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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common Breast Cancer Susceptibility Variants in <italic>LSP1</italic> and <italic>RAD51L1</italic> Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk</title><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name></author><author><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name></author><author><name sortKey="Gierach, Gretchen L" sort="Gierach, Gretchen L" uniqKey="Gierach G" first="Gretchen L." last="Gierach">Gretchen L. Gierach</name></author><author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M." last="Jud">Sebastian M. Jud</name></author><author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Pollan, Marina" sort="Pollan, Marina" uniqKey="Pollan M" first="Marina" last="Pollan">Marina Pollan</name></author><author><name sortKey="Fernandez Navarro, Pablo" sort="Fernandez Navarro, Pablo" uniqKey="Fernandez Navarro P" first="Pablo" last="Fernández-Navarro">Pablo Fernández-Navarro</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name></author><author><name sortKey="Lokate, Mariette" sort="Lokate, Mariette" uniqKey="Lokate M" first="Mariëtte" last="Lokate">Mariëtte Lokate</name></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name></author><author><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name></author><author><name sortKey="Varghese, Jajini S" sort="Varghese, Jajini S" uniqKey="Varghese J" first="Jajini S." last="Varghese">Jajini S. Varghese</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name></author><author><name sortKey="Warren, Ruth Ml" sort="Warren, Ruth Ml" uniqKey="Warren R" first="Ruth Ml" last="Warren">Ruth Ml Warren</name></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name></author><author><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name></author><author><name sortKey="Leach, Martin O" sort="Leach, Martin O" uniqKey="Leach M" first="Martin O." last="Leach">Martin O. Leach</name></author><author><name sortKey="Kwan Lim, Gek" sort="Kwan Lim, Gek" uniqKey="Kwan Lim G" first="Gek" last="Kwan-Lim">Gek Kwan-Lim</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></author><author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Walker, Kate" sort="Walker, Kate" uniqKey="Walker K" first="Kate" last="Walker">Kate Walker</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Mccormack, Valerie A" sort="Mccormack, Valerie A" uniqKey="Mccormack V" first="Valerie A." last="Mccormack">Valerie A. Mccormack</name></author><author><name sortKey="Biong, Margarethe" sort="Biong, Margarethe" uniqKey="Biong M" first="Margarethe" last="Biong">Margarethe Biong</name></author><author><name sortKey="Aln S, Grethe I G" sort="Aln S, Grethe I G" uniqKey="Aln S G" first="Grethe I. G." last="Aln S">Grethe I. G. Aln S</name></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Boyd, Norman F" sort="Boyd, Norman F" uniqKey="Boyd N" first="Norman F." last="Boyd">Norman F. Boyd</name></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Wesolowska, Ewa" sort="Wesolowska, Ewa" uniqKey="Wesolowska E" first="Ewa" last="Wesolowska">Ewa Wesolowska</name></author><author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name></author><author><name sortKey="Bukowska, Agnieszka" sort="Bukowska, Agnieszka" uniqKey="Bukowska A" first="Agnieszka" last="Bukowska">Agnieszka Bukowska</name></author><author><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name></author><author><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Audley, Tina" sort="Audley, Tina" uniqKey="Audley T" first="Tina" last="Audley">Tina Audley</name></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22454379</idno><idno type="pmc">3569092</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569092</idno><idno type="RBID">PMC:3569092</idno><idno type="doi">10.1158/1055-9965.EPI-12-0066</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002088</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Breast Cancer Susceptibility Variants in <italic>LSP1</italic> and <italic>RAD51L1</italic> Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk</title><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M." last="Vachon">Celine M. Vachon</name></author><author><name sortKey="Scott, Christopher G" sort="Scott, Christopher G" uniqKey="Scott C" first="Christopher G." last="Scott">Christopher G. Scott</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Odefrey, Fabrice" sort="Odefrey, Fabrice" uniqKey="Odefrey F" first="Fabrice" last="Odefrey">Fabrice Odefrey</name></author><author><name sortKey="Gierach, Gretchen L" sort="Gierach, Gretchen L" uniqKey="Gierach G" first="Gretchen L." last="Gierach">Gretchen L. Gierach</name></author><author><name sortKey="Jud, Sebastian M" sort="Jud, Sebastian M" uniqKey="Jud S" first="Sebastian M." last="Jud">Sebastian M. Jud</name></author><author><name sortKey="Heusinger, Katharina" sort="Heusinger, Katharina" uniqKey="Heusinger K" first="Katharina" last="Heusinger">Katharina Heusinger</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Pollan, Marina" sort="Pollan, Marina" uniqKey="Pollan M" first="Marina" last="Pollan">Marina