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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium</title><author><name sortKey="Warren, Helen" sort="Warren, Helen" uniqKey="Warren H" first="Helen" last="Warren">Helen Warren</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A5">Department of Pathology, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mahmoodi, Maryam" sort="Mahmoodi, Maryam" uniqKey="Mahmoodi M" first="Maryam" last="Mahmoodi">Maryam Mahmoodi</name><affiliation><nlm:aff id="A5">Department of Pathology, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A9">Department of Epidemiology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Braaf, Linda M" sort="Braaf, Linda M" uniqKey="Braaf L" first="Linda M." last="Braaf">Linda M. Braaf</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="A11">Warwick Medical School, Warwick University, Coventry, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A11">Warwick Medical School, Warwick University, Coventry, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation><nlm:aff id="A12">Department of Academic Support, The National Cancer Institute of Thailand, Ministry of Public Health, Nonthaburi</nlm:aff></affiliation></author><author><name sortKey="Wiangnon, Surapon" sort="Wiangnon, Surapon" uniqKey="Wiangnon S" first="Surapon" last="Wiangnon">Surapon Wiangnon</name><affiliation><nlm:aff id="A13">Department of Pediatrics, Medical School, Khon Kaen University, Khon Kaen, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A14">Department of Gynecology and Obstetrics, University Breast Center Franconia, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A14">Department of Gynecology and Obstetrics, University Breast Center Franconia, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A16">Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schulz Wendtland, Ruediger" sort="Schulz Wendtland, Ruediger" uniqKey="Schulz Wendtland R" first="Ruediger" last="Schulz-Wendtland">Ruediger Schulz-Wendtland</name><affiliation><nlm:aff id="A15">Institute of Diagnostic Radiology, University Hospital Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A3">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A17">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A18">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">National Center for Tumor Diseases, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">National Center for Tumor Diseases, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A26">INSERM, CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif</nlm:aff></affiliation><affiliation><nlm:aff id="A27">University Paris-Sud, UMRS1018, Villejuif</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A26">INSERM, CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif</nlm:aff></affiliation><affiliation><nlm:aff id="A27">University Paris-Sud, UMRS1018, Villejuif</nlm:aff></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:aff id="A28">Université Paris Descartes, INSERM UMR-S775 EPIGENETEC, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="A28">Université Paris Descartes, INSERM UMR-S775 EPIGENETEC, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A31">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A32">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A33">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="José-Ignacio" last="Arias-Pérez">José-Ignacio Arias-Pérez</name><affiliation><nlm:aff id="A34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A35">Servicio de Oncología Medica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A36">Department of Epidemiology, University of California Irvine, Irvine</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A36">Department of Epidemiology, University of California Irvine, Irvine</nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="A37">City of Hope, Duarte</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont, California</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Langheinz, Anne" sort="Langheinz, Anne" uniqKey="Langheinz A" first="Anne" last="Langheinz">Anne Langheinz</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A39">Division of Gynaecology and Obstetrics, Technical University of Munich, Munich</nlm:aff></affiliation></author><author><name sortKey="Golatta, Michael" sort="Golatta, Michael" uniqKey="Golatta M" first="Michael" last="Golatta">Michael Golatta</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="A25">Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A40">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A41">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A42">University of Tuebingen, Tuebingen</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A41">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A42">University of Tuebingen, Tuebingen</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A43">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A47">Department of Obstetrics and Gynecology, University of Ulm, Ulm</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation><nlm:aff id="A49">Clinics of Radiation Oncology (OE 8240), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A50">Clinics of Obstetrics and Gynaecology (OE 6410), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A51">Department of Obstetrics and Gynecology, Biomedicum Helsinki</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A51">Department of Obstetrics and Gynecology, Biomedicum Helsinki</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A52">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A53">Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Clinics of Radiation Oncology (OE 8240), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name><affiliation><nlm:aff id="A54">N.N. Aleksandrov Byelorussian Research Institute for Oncology and Medical Radiology</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuriy" sort="Rogov, Yuriy" uniqKey="Rogov