Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
Identifieur interne : 002220 ( Ncbi/Merge ); précédent : 002219; suivant : 002221Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
Auteurs : Rolf Altenburger [Allemagne] ; Selim Ait-Aissa [France] ; Philipp Antczak [Royaume-Uni] ; Thomas Backhaus [Suède] ; Damià Barcel [Espagne] ; Thomas-Benjamin Seiler [Allemagne] ; Francois Brion [France] ; Wibke Busch [Allemagne] ; Kevin Chipman [Royaume-Uni] ; Miren L Pez De Alda [Espagne] ; Gisela De Aragão Umbuzeiro [Brésil] ; Beate I. Escher [Allemagne] ; Francesco Falciani [Royaume-Uni] ; Michael Faust [Allemagne] ; Andreas Focks [Pays-Bas] ; Klara Hilscherova [République tchèque] ; Juliane Hollender [Suisse] ; Henner Hollert [Allemagne] ; Felix J Ger [Allemagne] ; Annika Jahnke [Allemagne] ; Andreas Kortenkamp [Royaume-Uni] ; Martin Krauss [Allemagne] ; Gregory F. Lemkine [France] ; John Munthe [Suède] ; Steffen Neumann [Allemagne] ; Emma L. Schymanski [Suisse] ; Mark Scrimshaw [Royaume-Uni] ; Helmut Segner [Suisse] ; Jaroslav Slobodnik ; Foppe Smedes [République tchèque] ; Subramaniam Kughathas [Royaume-Uni] ; Ivana Teodorovic [Serbie] ; Andrew J. Tindall [France] ; Knut Erik Tollefsen [Norvège] ; Karl-Heinz Walz [Allemagne] ; Tim D. Williams [Royaume-Uni] ; Paul J. Van Den Brink [Pays-Bas] ; Jos Van Gils [Pays-Bas] ; Branislav Vrana [République tchèque] ; Xiaowei Zhang [République populaire de Chine] ; Werner Brack [Allemagne]Source :
- The Science of the total environment [ 1879-1026 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Water Pollutants, Chemical.
- methods : Conservation of Natural Resources, Environmental Monitoring.
- standards : Water Quality.
- statistics & numerical data : Water Resources.
Abstract
Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.
DOI: 10.1016/j.scitotenv.2014.12.057
PubMed: 25644849
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<author><name sortKey="Falciani, Francesco" sort="Falciani, Francesco" uniqKey="Falciani F" first="Francesco" last="Falciani">Francesco Falciani</name>
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<author><name sortKey="Faust, Michael" sort="Faust, Michael" uniqKey="Faust M" first="Michael" last="Faust">Michael Faust</name>
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<author><name sortKey="Hilscherova, Klara" sort="Hilscherova, Klara" uniqKey="Hilscherova K" first="Klara" last="Hilscherova">Klara Hilscherova</name>
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<author><name sortKey="Hollender, Juliane" sort="Hollender, Juliane" uniqKey="Hollender J" first="Juliane" last="Hollender">Juliane Hollender</name>
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<author><name sortKey="Hollert, Henner" sort="Hollert, Henner" uniqKey="Hollert H" first="Henner" last="Hollert">Henner Hollert</name>
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<author><name sortKey="J Ger, Felix" sort="J Ger, Felix" uniqKey="J Ger F" first="Felix" last="J Ger">Felix J Ger</name>
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<author><name sortKey="Jahnke, Annika" sort="Jahnke, Annika" uniqKey="Jahnke A" first="Annika" last="Jahnke">Annika Jahnke</name>
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<author><name sortKey="Krauss, Martin" sort="Krauss, Martin" uniqKey="Krauss M" first="Martin" last="Krauss">Martin Krauss</name>
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<author><name sortKey="Lemkine, Gregory F" sort="Lemkine, Gregory F" uniqKey="Lemkine G" first="Gregory F" last="Lemkine">Gregory F. Lemkine</name>
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<author><name sortKey="Munthe, John" sort="Munthe, John" uniqKey="Munthe J" first="John" last="Munthe">John Munthe</name>
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<author><name sortKey="Neumann, Steffen" sort="Neumann, Steffen" uniqKey="Neumann S" first="Steffen" last="Neumann">Steffen Neumann</name>
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<author><name sortKey="Schymanski, Emma L" sort="Schymanski, Emma L" uniqKey="Schymanski E" first="Emma L" last="Schymanski">Emma L. Schymanski</name>
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<author><name sortKey="Scrimshaw, Mark" sort="Scrimshaw, Mark" uniqKey="Scrimshaw M" first="Mark" last="Scrimshaw">Mark Scrimshaw</name>
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<author><name sortKey="Segner, Helmut" sort="Segner, Helmut" uniqKey="Segner H" first="Helmut" last="Segner">Helmut Segner</name>
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<author><name sortKey="Slobodnik, Jaroslav" sort="Slobodnik, Jaroslav" uniqKey="Slobodnik J" first="Jaroslav" last="Slobodnik">Jaroslav Slobodnik</name>
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<author><name sortKey="Smedes, Foppe" sort="Smedes, Foppe" uniqKey="Smedes F" first="Foppe" last="Smedes">Foppe Smedes</name>
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<author><name sortKey="Kughathas, Subramaniam" sort="Kughathas, Subramaniam" uniqKey="Kughathas S" first="Subramaniam" last="Kughathas">Subramaniam Kughathas</name>
<affiliation wicri:level="1"><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Teodorovic, Ivana" sort="Teodorovic, Ivana" uniqKey="Teodorovic I" first="Ivana" last="Teodorovic">Ivana Teodorovic</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
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<country xml:lang="fr">République tchèque</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.</title>
