Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
Identifieur interne : 002E55 ( PubMed/Corpus ); précédent : 002E54; suivant : 002E56Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
Auteurs : Rolf Altenburger ; Selim Ait-Aissa ; Philipp Antczak ; Thomas Backhaus ; Damià Barcel ; Thomas-Benjamin Seiler ; Francois Brion ; Wibke Busch ; Kevin Chipman ; Miren L Pez De Alda ; Gisela De Aragão Umbuzeiro ; Beate I. Escher ; Francesco Falciani ; Michael Faust ; Andreas Focks ; Klara Hilscherova ; Juliane Hollender ; Henner Hollert ; Felix J Ger ; Annika Jahnke ; Andreas Kortenkamp ; Martin Krauss ; Gregory F. Lemkine ; John Munthe ; Steffen Neumann ; Emma L. Schymanski ; Mark Scrimshaw ; Helmut Segner ; Jaroslav Slobodnik ; Foppe Smedes ; Subramaniam Kughathas ; Ivana Teodorovic ; Andrew J. Tindall ; Knut Erik Tollefsen ; Karl-Heinz Walz ; Tim D. Williams ; Paul J. Van Den Brink ; Jos Van Gils ; Branislav Vrana ; Xiaowei Zhang ; Werner BrackSource :
- The Science of the total environment [ 1879-1026 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Water Pollutants, Chemical.
- methods : Conservation of Natural Resources, Environmental Monitoring.
- standards : Water Quality.
- statistics & numerical data : Water Resources.
Abstract
Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.
DOI: 10.1016/j.scitotenv.2014.12.057
PubMed: 25644849
Links to Exploration step
pubmed:25644849Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.</title><author><name sortKey="Altenburger, Rolf" sort="Altenburger, Rolf" uniqKey="Altenburger R" first="Rolf" last="Altenburger">Rolf Altenburger</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ait Aissa, Selim" sort="Ait Aissa, Selim" uniqKey="Ait Aissa S" first="Selim" last="Ait-Aissa">Selim Ait-Aissa</name><affiliation><nlm:affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</nlm:affiliation></affiliation></author><author><name sortKey="Antczak, Philipp" sort="Antczak, Philipp" uniqKey="Antczak P" first="Philipp" last="Antczak">Philipp Antczak</name><affiliation><nlm:affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Backhaus, Thomas" sort="Backhaus, Thomas" uniqKey="Backhaus T" first="Thomas" last="Backhaus">Thomas Backhaus</name><affiliation><nlm:affiliation>Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Barcel, Damia" sort="Barcel, Damia" uniqKey="Barcel D" first="Damià" last="Barcel">Damià Barcel</name><affiliation><nlm:affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Seiler, Thomas Benjamin" sort="Seiler, Thomas Benjamin" uniqKey="Seiler T" first="Thomas-Benjamin" last="Seiler">Thomas-Benjamin Seiler</name><affiliation><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="Francois" last="Brion">Francois Brion</name><affiliation><nlm:affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</nlm:affiliation></affiliation></author><author><name sortKey="Busch, Wibke" sort="Busch, Wibke" uniqKey="Busch W" first="Wibke" last="Busch">Wibke Busch</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chipman, Kevin" sort="Chipman, Kevin" uniqKey="Chipman K" first="Kevin" last="Chipman">Kevin Chipman</name><affiliation><nlm:affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Alda, Miren L Pez" sort="De Alda, Miren L Pez" uniqKey="De Alda M" first="Miren L Pez" last="De Alda">Miren L Pez De Alda</name><affiliation><nlm:affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="De Aragao Umbuzeiro, Gisela" sort="De Aragao Umbuzeiro, Gisela" uniqKey="De Aragao Umbuzeiro G" first="Gisela" last="De Aragão Umbuzeiro">Gisela De Aragão Umbuzeiro</name><affiliation><nlm:affiliation>University of Campinas, Limeira, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Escher, Beate I" sort="Escher, Beate I" uniqKey="Escher B" first="Beate I" last="Escher">Beate I. Escher</name><affiliation><nlm:affiliation>National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Falciani, Francesco" sort="Falciani, Francesco" uniqKey="Falciani F" first="Francesco" last="Falciani">Francesco Falciani</name><affiliation><nlm:affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Faust, Michael" sort="Faust, Michael" uniqKey="Faust M" first="Michael" last="Faust">Michael Faust</name><affiliation><nlm:affiliation>Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Focks, Andreas" sort="Focks, Andreas" uniqKey="Focks A" first="Andreas" last="Focks">Andreas Focks</name><affiliation><nlm:affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hilscherova, Klara" sort="Hilscherova, Klara" uniqKey="Hilscherova K" first="Klara" last="Hilscherova">Klara Hilscherova</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Hollender, Juliane" sort="Hollender, Juliane" uniqKey="Hollender J" first="Juliane" last="Hollender">Juliane