Y" first="Yuriy" last="Rogov">Yuriy Rogov</name><affiliation><nlm:aff id="A55">Department of Pathology, Belarussian Medical Academy of Post-Graduate Education, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofyeva, Darya" sort="Prokofyeva, Darya" uniqKey="Prokofyeva D" first="Darya" last="Prokofyeva">Darya Prokofyeva</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Zinnatullina, Guzel" sort="Zinnatullina, Guzel" uniqKey="Zinnatullina G" first="Guzel" last="Zinnatullina">Guzel Zinnatullina</name><affiliation><nlm:aff id="A57">Oncological Clinic of the Republic Bashkortostan Ufa Russia, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A58">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A60">Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A63">Institute of Clinical Medicine, Oncology, University of Eastern Finland, Cancer Center of Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A65">Vesalius Research Center, VIB</nlm:aff></affiliation></author><author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A67">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Buck, Katharina" sort="Buck, Katharina" uniqKey="Buck K" first="Katharina" last="Buck">Katharina Buck</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A68">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A70">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A71">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Consortium for Genomics Technology (Cogentech), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A69">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A68">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A70">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A73">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A73">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet" sort="Olson, Janet" uniqKey="Olson J" first="Janet" last="Olson">Janet Olson</name><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Cariona A" sort="Mclean, Cariona A" uniqKey="Mclean C" first="Cariona A." last="Mclean">Cariona A. Mclean</name><affiliation><nlm:aff id="A8">The Alfred Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont, California</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A75">Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A76">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A76">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A77">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A78">Department of Surgery, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A79">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Molecular Genetics, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A79">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A81">Department of Laboratory Medicine and Pathobiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Weerasooriya, Nayana" sort="Weerasooriya, Nayana" uniqKey="Weerasooriya N" first="Nayana" last="Weerasooriya">Nayana Weerasooriya</name><affiliation><nlm:aff id="A84">Princess Margaret Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A85">Department of Human Genetics, Leiden University Medical Center, Leiden</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Department of Pathology, Leiden University Medical Center, Leiden</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A87">Department of Surgical Oncology, Leiden University Medical Center, Leiden</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="A88">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline M" sort="Seynaeve, Caroline M" uniqKey="Seynaeve C" first="Caroline M." last="Seynaeve">Caroline M. Seynaeve</name><affiliation><nlm:aff id="A89">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A88">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, Madeleine M A" sort="Tilanus Linthorst, Madeleine M A" uniqKey="Tilanus Linthorst M" first="Madeleine M. A." last="Tilanus-Linthorst">Madeleine M. A. Tilanus-Linthorst</name><affiliation><nlm:aff id="A91">Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A59">Department of Medical Biostatistics and Epidemiology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A59">Department of Medical Biostatistics and Epidemiology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A92">Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A92">Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A94">Department of Neuroscience, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona M" sort="Blows, Fiona M" uniqKey="Blows F" first="Fiona M." last="Blows">Fiona M. Blows</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet" sort="Humphreys, Manjeet" uniqKey="Humphreys M" first="Manjeet" last="Humphreys">Manjeet Humphreys</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22859399</idno><idno type="pmc">3772723</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772723</idno><idno type="RBID">PMC:3772723</idno><idno type="doi">10.1158/1055-9965.EPI-12-0526</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002090</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002090</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium</title><author><name sortKey="Warren, Helen" sort="Warren, Helen" uniqKey="Warren H" first="Helen" last="Warren">Helen Warren</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A5">Department of Pathology, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mahmoodi, Maryam" sort="Mahmoodi, Maryam" uniqKey="Mahmoodi M" first="Maryam" last="Mahmoodi">Maryam Mahmoodi</name><affiliation><nlm:aff id="A5">Department of Pathology, The University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A9">Department of Epidemiology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Braaf, Linda M" sort="Braaf, Linda M" uniqKey="Braaf L" first="Linda M." last="Braaf">Linda M. Braaf</name><affiliation><nlm:aff id="A10">Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth R" sort="Muir, Kenneth