<author><name sortKey="Altenburger, Rolf" sort="Altenburger, Rolf" uniqKey="Altenburger R" first="Rolf" last="Altenburger">Rolf Altenburger</name>
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<country xml:lang="fr">Allemagne</country>
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</affiliation>
</author>
<author><name sortKey="Ait Aissa, Selim" sort="Ait Aissa, Selim" uniqKey="Ait Aissa S" first="Selim" last="Ait-Aissa">Selim Ait-Aissa</name>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB</wicri:regionArea>
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<author><name sortKey="Backhaus, Thomas" sort="Backhaus, Thomas" uniqKey="Backhaus T" first="Thomas" last="Backhaus">Thomas Backhaus</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg</wicri:regionArea>
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</author>
<author><name sortKey="Barcel, Damia" sort="Barcel, Damia" uniqKey="Barcel D" first="Damià" last="Barcel">Damià Barcel</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>RWTH Aachen University, Aachen</wicri:regionArea>
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<author><name sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="Francois" last="Brion">Francois Brion</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte</wicri:regionArea>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Chipman, Kevin" sort="Chipman, Kevin" uniqKey="Chipman K" first="Kevin" last="Chipman">Kevin Chipman</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biosciences, The University of Birmingham, Birmingham B15 2TT</wicri:regionArea>
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<author><name sortKey="De Alda, Miren L Pez" sort="De Alda, Miren L Pez" uniqKey="De Alda M" first="Miren L Pez" last="De Alda">Miren L Pez De Alda</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona</wicri:regionArea>
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<author><name sortKey="De Aragao Umbuzeiro, Gisela" sort="De Aragao Umbuzeiro, Gisela" uniqKey="De Aragao Umbuzeiro G" first="Gisela" last="De Aragão Umbuzeiro">Gisela De Aragão Umbuzeiro</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Campinas, Limeira, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>University of Campinas, Limeira</wicri:regionArea>
<wicri:noRegion>Limeira</wicri:noRegion>
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<author><name sortKey="Escher, Beate I" sort="Escher, Beate I" uniqKey="Escher B" first="Beate I" last="Escher">Beate I. Escher</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Faust, Michael" sort="Faust, Michael" uniqKey="Faust M" first="Michael" last="Faust">Michael Faust</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen</wicri:regionArea>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Focks, Andreas" sort="Focks, Andreas" uniqKey="Focks A" first="Andreas" last="Focks">Andreas Focks</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen</wicri:regionArea>
<wicri:noRegion>6700 AA Wageningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hilscherova, Klara" sort="Hilscherova, Klara" uniqKey="Hilscherova K" first="Klara" last="Hilscherova">Klara Hilscherova</name>
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<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Hollender, Juliane" sort="Hollender, Juliane" uniqKey="Hollender J" first="Juliane" last="Hollender">Juliane Hollender</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf</wicri:regionArea>
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</affiliation>
</author>
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<affiliation wicri:level="3"><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>RWTH Aachen University, Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
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<author><name sortKey="J Ger, Felix" sort="J Ger, Felix" uniqKey="J Ger F" first="Felix" last="J Ger">Felix J Ger</name>
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<wicri:regionArea>Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg</wicri:regionArea>
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</author>
<author><name sortKey="Jahnke, Annika" sort="Jahnke, Annika" uniqKey="Jahnke A" first="Annika" last="Jahnke">Annika Jahnke</name>
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<country xml:lang="fr">Allemagne</country>
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<placeName><region type="land" nuts="1">Saxe (Land)</region>
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<settlement type="city">Leipzig</settlement>
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</affiliation>
</author>
<author><name sortKey="Kortenkamp, Andreas" sort="Kortenkamp, Andreas" uniqKey="Kortenkamp A" first="Andreas" last="Kortenkamp">Andreas Kortenkamp</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Krauss, Martin" sort="Krauss, Martin" uniqKey="Krauss M" first="Martin" last="Krauss">Martin Krauss</name>
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<country xml:lang="fr">Allemagne</country>
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<placeName><region type="land" nuts="1">Saxe (Land)</region>
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</affiliation>
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<author><name sortKey="Lemkine, Gregory F" sort="Lemkine, Gregory F" uniqKey="Lemkine G" first="Gregory F" last="Lemkine">Gregory F. Lemkine</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry</wicri:regionArea>
