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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A non-synonymous polymorphism in <italic>IRS1</italic> modifies risk of developing breast and ovarian cancers in <italic>BRCA1</italic> and ovarian cancer in <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name><affiliation><nlm:aff id="A6">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A7">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation><nlm:aff id="A8">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kristoffersson, Ulf" sort="Kristoffersson, Ulf" uniqKey="Kristoffersson U" first="Ulf" last="Kristoffersson">Ulf Kristoffersson</name><affiliation><nlm:aff id="A9">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="A10">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Melin, Beatrice" sort="Melin, Beatrice" uniqKey="Melin B" first="Beatrice" last="Melin">Beatrice Melin</name><affiliation><nlm:aff id="A11">Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A14">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Spanish Network on Rare Diseases (CIBERER)</nlm:aff></affiliation></author><author><name sortKey="Cajal, Teresa Ram Ny" sort="Cajal, Teresa Ram Ny" uniqKey="Cajal T" first="Teresa Ram Ny" last="Cajal">Teresa Ram Ny Cajal</name><affiliation><nlm:aff id="A16">Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Stavropoulou, Alexandra V" sort="Stavropoulou, Alexandra V" uniqKey="Stavropoulou A" first="Alexandra V" last="Stavropoulou">Alexandra V. Stavropoulou</name><affiliation><nlm:aff id="A17">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, 15310 Athens Greece</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A18">Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain and Spanish Network on Rare Diseases (CIBERER)</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A19">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti" sort="Rookus, Matti" uniqKey="Rookus M" first="Matti" last="Rookus">Matti Rookus</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name><affiliation><nlm:aff id="A118">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Lange, Judith L" sort="De Lange, Judith L" uniqKey="De Lange J" first="Judith L." last="De Lange">Judith L. De Lange</name><affiliation><nlm:aff id="A119">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A120">Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oosterwijk, Jan C" sort="Oosterwijk, Jan C" uniqKey="Oosterwijk J" first="Jan C." last="Oosterwijk">Jan C. Oosterwijk</name><affiliation><nlm:aff id="A121">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="A122">Department of Clinical Genetics Leiden University Medical Center Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B. G Mez" last="García">Encarna B. G Mez García</name><affiliation><nlm:aff id="A123">Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A124">Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A125">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A126">Department of Medical Genetics, University Medical Center Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve D" sort="Ellis, Steve D" uniqKey="Ellis S" first="Steve D." last="Ellis">Steve D. Ellis</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="A22">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name><affiliation><nlm:aff id="A22">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A23">Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name><affiliation><nlm:aff id="A24">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A25">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A26">Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A27">Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A28">West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A29">Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A30">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A31">Department of Medical Genetics, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A32">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160</nlm:aff></affiliation></author><author><name sortKey="Pathak, Harsh" sort="Pathak, Harsh" uniqKey="Pathak H" first="Harsh" last="Pathak">Harsh Pathak</name><affiliation><nlm:aff id="A32">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Unité INSERM U830, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="A39">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Caux Moncoutier, Virginie" sort="Caux Moncoutier, Virginie" uniqKey="Caux Moncoutier V" first="Virginie" last="Caux-Moncoutier">Virginie Caux-Moncoutier</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="De Pauw, Antoine" sort="De Pauw, Antoine" uniqKey="De Pauw A" first="Antoine" last="De Pauw">Antoine De Pauw</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="A42">Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="A42">Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Dreyfus, Helene" sort="Dreyfus, Helene" uniqKey="Dreyfus H" first="Hélène" last="Dreyfus">Hélène Dreyfus</name><affiliation><nlm:aff id="A37">Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Institut Albert Bonniot, Université de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name><affiliation><nlm:aff id="A58">Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France</nlm:aff></affiliation></author><author><name sortKey="Collonge Rame, Marie Agnes" sort="Collonge Rame, Marie Agnes" uniqKey="Collonge Rame M" first="Marie-Agnès" last="Collonge-Rame">Marie-Agnès Collonge-Rame</name><affiliation><nlm:aff id="A40">Service de Génétique Biologique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France</nlm:aff></affiliation></author><author><name sortKey="Sokolowska, Johanna" sort="Sokolowska, Johanna" uniqKey="Sokolowska J" first="Johanna" last="Sokolowska">Johanna Sokolowska</name><affiliation><nlm:aff id="A41">Laboratoire de Génétique Médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra" sort="Buys, Saundra" uniqKey="Buys S" first="Saundra" last="Buys">Saundra Buys</name><affiliation><nlm:aff id="A44">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary" sort="Daly, Mary" uniqKey="Daly M" first="Mary" last="Daly">Mary Daly</name><affiliation><nlm:aff id="A45">Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alex" sort="Miron, Alex" uniqKey="Miron A" first="Alex" last="Miron">Alex Miron</name><affiliation><nlm:aff id="A46">Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A47">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy" sort="Chung, Wendy" uniqKey="Chung W" first="Wendy" last="Chung">Wendy Chung</name><affiliation><nlm:aff id="A47">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA, and Stanford University School of Medicine and Stanford Cancer Institute, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A49">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><affiliation><nlm:aff id="A50">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Maria, Muy Kheng Tea" sort="Maria, Muy Kheng Tea" uniqKey="Maria M" first="Muy-Kheng Tea" last="Maria">Muy-Kheng Tea