Biomarkers in kidney and heart disease
Identifieur interne : 001F84 ( PascalFrancis/Corpus ); précédent : 001F83; suivant : 001F85Biomarkers in kidney and heart disease
Auteurs : Alan S. Maisel ; Nevin Katz ; Hans L. Hillege ; Andrew Shaw ; Pierluigi Zanco ; Rinaldo Bellomo ; Inder Anand ; Stefan D. Anker ; Nadia Aspromonte ; Sean M. Bagshaw ; Tomas Berl ; Ilona Bobek ; Dinna N. Cruz ; Luciano Daliento ; Andrew Davenport ; Mikko Haapio ; Andrew A. House ; Sunil Mankad ; Peter Mccullough ; Alexandre Mebazaa ; Alberto Palazzuoli ; Piotr Ponikowski ; Federico Ronco ; Geoff Sheinfeld ; Sachin Soni ; Giorgio Vescovo ; Nereo Zamperetti ; Claudio RoncoSource :
- Nephrology, dialysis, transplantation : (Print) [ 0931-0509 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
| NO : | PASCAL 11-0118106 INIST |
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| ET : | Biomarkers in kidney and heart disease |
| AU : | MAISEL (Alan S.); KATZ (Nevin); HILLEGE (Hans L.); SHAW (Andrew); ZANCO (Pierluigi); BELLOMO (Rinaldo); ANAND (Inder); ANKER (Stefan D.); ASPROMONTE (Nadia); BAGSHAW (Sean M.); BERL (Tomas); BOBEK (Ilona); CRUZ (Dinna N.); DALIENTO (Luciano); DAVENPORT (Andrew); HAAPIO (Mikko); HOUSE (Andrew A.); MANKAD (Sunil); MCCULLOUGH (Peter); MEBAZAA (Alexandre); PALAZZUOLI (Alberto); PONIKOWSKI (Piotr); RONCO (Federico); SHEINFELD (Geoff); SONI (Sachin); VESCOVO (Giorgio); ZAMPERETTI (Nereo); RONCO (Claudio) |
| AF : | Department of Medicine and Cardiology, San Diego VA Medical Center and University of California/San Diego, CA/Etats-Unis (1 aut.); Department of Surgery, The George Washington University/Washington, DC/Etats-Unis (2 aut.); Trial Coordination Center, Department of Cardiology and Epidemiology, University Medical Center Groningen/Hanzeplein/Pays-Bas (3 aut.); Department of Anesthesiology, Duke University Medical Center/Durham, NC 27710/Etats-Unis (4 aut.); Department of Imaging and Nuclear Medicine, St Bortolo Hospital/Vicenza/Italie (5 aut.); Department of Intensive Care, Austin Hospital/Melbourne/Australie (6 aut., 11 aut.); Department of Nephrology St Bortolo Hospital/Vicenza/Italie (12 aut., 13 aut., 28 aut.); IRRIV, International Renal Research Institute of Vicenza/Vicenza/Italie (13 aut., 25 aut.); Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital/Royal Oak, MI/Etats-Unis (7 aut., 19 aut.); Department of Cardiology, Applied Cachexia Research, Charité, Campus Virchow-Klinikum/Berlin/Allemagne (8 aut.); Centre for Clinical and Basic Research, IRCCS San Raffaele/Rome/Italie (8 aut.); Department of Cardiology, St Spirito Hospital/Rome/Italie (9 aut.); Division of Critical Care Medicine, University of Alberta Hospital/Edmonton/Canada (10 aut.); Department of Cardiology, University of Padova/Padova/Italie (14 aut., 23 aut.); UCL Center for Nephrology, Royal Free and University College Medical School/London/Royaume-Uni (15 aut.); Division of Nephrology, Helsinki University Central Hospital/Helsinki/Finlande (16 aut.); Division of Nephrology, London Health Sciences Centre, University Hospital/London, ON/Canada (17 aut.); Department of Cardiology, Mayo Clinic/Rochester, MN/Etats-Unis (18 aut.); Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière, U 942 Inserm; University Paris 7, Paris Diderot/France (20 aut.); Department of Internal Medicine, University of Siena, Le Scotte Hospital/Siena/Italie (21 aut.); Cardiac Department, Faculty of Public Health, Medical University, Military Hospital/Wroclaw/Pologne (22 aut.); Department of Critical Care, University of Maryland/College Park, MD/Etats-Unis (24 aut.); Division of Nephrology, Mediciti Hospitals/Hyderabad/Inde (25 aut.); Department of Internal Medicine, San Bortolo Hospital/Vicenza/Italie (26 aut.); Department of Intensive Care, San Bortolo Hospital/Vicenza/Italie (27 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Nephrology, dialysis, transplantation : (Print); ISSN 0931-0509; Coden NDTREA; Royaume-Uni; Da. 2011; Vol. 26; No. 1; Pp. 62-74; Bibl. 97 ref. |
| LA : | Anglais |
| EA : | There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other. |
| CC : | 002B27B03; 002B14D01 |
| FD : | Pathologie du rein; Cardiopathie; Insuffisance cardiaque; Insuffisance rénale; Hémodialyse; Epuration extrarénale |