Hollender</name><affiliation><nlm:affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hollert, Henner" sort="Hollert, Henner" uniqKey="Hollert H" first="Henner" last="Hollert">Henner Hollert</name><affiliation><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="J Ger, Felix" sort="J Ger, Felix" uniqKey="J Ger F" first="Felix" last="J Ger">Felix J Ger</name><affiliation><nlm:affiliation>Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jahnke, Annika" sort="Jahnke, Annika" uniqKey="Jahnke A" first="Annika" last="Jahnke">Annika Jahnke</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kortenkamp, Andreas" sort="Kortenkamp, Andreas" uniqKey="Kortenkamp A" first="Andreas" last="Kortenkamp">Andreas Kortenkamp</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Martin" sort="Krauss, Martin" uniqKey="Krauss M" first="Martin" last="Krauss">Martin Krauss</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lemkine, Gregory F" sort="Lemkine, Gregory F" uniqKey="Lemkine G" first="Gregory F" last="Lemkine">Gregory F. Lemkine</name><affiliation><nlm:affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Munthe, John" sort="Munthe, John" uniqKey="Munthe J" first="John" last="Munthe">John Munthe</name><affiliation><nlm:affiliation>IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Neumann, Steffen" sort="Neumann, Steffen" uniqKey="Neumann S" first="Steffen" last="Neumann">Steffen Neumann</name><affiliation><nlm:affiliation>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schymanski, Emma L" sort="Schymanski, Emma L" uniqKey="Schymanski E" first="Emma L" last="Schymanski">Emma L. Schymanski</name><affiliation><nlm:affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Scrimshaw, Mark" sort="Scrimshaw, Mark" uniqKey="Scrimshaw M" first="Mark" last="Scrimshaw">Mark Scrimshaw</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Segner, Helmut" sort="Segner, Helmut" uniqKey="Segner H" first="Helmut" last="Segner">Helmut Segner</name><affiliation><nlm:affiliation>University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Slobodnik, Jaroslav" sort="Slobodnik, Jaroslav" uniqKey="Slobodnik J" first="Jaroslav" last="Slobodnik">Jaroslav Slobodnik</name><affiliation><nlm:affiliation>Environmental Institute, Okruzna 784/42, 97241 Kos, Slovak Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Smedes, Foppe" sort="Smedes, Foppe" uniqKey="Smedes F" first="Foppe" last="Smedes">Foppe Smedes</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Kughathas, Subramaniam" sort="Kughathas, Subramaniam" uniqKey="Kughathas S" first="Subramaniam" last="Kughathas">Subramaniam Kughathas</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Teodorovic, Ivana" sort="Teodorovic, Ivana" uniqKey="Teodorovic I" first="Ivana" last="Teodorovic">Ivana Teodorovic</name><affiliation><nlm:affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Tindall, Andrew J" sort="Tindall, Andrew J" uniqKey="Tindall A" first="Andrew J" last="Tindall">Andrew J. Tindall</name><affiliation><nlm:affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tollefsen, Knut Erik" sort="Tollefsen, Knut Erik" uniqKey="Tollefsen K" first="Knut Erik" last="Tollefsen">Knut Erik Tollefsen</name><affiliation><nlm:affiliation>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Walz, Karl Heinz" sort="Walz, Karl Heinz" uniqKey="Walz K" first="Karl-Heinz" last="Walz">Karl-Heinz Walz</name><affiliation><nlm:affiliation>MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, Tim D" sort="Williams, Tim D" uniqKey="Williams T" first="Tim D" last="Williams">Tim D. Williams</name><affiliation><nlm:affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Brink, Paul J" sort="Van Den Brink, Paul J" uniqKey="Van Den Brink P" first="Paul J" last="Van Den Brink">Paul J. Van Den Brink</name><affiliation><nlm:affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Gils, Jos" sort="Van Gils, Jos" uniqKey="Van Gils J" first="Jos" last="Van Gils">Jos Van Gils</name><affiliation><nlm:affiliation>Foundation Deltares, Potbus 177, 277 MH Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vrana, Branislav" sort="Vrana, Branislav" uniqKey="Vrana B" first="Branislav" last="Vrana">Branislav Vrana</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name><affiliation><nlm:affiliation>State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Brack, Werner" sort="Brack, Werner" uniqKey="Brack W" first="Werner" last="Brack">Werner Brack</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25644849</idno><idno type="pmid">25644849</idno><idno type="doi">10.1016/j.scitotenv.2014.12.057</idno><idno type="wicri:Area/PubMed/Corpus">002E55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.