Maria</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A52">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A53">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Johannsson, Oskar Th" sort="Johannsson, Oskar Th" uniqKey="Johannsson O" first="Oskar Th." last="Johannsson">Oskar Th. Johannsson</name><affiliation><nlm:aff id="A54">Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik Iceland</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A57">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="A59">Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion R" sort="Piedmonte, Marion R" uniqKey="Piedmonte M" first="Marion R" last="Piedmonte">Marion R. Piedmonte</name><affiliation><nlm:aff id="A60">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY,USA</nlm:aff></affiliation></author><author><name sortKey="Andrews, Lesley" sort="Andrews, Lesley" uniqKey="Andrews L" first="Lesley" last="Andrews">Lesley Andrews</name><affiliation><nlm:aff id="A61">Australia New Zealand Gynaecological Oncology Group</nlm:aff></affiliation></author><author><name sortKey="Cohn, David" sort="Cohn, David" uniqKey="Cohn D" first="David" last="Cohn">David Cohn</name><affiliation><nlm:aff id="A62">Ohio State University/Columbus Cancer Council; Columbus, OH 43026</nlm:aff></affiliation></author><author><name sortKey="Demars, Leslie R" sort="Demars, Leslie R" uniqKey="Demars L" first="Leslie R." last="Demars">Leslie R. Demars</name><affiliation><nlm:aff id="A63">Dartmouth-Hitchcock Medical Center, Gynecologic Oncology, Lebanon, NH 03756</nlm:aff></affiliation></author><author><name sortKey="Disilvestro, Paul" sort="Disilvestro, Paul" uniqKey="Disilvestro P" first="Paul" last="Disilvestro">Paul Disilvestro</name><affiliation><nlm:aff id="A64">Women and Infants Hospital, Providence, RI 02905</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo" sort="Rodriguez, Gustavo" uniqKey="Rodriguez G" first="Gustavo" last="Rodriguez">Gustavo Rodriguez</name><affiliation><nlm:aff id="A65">NorthShore University Health System, Evanston, IL 60201</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A66">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A67">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A67">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny" sort="Imyanitov, Evgeny" uniqKey="Imyanitov E" first="Evgeny" last="Imyanitov">Evgeny Imyanitov</name><affiliation><nlm:aff id="A68">N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A69">Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A70">Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st 2, LT-08661 Vilnius</nlm:aff></affiliation><affiliation><nlm:aff id="A71">State Research Institute Innovative Medicine Center, Zygimantu st. 9, LT-01102 Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A72">Molecular Diagnostic Unit, Hereditary Cancer Program, Laboratori de Recerca Translacional, Institut Català d'Oncologia, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A43">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Spain</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A73">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sucheston, Lara" sort="Sucheston, Lara" uniqKey="Sucheston L" first="Lara" last="Sucheston">Lara Sucheston</name><affiliation><nlm:aff id="A74">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A75">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gross, Jenny" sort="Gross, Jenny" uniqKey="Gross J" first="Jenny" last="Gross">Jenny Gross</name><affiliation><nlm:aff id="A75">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A76">UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center,Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A77">University of California, San Francisco, Departments of Medicine, Epidemiology, and Biostatistics, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A78">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A78">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A79">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A80">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A81">Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A82">Institute of Human Genetics, University of Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorotehea" sort="Gadzicki, Dorotehea" uniqKey="Gadzicki D" first="Dorotehea" last="Gadzicki">Dorotehea Gadzicki</name><affiliation><nlm:aff id="A83">Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A84">Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="A85">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A86">Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A87">Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A88">Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A89">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A90">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A91">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Canada</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Gail E" sort="Tomlinson, Gail E" uniqKey="Tomlinson G" first="Gail E." last="Tomlinson">Gail E. Tomlinson</name><affiliation><nlm:aff id="A93">Division of Pediatric Hematology Oncology, University of Texas Health Science Center at San Antonio</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation><nlm:aff id="A94">Department of Medicine, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A95">Departments of Medicine and Human Genetics, University of Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A96">NorthShore University HealthSystem, Evanston, IL; University of Chicago Pritzker, School of Medicine,Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A97">Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L." last="Blum">Joanne L. Blum</name><affiliation><nlm:aff id="A98">Baylor-Charles A. Sammons Cancer Center, Dallas, Texas</nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="A99">Women's College Hospital, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Brummel, Sean" sort="Brummel, Sean" uniqKey="Brummel S" first="Sean" last="Brummel">Sean Brummel</name><affiliation><nlm:aff id="A100">Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Gillen, Daniel L" sort="Gillen, Daniel L" uniqKey="Gillen D" first="Daniel L." last="Gillen">Daniel L. Gillen</name><affiliation><nlm:aff id="A101">Department of Statistics and Department of Epidemiology, University of California- Irvine, Irvine, CA;</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A102">Department of Medical Genetics, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A103">Department of Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="A103">Department of Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A104">Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A105">Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A106">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A105">Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A106">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A112">Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A113">Department of Clinical Genetics, Odense University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A114">Department of Clinical