Pollan</name></author><author><name sortKey="Fernandez Navarro, Pablo" sort="Fernandez Navarro, Pablo" uniqKey="Fernandez Navarro P" first="Pablo" last="Fernández-Navarro">Pablo Fernández-Navarro</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name></author><author><name sortKey="Van Gils, Carla H" sort="Van Gils, Carla H" uniqKey="Van Gils C" first="Carla H." last="Van Gils">Carla H. Van Gils</name></author><author><name sortKey="Lokate, Mariette" sort="Lokate, Mariette" uniqKey="Lokate M" first="Mariëtte" last="Lokate">Mariëtte Lokate</name></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name></author><author><name sortKey="Peeters, Petra H M" sort="Peeters, Petra H M" uniqKey="Peeters P" first="Petra H. M." last="Peeters">Petra H. M. Peeters</name></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name></author><author><name sortKey="Leyland, Jean" sort="Leyland, Jean" uniqKey="Leyland J" first="Jean" last="Leyland">Jean Leyland</name></author><author><name sortKey="Varghese, Jajini S" sort="Varghese, Jajini S" uniqKey="Varghese J" first="Jajini S." last="Varghese">Jajini S. Varghese</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Thompson, Deborah J" sort="Thompson, Deborah J" uniqKey="Thompson D" first="Deborah J." last="Thompson">Deborah J. Thompson</name></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name></author><author><name sortKey="Warren, Ruth Ml" sort="Warren, Ruth Ml" uniqKey="Warren R" first="Ruth Ml" last="Warren">Ruth Ml Warren</name></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name></author><author><name sortKey="Loos, Ruth Jf" sort="Loos, Ruth Jf" uniqKey="Loos R" first="Ruth Jf" last="Loos">Ruth Jf Loos</name></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A." last="Gayther">Simon A. Gayther</name></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J." last="Ramus">Susan J. Ramus</name></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name></author><author><name sortKey="Leach, Martin O" sort="Leach, Martin O" uniqKey="Leach M" first="Martin O." last="Leach">Martin O. Leach</name></author><author><name sortKey="Kwan Lim, Gek" sort="Kwan Lim, Gek" uniqKey="Kwan Lim G" first="Gek" last="Kwan-Lim">Gek Kwan-Lim</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></author><author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name></author><author><name sortKey="Woolcott, Christy" sort="Woolcott, Christy" uniqKey="Woolcott C" first="Christy" last="Woolcott">Christy Woolcott</name></author><author><name sortKey="Maskarinec, Gertraud" sort="Maskarinec, Gertraud" uniqKey="Maskarinec G" first="Gertraud" last="Maskarinec">Gertraud Maskarinec</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Walker, Kate" sort="Walker, Kate" uniqKey="Walker K" first="Kate" last="Walker">Kate Walker</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Mccormack, Valerie A" sort="Mccormack, Valerie A" uniqKey="Mccormack V" first="Valerie A." last="Mccormack">Valerie A. Mccormack</name></author><author><name sortKey="Biong, Margarethe" sort="Biong, Margarethe" uniqKey="Biong M" first="Margarethe" last="Biong">Margarethe Biong</name></author><author><name sortKey="Aln S, Grethe I G" sort="Aln S, Grethe I G" uniqKey="Aln S G" first="Grethe I. G." last="Aln S">Grethe I. G. Aln S</name></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name></author><author><name sortKey="Kristensen, Vessela N" sort="Kristensen, Vessela N" uniqKey="Kristensen V" first="Vessela N." last="Kristensen">Vessela N. Kristensen</name></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name></author><author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Boyd, Norman F" sort="Boyd, Norman F" uniqKey="Boyd N" first="Norman F." last="Boyd">Norman F. Boyd</name></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Wesolowska, Ewa" sort="Wesolowska, Ewa" uniqKey="Wesolowska E" first="Ewa" last="Wesolowska">Ewa Wesolowska</name></author><author><name sortKey="Peplonska, Beata" sort="Peplonska, Beata" uniqKey="Peplonska B" first="Beata" last="Peplonska">Beata Peplonska</name></author><author><name sortKey="Bukowska, Agnieszka" sort="Bukowska, Agnieszka" uniqKey="Bukowska A" first="Agnieszka" last="Bukowska">Agnieszka Bukowska</name></author><author><name sortKey="Reszka, Edyta" sort="Reszka, Edyta" uniqKey="Reszka E" first="Edyta" last="Reszka">Edyta Reszka</name></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name></author><author><name sortKey="Eriksson, Louise" sort="Eriksson, Louise" uniqKey="Eriksson L" first="Louise" last="Eriksson">Louise Eriksson</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Audley, Tina" sort="Audley, Tina" uniqKey="Audley T" first="Tina" last="Audley">Tina Audley</name></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H." last="Wu">Anna H. Wu</name></author><author><name sortKey="Pankratz, V Shane" sort="Pankratz, V Shane" uniqKey="Pankratz V" first="V. Shane" last="Pankratz">V. Shane Pankratz</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biological mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to inter-individual differences in mammographic density measures.