AustralieFrV1, PascalFrancis, Corpus, bibRecord, 001F85

Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep

Identifieur interne : 001F85 ( PascalFrancis/Corpus ); précédent : 001F84; suivant : 001F86

Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep

Auteurs : Rebecca E. Doyle ; Geoff N. Hinch ; Andrew D. Fisher ; Alain Boissy ; John M. Henshall ; Caroline Lee

Source :

Psychoneuroendocrinology [ 0306-4530 ] ; 2011.

RBID : Pascal:11-0118030

Descripteurs français

Pascal (Inist)
- Sérotonine, Inhibiteur, Optimisme pessimisme, Biais cognitif, Jugement, Mouton, Affect affectivité, Bien être économique, Emotion émotivité, Animal.

English descriptors

KwdEn :
- Affect affectivity, Animal, Cognitive bias, Emotion emotionality, Inhibitor, Judgment, Optimism pessimism, Serotonin, Sheep, Welfare.

Abstract

Judgement bias has potential as a measure of affective state in animals. The serotonergic system may be one mechanism involved with the formation of negative judgement biases. It was hypothesised that depletion of brain serotonin would induce negative judgement biases in sheep. A dose response trial established that 40 mg/kg of p-Chlorophenylalanine (pCPA) administered to sheep for 3 days did not affect feeding motivation or locomotion required for testing judgement biases. Thirty Merino ewes (10 months old) were trained to an operant task for 3 weeks. Sheep learnt to approach a bucket when it was placed in one corner of the testing facility to receive a feed reward (go response), and not approach it when in the alternate corner (no-go response) to avoid a negative reinforcer (exposure to a dog). Following training, 15 sheep were treated with pCPA (40 mg/kg daily) for an extended duration (5 days). Treated and control sheep were tested for judgement bias following 3 and 5 days of treatment, and again 5 days after cessation of treatment. Testing involved the bucket being presented in ambiguous locations between the two learnt locations, and the response of the sheep (go/no-go) measured their judgement of the bucket locations. Following 5 days of treatment, pCPA-treated sheep approached the most positive ambiguous location significantly less than control sheep, suggesting a pessimistic-like bias (treatment x bucket location interaction F_1,124.6 = 49.97, p = 0.011). A trend towards a significant interaction was still evident 5 days after the cessation of pCPA treatment (p = 0.068), however no significant interaction was seen on day 3 of testing (p = 0.867). These results support the suggestion that judgement bias is a cognitive measure of affective state, and that the serotonergic pathway may be involved.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 HINCH (Geoff N.)`
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A14	`03`			`@1 Faculty of Veterinary Science and Animal Welfare Science Centre, University of Melbourne @2 Victoria 3010 @3 AUS @Z 3 aut.`
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C03	`01`	`X`	`SPA`	`@0 Serotonina @2 NK @2 FR @5 01`
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C03	`02`	`X`	`ENG`	`@0 Inhibitor @5 02`
C03	`02`	`X`	`SPA`	`@0 Inhibidor @5 02`
C03	`03`	`X`	`FRE`	`@0 Optimisme pessimisme @5 03`
C03	`03`	`X`	`ENG`	`@0 Optimism pessimism @5 03`
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C03	`10`	`X`	`FRE`	`@0 Animal @5 18`
C03	`10`	`X`	`ENG`	`@0 Animal @5 18`
C03	`10`	`X`	`SPA`	`@0 Animal @5 18`
C07	`01`	`X`	`FRE`	`@0 Artiodactyla @2 NS`
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C07	`02`	`X`	`SPA`	`@0 Ungulata @2 NS`