</title><author><name sortKey="Altenburger, Rolf" sort="Altenburger, Rolf" uniqKey="Altenburger R" first="Rolf" last="Altenburger">Rolf Altenburger</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ait Aissa, Selim" sort="Ait Aissa, Selim" uniqKey="Ait Aissa S" first="Selim" last="Ait-Aissa">Selim Ait-Aissa</name><affiliation><nlm:affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</nlm:affiliation></affiliation></author><author><name sortKey="Antczak, Philipp" sort="Antczak, Philipp" uniqKey="Antczak P" first="Philipp" last="Antczak">Philipp Antczak</name><affiliation><nlm:affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Backhaus, Thomas" sort="Backhaus, Thomas" uniqKey="Backhaus T" first="Thomas" last="Backhaus">Thomas Backhaus</name><affiliation><nlm:affiliation>Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Barcel, Damia" sort="Barcel, Damia" uniqKey="Barcel D" first="Damià" last="Barcel">Damià Barcel</name><affiliation><nlm:affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Seiler, Thomas Benjamin" sort="Seiler, Thomas Benjamin" uniqKey="Seiler T" first="Thomas-Benjamin" last="Seiler">Thomas-Benjamin Seiler</name><affiliation><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="Francois" last="Brion">Francois Brion</name><affiliation><nlm:affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</nlm:affiliation></affiliation></author><author><name sortKey="Busch, Wibke" sort="Busch, Wibke" uniqKey="Busch W" first="Wibke" last="Busch">Wibke Busch</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chipman, Kevin" sort="Chipman, Kevin" uniqKey="Chipman K" first="Kevin" last="Chipman">Kevin Chipman</name><affiliation><nlm:affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Alda, Miren L Pez" sort="De Alda, Miren L Pez" uniqKey="De Alda M" first="Miren L Pez" last="De Alda">Miren L Pez De Alda</name><affiliation><nlm:affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="De Aragao Umbuzeiro, Gisela" sort="De Aragao Umbuzeiro, Gisela" uniqKey="De Aragao Umbuzeiro G" first="Gisela" last="De Aragão Umbuzeiro">Gisela De Aragão Umbuzeiro</name><affiliation><nlm:affiliation>University of Campinas, Limeira, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Escher, Beate I" sort="Escher, Beate I" uniqKey="Escher B" first="Beate I" last="Escher">Beate I. Escher</name><affiliation><nlm:affiliation>National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Falciani, Francesco" sort="Falciani, Francesco" uniqKey="Falciani F" first="Francesco" last="Falciani">Francesco Falciani</name><affiliation><nlm:affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Faust, Michael" sort="Faust, Michael" uniqKey="Faust M" first="Michael" last="Faust">Michael Faust</name><affiliation><nlm:affiliation>Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Focks, Andreas" sort="Focks, Andreas" uniqKey="Focks A" first="Andreas" last="Focks">Andreas Focks</name><affiliation><nlm:affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hilscherova, Klara" sort="Hilscherova, Klara" uniqKey="Hilscherova K" first="Klara" last="Hilscherova">Klara Hilscherova</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Hollender, Juliane" sort="Hollender, Juliane" uniqKey="Hollender J" first="Juliane" last="Hollender">Juliane Hollender</name><affiliation><nlm:affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hollert, Henner" sort="Hollert, Henner" uniqKey="Hollert H" first="Henner" last="Hollert">Henner Hollert</name><affiliation><nlm:affiliation>RWTH Aachen University, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="J Ger, Felix" sort="J Ger, Felix" uniqKey="J Ger F" first="Felix" last="J Ger">Felix J Ger</name><affiliation><nlm:affiliation>Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jahnke, Annika" sort="Jahnke, Annika" uniqKey="Jahnke A" first="Annika" last="Jahnke">Annika Jahnke</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kortenkamp, Andreas" sort="Kortenkamp, Andreas" uniqKey="Kortenkamp A" first="Andreas" last="Kortenkamp">Andreas Kortenkamp</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Martin" sort="Krauss, Martin" uniqKey="Krauss M" first="Martin" last="Krauss">Martin Krauss</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lemkine, Gregory F" sort="Lemkine, Gregory F" uniqKey="Lemkine G" first="Gregory F" last="Lemkine">Gregory F. Lemkine</name><affiliation><nlm:affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Munthe, John" sort="Munthe, John" uniqKey="Munthe J" first="John" last="Munthe">John Munthe</name><affiliation><nlm:affiliation>IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Neumann, Steffen" sort="Neumann, Steffen" uniqKey="Neumann S" first="Steffen" last="Neumann">Steffen