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and non-dense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, body mass index (BMI) and menopausal status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Consistent with their breast cancer associations, the C-allele of rs3817198 in <italic>LSP1</italic> was positively associated with both adjusted dense area (p=0.00005) and adjusted percent density (p=0.001) whereas the A-allele of rs10483813 in <italic>RAD51L1</italic> was inversely associated with adjusted percent density (p=0.003), but not with adjusted dense area (p=0.07).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">We identified two common breast cancer susceptibility variants associated with mammographic measures of radio-dense tissue in the breast gland.</p></sec><sec id="S5"><title>Impact</title><p id="P5">We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, <italic>LSP1</italic>-rs3817198 and <italic>RAD51L1</italic>-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22454379</article-id><article-id pub-id-type="pmc">3569092</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-12-0066</article-id><article-id pub-id-type="manuscript">NIHMS381732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common Breast Cancer Susceptibility Variants in <italic>LSP1</italic> and <italic>RAD51L1</italic> Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>Christopher G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tamimi</surname><given-names>Rulla M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stone</surname><given-names>Jennifer</given-names></name></contrib><contrib contrib-type="author"><name><surname>Apicella</surname><given-names>Carmel</given-names></name></contrib><contrib contrib-type="author"><name><surname>Odefrey</surname><given-names>Fabrice</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gierach</surname><given-names>Gretchen L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jud</surname><given-names>Sebastian M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Heusinger</surname><given-names>Katharina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pollan</surname><given-names>Marina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fernández-Navarro</surname><given-names>Pablo</given-names></name></contrib><contrib contrib-type="author"><name><surname>González-Neira</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name></contrib><contrib contrib-type="author"><name><surname>van Gils</surname><given-names>Carla H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lokate</surname><given-names>Mariëtte</given-names></name></contrib><contrib contrib-type="author"><name><surname>Onland-Moret</surname><given-names>N. Charlotte</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H.M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Judith</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leyland</surname><given-names>Jean</given-names></name></contrib><contrib contrib-type="author"><name><surname>Varghese</surname><given-names>Jajini S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Deborah J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Luben</surname><given-names>Robert N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Warren</surname><given-names>Ruth ML</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth JF</given-names></name></contrib><contrib contrib-type="author"><name><surname>Khaw</surname><given-names>Kay-Tee</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ursin</surname><given-names>Giske</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Eunjung</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gayther</surname><given-names>Simon A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ramus</surname><given-names>Susan J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leach</surname><given-names>Martin O.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kwan-Lim</surname><given-names>Gek</given-names></name><on-behalf-of>for the UK study of MRI screening for breast cancer in women at high risk (MARIBS)</on-behalf-of></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name></contrib><contrib contrib-type="author"><name><surname>Krishnan</surname><given-names>Kavitha</given-names></name></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kolonel</surname><given-names>Laurence N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Woolcott</surname><given-names>Christy</given-names></name></contrib><contrib contrib-type="author"><name><surname>Maskarinec</surname><given-names>Gertraud</given-names></name></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Walker</surname><given-names>Kate</given-names></name></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name></contrib><contrib contrib-type="author"><name><surname>McCormack</surname><given-names>Valerie A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Biong</surname><given-names>Margarethe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alnæs</surname><given-names>Grethe I.G.