R" uniqKey="Muir K" first="Kenneth R." last="Muir">Kenneth R. Muir</name><affiliation><nlm:aff id="A11">Warwick Medical School, Warwick University, Coventry, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A11">Warwick Medical School, Warwick University, Coventry, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Chaiwerawattana, Arkom" sort="Chaiwerawattana, Arkom" uniqKey="Chaiwerawattana A" first="Arkom" last="Chaiwerawattana">Arkom Chaiwerawattana</name><affiliation><nlm:aff id="A12">Department of Academic Support, The National Cancer Institute of Thailand, Ministry of Public Health, Nonthaburi</nlm:aff></affiliation></author><author><name sortKey="Wiangnon, Surapon" sort="Wiangnon, Surapon" uniqKey="Wiangnon S" first="Surapon" last="Wiangnon">Surapon Wiangnon</name><affiliation><nlm:aff id="A13">Department of Pediatrics, Medical School, Khon Kaen University, Khon Kaen, Thailand</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A14">Department of Gynecology and Obstetrics, University Breast Center Franconia, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A14">Department of Gynecology and Obstetrics, University Breast Center Franconia, Germany</nlm:aff></affiliation></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><affiliation><nlm:aff id="A16">Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Schulz Wendtland, Ruediger" sort="Schulz Wendtland, Ruediger" uniqKey="Schulz Wendtland R" first="Ruediger" last="Schulz-Wendtland">Ruediger Schulz-Wendtland</name><affiliation><nlm:aff id="A15">Institute of Diagnostic Radiology, University Hospital Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A3">Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A17">Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael" sort="Kerin, Michael" uniqKey="Kerin M" first="Michael" last="Kerin">Michael Kerin</name><affiliation><nlm:aff id="A18">Clinical Science Institute, University Hospital Galway, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">National Center for Tumor Diseases, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">National Center for Tumor Diseases, University of Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A26">INSERM, CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif</nlm:aff></affiliation><affiliation><nlm:aff id="A27">University Paris-Sud, UMRS1018, Villejuif</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A26">INSERM, CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif</nlm:aff></affiliation><affiliation><nlm:aff id="A27">University Paris-Sud, UMRS1018, Villejuif</nlm:aff></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:aff id="A28">Université Paris Descartes, INSERM UMR-S775 EPIGENETEC, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Mulot, Claire" sort="Mulot, Claire" uniqKey="Mulot C" first="Claire" last="Mulot">Claire Mulot</name><affiliation><nlm:aff id="A28">Université Paris Descartes, INSERM UMR-S775 EPIGENETEC, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A31">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="A29">Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Faculty of Health Sciences, Copenhagen University Hospital, Denmark</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A32">Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="A33">Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</nlm:aff></affiliation></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="José-Ignacio" last="Arias-Pérez">José-Ignacio Arias-Pérez</name><affiliation><nlm:aff id="A34">Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A35">Servicio de Oncología Medica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A36">Department of Epidemiology, University of California Irvine, Irvine</nlm:aff></affiliation></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name><affiliation><nlm:aff id="A36">Department of Epidemiology, University of California Irvine, Irvine</nlm:aff></affiliation></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><affiliation><nlm:aff id="A37">City of Hope, Duarte</nlm:aff></affiliation></author><author><name sortKey="Dur, Christina Clarke" sort="Dur, Christina Clarke" uniqKey="Dur C" first="Christina Clarke" last="Dur">Christina Clarke Dur</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont, California</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Muller, Heiko" sort="Muller, Heiko" uniqKey="Muller H" first="Heiko" last="Müller">Heiko Müller</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Langheinz, Anne" sort="Langheinz, Anne" uniqKey="Langheinz A" first="Anne" last="Langheinz">Anne Langheinz</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A39">Division of Gynaecology and Obstetrics, Technical University of Munich, Munich</nlm:aff></affiliation></author><author><name sortKey="Golatta, Michael" sort="Golatta, Michael" uniqKey="Golatta M" first="Michael" last="Golatta">Michael Golatta</name><affiliation><nlm:aff id="A19">Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Bartram, Claus R" sort="Bartram, Claus R" uniqKey="Bartram C" first="Claus R." last="Bartram">Claus R. Bartram</name><affiliation><nlm:aff id="A25">Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A40">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A41">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A42">University of Tuebingen, Tuebingen</nlm:aff></affiliation></author><author><name sortKey="Justenhoven, Christina" sort="Justenhoven, Christina" uniqKey="Justenhoven C" first="Christina" last="Justenhoven">Christina Justenhoven</name><affiliation><nlm:aff id="A41">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</nlm:aff></affiliation><affiliation><nlm:aff id="A42">University of Tuebingen, Tuebingen</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="A43">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A47">Department of Obstetrics and Gynecology, University of