| FG : | Pathologie de l'appareil urinaire; Pathologie de l'appareil circulatoire |
| ED : | Kidney disease; Heart disease; Heart failure; Renal failure; Hemodialysis; Extrarenal dialysis |
| EG : | Urinary system disease; Cardiovascular disease |
| SD : | Riñón patología; Cardiopatía; Insuficiencia cardíaca; Insuficiencia renal; Hemodiálisis; Depuración extrarrenal |
| LO : | INIST-21215.354000193657180140 |
| ID : | 11-0118106 |
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Pascal:11-0118106Le document en format XML
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Anker</name><affiliation><inist:fA14 i1="10"><s1>Department of Cardiology, Applied Cachexia Research, Charité, Campus Virchow-Klinikum</s1><s2>Berlin</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="11"><s1>Centre for Clinical and Basic Research, IRCCS San Raffaele</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Aspromonte, Nadia" sort="Aspromonte, Nadia" uniqKey="Aspromonte N" first="Nadia" last="Aspromonte">Nadia Aspromonte</name><affiliation><inist:fA14 i1="12"><s1>Department of Cardiology, St Spirito Hospital</s1><s2>Rome</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bagshaw, Sean M" sort="Bagshaw, Sean M" uniqKey="Bagshaw S" first="Sean M." last="Bagshaw">Sean M. Bagshaw</name><affiliation><inist:fA14 i1="13"><s1>Division of Critical Care Medicine, University of Alberta Hospital</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berl, Tomas" sort="Berl, Tomas" uniqKey="Berl T" first="Tomas" last="Berl">Tomas Berl</name><affiliation><inist:fA14 i1="06"><s1>Department of Intensive Care, Austin Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bobek, Ilona" sort="Bobek, Ilona" uniqKey="Bobek I" first="Ilona" last="Bobek">Ilona Bobek</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cruz, Dinna N" sort="Cruz, Dinna N" uniqKey="Cruz D" first="Dinna N." last="Cruz">Dinna N. Cruz</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="08"><s1>IRRIV, International Renal Research Institute of Vicenza</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daliento, Luciano" sort="Daliento, Luciano" uniqKey="Daliento L" first="Luciano" last="Daliento">Luciano Daliento</name><affiliation><inist:fA14 i1="14"><s1>Department of Cardiology, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Davenport, Andrew" sort="Davenport, Andrew" uniqKey="Davenport A" first="Andrew" last="Davenport">Andrew Davenport</name><affiliation><inist:fA14 i1="15"><s1>UCL Center for Nephrology, Royal Free and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Haapio, Mikko" sort="Haapio, Mikko" uniqKey="Haapio M" first="Mikko" last="Haapio">Mikko Haapio</name><affiliation><inist:fA14 i1="16"><s1>Division of Nephrology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="House, Andrew A" sort="House, Andrew A" uniqKey="House A" first="Andrew A." last="House">Andrew A. House</name><affiliation><inist:fA14 i1="17"><s1>Division of Nephrology, London Health Sciences Centre, University Hospital</s1><s2>London, ON</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mankad, Sunil" sort="Mankad, Sunil" uniqKey="Mankad S" first="Sunil" last="Mankad">Sunil Mankad</name><affiliation><inist:fA14 i1="18"><s1>Department of Cardiology, Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mccullough, Peter" sort="Mccullough, Peter" uniqKey="Mccullough P" first="Peter" last="Mccullough">Peter Mccullough</name><affiliation><inist:fA14 i1="09"><s1>Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital</s1><s2>Royal Oak, MI</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mebazaa, Alexandre" sort="Mebazaa, Alexandre" uniqKey="Mebazaa A" first="Alexandre" last="Mebazaa">Alexandre Mebazaa</name><affiliation><inist:fA14 i1="19"><s1>Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière, U 942 Inserm; University Paris 7, Paris Diderot</s1><s3>FRA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Palazzuoli, Alberto" sort="Palazzuoli, Alberto" uniqKey="Palazzuoli A" first="Alberto" last="Palazzuoli">Alberto Palazzuoli</name><affiliation><inist:fA14 i1="20"><s1>Department of Internal Medicine, University of Siena, Le Scotte Hospital</s1><s2>Siena</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation><inist:fA14 