C07	`03`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Vertebrata @2 NS`
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C07	`05`	`X`	`FRE`	`@0 Neurotransmetteur @5 37`
C07	`05`	`X`	`ENG`	`@0 Neurotransmitter @5 37`
C07	`05`	`X`	`SPA`	`@0 Neurotransmisor @5 37`
N21				`@1 073`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 11-0118030 INIST
ET :	Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep
AU :	DOYLE (Rebecca E.); HINCH (Geoff N.); FISHER (Andrew D.); BOISSY (Alain); HENSHALL (John M.); LEE (Caroline)
AF :	CSIRO Livestock Industries, Locked Bag 1/Armidale, NSW 2350/Australie (1 aut., 5 aut., 6 aut.); School of Environment and Rural Science, University of New England/Armidale, NSW 2351/Australie (1 aut., 2 aut.); Faculty of Veterinary Science and Animal Welfare Science Centre, University of Melbourne/Victoria 3010/Australie (3 aut.); INRA, UR1213 Herbivores/63122 St-Genès-Champanelle/France (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Psychoneuroendocrinology; ISSN 0306-4530; Coden PSYCDE; Royaume-Uni; Da. 2011; Vol. 36; No. 2; Pp. 279-288; Bibl. 1 p.1/4
LA :	Anglais
EA :	Judgement bias has potential as a measure of affective state in animals. The serotonergic system may be one mechanism involved with the formation of negative judgement biases. It was hypothesised that depletion of brain serotonin would induce negative judgement biases in sheep. A dose response trial established that 40 mg/kg of p-Chlorophenylalanine (pCPA) administered to sheep for 3 days did not affect feeding motivation or locomotion required for testing judgement biases. Thirty Merino ewes (10 months old) were trained to an operant task for 3 weeks. Sheep learnt to approach a bucket when it was placed in one corner of the testing facility to receive a feed reward (go response), and not approach it when in the alternate corner (no-go response) to avoid a negative reinforcer (exposure to a dog). Following training, 15 sheep were treated with pCPA (40 mg/kg daily) for an extended duration (5 days). Treated and control sheep were tested for judgement bias following 3 and 5 days of treatment, and again 5 days after cessation of treatment. Testing involved the bucket being presented in ambiguous locations between the two learnt locations, and the response of the sheep (go/no-go) measured their judgement of the bucket locations. Following 5 days of treatment, pCPA-treated sheep approached the most positive ambiguous location significantly less than control sheep, suggesting a pessimistic-like bias (treatment x bucket location interaction F_1,124.6 = 49.97, p = 0.011). A trend towards a significant interaction was still evident 5 days after the cessation of pCPA treatment (p = 0.068), however no significant interaction was seen on day 3 of testing (p = 0.867). These results support the suggestion that judgement bias is a cognitive measure of affective state, and that the serotonergic pathway may be involved.
CC :	002A26C03
FD :	Sérotonine; Inhibiteur; Optimisme pessimisme; Biais cognitif; Jugement; Mouton; Affect affectivité; Bien être économique; Emotion émotivité; Animal
FG :	Artiodactyla; Ungulata; Mammalia; Vertebrata; Neurotransmetteur
ED :	Serotonin; Inhibitor; Optimism pessimism; Cognitive bias; Judgment; Sheep; Affect affectivity; Welfare; Emotion emotionality; Animal
EG :	Artiodactyla; Ungulata; Mammalia; Vertebrata; Neurotransmitter
SD :	Serotonina; Inhibidor; Optimismo pesimismo; Seggo cognitivo; Juicio; Carnero; Afecto afectividad; Bienestar económico; Emoción emotividad; Animal
LO :	INIST-17200.354000193658410140
ID :	11-0118030