Genetics, Skejby Hospital, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="A115">Department of Clinical Genetics, Vejle Hospital; Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A116">Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22729394</idno><idno type="pmc">3415567</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415567</idno><idno type="RBID">PMC:3415567</idno><idno type="doi">10.1158/1055-9965.EPI-12-0229</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002089</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A non-synonymous polymorphism in <italic>IRS1</italic> modifies risk of developing breast and ovarian cancers in <italic>BRCA1</italic> and ovarian cancer in <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="A4">the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</nlm:aff></affiliation></author><author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name><affiliation><nlm:aff id="A6">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A7">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation><nlm:aff id="A8">Department of Oncology, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kristoffersson, Ulf" sort="Kristoffersson, Ulf" uniqKey="Kristoffersson U" first="Ulf" last="Kristoffersson">Ulf Kristoffersson</name><affiliation><nlm:aff id="A9">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Stenmark Askmalm, Marie" sort="Stenmark Askmalm, Marie" uniqKey="Stenmark Askmalm M" first="Marie" last="Stenmark-Askmalm">Marie Stenmark-Askmalm</name><affiliation><nlm:aff id="A10">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Melin, Beatrice" sort="Melin, Beatrice" uniqKey="Melin B" first="Beatrice" last="Melin">Beatrice Melin</name><affiliation><nlm:aff id="A11">Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A12">Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska, Katarzyna" sort="Jaworska, Katarzyna" uniqKey="Jaworska K" first="Katarzyna" last="Jaworska">Katarzyna Jaworska</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Huzarski, Tomasz" sort="Huzarski, Tomasz" uniqKey="Huzarski T" first="Tomasz" last="Huzarski">Tomasz Huzarski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Byrski, Tomasz" sort="Byrski, Tomasz" uniqKey="Byrski T" first="Tomasz" last="Byrski">Tomasz Byrski</name><affiliation><nlm:aff id="A13">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A14">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Spanish Network on Rare Diseases (CIBERER)</nlm:aff></affiliation></author><author><name sortKey="Cajal, Teresa Ram Ny" sort="Cajal, Teresa Ram Ny" uniqKey="Cajal T" first="Teresa Ram Ny" last="Cajal">Teresa Ram Ny Cajal</name><affiliation><nlm:aff id="A16">Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Stavropoulou, Alexandra V" sort="Stavropoulou, Alexandra V" uniqKey="Stavropoulou A" first="Alexandra V" last="Stavropoulou">Alexandra V. Stavropoulou</name><affiliation><nlm:aff id="A17">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, 15310 Athens Greece</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A18">Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain and Spanish Network on Rare Diseases (CIBERER)</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A19">Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti" sort="Rookus, Matti" uniqKey="Rookus M" first="Matti" last="Rookus">Matti Rookus</name><affiliation><nlm:aff id="A20">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name><affiliation><nlm:aff id="A118">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Lange, Judith L" sort="De Lange, Judith L" uniqKey="De Lange J" first="Judith L." last="De Lange">Judith L. De Lange</name><affiliation><nlm:aff id="A119">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A120">Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Oosterwijk, Jan C" sort="Oosterwijk, Jan C" uniqKey="Oosterwijk J" first="Jan C." last="Oosterwijk">Jan C. Oosterwijk</name><affiliation><nlm:aff id="A121">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><affiliation><nlm:aff id="A122">Department of Clinical Genetics Leiden University Medical Center Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Garcia, Encarna B G Mez" sort="Garcia, Encarna B G Mez" uniqKey="Garcia E" first="Encarna B. G Mez" last="García">Encarna B. G Mez García</name><affiliation><nlm:aff id="A123">Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A124">Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A125">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A126">Department of Medical Genetics, University Medical Center Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve D" sort="Ellis, Steve D" uniqKey="Ellis S" first="Steve D." last="Ellis">Steve D. Ellis</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Fineberg, Elena" sort="Fineberg, Elena" uniqKey="Fineberg E" first="Elena" last="Fineberg">Elena Fineberg</name><affiliation><nlm:aff id="A21">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="A22">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name><affiliation><nlm:aff id="A22">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A23">Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name><affiliation><nlm:aff id="A24">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A25">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A26">Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A27">Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A28">West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A29">Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A30">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A31">Department of Medical Genetics, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A32">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160</nlm:aff></affiliation></author><author><name sortKey="Pathak, Harsh" sort="Pathak, Harsh" uniqKey="Pathak H" first="Harsh" last="Pathak">Harsh Pathak</name><affiliation><nlm:aff id="A32">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Unité INSERM U830, Institut Curie, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Université Paris Descartes, Faculté de Médecine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="A38">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><nlm:aff id="A39">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Caux Moncoutier, Virginie" sort="Caux Moncoutier, Virginie" uniqKey="Caux Moncoutier V" first="Virginie" last="Caux-Moncoutier">Virginie Caux-Moncoutier</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="De Pauw, Antoine" sort="De Pauw, Antoine" uniqKey="De Pauw A" first="Antoine" last="De Pauw">Antoine De Pauw</name><affiliation><nlm:aff id="A33">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Hardouin, Agnes" sort="Hardouin, Agnes" uniqKey="Hardouin A" first="Agnès" last="Hardouin">Agnès Hardouin</name><affiliation><nlm:aff id="A42">Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Berthet, Pascaline" sort="Berthet, Pascaline" uniqKey="Berthet P" first="Pascaline" last="Berthet">Pascaline Berthet</name><affiliation><nlm:aff id="A42">Centre François