i1="21"><s1>Cardiac Department, Faculty of Public Health, Medical University, Military Hospital</s1><s2>Wroclaw</s2><s3>POL</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ronco, Federico" sort="Ronco, Federico" uniqKey="Ronco F" first="Federico" last="Ronco">Federico Ronco</name><affiliation><inist:fA14 i1="14"><s1>Department of Cardiology, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sheinfeld, Geoff" sort="Sheinfeld, Geoff" uniqKey="Sheinfeld G" first="Geoff" last="Sheinfeld">Geoff Sheinfeld</name><affiliation><inist:fA14 i1="22"><s1>Department of Critical Care, University of Maryland</s1><s2>College Park, MD</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Soni, Sachin" sort="Soni, Sachin" uniqKey="Soni S" first="Sachin" last="Soni">Sachin Soni</name><affiliation><inist:fA14 i1="08"><s1>IRRIV, International Renal Research Institute of Vicenza</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="23"><s1>Division of Nephrology, Mediciti Hospitals</s1><s2>Hyderabad</s2><s3>IND</s3><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vescovo, Giorgio" sort="Vescovo, Giorgio" uniqKey="Vescovo G" first="Giorgio" last="Vescovo">Giorgio Vescovo</name><affiliation><inist:fA14 i1="24"><s1>Department of Internal Medicine, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zamperetti, Nereo" sort="Zamperetti, Nereo" uniqKey="Zamperetti N" first="Nereo" last="Zamperetti">Nereo Zamperetti</name><affiliation><inist:fA14 i1="25"><s1>Department of Intensive Care, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ronco, Claudio" sort="Ronco, Claudio" uniqKey="Ronco C" first="Claudio" last="Ronco">Claudio Ronco</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0118106</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0118106 INIST</idno><idno type="RBID">Pascal:11-0118106</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Biomarkers in kidney and heart disease</title><author><name sortKey="Maisel, Alan S" sort="Maisel, Alan S" uniqKey="Maisel A" first="Alan S." last="Maisel">Alan S. Maisel</name><affiliation><inist:fA14 i1="01"><s1>Department of Medicine and Cardiology, San Diego VA Medical Center and University of California</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Katz, Nevin" sort="Katz, Nevin" uniqKey="Katz N" first="Nevin" last="Katz">Nevin Katz</name><affiliation><inist:fA14 i1="02"><s1>Department of Surgery, The George Washington University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name><affiliation><inist:fA14 i1="03"><s1>Trial Coordination Center, Department of Cardiology and Epidemiology, University Medical Center Groningen</s1><s2>Hanzeplein</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Shaw, Andrew" sort="Shaw, Andrew" uniqKey="Shaw A" first="Andrew" last="Shaw">Andrew Shaw</name><affiliation><inist:fA14 i1="04"><s1>Department of Anesthesiology, Duke University Medical Center</s1><s2>Durham, NC 27710</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zanco, Pierluigi" sort="Zanco, Pierluigi" uniqKey="Zanco P" first="Pierluigi" last="Zanco">Pierluigi Zanco</name><affiliation><inist:fA14 i1="05"><s1>Department of Imaging and Nuclear Medicine, St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation><inist:fA14 i1="06"><s1>Department of Intensive Care, Austin Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Anand, Inder" sort="Anand, Inder" uniqKey="Anand I" first="Inder" last="Anand">Inder Anand</name><affiliation><inist:fA14 i1="09"><s1>Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital</s1><s2>Royal Oak, MI</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Anker, Stefan D" sort="Anker, Stefan D" uniqKey="Anker S" first="Stefan D." last="Anker">Stefan D. Anker</name><affiliation><inist:fA14 i1="10"><s1>Department of Cardiology, Applied Cachexia Research, Charité, Campus Virchow-Klinikum</s1><s2>Berlin</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="11"><s1>Centre for Clinical and Basic Research, IRCCS San Raffaele</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Aspromonte, Nadia" sort="Aspromonte, Nadia" uniqKey="Aspromonte N" first="Nadia" last="Aspromonte">Nadia Aspromonte</name><affiliation><inist:fA14 i1="12"><s1>Department of