Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice
Identifieur interne : 004415 ( PascalFrancis/Corpus ); précédent : 004414; suivant : 004416Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice
Auteurs : J. L. Short ; C. Ledent ; E. Borrelli ; J. Drago ; A. J. LawrenceSource :
- Neuroscience [ 0306-4522 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D2 receptor was elevated in the caudate putamen of D1, D3 and A2A receptor knockout mice; this was mirrored by an increase in D2 receptor protein in D1 and D3 receptor knockout mice, but not in A2A knockout mice. Dopamine D1 receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D2 receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D3 receptor knockout mice, but elevated in A2A receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A2A receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 06-0244695 INIST |
---|---|
ET : | Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice |
AU : | SHORT (J. L.); LEDENT (C.); BORRELLI (E.); DRAGO (J.); LAWRENCE (A. J.) |
AF : | Department of Pharmacology, Faculty of Medicine, Monash University/Clayton, Victoria 3800/Australie (1 aut.); Department of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Monash University/Parkville, Victoria 3052/Australie (1 aut.); Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite de Bruxelles/Brussels/Belgique (2 aut.); Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg/Illkirch/France (3 aut.); Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade/Parkville, Victoria 3010/Australie (4 aut., 5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2006; Vol. 139; No. 2; Pp. 661-670; Bibl. 1 p.3/4 |
LA : | Anglais |
EA : | Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D2 receptor was elevated in the caudate putamen of D1, D3 and A2A receptor knockout mice; this was mirrored by an increase in D2 receptor protein in D1 and D3 receptor knockout mice, but not in A2A knockout mice. Dopamine D1 receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D2 receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D3 receptor knockout mice, but elevated in A2A receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A2A receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions. |
CC : | 002A25 |
FD : | Récepteur adénosinique; Récepteur dopaminergique; Récepteur biologique; Mutation; Dopamine; Récepteur dopaminergique D2; Récepteur dopaminergique D3; Récepteur adénosinique A2A; Protéine transport; Souris; Animal |
FG : | Catécholamine; Neurotransmetteur; Rodentia; Mammalia; Vertebrata |
ED : | Adenosine receptor; Dopamine receptor; Biological receptor; Mutation; Dopamine; D2 Dopamine receptor; D3 Dopamine receptor; A2A adenosine receptor; Carrier protein; Mouse; Animal |
EG : | Catecholamine; Neurotransmitter; Rodentia; Mammalia; Vertebrata |
SD : | Receptor adenosínico; Receptor dopaminérgico; Receptor biológico; Mutación; Dopamina; Receptor dopaminérgico D2; Receptor dopaminérgico D3; Receptor adenosínico A2A; Proteína transportador; Ratón; Animal |
LO : | INIST-17194.354000142741960200 |
ID : | 06-0244695 |
Links to Exploration step
Pascal:06-0244695Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice</title>
<author><name sortKey="Short, J L" sort="Short, J L" uniqKey="Short J" first="J. L." last="Short">J. L. Short</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pharmacology, Faculty of Medicine, Monash University</s1>
<s2>Clayton, Victoria 3800</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Monash University</s1>
<s2>Parkville, Victoria 3052</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ledent, C" sort="Ledent, C" uniqKey="Ledent C" first="C." last="Ledent">C. Ledent</name>
<affiliation><inist:fA14 i1="03"><s1>Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite de Bruxelles</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Borrelli, E" sort="Borrelli, E" uniqKey="Borrelli E" first="E." last="Borrelli">E. Borrelli</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg</s1>
<s2>Illkirch</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Drago, J" sort="Drago, J" uniqKey="Drago J" first="J." last="Drago">J. Drago</name>
<affiliation><inist:fA14 i1="05"><s1>Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade</s1>
<s2>Parkville, Victoria 3010</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lawrence, A J" sort="Lawrence, A J" uniqKey="Lawrence A" first="A. J." last="Lawrence">A. J. Lawrence</name>
<affiliation><inist:fA14 i1="05"><s1>Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade</s1>
<s2>Parkville, Victoria 3010</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0244695</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0244695 INIST</idno>
<idno type="RBID">Pascal:06-0244695</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">004415</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice</title>
<author><name sortKey="Short, J L" sort="Short, J L" uniqKey="Short J" first="J. L." last="Short">J. L. Short</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pharmacology, Faculty of Medicine, Monash University</s1>
<s2>Clayton, Victoria 3800</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Monash University</s1>