Baclesse, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Dreyfus, Helene" sort="Dreyfus, Helene" uniqKey="Dreyfus H" first="Hélène" last="Dreyfus">Hélène Dreyfus</name><affiliation><nlm:aff id="A37">Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</nlm:aff></affiliation><affiliation><nlm:aff id="A56">Institut Albert Bonniot, Université de Grenoble, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name><affiliation><nlm:aff id="A58">Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France</nlm:aff></affiliation></author><author><name sortKey="Collonge Rame, Marie Agnes" sort="Collonge Rame, Marie Agnes" uniqKey="Collonge Rame M" first="Marie-Agnès" last="Collonge-Rame">Marie-Agnès Collonge-Rame</name><affiliation><nlm:aff id="A40">Service de Génétique Biologique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France</nlm:aff></affiliation></author><author><name sortKey="Sokolowska, Johanna" sort="Sokolowska, Johanna" uniqKey="Sokolowska J" first="Johanna" last="Sokolowska">Johanna Sokolowska</name><affiliation><nlm:aff id="A41">Laboratoire de Génétique Médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra" sort="Buys, Saundra" uniqKey="Buys S" first="Saundra" last="Buys">Saundra Buys</name><affiliation><nlm:aff id="A44">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Daly, Mary" sort="Daly, Mary" uniqKey="Daly M" first="Mary" last="Daly">Mary Daly</name><affiliation><nlm:aff id="A45">Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alex" sort="Miron, Alex" uniqKey="Miron A" first="Alex" last="Miron">Alex Miron</name><affiliation><nlm:aff id="A46">Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation><nlm:aff id="A47">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy" sort="Chung, Wendy" uniqKey="Chung W" first="Wendy" last="Chung">Wendy Chung</name><affiliation><nlm:aff id="A47">Department of Epidemiology, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:aff id="A48">Cancer Prevention Institute of California, Fremont, California, USA, and Stanford University School of Medicine and Stanford Cancer Institute, Palo Alto, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name><affiliation><nlm:aff id="A49">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><affiliation><nlm:aff id="A50">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Maria, Muy Kheng Tea" sort="Maria, Muy Kheng Tea" uniqKey="Maria M" first="Muy-Kheng Tea" last="Maria">Muy-Kheng Tea Maria</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Fink Retter, Anneliese" sort="Fink Retter, Anneliese" uniqKey="Fink Retter A" first="Anneliese" last="Fink-Retter">Anneliese Fink-Retter</name><affiliation><nlm:aff id="A51">Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A52">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A53">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Johannsson, Oskar Th" sort="Johannsson, Oskar Th" uniqKey="Johannsson O" first="Oskar Th." last="Johannsson">Oskar Th. Johannsson</name><affiliation><nlm:aff id="A54">Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik Iceland</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Sarrel, Kara" sort="Sarrel, Kara" uniqKey="Sarrel K" first="Kara" last="Sarrel">Kara Sarrel</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A57">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:aff id="A55">Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><affiliation><nlm:aff id="A59">Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion R" sort="Piedmonte, Marion R" uniqKey="Piedmonte M" first="Marion R" last="Piedmonte">Marion R. Piedmonte</name><affiliation><nlm:aff id="A60">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY,USA</nlm:aff></affiliation></author><author><name sortKey="Andrews, Lesley" sort="Andrews, Lesley" uniqKey="Andrews L" first="Lesley" last="Andrews">Lesley Andrews</name><affiliation><nlm:aff id="A61">Australia New Zealand Gynaecological Oncology Group</nlm:aff></affiliation></author><author><name sortKey="Cohn, David" sort="Cohn, David" uniqKey="Cohn D" first="David" last="Cohn">David Cohn</name><affiliation><nlm:aff id="A62">Ohio State University/Columbus Cancer Council; Columbus, OH 43026</nlm:aff></affiliation></author><author><name sortKey="Demars, Leslie R" sort="Demars, Leslie R" uniqKey="Demars L" first="Leslie R." last="Demars">Leslie R. Demars</name><affiliation><nlm:aff id="A63">Dartmouth-Hitchcock Medical Center, Gynecologic Oncology, Lebanon, NH 03756</nlm:aff></affiliation></author><author><name sortKey="Disilvestro, Paul" sort="Disilvestro, Paul" uniqKey="Disilvestro P" first="Paul" last="Disilvestro">Paul Disilvestro</name><affiliation><nlm:aff id="A64">Women and Infants Hospital, Providence, RI 02905</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo" sort="Rodriguez, Gustavo" uniqKey="Rodriguez G" first="Gustavo" last="Rodriguez">Gustavo Rodriguez</name><affiliation><nlm:aff id="A65">NorthShore University Health System, Evanston, IL 60201</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A66">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A67">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Agata, Simona" sort="Agata, Simona" uniqKey="Agata S" first="Simona" last="Agata">Simona Agata</name><affiliation><nlm:aff id="A67">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Imyanitov, Evgeny" sort="Imyanitov, Evgeny" uniqKey="Imyanitov E" first="Evgeny" last="Imyanitov">Evgeny Imyanitov</name><affiliation><nlm:aff id="A68">N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="A69">Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A70">Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st 2, LT-08661 Vilnius</nlm:aff></affiliation><affiliation><nlm:aff id="A71">State Research Institute Innovative Medicine Center, Zygimantu st. 9, LT-01102 Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A72">Molecular Diagnostic Unit, Hereditary Cancer Program, Laboratori de Recerca Translacional, Institut Català d'Oncologia, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A43">Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Spain</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A73">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, USA</nlm:aff></affiliation></author><author><name sortKey="Sucheston, Lara" sort="Sucheston, Lara" uniqKey="Sucheston L" first="Lara" last="Sucheston">Lara Sucheston</name><affiliation><nlm:aff id="A74">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A75">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Gross, Jenny" sort="Gross, Jenny" uniqKey="Gross J" first="Jenny" last="Gross">Jenny Gross</name><affiliation><nlm:aff id="A75">Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="A76">UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center,Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Beattie, Mary S" sort="Beattie, Mary S" uniqKey="Beattie M" first="Mary S." last="Beattie">Mary S. Beattie</name><affiliation><nlm:aff id="A77">University of California, San Francisco, Departments of Medicine, Epidemiology, and