and rs6504950 (17q23) (<italic>P</italic>
= 0.002)<italic>.</italic>
The two candidate loci, <italic>CASP8</italic>
(rs1045485, rs17468277) and <italic>TGFB1</italic>
(rs1982073), were most strongly related with the risk of PR negative tumors (<italic>P</italic>
= 5.1 × 10<sup>−6</sup>
and <italic>P</italic>
= 4.1 × 10<sup>−4</sup>
, respectively), as previously suggested. Four of the eight loci identified in GWAS were associated with triple negative tumors (<italic>P</italic>
≤ 0.016): rs3803662 (16q12), rs889312 (5q11), rs3817198 (11p15) and rs13387042 (2q35); however, only two of them (16q12 and 2q35) were associated with tumors with the core basal phenotype (<italic>P</italic>
≤ 0.002). These analyses are consistent with different biological origins of breast cancers, and indicate that tumor stratification might help in the identification and characterization of novel risk factors for breast cancer subtypes. This may eventually result in further improvements in prevention, early detection and treatment.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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