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gram</surname><given-names>Inger Torhild</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lindström</surname><given-names>Sara</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hankinson</surname><given-names>Susan E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boyd</surname><given-names>Norman F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lissowska</surname><given-names>Jolanta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wesolowska</surname><given-names>Ewa</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peplonska</surname><given-names>Beata</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bukowska</surname><given-names>Agnieszka</given-names></name></contrib><contrib contrib-type="author"><name><surname>Reszka</surname><given-names>Edyta</given-names></name></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>JianJun</given-names></name></contrib><contrib contrib-type="author"><name><surname>Eriksson</surname><given-names>Louise</given-names></name></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name></contrib><contrib contrib-type="author"><name><surname>Audley</surname><given-names>Tina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Anna H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pankratz</surname><given-names>V. Shane</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname><given-names>Isabel</given-names></name></contrib><aff id="A1"><bold>AMDTSS:</bold> John L. Hopper, Jennifer Stone and Carmel Apicella, University of Melbourne, School of Population Health, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne, Australia; Fabrice Odefrey, University of Melbourne, Department of Pathology, Melbourne, Australia</aff><aff id="A2"><bold>BBCC:</bold> Peter A. Fasching, University of California at Los Angeles, Department of Medicine, Division of Hematology and Oncology, Dafid Geffen School of Medicine, USA; Sebastian M. Jud, Katharina Heusinger and Matthias W. Beckmann, University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Germany</aff><aff id="A3"><bold>DDM-Spain:</bold> Marina Pollan and Pablo Fernández-Navarro, Área de Epidemiología Ambiental y Cáncer, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública CIBERESP), Madrid, Spain; Anna González-Neira and Javier Benítez, Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain</aff><aff id="A4"><bold>EPIC-NL:</bold> Carla H. van Gils, Mariëtte Lokate, N. Charlotte Onland-Moret, and Petra H.M. Peeters, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A5"><bold>EPIC-Norfolk I and II:</bold> Judith Brown, Jean Leyland, Jajini Varghese, Douglas F Easton, Deborah J Thompson, and Robert N Luben, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Ruth ML Warren, Department of Radiology, University of Cambridge, Addenbrooke’s NHS Foundation Trust Cambridge, UK; Nick J Wareham and Ruth JF Loos, MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK; K-T Khaw, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), University of Cambridge, Cambridge, UK</aff><aff id="A6"><bold>LIFE:</bold> Giske Ursin, Cancer Registry of Norway, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway, and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USA; Eunjung Lee, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USA</aff><aff id="A7"><bold>MARIBS:</bold> Deborah J Thompson, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Ruth ML Warren, Department of Radiology, University of Cambridge, Addenbrooke’s NHS Foundation Trust Cambridge, UK; Simon Gayther and Susan J Ramus, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; Rosalind Eeles, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK; Martin O Leach, and Gek Kwan-Lim, CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK, for the UK study of MRI screening for breast cancer in women at high risk (MARIBS)</aff><aff id="A8"><bold>MCBCS:</bold> Celine M. Vachon, Christopher G. Scott, V. Shane Pankratz, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA; Fergus J. Couch, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</aff><aff id="A9"><bold>MCCS:</bold> Graham G. Giles and Laura Baglietto, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia, and Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia; Kavitha Krishnan, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Melissa C. Southey, Department of Pathology, University of Melbourne, Melbourne, Australia</aff><aff id="A10"><bold>MEC:</bold> Loic Le Marchand, Laurence N Kolonel, Christy Woolcott, Gertraud Maskarinec, University of Hawaii Cancer Center, Honolulu, HI 96813, USA; Christopher Haiman, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA</aff><aff id="A11"><bold>MOG:</bold> Isabel dos-Santos-Silva and Kate Walker, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK; Nichola Johnson, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK; Valerie McCormack, Section of Environment and Radiation, International Agency for Research on Cancer, Lyon 69008, France</aff><aff id="A12"><bold>NBCS:</bold> Margarethe Biong, Grethe I.G. Alnæs, Vessela N. Kristensen, and Anne-Lise Børresen-Dale, Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway; Inger Torhild Gram, Institute of Community Medicine, Faculty of Health Sciences, University of Tromsø, Norway</aff><aff id="A13"><bold>NHS:</bold> Rulla M. Tamimi and Susan E