Biostatistics, USA</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A78">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A78">Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A79">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A80">Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A81">Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Preisler Adams, Sabine" sort="Preisler Adams, Sabine" uniqKey="Preisler Adams S" first="Sabine" last="Preisler-Adams">Sabine Preisler-Adams</name><affiliation><nlm:aff id="A82">Institute of Human Genetics, University of Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Gadzicki, Dorotehea" sort="Gadzicki, Dorotehea" uniqKey="Gadzicki D" first="Dorotehea" last="Gadzicki">Dorotehea Gadzicki</name><affiliation><nlm:aff id="A83">Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A84">Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="A85">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A86">Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A87">Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A88">Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A89">Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A90">Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A91">Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Canada</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Gail E" sort="Tomlinson, Gail E" uniqKey="Tomlinson G" first="Gail E." last="Tomlinson">Gail E. Tomlinson</name><affiliation><nlm:aff id="A93">Division of Pediatric Hematology Oncology, University of Texas Health Science Center at San Antonio</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation><nlm:aff id="A94">Department of Medicine, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A95">Departments of Medicine and Human Genetics, University of Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Rubinstein, Wendy S" sort="Rubinstein, Wendy S" uniqKey="Rubinstein W" first="Wendy S." last="Rubinstein">Wendy S. Rubinstein</name><affiliation><nlm:aff id="A96">NorthShore University HealthSystem, Evanston, IL; University of Chicago Pritzker, School of Medicine,Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Tung, Nadine" sort="Tung, Nadine" uniqKey="Tung N" first="Nadine" last="Tung">Nadine Tung</name><affiliation><nlm:aff id="A97">Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L." last="Blum">Joanne L. Blum</name><affiliation><nlm:aff id="A98">Baylor-Charles A. Sammons Cancer Center, Dallas, Texas</nlm:aff></affiliation></author><author><name sortKey="Narod, Steven A" sort="Narod, Steven A" uniqKey="Narod S" first="Steven A." last="Narod">Steven A. Narod</name><affiliation><nlm:aff id="A99">Women's College Hospital, Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Brummel, Sean" sort="Brummel, Sean" uniqKey="Brummel S" first="Sean" last="Brummel">Sean Brummel</name><affiliation><nlm:aff id="A100">Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Gillen, Daniel L" sort="Gillen, Daniel L" uniqKey="Gillen D" first="Daniel L." last="Gillen">Daniel L. Gillen</name><affiliation><nlm:aff id="A101">Department of Statistics and Department of Epidemiology, University of California- Irvine, Irvine, CA;</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name><affiliation><nlm:aff id="A102">Department of Medical Genetics, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><nlm:aff id="A103">Department of Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><affiliation><nlm:aff id="A103">Department of Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A104">Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, USA</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A105">Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A106">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A105">Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A106">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Loud, Jennifer T" sort="Loud, Jennifer T" uniqKey="Loud J" first="Jennifer T." last="Loud">Jennifer T. Loud</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A107">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="A108">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A112">Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A113">Department of Clinical Genetics, Odense University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A114">Department of Clinical Genetics, Skejby Hospital, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Skytte, Anne Bine" sort="Skytte, Anne Bine" uniqKey="Skytte A" first="Anne-Bine" last="Skytte">Anne-Bine Skytte</name><affiliation><nlm:aff id="A115">Department of Clinical Genetics, Vejle Hospital; Denmark</nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="A116">Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A3">Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A2">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A1">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">We previously reported significant associations between genetic variants in insulin receptor substrate 1 (<italic>IRS1)</italic> and breast cancer risk in women carrying <italic>BRCA1</italic> mutations. The objectives of this study were to investigate whether the <italic>IRS1</italic> variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S2"><title>Methods</title><p id="P2"><italic>IRS1</italic> rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by <italic>BRCA1</italic> and <italic>BRCA2</italic> status and mutation class in <italic>BRCA1</italic> carriers.</p></sec><sec id="S3"><title>Results</title><p id="P3">Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both <italic>BRCA1</italic> [Hazard ratio (HR) = 1.43; 95% CI: 1.06–1.92; p = 0.019] and <italic>BRCA2</italic> mutation carriers (HR=2.21; 95% CI: 1.39–3.52, p=0.0008). For <italic>BRCA1</italic> mutation carriers, the breast cancer risk was higher in carriers with class 2 mutations than class 1 (mutations (class 2 HR=1.86, 95% CI: 1.28–2.70; class 1 HR=0.86, 95%CI:0.69–1.09; p-for difference=0.0006). Rs13306465 was associated with ovarian cancer risk in <italic>BRCA1</italic> class 2 mutation carriers (HR = 2.42; p = 0.03).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The <italic>IRS1</italic> Gly972Arg SNP, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers and breast cancer risk in <italic>BRCA1</italic> class 2 mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P5">These findings may prove useful for risk prediction for breast and ovarian cancers in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22729394</article-id><article-id pub-id-type="pmc">3415567</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-12-0229</article-id><article-id pub-id-type="manuscript">NIHMS388571</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A non-synonymous polymorphism in <italic>IRS1</italic> modifies risk of developing breast and ovarian cancers in <italic>BRCA1</italic> and ovarian cancer in <italic>BRCA2</italic> mutation 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contrib-type="author"><name><surname>Gross</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A75">77</xref></contrib><contrib contrib-type="author"><name><surname>Ganz</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="A76">78</xref></contrib><contrib contrib-type="author"><name><surname>Beattie</surname><given-names>Mary S.