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<author><name sortKey="Munthe, John" sort="Munthe, John" uniqKey="Munthe J" first="John" last="Munthe">John Munthe</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg</wicri:regionArea>
<wicri:noRegion>400 14 Göteborg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neumann, Steffen" sort="Neumann, Steffen" uniqKey="Neumann S" first="Steffen" last="Neumann">Steffen Neumann</name>
<affiliation wicri:level="1"><nlm:affiliation>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle</wicri:regionArea>
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<wicri:noRegion>06120 Halle</wicri:noRegion>
<wicri:noRegion>06120 Halle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schymanski, Emma L" sort="Schymanski, Emma L" uniqKey="Schymanski E" first="Emma L" last="Schymanski">Emma L. Schymanski</name>
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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Scrimshaw, Mark" sort="Scrimshaw, Mark" uniqKey="Scrimshaw M" first="Mark" last="Scrimshaw">Mark Scrimshaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:affiliation>University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.</nlm:affiliation>
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<author><name sortKey="Kughathas, Subramaniam" sort="Kughathas, Subramaniam" uniqKey="Kughathas S" first="Subramaniam" last="Kughathas">Subramaniam Kughathas</name>
<affiliation wicri:level="1"><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation>
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<wicri:regionArea>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH</wicri:regionArea>
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<author><name sortKey="Teodorovic, Ivana" sort="Teodorovic, Ivana" uniqKey="Teodorovic I" first="Ivana" last="Teodorovic">Ivana Teodorovic</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</nlm:affiliation>
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<wicri:regionArea>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad</wicri:regionArea>
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<author><name sortKey="Tindall, Andrew J" sort="Tindall, Andrew J" uniqKey="Tindall A" first="Andrew J" last="Tindall">Andrew J. Tindall</name>
<affiliation wicri:level="1"><nlm:affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry</wicri:regionArea>
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<author><name sortKey="Tollefsen, Knut Erik" sort="Tollefsen, Knut Erik" uniqKey="Tollefsen K" first="Knut Erik" last="Tollefsen">Knut Erik Tollefsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo</wicri:regionArea>
<wicri:noRegion>N-0349 Oslo</wicri:noRegion>
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</author>
<author><name sortKey="Walz, Karl Heinz" sort="Walz, Karl Heinz" uniqKey="Walz K" first="Karl-Heinz" last="Walz">Karl-Heinz Walz</name>
<affiliation wicri:level="1"><nlm:affiliation>MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen, Germany.</nlm:affiliation>
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<wicri:regionArea>MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen</wicri:regionArea>
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<wicri:noRegion>72414 Rangendingen</wicri:noRegion>
<wicri:noRegion>D-72414 Rangendingen</wicri:noRegion>
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<author><name sortKey="Williams, Tim D" sort="Williams, Tim D" uniqKey="Williams T" first="Tim D" last="Williams">Tim D. Williams</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biosciences, The University of Birmingham, Birmingham B15 2TT</wicri:regionArea>
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<author><name sortKey="Van Den Brink, Paul J" sort="Van Den Brink, Paul J" uniqKey="Van Den Brink P" first="Paul J" last="Van Den Brink">Paul J. Van Den Brink</name>
<affiliation wicri:level="1"><nlm:affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen</wicri:regionArea>
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<author><name sortKey="Van Gils, Jos" sort="Van Gils, Jos" uniqKey="Van Gils J" first="Jos" last="Van Gils">Jos Van Gils</name>
<affiliation wicri:level="1"><nlm:affiliation>Foundation Deltares, Potbus 177, 277 MH Delft, The Netherlands.</nlm:affiliation>
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<wicri:regionArea>Foundation Deltares, Potbus 177, 277 MH Delft</wicri:regionArea>
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<author><name sortKey="Vrana, Branislav" sort="Vrana, Branislav" uniqKey="Vrana B" first="Branislav" last="Vrana">Branislav Vrana</name>
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<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno</wicri:regionArea>
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<author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.</nlm:affiliation>
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<series><title level="j">The Science of the total environment</title>
<idno type="eISSN">1879-1026</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Water Quality (standards)</term>
<term>Water Resources (statistics & numerical data)</term>
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<term>Polluants chimiques de l'eau (analyse)</term>
<term>Qualité de l'eau (normes)</term>
<term>Ressources en eau ()</term>
<term>Surveillance de l'environnement ()</term>