Hankinson, Channing Laboratory, Brigham and Women’s Hospital, Boston, MA 02115, USA, and Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115; Sara Lindström and David J Hunter, Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA</aff><aff id="A14"><bold>OFBCR:</bold> Irene L. Andrulis, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Julia A. Knight, Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Norman F. Boyd, Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada</aff><aff id="A15"><bold>PBCS:</bold> Gretchen L. Gierach and Jonine D. Figueroa, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Jola Lissowska and Ewa Wesolowska, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</aff><aff id="A16"><bold>PNS:</bold> Beata Peplonska, Agnieszka Bukowska, MSc, Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland; Edyta Reszka, Department of Toxicology and Carcinogenesis Nofer Institute of Occupational Medicine, Lodz, Poland; Giske Ursin, Cancer Registry of Norway, Oslo, Norway and Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA 90089, USA</aff><aff id="A17"><bold>SASBAC:</bold> Jingmei Li, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden, and Human Genetics, Genome Institute of Singapore, Singapore; JianJun Liu, Human Genetics, Genome Institute of Singapore, Singapore; Louise Eriksson, Kamila Czene and Per Hall, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</aff><aff id="A18"><bold>SIBS:</bold> Jajini Varghese, Douglas F Easton, Deborah J Thompson, Tina Audley, Judith Brown and Jean Leyland, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Ruth ML Warren, Department of Radiology, University of Cambridge, Addenbrooke’s NHS Foundation Trust Cambridge, UK</aff><aff id="A19">Anna H. Wu, Professor of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089</aff></contrib-group><author-notes><corresp id="FN1">Corresponding Author: Celine M. Vachon, PhD, Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, <email>vachon@mayo.edu</email>, tel: 507-284-9977, fax: 507-266-2478; Isabel dos-Santos-Silva, MD, PhD, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK, <email>isabel.silva@lshtm.ac.uk</email>, tel: +44 (0)20 7927 2113, fax: +44 (0)20 7436 4230</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>2</month><year>2013</year></pub-date><volume>21</volume><issue>7</issue><fpage>1156</fpage><lpage>1166</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biological mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to inter-individual differences in mammographic density measures.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and non-dense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, body mass index (BMI) and menopausal status.</p></sec><sec id="S3"><title>Results</title><p id="P3">Consistent with their breast cancer associations, the C-allele of rs3817198 in <italic>LSP1</italic> was positively associated with both adjusted dense area (p=0.00005) and adjusted percent density (p=0.001) whereas the A-allele of rs10483813 in <italic>RAD51L1</italic> was inversely associated with adjusted percent density (p=0.003), but not with adjusted dense area (p=0.07).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">We identified two common breast cancer susceptibility variants associated with mammographic measures of radio-dense tissue in the breast gland.</p></sec><sec id="S5"><title>Impact</title><p id="P5">We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, <italic>LSP1</italic>-rs3817198 and <italic>RAD51L1</italic>-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association.</p></sec></abstract><kwd-group><kwd>breast density</kwd><kwd>breast cancer</kwd><kwd>genetics</kwd><kwd>biomarkers</kwd><kwd>mammography</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA113916 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA098233 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U01 CA069631 || CA</award-id></award-group><award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source><award-id>T32 ES013678 || ES</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R37 CA054281 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R25 CA090956 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA160565 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA132839 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA131332 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA128931 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA122340 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA085265 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA074847 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA063464 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA049449 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA116201 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA116201 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA089393 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA083638 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA087969 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA017054 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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