Neumann</name><affiliation><nlm:affiliation>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schymanski, Emma L" sort="Schymanski, Emma L" uniqKey="Schymanski E" first="Emma L" last="Schymanski">Emma L. Schymanski</name><affiliation><nlm:affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Scrimshaw, Mark" sort="Scrimshaw, Mark" uniqKey="Scrimshaw M" first="Mark" last="Scrimshaw">Mark Scrimshaw</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Segner, Helmut" sort="Segner, Helmut" uniqKey="Segner H" first="Helmut" last="Segner">Helmut Segner</name><affiliation><nlm:affiliation>University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Slobodnik, Jaroslav" sort="Slobodnik, Jaroslav" uniqKey="Slobodnik J" first="Jaroslav" last="Slobodnik">Jaroslav Slobodnik</name><affiliation><nlm:affiliation>Environmental Institute, Okruzna 784/42, 97241 Kos, Slovak Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Smedes, Foppe" sort="Smedes, Foppe" uniqKey="Smedes F" first="Foppe" last="Smedes">Foppe Smedes</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Kughathas, Subramaniam" sort="Kughathas, Subramaniam" uniqKey="Kughathas S" first="Subramaniam" last="Kughathas">Subramaniam Kughathas</name><affiliation><nlm:affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Teodorovic, Ivana" sort="Teodorovic, Ivana" uniqKey="Teodorovic I" first="Ivana" last="Teodorovic">Ivana Teodorovic</name><affiliation><nlm:affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Tindall, Andrew J" sort="Tindall, Andrew J" uniqKey="Tindall A" first="Andrew J" last="Tindall">Andrew J. Tindall</name><affiliation><nlm:affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tollefsen, Knut Erik" sort="Tollefsen, Knut Erik" uniqKey="Tollefsen K" first="Knut Erik" last="Tollefsen">Knut Erik Tollefsen</name><affiliation><nlm:affiliation>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Walz, Karl Heinz" sort="Walz, Karl Heinz" uniqKey="Walz K" first="Karl-Heinz" last="Walz">Karl-Heinz Walz</name><affiliation><nlm:affiliation>MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, Tim D" sort="Williams, Tim D" uniqKey="Williams T" first="Tim D" last="Williams">Tim D. Williams</name><affiliation><nlm:affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Brink, Paul J" sort="Van Den Brink, Paul J" uniqKey="Van Den Brink P" first="Paul J" last="Van Den Brink">Paul J. Van Den Brink</name><affiliation><nlm:affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Gils, Jos" sort="Van Gils, Jos" uniqKey="Van Gils J" first="Jos" last="Van Gils">Jos Van Gils</name><affiliation><nlm:affiliation>Foundation Deltares, Potbus 177, 277 MH Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vrana, Branislav" sort="Vrana, Branislav" uniqKey="Vrana B" first="Branislav" last="Vrana">Branislav Vrana</name><affiliation><nlm:affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name><affiliation><nlm:affiliation>State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Brack, Werner" sort="Brack, Werner" uniqKey="Brack W" first="Werner" last="Brack">Werner Brack</name><affiliation><nlm:affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Science of the total environment</title><idno type="eISSN">1879-1026</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Conservation of Natural Resources (methods)</term><term>Environmental Monitoring (methods)</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Quality (standards)</term><term>Water Resources (statistics & numerical data)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Conservation of Natural Resources</term><term>Environmental Monitoring</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Water Quality</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Water Resources</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25644849</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>23</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1026</ISSN><JournalIssue CitedMedium="Internet"><Volume>512-513</Volume><PubDate><Year>2015</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>The Science of the total environment</Title><ISOAbbreviation>Sci. Total Environ.</ISOAbbreviation></Journal><ArticleTitle>Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.