Ulm, Ulm</nlm:aff></affiliation></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><affiliation><nlm:aff id="A49">Clinics of Radiation Oncology (OE 8240), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><affiliation><nlm:aff id="A50">Clinics of Obstetrics and Gynaecology (OE 6410), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A51">Department of Obstetrics and Gynecology, Biomedicum Helsinki</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A51">Department of Obstetrics and Gynecology, Biomedicum Helsinki</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A52">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A53">Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia" sort="Bogdanova, Natalia" uniqKey="Bogdanova N" first="Natalia" last="Bogdanova">Natalia Bogdanova</name><affiliation><nlm:aff id="A48">Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Clinics of Radiation Oncology (OE 8240), Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Antonenkova, Natalia" sort="Antonenkova, Natalia" uniqKey="Antonenkova N" first="Natalia" last="Antonenkova">Natalia Antonenkova</name><affiliation><nlm:aff id="A54">N.N. Aleksandrov Byelorussian Research Institute for Oncology and Medical Radiology</nlm:aff></affiliation></author><author><name sortKey="Rogov, Yuriy" sort="Rogov, Yuriy" uniqKey="Rogov Y" first="Yuriy" last="Rogov">Yuriy Rogov</name><affiliation><nlm:aff id="A55">Department of Pathology, Belarussian Medical Academy of Post-Graduate Education, Minsk, Belarus</nlm:aff></affiliation></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Prokofyeva, Darya" sort="Prokofyeva, Darya" uniqKey="Prokofyeva D" first="Darya" last="Prokofyeva">Darya Prokofyeva</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Zinnatullina, Guzel" sort="Zinnatullina, Guzel" uniqKey="Zinnatullina G" first="Guzel" last="Zinnatullina">Guzel Zinnatullina</name><affiliation><nlm:aff id="A57">Oncological Clinic of the Republic Bashkortostan Ufa Russia, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation><nlm:aff id="A56">Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A58">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A60">Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><affiliation><nlm:aff id="A61">Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><affiliation><nlm:aff id="A63">Institute of Clinical Medicine, Oncology, University of Eastern Finland, Cancer Center of Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="A65">Vesalius Research Center, VIB</nlm:aff></affiliation></author><author><name sortKey="Smeets, Ann" sort="Smeets, Ann" uniqKey="Smeets A" first="Ann" last="Smeets">Ann Smeets</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Paridaens, Robert" sort="Paridaens, Robert" uniqKey="Paridaens R" first="Robert" last="Paridaens">Robert Paridaens</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Weltens, Caroline" sort="Weltens, Caroline" uniqKey="Weltens C" first="Caroline" last="Weltens">Caroline Weltens</name><affiliation><nlm:aff id="A66">Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A67">Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Buck, Katharina" sort="Buck, Katharina" uniqKey="Buck K" first="Katharina" last="Buck">Katharina Buck</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Behrens, Sabine" sort="Behrens, Sabine" uniqKey="Behrens S" first="Sabine" last="Behrens">Sabine Behrens</name><affiliation><nlm:aff id="A22">Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A68">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A70">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><nlm:aff id="A71">Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Consortium for Genomics Technology (Cogentech), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A69">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A68">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A70">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A73">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A73">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet" sort="Olson, Janet" uniqKey="Olson J" first="Janet" last="Olson">Janet Olson</name><affiliation><nlm:aff id="A74">Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Mclean, Cariona A" sort="Mclean, Cariona A" uniqKey="Mclean C" first="Cariona A." last="Mclean">Cariona A. Mclean</name><affiliation><nlm:aff id="A8">The Alfred Hospital, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A4">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A38">Cancer Prevention Institute of California, Fremont, California</nlm:aff></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><nlm:aff id="A75">Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A76">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A76">Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu</nlm:aff></affiliation></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><affiliation><nlm:aff id="A77">Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><affiliation><nlm:aff id="A78">Department of Surgery, University of Oulu, Oulu University Hospital, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A79">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Molecular Genetics, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A79">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A81">Department of Laboratory Medicine and Pathobiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Weerasooriya, Nayana" sort="Weerasooriya, Nayana" uniqKey="Weerasooriya N" first="Nayana" last="Weerasooriya">Nayana Weerasooriya</name><affiliation><nlm:aff id="A84">Princess Margaret Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="A85">Department of Human Genetics, Leiden University Medical Center, Leiden</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Department of Pathology, Leiden University Medical Center, Leiden</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><affiliation><nlm:aff