Cardiology, St Spirito Hospital</s1><s2>Rome</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bagshaw, Sean M" sort="Bagshaw, Sean M" uniqKey="Bagshaw S" first="Sean M." last="Bagshaw">Sean M. Bagshaw</name><affiliation><inist:fA14 i1="13"><s1>Division of Critical Care Medicine, University of Alberta Hospital</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berl, Tomas" sort="Berl, Tomas" uniqKey="Berl T" first="Tomas" last="Berl">Tomas Berl</name><affiliation><inist:fA14 i1="06"><s1>Department of Intensive Care, Austin Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bobek, Ilona" sort="Bobek, Ilona" uniqKey="Bobek I" first="Ilona" last="Bobek">Ilona Bobek</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cruz, Dinna N" sort="Cruz, Dinna N" uniqKey="Cruz D" first="Dinna N." last="Cruz">Dinna N. Cruz</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="08"><s1>IRRIV, International Renal Research Institute of Vicenza</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daliento, Luciano" sort="Daliento, Luciano" uniqKey="Daliento L" first="Luciano" last="Daliento">Luciano Daliento</name><affiliation><inist:fA14 i1="14"><s1>Department of Cardiology, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Davenport, Andrew" sort="Davenport, Andrew" uniqKey="Davenport A" first="Andrew" last="Davenport">Andrew Davenport</name><affiliation><inist:fA14 i1="15"><s1>UCL Center for Nephrology, Royal Free and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Haapio, Mikko" sort="Haapio, Mikko" uniqKey="Haapio M" first="Mikko" last="Haapio">Mikko Haapio</name><affiliation><inist:fA14 i1="16"><s1>Division of Nephrology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="House, Andrew A" sort="House, Andrew A" uniqKey="House A" first="Andrew A." last="House">Andrew A. House</name><affiliation><inist:fA14 i1="17"><s1>Division of Nephrology, London Health Sciences Centre, University Hospital</s1><s2>London, ON</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mankad, Sunil" sort="Mankad, Sunil" uniqKey="Mankad S" first="Sunil" last="Mankad">Sunil Mankad</name><affiliation><inist:fA14 i1="18"><s1>Department of Cardiology, Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mccullough, Peter" sort="Mccullough, Peter" uniqKey="Mccullough P" first="Peter" last="Mccullough">Peter Mccullough</name><affiliation><inist:fA14 i1="09"><s1>Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital</s1><s2>Royal Oak, MI</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mebazaa, Alexandre" sort="Mebazaa, Alexandre" uniqKey="Mebazaa A" first="Alexandre" last="Mebazaa">Alexandre Mebazaa</name><affiliation><inist:fA14 i1="19"><s1>Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière, U 942 Inserm; University Paris 7, Paris Diderot</s1><s3>FRA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Palazzuoli, Alberto" sort="Palazzuoli, Alberto" uniqKey="Palazzuoli A" first="Alberto" last="Palazzuoli">Alberto Palazzuoli</name><affiliation><inist:fA14 i1="20"><s1>Department of Internal Medicine, University of Siena, Le Scotte Hospital</s1><s2>Siena</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation><inist:fA14 i1="21"><s1>Cardiac Department, Faculty of Public Health, Medical University, Military Hospital</s1><s2>Wroclaw</s2><s3>POL</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ronco, Federico" sort="Ronco, Federico" uniqKey="Ronco F" first="Federico" last="Ronco">Federico Ronco</name><affiliation><inist:fA14 i1="14"><s1>Department of Cardiology, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sheinfeld, Geoff" sort="Sheinfeld, Geoff" uniqKey="Sheinfeld G" first="Geoff" last="Sheinfeld">Geoff Sheinfeld</name><affiliation><inist:fA14 i1="22"><s1>Department of Critical Care, University of Maryland</s1><s2>College Park, MD</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Soni, Sachin" sort="Soni, Sachin" uniqKey="Soni S" first="Sachin" last="Soni">Sachin Soni</name><affiliation><inist:fA14 i1="08"><s1>IRRIV, International Renal Research Institute of Vicenza</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="23"><s1>Division of Nephrology, Mediciti Hospitals</s1><s2>Hyderabad</s2><s3>IND</s3><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vescovo, Giorgio" sort="Vescovo, Giorgio" uniqKey="Vescovo