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<term>Environmental Monitoring</term>
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<front><div type="abstract" xml:lang="en">Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25644849</PMID>
<DateCreated><Year>2015</Year>
<Month>02</Month>
<Day>23</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>08</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>08</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1026</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>512-513</Volume>
<PubDate><Year>2015</Year>
<Month>Apr</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Science of the total environment</Title>
<ISOAbbreviation>Sci. Total Environ.</ISOAbbreviation>
</Journal>
<ArticleTitle>Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.</ArticleTitle>
<Pagination><MedlinePgn>540-551</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0048-9697(14)01759-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.scitotenv.2014.12.057</ELocationID>
<Abstract><AbstractText>Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Altenburger</LastName>
<ForeName>Rolf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University, Aachen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ait-Aissa</LastName>
<ForeName>Selim</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Antczak</LastName>
<ForeName>Philipp</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Backhaus</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barceló</LastName>
<ForeName>Damià</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seiler</LastName>
<ForeName>Thomas-Benjamin</ForeName>
<Initials>TB</Initials>
<AffiliationInfo><Affiliation>RWTH Aachen University, Aachen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brion</LastName>
<ForeName>Francois</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Busch</LastName>
<ForeName>Wibke</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chipman</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Alda</LastName>
<ForeName>Miren López</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Aragão Umbuzeiro</LastName>
<ForeName>Gisela</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>University of Campinas, Limeira, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Escher</LastName>
<ForeName>Beate I</ForeName>
<Initials>BI</Initials>
<AffiliationInfo><Affiliation>National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Falciani</LastName>
<ForeName>Francesco</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Faust</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Focks</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hilscherova</LastName>
<ForeName>Klara</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hollender</LastName>
<ForeName>Juliane</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hollert</LastName>
<ForeName>Henner</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>RWTH Aachen University, Aachen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jäger</LastName>
<ForeName>Felix</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jahnke</LastName>
<ForeName>Annika</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kortenkamp</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krauss</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lemkine</LastName>
<ForeName>Gregory F</ForeName>
<Initials>GF</Initials>
<AffiliationInfo><Affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Munthe</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Neumann</LastName>
<ForeName>Steffen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schymanski</LastName>
<ForeName>Emma L</ForeName>
<Initials>EL</Initials>
<AffiliationInfo><Affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scrimshaw</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Segner</LastName>
<ForeName>Helmut</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slobodnik</LastName>
<ForeName>Jaroslav</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Environmental Institute, Okruzna 784/42, 97241 Kos, Slovak Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smedes</LastName>
<ForeName>Foppe</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kughathas</LastName>
<ForeName>Subramaniam</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Teodorovic</LastName>
<ForeName>Ivana</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tindall</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tollefsen</LastName>
<ForeName>Knut Erik</ForeName>
<Initials>KE</Initials>
<AffiliationInfo><Affiliation>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walz</LastName>
<ForeName>Karl-Heinz</ForeName>
<Initials>KH</Initials>
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<ForeName>Tim D</ForeName>
<Initials>TD</Initials>
<AffiliationInfo><Affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</Affiliation>
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<Initials>J</Initials>
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<Initials>B</Initials>
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<Initials>X</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.</Affiliation>
</AffiliationInfo>
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<Initials>W</Initials>
<AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation>
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<Month>01</Month>
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