id="A87">Department of Surgical Oncology, Leiden University Medical Center, Leiden</nlm:aff></affiliation></author><author><name sortKey="Martens, John W M" sort="Martens, John W M" uniqKey="Martens J" first="John W. M." last="Martens">John W. M. Martens</name><affiliation><nlm:aff id="A88">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seynaeve, Caroline M" sort="Seynaeve, Caroline M" uniqKey="Seynaeve C" first="Caroline M." last="Seynaeve">Caroline M. Seynaeve</name><affiliation><nlm:aff id="A89">Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="A88">Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Jager, Agnes" sort="Jager, Agnes" uniqKey="Jager A" first="Agnes" last="Jager">Agnes Jager</name><affiliation><nlm:aff id="A90">Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tilanus Linthorst, Madeleine M A" sort="Tilanus Linthorst, Madeleine M A" uniqKey="Tilanus Linthorst M" first="Madeleine M. A." last="Tilanus-Linthorst">Madeleine M. A. Tilanus-Linthorst</name><affiliation><nlm:aff id="A91">Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A59">Department of Medical Biostatistics and Epidemiology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A59">Department of Medical Biostatistics and Epidemiology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A92">Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A92">Human Genetics, Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A94">Department of Neuroscience, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Brock, Ian W" sort="Brock, Ian W" uniqKey="Brock I" first="Ian W." last="Brock">Ian W. Brock</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><affiliation><nlm:aff id="A93">Department of Oncology, University of Sheffield, Shef-field</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Blows, Fiona M" sort="Blows, Fiona M" uniqKey="Blows F" first="Fiona M." last="Blows">Fiona M. Blows</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Ghoussaini, Maya" sort="Ghoussaini, Maya" uniqKey="Ghoussaini M" first="Maya" last="Ghoussaini">Maya Ghoussaini</name><affiliation><nlm:aff id="A95">Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation><nlm:aff id="A2">The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A97">Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Humphreys, Manjeet" sort="Humphreys, Manjeet" uniqKey="Humphreys M" first="Manjeet" last="Humphreys">Manjeet Humphreys</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A96">Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A1">Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).</p></sec><sec id="S2"><title>Methods</title><p id="P2">To further investigate the rs865686–breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case–control studies (48,394 cases, 50,836 controls).</p></sec><sec id="S3"><title>Results</title><p id="P3">This replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, <italic>P</italic> = 2.01 × 10<sup>–29</sup>] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; <italic>P</italic> for heterogeneity (<italic>P</italic><sub>het</sub>) = 1.3 × 10<sup>–143</sup>], but no evidence of ethnic differences in per allele OR (<italic>P</italic><sub>het</sub> = 0.43). rs865686 was associated with estrogen receptor–positive (ER<sup>+</sup>) disease (per G-allele OR, 0.89; 95% CI, 0.86–0.91; <italic>P</italic> = 3.13 × 10<sup>–22</sup>) but less strongly, if at all, with ER-negative (ER<sup>–</sup>) disease (OR, 0.98; 95% CI, 0.94–1.02; <italic>P</italic> = 0.26; <italic>P</italic><sub>het</sub> = 1.16 × 10<sup>–6</sup>), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the G allele with increasing age at diagnosis (<italic>P</italic> for linear trend = 0.0095), but only among women with ER<sup>+</sup> tumors.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This study is the first to show that rs865686 is a susceptibility marker for ER<sup>+</sup> breast cancer.</p></sec><sec id="S5"><title>Impact</title><p id="P5">The findings further support the view that genetic susceptibility varies according to tumor subtype.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22859399</article-id><article-id pub-id-type="pmc">3772723</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-12-0526</article-id><article-id pub-id-type="manuscript">NIHMS498621</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Warren</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dudbridge</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Apicella</surname><given-names>Carmel</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Mahmoodi</surname><given-names>Maryam</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Broeks</surname><given-names>Annegien</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Cornelissen</surname><given-names>Sten</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Braaf</surname><given-names>Linda M.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth R.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lophatananon</surname><given-names>Artitaya</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Chaiwerawattana</surname><given-names>Arkom</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Wiangnon</surname><given-names>Surapon</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Ekici</surname><given-names>Arif B.</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Schulz-Wendtland</surname><given-names>Ruediger</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kerin</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Schneeweiss</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Sohn</surname><given-names>Christof</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Laurent-Puig</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Mulot</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E</given-names></name><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Sune F.