</given-names></name><xref ref-type="aff" rid="A77">79</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A78">80</xref></contrib><contrib contrib-type="author"><name><surname>Wappenschmidt</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A78">80</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A79">81</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Norbert</given-names></name><xref ref-type="aff" rid="A80">82</xref></contrib><contrib contrib-type="author"><name><surname>Niederacher</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A81">83</xref></contrib><contrib contrib-type="author"><name><surname>Preisler-Adams</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="A82">84</xref></contrib><contrib contrib-type="author"><name><surname>Gadzicki</surname><given-names>Dorotehea</given-names></name><xref ref-type="aff" rid="A83">85</xref></contrib><contrib contrib-type="author"><name><surname>Varon-Mateeva</surname><given-names>Raymonda</given-names></name><xref ref-type="aff" rid="A84">86</xref></contrib><contrib contrib-type="author"><name><surname>Deissler</surname><given-names>Helmut</given-names></name><xref ref-type="aff" rid="A85">87</xref></contrib><contrib contrib-type="author"><name><surname>Gehrig</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="A86">88</xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A87">89</xref></contrib><contrib contrib-type="author"><name><surname>Kast</surname><given-names>Karin</given-names></name><xref ref-type="aff" rid="A88">90</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A89">91</xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="A90">92</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A91">93</xref></contrib><contrib contrib-type="author"><collab>KConFab Investigators</collab><xref ref-type="aff" rid="A92">94</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Gail E.</given-names></name><xref ref-type="aff" rid="A93">95</xref></contrib><contrib contrib-type="author"><name><surname>Weitzel</surname><given-names>Jeffrey</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Garber</surname><given-names>Judy E.</given-names></name><xref ref-type="aff" rid="A94">96</xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olufunmilayo I.</given-names></name><xref ref-type="aff" rid="A95">97</xref></contrib><contrib contrib-type="author"><name><surname>Rubinstein</surname><given-names>Wendy S.</given-names></name><xref ref-type="aff" rid="A96">98</xref></contrib><contrib contrib-type="author"><name><surname>Tung</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="A97">99</xref></contrib><contrib contrib-type="author"><name><surname>Blum</surname><given-names>Joanne L.</given-names></name><xref ref-type="aff" rid="A98">100</xref></contrib><contrib contrib-type="author"><name><surname>Narod</surname><given-names>Steven A.</given-names></name><xref ref-type="aff" rid="A99">101</xref></contrib><contrib contrib-type="author"><name><surname>Brummel</surname><given-names>Sean</given-names></name><xref ref-type="aff" rid="A100">102</xref></contrib><contrib contrib-type="author"><name><surname>Gillen</surname><given-names>Daniel L.</given-names></name><xref ref-type="aff" rid="A101">103</xref></contrib><contrib contrib-type="author"><name><surname>Lindor</surname><given-names>Noralane</given-names></name><xref ref-type="aff" rid="A102">105</xref></contrib><contrib contrib-type="author"><name><surname>Fredericksen</surname><given-names>Zachary</given-names></name><xref ref-type="aff" rid="A103">106</xref></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>Vernon S.</given-names></name><xref ref-type="aff" rid="A103">106</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A104">107</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A105">108</xref><xref ref-type="aff" rid="A106">109</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A105">108</xref><xref ref-type="aff" rid="A106">109</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H.</given-names></name><xref ref-type="aff" rid="A107">110</xref></contrib><contrib contrib-type="author"><name><surname>Loud</surname><given-names>Jennifer T.</given-names></name><xref ref-type="aff" rid="A107">110</xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L.</given-names></name><xref ref-type="aff" rid="A107">110</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A108">111</xref><xref ref-type="aff" rid="A109">112</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="A108">111</xref></contrib><contrib contrib-type="author"><name><surname>Ozcelik</surname><given-names>Hilmi</given-names></name><xref ref-type="aff" rid="A108">111</xref><xref ref-type="aff" rid="A110">113</xref></contrib><contrib contrib-type="author"><collab>OCGN</collab><xref ref-type="aff" rid="A111">114</xref></contrib><contrib contrib-type="author"><name><surname>Gerdes</surname><given-names>Anne-Marie</given-names></name><xref ref-type="aff" rid="A112">115</xref></contrib><contrib contrib-type="author"><name><surname>Thomassen</surname><given-names>Mads</given-names></name><xref ref-type="aff" rid="A113">116</xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Uffe Birk</given-names></name><xref ref-type="aff" rid="A114">117</xref></contrib><contrib contrib-type="author"><name><surname>Skytte</surname><given-names>Anne-Bine</given-names></name><xref ref-type="aff" rid="A115">118</xref></contrib><contrib contrib-type="author"><name><surname>Caligo</surname><given-names>Maria A.</given-names></name><xref ref-type="aff" rid="A116">119</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib><contrib contrib-type="author"><collab>on behalf of Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)</collab></contrib></contrib-group><aff id="A1"><label>1</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. USA</aff><aff id="A2"><label>2</label>Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge Worts Causeway,Cambridge CB1 8RN, UK</aff><aff id="A3"><label>3</label>Genetics and Population Health Division, Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Brisbane, Australia</aff><aff id="A4"><label>4</label>the Oncogenetics unit and the Institute of Oncology, The Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel</aff><aff id="A5"><label>5</label>Swedish Breast Cancer Study, Sweden</aff><aff id="A6"><label>6</label>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A7"><label>7</label>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A8"><label>8</label>Department of Oncology, Lund University Hospital, Lund, Sweden</aff><aff id="A9"><label>9</label>Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</aff><aff id="A10"><label>10</label>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</aff><aff id="A11"><label>11</label>Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden</aff><aff id="A12"><label>12</label>Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA</aff><aff