</ArticleTitle><Pagination><MedlinePgn>540-551</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0048-9697(14)01759-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.scitotenv.2014.12.057</ELocationID><Abstract><AbstractText>Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Altenburger</LastName><ForeName>Rolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ait-Aissa</LastName><ForeName>Selim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antczak</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Backhaus</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barceló</LastName><ForeName>Damià</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seiler</LastName><ForeName>Thomas-Benjamin</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brion</LastName><ForeName>Francois</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Busch</LastName><ForeName>Wibke</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chipman</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Alda</LastName><ForeName>Miren López</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Aragão Umbuzeiro</LastName><ForeName>Gisela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of Campinas, Limeira, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Escher</LastName><ForeName>Beate I</ForeName><Initials>BI</Initials><AffiliationInfo><Affiliation>National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falciani</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faust</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Focks</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hilscherova</LastName><ForeName>Klara</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hollender</LastName><ForeName>Juliane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hollert</LastName><ForeName>Henner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>RWTH Aachen University, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jäger</LastName><ForeName>Felix</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahnke</LastName><ForeName>Annika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kortenkamp</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krauss</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemkine</LastName><ForeName>Gregory F</ForeName><Initials>GF</Initials><AffiliationInfo><Affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Munthe</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neumann</LastName><ForeName>Steffen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schymanski</LastName><ForeName>Emma L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scrimshaw</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segner</LastName><ForeName>Helmut</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slobodnik</LastName><ForeName>Jaroslav</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Environmental Institute, Okruzna 784/42, 97241 Kos, Slovak Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smedes</LastName><ForeName>Foppe</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kughathas</LastName><ForeName>Subramaniam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teodorovic</LastName><ForeName>Ivana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tindall</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tollefsen</LastName><ForeName>Knut Erik</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walz</LastName><ForeName>Karl-Heinz</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Tim D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van den Brink</LastName><ForeName>Paul J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Gils</LastName><ForeName>Jos</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Foundation Deltares, Potbus 177, 277 MH Delft, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vrana</LastName><ForeName>Branislav</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xiaowei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brack</LastName><ForeName>Werner</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Sci Total Environ</MedlineTA><NlmUniqueID>0330500</NlmUniqueID><ISSNLinking>0048-9697</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003247" MajorTopicYN="N">Conservation of Natural Resources</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004784" MajorTopicYN="N">Environmental Monitoring</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060753" MajorTopicYN="N">Water Quality</DescriptorName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062066" MajorTopicYN="N">Water Resources</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chemical status</Keyword><Keyword MajorTopicYN="N">Ecological status</Keyword><Keyword MajorTopicYN="N">Effect-based tools</Keyword><Keyword MajorTopicYN="N">Mixture toxicity</Keyword><Keyword MajorTopicYN="N">Priority chemicals</Keyword><Keyword MajorTopicYN="N">WFD</Keyword><Keyword MajorTopicYN="N">Water quality</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25644849</ArticleId><ArticleId IdType="pii">S0048-9697(14)01759-8</ArticleId><ArticleId IdType="doi">10.1016/j.scitotenv.2014.12.057</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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