</given-names></name><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Nordestgaard</surname><given-names>Børge G</given-names></name><xref ref-type="aff" rid="A29">29</xref><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Arias-Pérez</surname><given-names>José-Ignacio</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M. Pilar</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Ziogas</surname><given-names>Argyrios</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Bernstein</surname><given-names>Leslie</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Dur</surname><given-names>Christina Clarke</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Heiko</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Langheinz</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Golatta</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Bartram</surname><given-names>Claus R.</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Justenhoven</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><collab>The GENICA Network</collab><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A41">41</xref><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A43">43</xref><xref ref-type="aff" rid="A44">44</xref><xref ref-type="aff" rid="A45">45</xref><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Eilber</surname><given-names>Ursula</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Schürmann</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Bremer</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Hillemanns</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Blomqvist</surname><given-names>Carl</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Antonenkova</surname><given-names>Natalia</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Rogov</surname><given-names>Yuriy</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Bermisheva</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Prokofyeva</surname><given-names>Darya</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Zinnatullina</surname><given-names>Guzel</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Khusnutdinova</surname><given-names>Elza</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Jaana M.</given-names></name><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Kataja</surname><given-names>Vesa</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><collab>kConFab Investigators</collab><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><collab>Australian Ovarian Cancer Study Group</collab><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Smeets</surname><given-names>Ann</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Paridaens</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Weltens</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Buck</surname><given-names>Katharina</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Behrens</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A68">68</xref><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Bernard</surname><given-names>Loris</given-names></name><xref ref-type="aff" rid="A71">71</xref><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A68">68</xref><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A73">73</xref><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Vachon</surname><given-names>Celine</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xianshu</given-names></name><xref ref-type="aff" rid="A73">73</xref><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet</given-names></name><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Cariona A.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M.</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Miron</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Jukkola-Vuorinen</surname><given-names>Arja</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Grip</surname><given-names>Mervi</given-names></name><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><xref ref-type="aff" rid="A81">81</xref><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Weerasooriya</surname><given-names>Nayana</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A85">85</xref><xref ref-type="aff" rid="A86">86</xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Robert A.E.M.</given-names></name><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Martens</surname><given-names>John W.M.</given-names></name><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Seynaeve</surname><given-names>Caroline M.</given-names></name><xref ref-type="aff" rid="A89">89</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje J.</given-names></name><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Hollestelle</surname><given-names>Antoinette</given-names></name><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Jager</surname><given-names>Agnes</given-names></name><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Tilanus-Linthorst</surname><given-names>Madeleine M.A.</given-names></name><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jianjun</given-names></name><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><name><surname>Brock</surname><given-names>Ian W.</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Reed</surname><given-names>Malcolm W.R.</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Blows</surname><given-names>Fiona M.