id="A13"><label>13</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A14"><label>14</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A15"><label>15</label>Spanish Network on Rare Diseases (CIBERER)</aff><aff id="A16"><label>16</label>Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</aff><aff id="A17"><label>17</label>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, 15310 Athens Greece</aff><aff id="A18"><label>18</label>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain and Spanish Network on Rare Diseases (CIBERER)</aff><aff id="A19"><label>19</label>Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany</aff><aff id="A20"><label>20</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A21"><label>21</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</aff><aff id="A22"><label>22</label>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</aff><aff id="A23"><label>23</label>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK</aff><aff id="A24"><label>24</label>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</aff><aff id="A25"><label>25</label>Yorkshire Regional Genetics Service, Leeds, UK</aff><aff id="A26"><label>26</label>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, UK</aff><aff id="A27"><label>27</label>Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK</aff><aff id="A28"><label>28</label>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</aff><aff id="A29"><label>29</label>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK</aff><aff id="A30"><label>30</label>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</aff><aff id="A31"><label>31</label>Department of Medical Genetics, University of Cambridge, UK</aff><aff id="A32"><label>32</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160</aff><aff id="A33"><label>33</label>Institut Curie, Department of Tumour Biology, Paris, France</aff><aff id="A34"><label>34</label>Unité INSERM U830, Institut Curie, Paris, France</aff><aff id="A35"><label>35</label>Université Paris Descartes, Faculté de Médecine, Paris, France</aff><aff id="A36"><label>36</label>GEMO: National Cancer Genetics Network «UNICANCER Genetic Group», France</aff><aff id="A37"><label>37</label>Department of Genetics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</aff><aff id="A38"><label>38</label>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A39"><label>39</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon / Centre Léon Bérard, Lyon, France</aff><aff id="A40"><label>40</label>Service de Génétique Biologique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France</aff><aff id="A41"><label>41</label>Laboratoire de Génétique Médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France</aff><aff id="A42"><label>42</label>Centre François Baclesse, Caen, France</aff><aff id="A43"><label>43</label>Genetic Counseling Unit, Hereditari Cancer Program, IDIBELL-Catalan Institute of Oncology, Spain</aff><aff id="A44"><label>46</label>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA</aff><aff id="A45"><label>47</label>Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</aff><aff id="A46"><label>48</label>Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA</aff><aff id="A47"><label>49</label>Department of Epidemiology, Columbia University, New York, NY, USA</aff><aff id="A48"><label>50</label>Cancer Prevention Institute of California, Fremont, California, USA, and Stanford University School of Medicine and Stanford Cancer Institute, Palo Alto, CA, USA</aff><aff id="A49"><label>51</label>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Australia</aff><aff id="A50"><label>52</label>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A51"><label>53</label>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria</aff><aff id="A52"><label>54</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A53"><label>55</label>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A54"><label>56</label>Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik Iceland</aff><aff id="A55"><label>57</label>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY</aff><aff id="A56"><label>58</label>Institut Albert Bonniot, Université de Grenoble, Grenoble, France</aff><aff id="A57"><label>59</label>Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</aff><aff id="A58"><label>60</label>Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France</aff><aff id="A59"><label>61</label>Memorial Sloan-Kettering Cancer Center, New York, NY</aff><aff id="A60"><label>62</label>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY,USA</aff><aff id="A61"><label>63</label>Australia New Zealand Gynaecological Oncology Group</aff><aff id="A62"><label>64</label>Ohio State University/Columbus Cancer Council; Columbus, OH 43026</aff><aff id="A63"><label>65</label>Dartmouth-Hitchcock Medical Center, Gynecologic Oncology, Lebanon, NH 03756</aff><aff id="A64"><label>66</label>Women and Infants Hospital, Providence, RI 02905</aff><aff id="A65"><label>67</label>NorthShore University Health System, Evanston, IL 60201</aff><aff id="A66"><label>68</label>Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</aff><aff id="A67"><label>69</label>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</aff><aff id="A68"><label>70</label>N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</aff><aff id="A69"><label>71</label>Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA</aff><aff id="A70"><label>72</label>Dept. of Molecular and Regenerative medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu st 2, LT-08661 Vilnius</aff><aff id="A71"><label>73</label>State Research Institute Innovative Medicine Center, Zygimantu st. 9, LT-01102 Vilnius, Lithuania</aff><aff id="A72"><label>74</label>Molecular Diagnostic Unit, Hereditary Cancer Program, Laboratori de Recerca Translacional, Institut Català d'Oncologia, Barcelona, Spain</aff><aff id="A73"><label>75</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, USA</aff><aff id="A74"><label>76</label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A75"><label>77</label>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</aff><aff id="A76"><label>78</label>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center,Los Angeles, CA, USA</aff><aff id="A77"><label>79</label>University of California, San Francisco, Departments of Medicine, Epidemiology, and Biostatistics, USA</aff><aff id="A78"><label>80</label>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne, Germany</aff><aff id="A79"><label>81</label>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</aff><aff id="A80"><label>82</label>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Germany</aff><aff id="A81"><label>83</label>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Germany</aff><aff id="A82"><label>84</label>Institute of Human Genetics, University of Münster, Münster, Germany</aff><aff id="A83"><label>85</label>Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany</aff><aff id="A84"><label>86</label>Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Germany</aff><aff id="A85"><label>87</label>Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</aff><aff