AustralieFrV1, PascalFrancis, Curation, bibRecord, 001C80

Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice

Identifieur interne : 001C80 ( PascalFrancis/Curation ); précédent : 001C79; suivant : 001C81

Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice

Auteurs : J. L. Short [Australie] ; C. Ledent [Belgique] ; E. Borrelli [France] ; J. Drago [Australie] ; A. J. Lawrence [Australie]

Source :

Neuroscience [ 0306-4522 ] ; 2006.

RBID : Pascal:06-0244695

Descripteurs français

Pascal (Inist)
- Récepteur adénosinique, Récepteur dopaminergique, Récepteur biologique, Mutation, Dopamine, Récepteur dopaminergique D2, Récepteur dopaminergique D3, Récepteur adénosinique A2A, Protéine transport, Souris, Animal.

English descriptors

KwdEn :
- A2A adenosine receptor, Adenosine receptor, Animal, Biological receptor, Carrier protein, D2 Dopamine receptor, D3 Dopamine receptor, Dopamine, Dopamine receptor, Mouse, Mutation.

Abstract

Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D₂ receptor was elevated in the caudate putamen of D₁, D₃ and A_2A receptor knockout mice; this was mirrored by an increase in D₂ receptor protein in D₁ and D₃ receptor knockout mice, but not in A_2A knockout mice. Dopamine D₁ receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D₂ receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D₃ receptor knockout mice, but elevated in A_2A receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A_2A receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions.

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A14	`04`			`@1 Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg @2 Illkirch @3 FRA @Z 3 aut.`
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C03	`08`	`X`	`FRE`	`@0 Récepteur adénosinique A2A @5 08`
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Le document en format XML

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<front><div type="abstract" xml:lang="en">Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D<sub>2</sub>
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 receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D<sub>3</sub>
 receptor knockout mice, but elevated in A<sub>2A</sub>
 receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A<sub>2A</sub>
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 receptor was elevated in the caudate putamen of D<sub>1</sub>
, D<sub>3</sub>
 and A<sub>2A</sub>
 receptor knockout mice; this was mirrored by an increase in D<sub>2</sub>
 receptor protein in D<sub>1</sub>
 and D<sub>3</sub>
 receptor knockout mice, but not in A<sub>2A</sub>
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 receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D<sub>2</sub>
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</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Receptor adenosínico</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Récepteur dopaminergique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Dopamine receptor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Receptor dopaminérgico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Récepteur biologique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Biological receptor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Receptor biológico</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Mutation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Mutation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Mutación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Récepteur dopaminergique D2</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>D2 Dopamine receptor</s0>
<s5>06</s5>
<s6>«D2» Dopamine receptor</s6>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Receptor dopaminérgico D2</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Récepteur dopaminergique D3</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>D3 Dopamine receptor</s0>
<s5>07</s5>
<s6>«D3» Dopamine receptor</s6>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Receptor dopaminérgico D3</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Récepteur adénosinique A2A</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>A2A adenosine receptor</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Receptor adenosínico A2A</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Protéine transport</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Carrier protein</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Proteína transportador</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Souris</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Mouse</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Ratón</s0>
<s5>54</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>156</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |texte=   Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice

Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice

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