</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Ghoussaini</surname><given-names>Maya</given-names></name><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Ashworth</surname><given-names>Alan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Humphreys</surname><given-names>Manjeet</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom</aff><aff id="A2"><label>2</label>The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</aff><aff id="A3"><label>3</label>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London, London, United Kingdom</aff><aff id="A4"><label>4</label>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Victoria, Australia</aff><aff id="A5"><label>5</label>Department of Pathology, The University of Melbourne, Victoria, Australia</aff><aff id="A6"><label>6</label>Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Research Division, Peter MacCallumCancer Center, Victoria, Australia</aff><aff id="A7"><label>7</label>Cancer Epidemiology Centre, Cancer Council Victoria, Victoria, Australia</aff><aff id="A8"><label>8</label>The Alfred Hospital, Melbourne, Victoria, Australia</aff><aff id="A9"><label>9</label>Department of Epidemiology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</aff><aff id="A10"><label>10</label>Department of Molecular Pathology, The Netherlands Cancer Institute - The Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</aff><aff id="A11"><label>11</label>Warwick Medical School, Warwick University, Coventry, United Kingdom</aff><aff id="A12"><label>12</label>Department of Academic Support, The National Cancer Institute of Thailand, Ministry of Public Health, Nonthaburi</aff><aff id="A13"><label>13</label>Department of Pediatrics, Medical School, Khon Kaen University, Khon Kaen, Thailand</aff><aff id="A14"><label>14</label>Department of Gynecology and Obstetrics, University Breast Center Franconia, Germany</aff><aff id="A15"><label>15</label>Institute of Diagnostic Radiology, University Hospital Erlangen, Germany</aff><aff id="A16"><label>16</label>Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A17"><label>17</label>Welcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</aff><aff id="A18"><label>18</label>Clinical Science Institute, University Hospital Galway, Galway, Ireland</aff><aff id="A19"><label>19</label>Department of Obstetrics and Gynecology, University Hospital Heidelberg, Germany</aff><aff id="A20"><label>20</label>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Germany</aff><aff id="A21"><label>21</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Germany</aff><aff id="A22"><label>22</label>Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Germany</aff><aff id="A23"><label>23</label>Division of Molecular Genetics of Breast Cancer, German Cancer Research Centre (DKFZ), Germany</aff><aff id="A24"><label>24</label>National Center for Tumor Diseases, University of Heidelberg, Germany</aff><aff id="A25"><label>25</label>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany</aff><aff id="A26"><label>26</label>INSERM, CESP Center for Research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif</aff><aff id="A27"><label>27</label>University Paris-Sud, UMRS1018, Villejuif</aff><aff id="A28"><label>28</label>Université Paris Descartes, INSERM UMR-S775 EPIGENETEC, Paris, France</aff><aff id="A29"><label>29</label>Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark</aff><aff id="A30"><label>30</label>Faculty of Health Sciences, Copenhagen University Hospital, Denmark</aff><aff id="A31"><label>31</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Denmark</aff><aff id="A32"><label>32</label>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</aff><aff id="A33"><label>33</label>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid</aff><aff id="A34"><label>34</label>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo</aff><aff id="A35"><label>35</label>Servicio de Oncología Medica, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A36"><label>36</label>Department of Epidemiology, University of California Irvine, Irvine</aff><aff id="A37"><label>37</label>City of Hope, Duarte</aff><aff id="A38"><label>38</label>Cancer Prevention Institute of California, Fremont, California</aff><aff id="A39"><label>39</label>Division of Gynaecology and Obstetrics, Technical University of Munich, Munich</aff><aff id="A40"><label>40</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne</aff><aff id="A41"><label>41</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</aff><aff id="A42"><label>42</label>University of Tuebingen, Tuebingen</aff><aff id="A43"><label>43</label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum</aff><aff id="A44"><label>44</label>Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Medical Faculty of the University of Bonn, Bonn</aff><aff id="A45"><label>45</label>Institute of Pathology, Medical Faculty of the University of Bonn, Bonn</aff><aff id="A46"><label>46</label>Institute and Outpatient Clinic of Occupational Medicine, Saarland University Medical Center, Saarland University Faculty of Medicine, Homburg</aff><aff id="A47"><label>47</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm</aff><aff id="A48"><label>48</label>Gynaecology Research Unit (OE 6411), Hannover Medical School, Hannover, Germany</aff><aff id="A49"><label>49</label>Clinics of Radiation Oncology (OE 8240), Hannover Medical School, Hannover, Germany</aff><aff id="A50"><label>50</label>Clinics of Obstetrics and Gynaecology (OE 6410), Hannover Medical School, Hannover, Germany</aff><aff id="A51"><label>51</label>Department of Obstetrics and Gynecology, Biomedicum Helsinki</aff><aff id="A52"><label>52</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A53"><label>53</label>Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A54"><label>54</label>N.N. Aleksandrov Byelorussian Research Institute for Oncology and Medical Radiology</aff><aff id="A55"><label>55</label>Department of Pathology, Belarussian Medical Academy of Post-Graduate Education, Minsk, Belarus</aff><aff id="A56"><label>56</label>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia</aff><aff id="A57"><label>57</label>Oncological Clinic of the Republic Bashkortostan Ufa Russia, Ufa, Russia</aff><aff id="A58"><label>58</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A59"><label>59</label>Department of Medical Biostatistics and Epidemiology, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A60"><label>60</label>Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A61"><label>61</label>Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland University of Eastern Finland, Kuopio, Finland</aff><aff id="A62"><label>62</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A63"><label>63</label>Institute of Clinical Medicine, Oncology, University of Eastern Finland, Cancer Center of Kuopio University Hospital, Kuopio, Finland</aff><aff id="A64"><label>64</label>Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia</aff><aff id="A65"><label>65</label>Vesalius Research Center, VIB</aff><aff id="A66"><label>66</label>Leuven Multidisciplinary Breast Center (LMBC), Gasthuisberg Hospitals, University of Leuven, Leuven, Belgium</aff><aff id="A67"><label>67</label>Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A68"><label>68</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A69"><label>69</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A70"><label>70</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A71"><label>71</label>Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A72"><label>72</label>Consortium for Genomics Technology (Cogentech), Milan, Italy</aff><aff id="A73"><label>73</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</aff><aff id="A74"><label>74</label>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</aff><aff id="A75"><label>75</label>Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts</aff><aff id="A76"><label>76</label>Laboratory of Cancer Genetics, Department of Clinical Genetics and Biocenter Oulu</aff><aff id="A77"><label>77</label>Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland</aff><aff id="A78"><label>78</label>Department of Surgery, University of Oulu, Oulu University Hospital, Oulu, Finland</aff><aff id="A79"><label>79</label>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada</aff><aff id="A80"><label>80</label>Department of Molecular Genetics, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</aff><aff id="A81"><label>81</label>Department of Laboratory Medicine and Pathobiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</aff><aff id="A82"><label>82</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</aff><aff id="A83"><label>83</label>Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Ontario, Canada</aff><aff id="A84"><label>84</label>Princess Margaret Hospital, Toronto, Ontario, Canada</aff><aff id="A85"><label>85</label>Department of Human Genetics, Leiden University Medical Center, Leiden</aff><aff id="A86"><label>86</label>Department of Pathology, Leiden University Medical Center, Leiden</aff><aff id="A87"><label>87</label>Department of Surgical Oncology, Leiden University Medical Center, Leiden</aff><aff id="A88"><label>88</label>Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A89"><label>89</label>Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</aff><aff id="A90"><label>90</label>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A91"><label>91</label>Department of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A92"><label>92</label>Human Genetics, Genome Institute of Singapore, Singapore</aff><aff id="A93"><label>93</label>Department of Oncology, University of Sheffield, Shef-field</aff><aff id="A94"><label>94</label>Department of Neuroscience, University of Sheffield, Shef-field</aff><aff id="A95"><label>95</label>Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</aff><aff id="A96"><label>96</label>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge</aff><aff id="A97"><label>97</label>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom</aff><author-notes><corresp id="CR1"><bold>Corresponding Author:</bold> Isabel dos Santos Silva, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom. Phone: 44-0-20-7927-2113; Fax: 44-0-20-7580-6897; <email>isabel.silva@lshtm.ac.uk</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>02</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2013</year></pub-date><volume>21</volume><issue>10</issue><fpage>1783</fpage><lpage>1791</lpage><permissions><copyright-statement>©2012 American Association for Cancer Research.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P1">Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).</p></sec><sec id="S2"><title>Methods</title><p id="P2">To further investigate the rs865686–breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case–control studies (48,394 cases, 50,836 controls).</p></sec><sec id="S3"><title>Results</title><p id="P3">This replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, <italic>P</italic> = 2.01 × 10<sup>–29</sup>] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; <italic>P</italic> for heterogeneity (<italic>P</italic><sub>het</sub>) = 1.3 × 10<sup>–143</sup>], but no evidence of ethnic differences in per allele OR (<italic>P</italic><sub>het</sub> = 0.43). rs865686 was associated with estrogen receptor–positive (ER<sup>+</sup>) disease (per G-allele OR, 0.89; 95% CI, 0.86–0.91; <italic>P</italic> = 3.13 × 10<sup>–22</sup>) but less strongly, if at all, with ER-negative (ER<sup>–</sup>) disease (OR, 0.98; 95% CI, 0.94–1.02; <italic>P</italic> = 0.26; <italic>P</italic><sub>het</sub> = 1.16 × 10<sup>–6</sup>), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the G allele with increasing age at diagnosis (<italic>P</italic> for linear trend = 0.0095), but only among women with ER<sup>+</sup> tumors.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This study is the first to show that rs865686 is a susceptibility marker for ER<sup>+</sup> breast cancer.</p></sec><sec id="S5"><title>Impact</title><p id="P5">The findings further support the view that genetic susceptibility varies according to tumor subtype.</p></sec></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA122340 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P50 CA116201 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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