id="A86"><label>88</label>Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Germany</aff><aff id="A87"><label>89</label>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Germany</aff><aff id="A88"><label>90</label>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Germany</aff><aff id="A89"><label>91</label>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A90"><label>92</label>Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A91"><label>93</label>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Canada</aff><aff id="A92"><label>94</label>Kathleen Cuningham Consortium for Research into Familial Breast Cancer – Peter MacCallum Cancer Center, Melbourne, Australia (kConFab)</aff><aff id="A93"><label>95</label>Division of Pediatric Hematology Oncology, University of Texas Health Science Center at San Antonio</aff><aff id="A94"><label>96</label>Department of Medicine, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA</aff><aff id="A95"><label>97</label>Departments of Medicine and Human Genetics, University of Chicago, Chicago, IL</aff><aff id="A96"><label>98</label>NorthShore University HealthSystem, Evanston, IL; University of Chicago Pritzker, School of Medicine,Chicago, IL</aff><aff id="A97"><label>99</label>Beth Israel Deaconess Medical Center, Boston, MA</aff><aff id="A98"><label>100</label>Baylor-Charles A. Sammons Cancer Center, Dallas, Texas</aff><aff id="A99"><label>101</label>Women's College Hospital, Toronto, Ontario</aff><aff id="A100"><label>102</label>Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA;</aff><aff id="A101"><label>103</label>Department of Statistics and Department of Epidemiology, University of California- Irvine, Irvine, CA;</aff><aff id="A102"><label>105</label>Department of Medical Genetics, Mayo Clinic, USA</aff><aff id="A103"><label>106</label>Department of Health Sciences Research, Mayo Clinic, USA</aff><aff id="A104"><label>107</label>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, USA</aff><aff id="A105"><label>108</label>Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A106"><label>109</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A107"><label>110</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852</aff><aff id="A108"><label>111</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</aff><aff id="A109"><label>112</label>Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario</aff><aff id="A110"><label>113</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario</aff><aff id="A111"><label>114</label>Ontario Cancer Genetics Network, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1×5</aff><aff id="A112"><label>115</label>Clinical Genetics, Rigshospitalet, Copenhagen, Denmark</aff><aff id="A113"><label>116</label>Department of Clinical Genetics, Odense University Hospital, Denmark</aff><aff id="A114"><label>117</label>Department of Clinical Genetics, Skejby Hospital, Aarhus, Denmark</aff><aff id="A115"><label>118</label>Department of Clinical Genetics, Vejle Hospital; Denmark</aff><aff id="A116"><label>119</label>Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy</aff><aff id="A117"><label>120</label>The Hereditary Breast and Ovarian Cancer Research Group Netherlands</aff><aff id="A118"><label>121</label>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A119"><label>122</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A120"><label>123</label>Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands</aff><aff id="A121"><label>124</label>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</aff><aff id="A122"><label>125</label>Department of Clinical Genetics Leiden University Medical Center Leiden, The Netherlands</aff><aff id="A123"><label>126</label>Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands</aff><aff id="A124"><label>127</label>Hereditary Cancer Clinic, Radboud University Nijmegen Medical Center, The Netherlands</aff><aff id="A125"><label>128</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A126"><label>129</label>Department of Medical Genetics, University Medical Center Utrecht, The Netherlands</aff><author-notes><corresp id="CR1"><label>*</label>To whom correspondence should be addressed: Susan L. Neuhausen, Ph.D. The Morris and Horowitz Families Professor in Cancer Etiology and Outcomes Research Department of Population Sciences Beckman Research Institute of the City of Hope 1500 East Duarte Road Duarte, CA 91010, USA Phone: 626-471-9261 FAX: 626-471-9269 <email>sneuhausen@coh.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>22</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2013</year></pub-date><volume>21</volume><issue>8</issue><fpage>1362</fpage><lpage>1370</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">We previously reported significant associations between genetic variants in insulin receptor substrate 1 (<italic>IRS1)</italic> and breast cancer risk in women carrying <italic>BRCA1</italic> mutations. The objectives of this study were to investigate whether the <italic>IRS1</italic> variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S2"><title>Methods</title><p id="P2"><italic>IRS1</italic> rs1801123, rs1330645, and rs1801278 were genotyped in samples from 36 centers in the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA). Data were analyzed by a retrospective cohort approach modeling the associations with breast and ovarian cancer risks simultaneously. Analyses were stratified by <italic>BRCA1</italic> and <italic>BRCA2</italic> status and mutation class in <italic>BRCA1</italic> carriers.</p></sec><sec id="S3"><title>Results</title><p id="P3">Rs1801278 (Gly972Arg) was associated with ovarian cancer risk for both <italic>BRCA1</italic> [Hazard ratio (HR) = 1.43; 95% CI: 1.06–1.92; p = 0.019] and <italic>BRCA2</italic> mutation carriers (HR=2.21; 95% CI: 1.39–3.52, p=0.0008). For <italic>BRCA1</italic> mutation carriers, the breast cancer risk was higher in carriers with class 2 mutations than class 1 (mutations (class 2 HR=1.86, 95% CI: 1.28–2.70; class 1 HR=0.86, 95%CI:0.69–1.09; p-for difference=0.0006). Rs13306465 was associated with ovarian cancer risk in <italic>BRCA1</italic> class 2 mutation carriers (HR = 2.42; p = 0.03).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The <italic>IRS1</italic> Gly972Arg SNP, which affects insulin-like growth factor and insulin signaling, modifies ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers and breast cancer risk in <italic>BRCA1</italic> class 2 mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P5">These findings may prove useful for risk prediction for breast and ovarian cancers in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers.</p></sec></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>Ovarian cancer</kwd><kwd><italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</kwd><kwd>insulin receptor substrate 1</kwd><kwd>Insulin-like growth factor /insulin (IGF/INS) signaling</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA074415 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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