G" first="Giorgio" last="Vescovo">Giorgio Vescovo</name><affiliation><inist:fA14 i1="24"><s1>Department of Internal Medicine, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zamperetti, Nereo" sort="Zamperetti, Nereo" uniqKey="Zamperetti N" first="Nereo" last="Zamperetti">Nereo Zamperetti</name><affiliation><inist:fA14 i1="25"><s1>Department of Intensive Care, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ronco, Claudio" sort="Ronco, Claudio" uniqKey="Ronco C" first="Claudio" last="Ronco">Claudio Ronco</name><affiliation><inist:fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Nephrology, dialysis, transplantation : (Print)</title><title level="j" type="abbreviated">Nephrol. dial. transplant. : (Print)</title><idno type="ISSN">0931-0509</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nephrology, dialysis, transplantation : (Print)</title><title level="j" type="abbreviated">Nephrol. dial. transplant. : (Print)</title><idno type="ISSN">0931-0509</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Extrarenal dialysis</term><term>Heart disease</term><term>Heart failure</term><term>Hemodialysis</term><term>Kidney disease</term><term>Renal failure</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du rein</term><term>Cardiopathie</term><term>Insuffisance cardiaque</term><term>Insuffisance rénale</term><term>Hémodialyse</term><term>Epuration extrarénale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0931-0509</s0></fA01><fA02 i1="01"><s0>NDTREA</s0></fA02><fA03 i2="1"><s0>Nephrol. dial. transplant. : (Print)</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Biomarkers in kidney and heart disease</s1></fA08><fA11 i1="01" i2="1"><s1>MAISEL (Alan S.)</s1></fA11><fA11 i1="02" i2="1"><s1>KATZ (Nevin)</s1></fA11><fA11 i1="03" i2="1"><s1>HILLEGE (Hans L.)</s1></fA11><fA11 i1="04" i2="1"><s1>SHAW (Andrew)</s1></fA11><fA11 i1="05" i2="1"><s1>ZANCO (Pierluigi)</s1></fA11><fA11 i1="06" i2="1"><s1>BELLOMO (Rinaldo)</s1></fA11><fA11 i1="07" i2="1"><s1>ANAND (Inder)</s1></fA11><fA11 i1="08" i2="1"><s1>ANKER (Stefan D.)</s1></fA11><fA11 i1="09" i2="1"><s1>ASPROMONTE (Nadia)</s1></fA11><fA11 i1="10" i2="1"><s1>BAGSHAW (Sean M.)</s1></fA11><fA11 i1="11" i2="1"><s1>BERL (Tomas)</s1></fA11><fA11 i1="12" i2="1"><s1>BOBEK (Ilona)</s1></fA11><fA11 i1="13" i2="1"><s1>CRUZ (Dinna N.)</s1></fA11><fA11 i1="14" i2="1"><s1>DALIENTO (Luciano)</s1></fA11><fA11 i1="15" i2="1"><s1>DAVENPORT (Andrew)</s1></fA11><fA11 i1="16" i2="1"><s1>HAAPIO (Mikko)</s1></fA11><fA11 i1="17" i2="1"><s1>HOUSE (Andrew A.)</s1></fA11><fA11 i1="18" i2="1"><s1>MANKAD (Sunil)</s1></fA11><fA11 i1="19" i2="1"><s1>MCCULLOUGH (Peter)</s1></fA11><fA11 i1="20" i2="1"><s1>MEBAZAA (Alexandre)</s1></fA11><fA11 i1="21" i2="1"><s1>PALAZZUOLI (Alberto)</s1></fA11><fA11 i1="22" i2="1"><s1>PONIKOWSKI (Piotr)</s1></fA11><fA11 i1="23" i2="1"><s1>RONCO (Federico)</s1></fA11><fA11 i1="24" i2="1"><s1>SHEINFELD (Geoff)</s1></fA11><fA11 i1="25" i2="1"><s1>SONI (Sachin)</s1></fA11><fA11 i1="26" i2="1"><s1>VESCOVO (Giorgio)</s1></fA11><fA11 i1="27" i2="1"><s1>ZAMPERETTI (Nereo)</s1></fA11><fA11 i1="28" i2="1"><s1>RONCO (Claudio)</s1></fA11><fA14 i1="01"><s1>Department of Medicine and Cardiology, San Diego VA Medical Center and University of California</s1><s2>San Diego, CA</s2><s3>USA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Surgery, The George Washington University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Trial Coordination Center, Department of Cardiology and Epidemiology, University Medical Center Groningen</s1><s2>Hanzeplein</s2><s3>NLD</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Anesthesiology, Duke University Medical Center</s1><s2>Durham, NC 27710</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Imaging and Nuclear Medicine, St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Intensive Care, Austin Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Nephrology St Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>28 aut.</sZ></fA14><fA14 i1="08"><s1>IRRIV, International Renal Research Institute of Vicenza</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>13 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="09"><s1>Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital</s1><s2>Royal Oak, MI</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Cardiology, Applied Cachexia Research, Charité, Campus Virchow-Klinikum</s1><s2>Berlin</s2><s3>DEU</s3><sZ>8 aut.</sZ></fA14><fA14 i1="11"><s1>Centre for Clinical and Basic Research, IRCCS San Raffaele</s1><s2>Rome</s2><s3>ITA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Cardiology, St Spirito Hospital</s1><s2>Rome</s2><s3>ITA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="13"><s1>Division of Critical Care Medicine, University of Alberta Hospital</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>10 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Cardiology, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="15"><s1>UCL Center for Nephrology, Royal Free and University College Medical School</s1><s2>London</s2><s3>GBR</s3><sZ>15 aut.</sZ></fA14><fA14 i1="16"><s1>Division of Nephrology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>16 aut.</sZ></fA14><fA14 i1="17"><s1>Division of Nephrology, London Health Sciences Centre, University Hospital</s1><s2>London, ON</s2><s3>CAN</s3><sZ>17 aut.</sZ></fA14><fA14 i1="18"><s1>Department of Cardiology, Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="19"><s1>Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière, U 942 Inserm; University Paris 7, Paris Diderot</s1><s3>FRA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="20"><s1>Department of Internal Medicine, University of Siena, Le Scotte Hospital</s1><s2>Siena</s2><s3>ITA</s3><sZ>21 aut.</sZ></fA14><fA14 i1="21"><s1>Cardiac Department, Faculty of Public Health, Medical University, Military Hospital</s1><s2>Wroclaw</s2><s3>POL</s3><sZ>22 aut.</sZ></fA14><fA14 i1="22"><s1>Department of Critical Care, University of Maryland</s1><s2>College Park, MD</s2><s3>USA</s3><sZ>24 aut.</sZ></fA14><fA14 i1="23"><s1>Division of Nephrology, Mediciti Hospitals</s1><s2>Hyderabad</s2><s3>IND</s3><sZ>25 aut.</sZ></fA14><fA14 i1="24"><s1>Department of Internal Medicine, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>26 aut.</sZ></fA14><fA14 i1="25"><s1>Department of Intensive Care, San Bortolo Hospital</s1><s2>Vicenza</s2><s3>ITA</s3><sZ>27 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>Acute Dialysis Quality Initiative (ADQI) consensus group</s1><s3>INC</s3></fA17><fA20><s1>62-74</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>21215</s2><s5>354000193657180140</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>97 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0118106</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Nephrology, dialysis, transplantation : (Print)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.</s0></fC01><fC02 i1="01" i2="X"><s0>002B27B03</s0></fC02><fC02 i1="02" i2="X"><s0>002B14D01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Pathologie du rein</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Kidney disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Riñón patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Cardiopathie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Heart disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Cardiopatía</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Insuffisance cardiaque</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Heart failure</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Insuficiencia cardíaca</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Insuffisance rénale</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Renal failure</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Insuficiencia renal</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Hémodialyse</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Hemodialysis</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hemodiálisis</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Epuration extrarénale</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Extrarenal dialysis</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Depuración extrarrenal</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil urinaire</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Urinary system disease</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Aparato urinario patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>38</s5></fC07><fN21><s1>073</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0118106 INIST</NO><ET>Biomarkers in kidney and heart disease</ET><AU>MAISEL (Alan S.); KATZ (Nevin); HILLEGE (Hans L.); SHAW (Andrew); ZANCO (Pierluigi); BELLOMO (Rinaldo); ANAND (Inder); ANKER (Stefan D.); ASPROMONTE (Nadia); BAGSHAW (Sean M.); BERL (Tomas); BOBEK (Ilona); CRUZ (Dinna N.); DALIENTO (Luciano); DAVENPORT (Andrew); HAAPIO (Mikko); HOUSE (Andrew A.); MANKAD (Sunil); MCCULLOUGH (Peter); MEBAZAA (Alexandre); PALAZZUOLI (Alberto); PONIKOWSKI (Piotr); RONCO (Federico); SHEINFELD (Geoff); SONI (Sachin); VESCOVO (Giorgio); ZAMPERETTI (Nereo); RONCO (Claudio)</AU><AF>Department of Medicine and Cardiology, San Diego VA Medical Center and University of California/San Diego, CA/Etats-Unis (1 aut.); Department of Surgery, The George Washington University/Washington, DC/Etats-Unis (2 aut.); Trial Coordination Center, Department of Cardiology and Epidemiology, University Medical Center Groningen/Hanzeplein/Pays-Bas (3 aut.); Department of Anesthesiology, Duke University Medical Center/Durham, NC 27710/Etats-Unis (4 aut.); Department of Imaging and Nuclear Medicine, St Bortolo Hospital/Vicenza/Italie (5 aut.); Department of Intensive Care, Austin Hospital/Melbourne/Australie (6 aut., 11 aut.); Department of Nephrology St Bortolo Hospital/Vicenza/Italie (12 aut., 13 aut., 28 aut.); IRRIV, International Renal Research Institute of Vicenza/Vicenza/Italie (13 aut., 25 aut.); Division of Cardiology, Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital/Royal Oak, MI/Etats-Unis (7 aut., 19 aut.); Department of Cardiology, Applied Cachexia Research, Charité, Campus Virchow-Klinikum/Berlin/Allemagne (8 aut.); Centre for Clinical and Basic Research, IRCCS San Raffaele/Rome/Italie (8 aut.); Department of Cardiology, St Spirito Hospital/Rome/Italie (9 aut.); Division of Critical Care Medicine, University of Alberta Hospital/Edmonton/Canada (10 aut.); Department of Cardiology, University of Padova/Padova/Italie (14 aut., 23 aut.); UCL Center for Nephrology, Royal Free and University College Medical School/London/Royaume-Uni (15 aut.); Division of Nephrology, Helsinki University Central Hospital/Helsinki/Finlande (16 aut.); Division of Nephrology, London Health Sciences Centre, University Hospital/London, ON/Canada (17 aut.); Department of Cardiology, Mayo Clinic/Rochester, MN/Etats-Unis (18 aut.); Department of Anesthesiology and Critical Care Medicine, Hôpital Lariboisière, U 942 Inserm; University Paris 7, Paris Diderot/France (20 aut.); Department of Internal Medicine, University of Siena, Le Scotte Hospital/Siena/Italie (21 aut.); Cardiac Department, Faculty of Public Health, Medical University, Military Hospital/Wroclaw/Pologne (22 aut.); Department of Critical Care, University of Maryland/College Park, MD/Etats-Unis (24 aut.); Division of Nephrology, Mediciti Hospitals/Hyderabad/Inde (25 aut.); Department of Internal Medicine, San Bortolo Hospital/Vicenza/Italie (26 aut.); Department of Intensive Care, San Bortolo Hospital/Vicenza/Italie (27 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Nephrology, dialysis, transplantation : (Print); ISSN 0931-0509; Coden NDTREA; Royaume-Uni; Da. 2011; Vol. 26; No. 1; Pp. 62-74; Bibl. 97 ref.</SO><LA>Anglais</LA><EA>There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians' diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.</EA><CC>002B27B03; 002B14D01</CC><FD>Pathologie du rein; Cardiopathie; Insuffisance cardiaque; Insuffisance rénale; Hémodialyse; Epuration extrarénale</FD><FG>Pathologie de l'appareil urinaire; Pathologie de l'appareil circulatoire</FG><ED>Kidney disease; Heart disease; Heart failure; Renal failure; Hemodialysis; Extrarenal dialysis</ED><EG>Urinary system disease; Cardiovascular disease</EG><SD>Riñón patología; Cardiopatía; Insuficiencia cardíaca; Insuficiencia renal; Hemodiálisis; Depuración extrarrenal</SD><LO>INIST-21215.354000193657180140</LO><ID>11-0118106</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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