<s2>Parkville, Victoria 3052</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ledent, C" sort="Ledent, C" uniqKey="Ledent C" first="C." last="Ledent">C. Ledent</name>
<affiliation><inist:fA14 i1="03"><s1>Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite de Bruxelles</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Borrelli, E" sort="Borrelli, E" uniqKey="Borrelli E" first="E." last="Borrelli">E. Borrelli</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg</s1>
<s2>Illkirch</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Drago, J" sort="Drago, J" uniqKey="Drago J" first="J." last="Drago">J. Drago</name>
<affiliation><inist:fA14 i1="05"><s1>Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade</s1>
<s2>Parkville, Victoria 3010</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lawrence, A J" sort="Lawrence, A J" uniqKey="Lawrence A" first="A. J." last="Lawrence">A. J. Lawrence</name>
<affiliation><inist:fA14 i1="05"><s1>Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade</s1>
<s2>Parkville, Victoria 3010</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuroscience</title>
<title level="j" type="abbreviated">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuroscience</title>
<title level="j" type="abbreviated">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A2A adenosine receptor</term>
<term>Adenosine receptor</term>
<term>Animal</term>
<term>Biological receptor</term>
<term>Carrier protein</term>
<term>D2 Dopamine receptor</term>
<term>D3 Dopamine receptor</term>
<term>Dopamine</term>
<term>Dopamine receptor</term>
<term>Mouse</term>
<term>Mutation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Récepteur adénosinique</term>
<term>Récepteur dopaminergique</term>
<term>Récepteur biologique</term>
<term>Mutation</term>
<term>Dopamine</term>
<term>Récepteur dopaminergique D2</term>
<term>Récepteur dopaminergique D3</term>
<term>Récepteur adénosinique A2A</term>
<term>Protéine transport</term>
<term>Souris</term>
<term>Animal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D<sub>2</sub>
receptor was elevated in the caudate putamen of D<sub>1</sub>
, D<sub>3</sub>
and A<sub>2A</sub>
receptor knockout mice; this was mirrored by an increase in D<sub>2</sub>
receptor protein in D<sub>1</sub>
and D<sub>3</sub>
receptor knockout mice, but not in A<sub>2A</sub>
knockout mice. Dopamine D<sub>1</sub>
receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D<sub>2</sub>
receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D<sub>3</sub>
receptor knockout mice, but elevated in A<sub>2A</sub>
receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A<sub>2A</sub>
receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0306-4522</s0>
</fA01>
<fA02 i1="01"><s0>NRSCDN</s0>
</fA02>
<fA03 i2="1"><s0>Neuroscience</s0>
</fA03>
<fA05><s2>139</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>SHORT (J. L.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LEDENT (C.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BORRELLI (E.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>DRAGO (J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LAWRENCE (A. J.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pharmacology, Faculty of Medicine, Monash University</s1>
<s2>Clayton, Victoria 3800</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Monash University</s1>
<s2>Parkville, Victoria 3052</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite de Bruxelles</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg</s1>
<s2>Illkirch</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade</s1>
<s2>Parkville, Victoria 3010</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>661-670</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17194</s2>
<s5>354000142741960200</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1 p.3/4</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0244695</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuroscience</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D<sub>2</sub>
receptor was elevated in the caudate putamen of D<sub>1</sub>
, D<sub>3</sub>
and A<sub>2A</sub>
receptor knockout mice; this was mirrored by an increase in D<sub>2</sub>
receptor protein in D<sub>1</sub>
and D<sub>3</sub>
receptor knockout mice, but not in A<sub>2A</sub>
knockout mice. Dopamine D<sub>1</sub>
receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D<sub>2</sub>
receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D<sub>3</sub>
receptor knockout mice, but elevated in A<sub>2A</sub>
receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A<sub>2A</sub>
receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Récepteur adénosinique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Adenosine receptor</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Receptor adenosínico</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Récepteur dopaminergique</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Dopamine receptor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Receptor dopaminérgico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Récepteur biologique</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Biological receptor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Receptor biológico</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Mutation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Mutation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Mutación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Récepteur dopaminergique D2</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>D2 Dopamine receptor</s0>