Links to Exploration step

Pascal:11-0118030

Le document en format XML

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<term>Optimism pessimism</term>
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<front><div type="abstract" xml:lang="en">Judgement bias has potential as a measure of affective state in animals. The serotonergic system may be one mechanism involved with the formation of negative judgement biases. It was hypothesised that depletion of brain serotonin would induce negative judgement biases in sheep. A dose response trial established that 40 mg/kg of p-Chlorophenylalanine (pCPA) administered to sheep for 3 days did not affect feeding motivation or locomotion required for testing judgement biases. Thirty Merino ewes (10 months old) were trained to an operant task for 3 weeks. Sheep learnt to approach a bucket when it was placed in one corner of the testing facility to receive a feed reward (go response), and not approach it when in the alternate corner (no-go response) to avoid a negative reinforcer (exposure to a dog). Following training, 15 sheep were treated with pCPA (40 mg/kg daily) for an extended duration (5 days). Treated and control sheep were tested for judgement bias following 3 and 5 days of treatment, and again 5 days after cessation of treatment. Testing involved the bucket being presented in ambiguous locations between the two learnt locations, and the response of the sheep (go/no-go) measured their judgement of the bucket locations. Following 5 days of treatment, pCPA-treated sheep approached the most positive ambiguous location significantly less than control sheep, suggesting a pessimistic-like bias (treatment x bucket location interaction F<sub>1,124.6</sub>
 = 49.97, p = 0.011). A trend towards a significant interaction was still evident 5 days after the cessation of pCPA treatment (p = 0.068), however no significant interaction was seen on day 3 of testing (p = 0.867). These results support the suggestion that judgement bias is a cognitive measure of affective state, and that the serotonergic pathway may be involved.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep</s1>
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<fA11 i1="01" i2="1"><s1>DOYLE (Rebecca E.)</s1>
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<fA11 i1="02" i2="1"><s1>HINCH (Geoff N.)</s1>
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<fA11 i1="03" i2="1"><s1>FISHER (Andrew D.)</s1>
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<fA11 i1="05" i2="1"><s1>HENSHALL (John M.)</s1>
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<fA11 i1="06" i2="1"><s1>LEE (Caroline)</s1>
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<fA14 i1="01"><s1>CSIRO Livestock Industries, Locked Bag 1</s1>
<s2>Armidale, NSW 2350</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>School of Environment and Rural Science, University of New England</s1>
<s2>Armidale, NSW 2351</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Faculty of Veterinary Science and Animal Welfare Science Centre, University of Melbourne</s1>
<s2>Victoria 3010</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>INRA, UR1213 Herbivores</s1>
<s2>63122 St-Genès-Champanelle</s2>
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 = 49.97, p = 0.011). A trend towards a significant interaction was still evident 5 days after the cessation of pCPA treatment (p = 0.068), however no significant interaction was seen on day 3 of testing (p = 0.867). These results support the suggestion that judgement bias is a cognitive measure of affective state, and that the serotonergic pathway may be involved.</s0>
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<server><NO>PASCAL 11-0118030 INIST</NO>
<ET>Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep</ET>
<AU>DOYLE (Rebecca E.); HINCH (Geoff N.); FISHER (Andrew D.); BOISSY (Alain); HENSHALL (John M.); LEE (Caroline)</AU>
<AF>CSIRO Livestock Industries, Locked Bag 1/Armidale, NSW 2350/Australie (1 aut., 5 aut., 6 aut.); School of Environment and Rural Science, University of New England/Armidale, NSW 2351/Australie (1 aut., 2 aut.); Faculty of Veterinary Science and Animal Welfare Science Centre, University of Melbourne/Victoria 3010/Australie (3 aut.); INRA, UR1213 Herbivores/63122 St-Genès-Champanelle/France (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Psychoneuroendocrinology; ISSN 0306-4530; Coden PSYCDE; Royaume-Uni; Da. 2011; Vol. 36; No. 2; Pp. 279-288; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Judgement bias has potential as a measure of affective state in animals. The serotonergic system may be one mechanism involved with the formation of negative judgement biases. It was hypothesised that depletion of brain serotonin would induce negative judgement biases in sheep. A dose response trial established that 40 mg/kg of p-Chlorophenylalanine (pCPA) administered to sheep for 3 days did not affect feeding motivation or locomotion required for testing judgement biases. Thirty Merino ewes (10 months old) were trained to an operant task for 3 weeks. Sheep learnt to approach a bucket when it was placed in one corner of the testing facility to receive a feed reward (go response), and not approach it when in the alternate corner (no-go response) to avoid a negative reinforcer (exposure to a dog). Following training, 15 sheep were treated with pCPA (40 mg/kg daily) for an extended duration (5 days). Treated and control sheep were tested for judgement bias following 3 and 5 days of treatment, and again 5 days after cessation of treatment. Testing involved the bucket being presented in ambiguous locations between the two learnt locations, and the response of the sheep (go/no-go) measured their judgement of the bucket locations. Following 5 days of treatment, pCPA-treated sheep approached the most positive ambiguous location significantly less than control sheep, suggesting a pessimistic-like bias (treatment x bucket location interaction F<sub>1,124.6</sub>
 = 49.97, p = 0.011). A trend towards a significant interaction was still evident 5 days after the cessation of pCPA treatment (p = 0.068), however no significant interaction was seen on day 3 of testing (p = 0.867). These results support the suggestion that judgement bias is a cognitive measure of affective state, and that the serotonergic pathway may be involved.</EA>
<CC>002A26C03</CC>
<FD>Sérotonine; Inhibiteur; Optimisme pessimisme; Biais cognitif; Jugement; Mouton; Affect affectivité; Bien être économique; Emotion émotivité; Animal</FD>
<FG>Artiodactyla; Ungulata; Mammalia; Vertebrata; Neurotransmetteur</FG>
<ED>Serotonin; Inhibitor; Optimism pessimism; Cognitive bias; Judgment; Sheep; Affect affectivity; Welfare; Emotion emotionality; Animal</ED>
<EG>Artiodactyla; Ungulata; Mammalia; Vertebrata; Neurotransmitter</EG>
<SD>Serotonina; Inhibidor; Optimismo pesimismo; Seggo cognitivo; Juicio; Carnero; Afecto afectividad; Bienestar económico; Emoción emotividad; Animal</SD>
<LO>INIST-17200.354000193658410140</LO>
<ID>11-0118030</ID>
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Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep

Administration of serotonin inhibitor p-Chlorophenytalanine induces pessimistic-like judgement bias in sheep

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