<s5>06</s5>
<s6>«D2» Dopamine receptor</s6>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Receptor dopaminérgico D2</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Récepteur dopaminergique D3</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>D3 Dopamine receptor</s0>
<s5>07</s5>
<s6>«D3» Dopamine receptor</s6>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Receptor dopaminérgico D3</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Récepteur adénosinique A2A</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>A2A adenosine receptor</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Receptor adenosínico A2A</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Protéine transport</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Carrier protein</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Proteína transportador</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Souris</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Mouse</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Ratón</s0>
<s5>54</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>156</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0244695 INIST</NO>
<ET>Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice</ET>
<AU>SHORT (J. L.); LEDENT (C.); BORRELLI (E.); DRAGO (J.); LAWRENCE (A. J.)</AU>
<AF>Department of Pharmacology, Faculty of Medicine, Monash University/Clayton, Victoria 3800/Australie (1 aut.); Department of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Monash University/Parkville, Victoria 3052/Australie (1 aut.); Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite de Bruxelles/Brussels/Belgique (2 aut.); Department of Neurobiology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Universite de Strasbourg/Illkirch/France (3 aut.); Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade/Parkville, Victoria 3010/Australie (4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2006; Vol. 139; No. 2; Pp. 661-670; Bibl. 1 p.3/4</SO>
<LA>Anglais</LA>
<EA>Dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine receptors have been demonstrated to exhibit a parallel distribution on certain neuronal populations, and even when not directly co-localized, relationships (both antagonistic and synergistic) have been described. This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors. In situ hybridization histochemistry and autoradiography was used to examine the level of mRNA and protein expression of specific receptors and transporters in dopaminergic pathways. Expression of the mRNA encoding the dopamine D<sub>2</sub>
receptor was elevated in the caudate putamen of D<sub>1</sub>
, D<sub>3</sub>
and A<sub>2A</sub>
receptor knockout mice; this was mirrored by an increase in D<sub>2</sub>
receptor protein in D<sub>1</sub>
and D<sub>3</sub>
receptor knockout mice, but not in A<sub>2A</sub>
knockout mice. Dopamine D<sub>1</sub>
receptor binding was decreased in the caudate putamen, nucleus accumbens, olfactory tubercle and ventral pallidum of D<sub>2</sub>
receptor knockout mice. In substantia nigra pars compacta, dopamine transporter mRNA expression was dramatically decreased in D<sub>3</sub>
receptor knockout mice, but elevated in A<sub>2A</sub>
receptor knockout mice. All dopamine receptor knockout mice examined exhibited increased A<sub>2A</sub>
receptor binding in the caudate putamen, nucleus accumbens and olfactory tubercle. These data are consistent with the existence of functional interactions between dopaminergic and purinergic systems in these reward and motor-related brain regions.</EA>
<CC>002A25</CC>
<FD>Récepteur adénosinique; Récepteur dopaminergique; Récepteur biologique; Mutation; Dopamine; Récepteur dopaminergique D2; Récepteur dopaminergique D3; Récepteur adénosinique A2A; Protéine transport; Souris; Animal</FD>
<FG>Catécholamine; Neurotransmetteur; Rodentia; Mammalia; Vertebrata</FG>
<ED>Adenosine receptor; Dopamine receptor; Biological receptor; Mutation; Dopamine; D2 Dopamine receptor; D3 Dopamine receptor; A2A adenosine receptor; Carrier protein; Mouse; Animal</ED>
<EG>Catecholamine; Neurotransmitter; Rodentia; Mammalia; Vertebrata</EG>
<SD>Receptor adenosínico; Receptor dopaminérgico; Receptor biológico; Mutación; Dopamina; Receptor dopaminérgico D2; Receptor dopaminérgico D3; Receptor adenosínico A2A; Proteína transportador; Ratón; Animal</SD>
<LO>INIST-17194.354000142741960200</LO>
<ID>06-0244695</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004415 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 004415 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:06-0244695 |texte= Genetic interdependence of adenosine and dopamine receptors : Evidence from receptor knockout mice }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |