Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
Identifieur interne : 001465 ( Ncbi/Curation ); précédent : 001464; suivant : 001466Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
Auteurs : Nuno Palha [France] ; Florence Guivel-Benhassine [France] ; Valérie Briolat [France] ; Georges Lutfalla [France] ; Marion Sourisseau [France] ; Felix Ellett [Australie] ; Chieh-Huei Wang [Australie] ; Graham J. Lieschke [Australie] ; Philippe Herbomel [France] ; Olivier Schwartz [France] ; Jean-Pierre Levraud [France]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2013.
Abstract
Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ∼14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the brain. As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes. Cell type specific ablation experiments further demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment. Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus.
Url:
DOI: 10.1371/journal.ppat.1003619
PubMed: 24039582
PubMed Central: 3764224
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Biology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Pierre et Marie Curie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Guivel Benhassine, Florence" sort="Guivel Benhassine, Florence" uniqKey="Guivel Benhassine F" first="Florence" last="Guivel-Benhassine">Florence Guivel-Benhassine</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Virus et Immunité, Department of Virology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>CNRS URA3015, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA3015, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Briolat, Valerie" sort="Briolat, Valerie" uniqKey="Briolat V" first="Valérie" last="Briolat">Valérie Briolat</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lutfalla, Georges" sort="Lutfalla, Georges" uniqKey="Lutfalla G" first="Georges" last="Lutfalla">Georges Lutfalla</name><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>CNRS UMR5235, Dynamiques des Interactions Membranaires et Pathologiques, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR5235, Dynamiques des Interactions Membranaires et Pathologiques, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff7"><addr-line>Université Montpellier II, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Montpellier II, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 2</orgName></affiliation></author><author><name sortKey="Sourisseau, Marion" sort="Sourisseau, Marion" uniqKey="Sourisseau M" first="Marion" last="Sourisseau">Marion Sourisseau</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Virus et Immunité, Department of Virology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>CNRS URA3015, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA3015, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ellett, Felix" sort="Ellett, Felix" uniqKey="Ellett F" first="Felix" last="Ellett">Felix Ellett</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Chieh Huei" sort="Wang, Chieh Huei" uniqKey="Wang C" first="Chieh-Huei" last="Wang">Chieh-Huei Wang</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Lieschke, Graham J" sort="Lieschke, Graham J" uniqKey="Lieschke G" first="Graham J." last="Lieschke">Graham J. Lieschke</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Herbomel, Philippe" sort="Herbomel, Philippe" uniqKey="Herbomel P" first="Philippe" last="Herbomel">Philippe Herbomel</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schwartz, Olivier" sort="Schwartz, Olivier" uniqKey="Schwartz O" first="Olivier" last="Schwartz">Olivier Schwartz</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Virus et Immunité, Department of Virology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>CNRS URA3015, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA3015, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levraud, Jean Pierre" sort="Levraud, Jean Pierre" uniqKey="Levraud J" first="Jean-Pierre" last="Levraud">Jean-Pierre Levraud</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ∼14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the brain. As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes. Cell type specific ablation experiments further demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment. Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Burt, Fj" uniqKey="Burt F">FJ Burt</name></author><author><name sortKey="Rolph, Ms" uniqKey="Rolph M">MS Rolph</name></author><author><name sortKey="Rulli, Ne" uniqKey="Rulli N">NE Rulli</name></author><author><name sortKey="Mahalingam, S" uniqKey="Mahalingam S">S Mahalingam</name></author><author><name sortKey="Heise, Mt" uniqKey="Heise M">MT Heise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuffenecker, I" uniqKey="Schuffenecker I">I Schuffenecker</name></author><author><name sortKey="Iteman, I" uniqKey="Iteman I">I Iteman</name></author><author><name sortKey="Michault, A" uniqKey="Michault A">A Michault</name></author><author><name sortKey="Murri, S" uniqKey="Murri S">S Murri</name></author><author><name sortKey="Frangeul, L" uniqKey="Frangeul L">L Frangeul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsetsarkin, K" uniqKey="Tsetsarkin K">K Tsetsarkin</name></author><author><name sortKey="Higgs, S" uniqKey="Higgs S">S Higgs</name></author><author><name sortKey="Mcgee, Ce" uniqKey="Mcgee C">CE McGee</name></author><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X De Lamballerie</name></author><author><name sortKey="Charrel, Rn" uniqKey="Charrel R">RN Charrel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name></author><author><name sortKey="Leroy, E" uniqKey="Leroy E">E Leroy</name></author><author><name sortKey="Charrel, Rn" uniqKey="Charrel R">RN Charrel</name></author><author><name sortKey="Ttsetsarkin, K" uniqKey="Ttsetsarkin K">K Ttsetsarkin</name></author><author><name sortKey="Higgs, S" uniqKey="Higgs S">S Higgs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsetsarkin, Ka" uniqKey="Tsetsarkin K">KA Tsetsarkin</name></author><author><name sortKey="Weaver, Sc" uniqKey="Weaver S">SC Weaver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medlock, Jm" uniqKey="Medlock J">JM Medlock</name></author><author><name sortKey="Hansford, Km" uniqKey="Hansford K">KM Hansford</name></author><author><name sortKey="Schaffner, F" uniqKey="Schaffner F">F Schaffner</name></author><author><name sortKey="Versteirt, V" uniqKey="Versteirt V">V Versteirt</name></author><author><name sortKey="Hendrickx, G" uniqKey="Hendrickx G">G Hendrickx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vega Rua, A" uniqKey="Vega Rua A">A Vega-Rua</name></author><author><name sortKey="Zouache, K" uniqKey="Zouache K">K Zouache</name></author><author><name sortKey="Caro, V" uniqKey="Caro V">V Caro</name></author><author><name sortKey="Diancourt, L" uniqKey="Diancourt L">L Diancourt</name></author><author><name sortKey="Delaunay, P" uniqKey="Delaunay P">P Delaunay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, O" uniqKey="Schwartz O">O Schwartz</name></author><author><name sortKey="Albert, Ml" uniqKey="Albert M">ML Albert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dupuis Maguiraga, L" uniqKey="Dupuis Maguiraga L">L Dupuis-Maguiraga</name></author><author><name sortKey="Noret, M" uniqKey="Noret M">M Noret</name></author><author><name sortKey="Brun, S" uniqKey="Brun S">S Brun</name></author><author><name sortKey="Le Grand, R" uniqKey="Le Grand R">R Le Grand</name></author><author><name sortKey="Gras, G" uniqKey="Gras G">G Gras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suhrbier, A" uniqKey="Suhrbier A">A Suhrbier</name></author><author><name sortKey="Jaffar Bandjee, Mc" uniqKey="Jaffar Bandjee M">MC Jaffar-Bandjee</name></author><author><name sortKey="Gasque, P" uniqKey="Gasque P">P Gasque</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lum, Fm" uniqKey="Lum F">FM Lum</name></author><author><name sortKey="Teo, Th" uniqKey="Teo T">TH Teo</name></author><author><name sortKey="Lee, Ww" uniqKey="Lee W">WW Lee</name></author><author><name sortKey="Kam, Yw" uniqKey="Kam Y">YW Kam</name></author><author><name sortKey="Renia, L" uniqKey="Renia L">L Renia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozden, S" uniqKey="Ozden S">S Ozden</name></author><author><name sortKey="Huerre, M" uniqKey="Huerre M">M Huerre</name></author><author><name sortKey="Riviere, Jp" uniqKey="Riviere J">JP Riviere</name></author><author><name sortKey="Coffey, Ll" uniqKey="Coffey L">LL Coffey</name></author><author><name sortKey="Afonso, Pv" uniqKey="Afonso P">PV Afonso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sourisseau, M" uniqKey="Sourisseau M">M Sourisseau</name></author><author><name sortKey="Schilte, C" uniqKey="Schilte C">C Schilte</name></author><author><name sortKey="Casartelli, N" uniqKey="Casartelli N">N Casartelli</name></author><author><name sortKey="Trouillet, C" uniqKey="Trouillet C">C Trouillet</name></author><author><name sortKey="Guivel Benhassine, F" uniqKey="Guivel Benhassine F">F Guivel-Benhassine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerardin, P" uniqKey="Gerardin P">P Gerardin</name></author><author><name sortKey="Barau, G" uniqKey="Barau G">G Barau</name></author><author><name sortKey="Michault, A" uniqKey="Michault A">A Michault</name></author><author><name sortKey="Bintner, M" uniqKey="Bintner M">M Bintner</name></author><author><name sortKey="Randrianaivo, H" uniqKey="Randrianaivo H">H Randrianaivo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Economopoulou, A" uniqKey="Economopoulou A">A Economopoulou</name></author><author><name sortKey="Dominguez, M" uniqKey="Dominguez M">M Dominguez</name></author><author><name sortKey="Helynck, B" uniqKey="Helynck B">B Helynck</name></author><author><name sortKey="Sissoko, D" uniqKey="Sissoko D">D Sissoko</name></author><author><name sortKey="Wichmann, O" uniqKey="Wichmann O">O Wichmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arpino, C" uniqKey="Arpino C">C Arpino</name></author><author><name sortKey="Curatolo, P" uniqKey="Curatolo P">P Curatolo</name></author><author><name sortKey="Rezza, G" uniqKey="Rezza G">G Rezza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, T" uniqKey="Das T">T Das</name></author><author><name sortKey="Jaffar Bandjee, Mc" uniqKey="Jaffar Bandjee M">MC Jaffar-Bandjee</name></author><author><name sortKey="Hoarau, Jj" uniqKey="Hoarau J">JJ Hoarau</name></author><author><name sortKey="Krejbich Trotot, P" uniqKey="Krejbich Trotot P">P Krejbich Trotot</name></author><author><name sortKey="Denizot, M" uniqKey="Denizot M">M Denizot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couderc, T" uniqKey="Couderc T">T Couderc</name></author><author><name sortKey="Chretien, F" uniqKey="Chretien F">F Chretien</name></author><author><name sortKey="Schilte, C" uniqKey="Schilte C">C Schilte</name></author><author><name sortKey="Disson, O" uniqKey="Disson O">O Disson</name></author><author><name sortKey="Brigitte, M" uniqKey="Brigitte M">M Brigitte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Labadie, K" uniqKey="Labadie K">K Labadie</name></author><author><name sortKey="Larcher, T" uniqKey="Larcher T">T Larcher</name></author><author><name sortKey="Joubert, C" uniqKey="Joubert C">C Joubert</name></author><author><name sortKey="Mannioui, A" uniqKey="Mannioui A">A Mannioui</name></author><author><name sortKey="Delache, B" uniqKey="Delache B">B Delache</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schilte, C" uniqKey="Schilte C">C Schilte</name></author><author><name sortKey="Couderc, T" uniqKey="Couderc T">T Couderc</name></author><author><name sortKey="Chretien, F" uniqKey="Chretien F">F Chretien</name></author><author><name sortKey="Sourisseau, M" uniqKey="Sourisseau M">M Sourisseau</name></author><author><name sortKey="Gangneux, N" uniqKey="Gangneux N">N Gangneux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardner, J" uniqKey="Gardner J">J Gardner</name></author><author><name sortKey="Anraku, I" uniqKey="Anraku I">I Anraku</name></author><author><name sortKey="Le, Tt" uniqKey="Le T">TT Le</name></author><author><name sortKey="Larcher, T" uniqKey="Larcher T">T Larcher</name></author><author><name sortKey="Major, L" uniqKey="Major L">L Major</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tobin, Dm" uniqKey="Tobin D">DM Tobin</name></author><author><name sortKey="May, Rc" uniqKey="May R">RC May</name></author><author><name sortKey="Wheeler, Rt" uniqKey="Wheeler R">RT Wheeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lieschke, Gj" uniqKey="Lieschke G">GJ Lieschke</name></author><author><name sortKey="Oates, Ac" uniqKey="Oates A">AC Oates</name></author><author><name sortKey="Crowhurst, Mo" uniqKey="Crowhurst M">MO Crowhurst</name></author><author><name sortKey="Ward, Ac" uniqKey="Ward A">AC Ward</name></author><author><name sortKey="Layton, Je" uniqKey="Layton J">JE Layton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Guyader, D" uniqKey="Le Guyader D">D Le Guyader</name></author><author><name sortKey="Redd, Mj" uniqKey="Redd M">MJ Redd</name></author><author><name sortKey="Colucci Guyon, E" uniqKey="Colucci Guyon E">E Colucci-Guyon</name></author><author><name sortKey="Murayama, E" uniqKey="Murayama E">E Murayama</name></author><author><name sortKey="Kissa, K" uniqKey="Kissa K">K Kissa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zou, J" uniqKey="Zou J">J Zou</name></author><author><name sortKey="Tafalla, C" uniqKey="Tafalla C">C Tafalla</name></author><author><name sortKey="Truckle, J" uniqKey="Truckle J">J Truckle</name></author><author><name sortKey="Secombes, Cj" uniqKey="Secombes C">CJ Secombes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggad, D" uniqKey="Aggad D">D Aggad</name></author><author><name sortKey="Mazel, M" uniqKey="Mazel M">M Mazel</name></author><author><name sortKey="Boudinot, P" uniqKey="Boudinot P">P Boudinot</name></author><author><name sortKey="Mogensen, Ke" uniqKey="Mogensen K">KE Mogensen</name></author><author><name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name></author><author><name sortKey="Lutfalla, G" uniqKey="Lutfalla G">G Lutfalla</name></author><author><name sortKey="Levraud, Jp" uniqKey="Levraud J">JP Levraud</name></author><author><name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levraud, Jp" uniqKey="Levraud J">JP Levraud</name></author><author><name sortKey="Boudinot, P" uniqKey="Boudinot P">P Boudinot</name></author><author><name sortKey="Colin, I" uniqKey="Colin I">I Colin</name></author><author><name sortKey="Benmansour, A" uniqKey="Benmansour A">A Benmansour</name></author><author><name sortKey="Peyrieras, N" uniqKey="Peyrieras N">N Peyrieras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weston, J" uniqKey="Weston J">J Weston</name></author><author><name sortKey="Villoing, S" uniqKey="Villoing S">S Villoing</name></author><author><name sortKey="Bremont, M" uniqKey="Bremont M">M Bremont</name></author><author><name sortKey="Castric, J" uniqKey="Castric J">J Castric</name></author><author><name sortKey="Pfeffer, M" uniqKey="Pfeffer M">M Pfeffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forrester, Nl" uniqKey="Forrester N">NL Forrester</name></author><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name></author><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author><author><name sortKey="Savji, N" uniqKey="Savji N">N Savji</name></author><author><name sortKey="Guzman, H" uniqKey="Guzman H">H Guzman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durbin, R" uniqKey="Durbin R">R Durbin</name></author><author><name sortKey="Kane, A" uniqKey="Kane A">A Kane</name></author><author><name sortKey="Stollar, V" uniqKey="Stollar V">V Stollar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phelan, Pe" uniqKey="Phelan P">PE Phelan</name></author><author><name sortKey="Pressley, Me" uniqKey="Pressley M">ME Pressley</name></author><author><name sortKey="Witten, Pe" uniqKey="Witten P">PE Witten</name></author><author><name sortKey="Mellon, Mt" uniqKey="Mellon M">MT Mellon</name></author><author><name sortKey="Blake, S" uniqKey="Blake S">S Blake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Munoz, A" uniqKey="Lopez Munoz A">A Lopez-Munoz</name></author><author><name sortKey="Roca, Fj" uniqKey="Roca F">FJ Roca</name></author><author><name sortKey="Sepulcre, Mp" uniqKey="Sepulcre M">MP Sepulcre</name></author><author><name sortKey="Meseguer, J" uniqKey="Meseguer J">J Meseguer</name></author><author><name sortKey="Mulero, V" uniqKey="Mulero V">V Mulero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, M" uniqKey="Ludwig M">M Ludwig</name></author><author><name sortKey="Palha, N" uniqKey="Palha N">N Palha</name></author><author><name sortKey="Torhy, C" uniqKey="Torhy C">C Torhy</name></author><author><name sortKey="Briolat, V" uniqKey="Briolat V">V Briolat</name></author><author><name sortKey="Colucci Guyon, E" uniqKey="Colucci Guyon E">E Colucci-Guyon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudd, Pa" uniqKey="Rudd P">PA Rudd</name></author><author><name sortKey="Wilson, J" uniqKey="Wilson J">J Wilson</name></author><author><name sortKey="Gardner, J" uniqKey="Gardner J">J Gardner</name></author><author><name sortKey="Larcher, T" uniqKey="Larcher T">T Larcher</name></author><author><name sortKey="Babarit, C" uniqKey="Babarit C">C Babarit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schilte, C" uniqKey="Schilte C">C Schilte</name></author><author><name sortKey="Buckwalter, Mr" uniqKey="Buckwalter M">MR Buckwalter</name></author><author><name sortKey="Laird, Me" uniqKey="Laird M">ME Laird</name></author><author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name></author><author><name sortKey="Schwartz, O" uniqKey="Schwartz O">O Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brannon, Mk" uniqKey="Brannon M">MK Brannon</name></author><author><name sortKey="Davis, Jm" uniqKey="Davis J">JM Davis</name></author><author><name sortKey="Mathias, Jr" uniqKey="Mathias J">JR Mathias</name></author><author><name sortKey="Hall, Cj" uniqKey="Hall C">CJ Hall</name></author><author><name sortKey="Emerson, Jc" uniqKey="Emerson J">JC Emerson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davison, Jm" uniqKey="Davison J">JM Davison</name></author><author><name sortKey="Akitake, Cm" uniqKey="Akitake C">CM Akitake</name></author><author><name sortKey="Goll, Mg" uniqKey="Goll M">MG Goll</name></author><author><name sortKey="Rhee, Jm" uniqKey="Rhee J">JM Rhee</name></author><author><name sortKey="Gosse, N" uniqKey="Gosse N">N Gosse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liongue, C" uniqKey="Liongue C">C Liongue</name></author><author><name sortKey="Hall, Cj" uniqKey="Hall C">CJ Hall</name></author><author><name sortKey="O Connell, Ba" uniqKey="O Connell B">BA O'Connell</name></author><author><name sortKey="Crosier, P" uniqKey="Crosier P">P Crosier</name></author><author><name sortKey="Ward, Ac" uniqKey="Ward A">AC Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Cj" uniqKey="Hall C">CJ Hall</name></author><author><name sortKey="Flores, Mv" uniqKey="Flores M">MV Flores</name></author><author><name sortKey="Oehlers, Sh" uniqKey="Oehlers S">SH Oehlers</name></author><author><name sortKey="Sanderson, Le" uniqKey="Sanderson L">LE Sanderson</name></author><author><name sortKey="Lam, Ey" uniqKey="Lam E">EY Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curado, S" uniqKey="Curado S">S Curado</name></author><author><name sortKey="Ober, Ea" uniqKey="Ober E">EA Ober</name></author><author><name sortKey="Walsh, S" uniqKey="Walsh S">S Walsh</name></author><author><name sortKey="Cortes Hernandez, P" uniqKey="Cortes Hernandez P">P Cortes-Hernandez</name></author><author><name sortKey="Verkade, H" uniqKey="Verkade H">H Verkade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziegler, Sa" uniqKey="Ziegler S">SA Ziegler</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Da Rosa, Ap" uniqKey="Da Rosa A">AP da Rosa</name></author><author><name sortKey="Xiao, Sy" uniqKey="Xiao S">SY Xiao</name></author><author><name sortKey="Tesh, Rb" uniqKey="Tesh R">RB Tesh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name></author><author><name sortKey="Volkova, E" uniqKey="Volkova E">E Volkova</name></author><author><name sortKey="Adams, Ap" uniqKey="Adams A">AP Adams</name></author><author><name sortKey="Forrester, N" uniqKey="Forrester N">N Forrester</name></author><author><name sortKey="Xiao, Sy" uniqKey="Xiao S">SY Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name></author><author><name sortKey="Zhang, Yb" uniqKey="Zhang Y">YB Zhang</name></author><author><name sortKey="Liu, Tk" uniqKey="Liu T">TK Liu</name></author><author><name sortKey="Gan, L" uniqKey="Gan L">L Gan</name></author><author><name sortKey="Yu, Ff" uniqKey="Yu F">FF Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takauji, R" uniqKey="Takauji R">R Takauji</name></author><author><name sortKey="Iho, S" uniqKey="Iho S">S Iho</name></author><author><name sortKey="Takatsuka, H" uniqKey="Takatsuka H">H Takatsuka</name></author><author><name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S Yamamoto</name></author><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pulverer, Je" uniqKey="Pulverer J">JE Pulverer</name></author><author><name sortKey="Rand, U" uniqKey="Rand U">U Rand</name></author><author><name sortKey="Lienenklaus, S" uniqKey="Lienenklaus S">S Lienenklaus</name></author><author><name sortKey="Kugel, D" uniqKey="Kugel D">D Kugel</name></author><author><name sortKey="Zietara, N" uniqKey="Zietara N">N Zietara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayashi, F" uniqKey="Hayashi F">F Hayashi</name></author><author><name sortKey="Means, Tk" uniqKey="Means T">TK Means</name></author><author><name sortKey="Luster, Ad" uniqKey="Luster A">AD Luster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamassia, N" uniqKey="Tamassia N">N Tamassia</name></author><author><name sortKey="Le Moigne, V" uniqKey="Le Moigne V">V Le Moigne</name></author><author><name sortKey="Rossato, M" uniqKey="Rossato M">M Rossato</name></author><author><name sortKey="Donini, M" uniqKey="Donini M">M Donini</name></author><author><name sortKey="Mccartney, S" uniqKey="Mccartney S">S McCartney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drescher, B" uniqKey="Drescher B">B Drescher</name></author><author><name sortKey="Bai, F" uniqKey="Bai F">F Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenne, Cn" uniqKey="Jenne C">CN Jenne</name></author><author><name sortKey="Wong, Chy" uniqKey="Wong C">CHY Wong</name></author><author><name sortKey="Zemp, Fj" uniqKey="Zemp F">FJ Zemp</name></author><author><name sortKey="Mcdonald, B" uniqKey="Mcdonald B">B McDonald</name></author><author><name sortKey="Rahman, Mm" uniqKey="Rahman M">MM Rahman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saitoh, T" uniqKey="Saitoh T">T Saitoh</name></author><author><name sortKey="Komano, J" uniqKey="Komano J">J Komano</name></author><author><name sortKey="Saitoh, Y" uniqKey="Saitoh Y">Y Saitoh</name></author><author><name sortKey="Misawa, T" uniqKey="Misawa T">T Misawa</name></author><author><name sortKey="Takahama, M" uniqKey="Takahama M">M Takahama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palic, D" uniqKey="Palic D">D Palic</name></author><author><name sortKey="Andreasen, Cb" uniqKey="Andreasen C">CB Andreasen</name></author><author><name sortKey="Ostojic, J" uniqKey="Ostojic J">J Ostojic</name></author><author><name sortKey="Tell, Rm" uniqKey="Tell R">RM Tell</name></author><author><name sortKey="Roth, Ja" uniqKey="Roth J">JA Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colucci Guyon, E" uniqKey="Colucci Guyon E">E Colucci-Guyon</name></author><author><name sortKey="Tinevez, Jy" uniqKey="Tinevez J">JY Tinevez</name></author><author><name sortKey="Renshaw, Sa" uniqKey="Renshaw S">SA Renshaw</name></author><author><name sortKey="Herbomel, P" uniqKey="Herbomel P">P Herbomel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Ct" uniqKey="Yang C">CT Yang</name></author><author><name sortKey="Cambier, Cj" uniqKey="Cambier C">CJ Cambier</name></author><author><name sortKey="Davis, Jm" uniqKey="Davis J">JM Davis</name></author><author><name sortKey="Hall, Cj" uniqKey="Hall C">CJ Hall</name></author><author><name sortKey="Crosier, Ps" uniqKey="Crosier P">PS Crosier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarini, Aa" uniqKey="Navarini A">AA Navarini</name></author><author><name sortKey="Recher, M" uniqKey="Recher M">M Recher</name></author><author><name sortKey="Lang, Ks" uniqKey="Lang K">KS Lang</name></author><author><name sortKey="Georgiev, P" uniqKey="Georgiev P">P Georgiev</name></author><author><name sortKey="Meury, S" uniqKey="Meury S">S Meury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ronneseth, A" uniqKey="Ronneseth A">A Ronneseth</name></author><author><name sortKey="Pettersen, Ef" uniqKey="Pettersen E">EF Pettersen</name></author><author><name sortKey="Wergeland, Hi" uniqKey="Wergeland H">HI Wergeland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chow, A" uniqKey="Chow A">A Chow</name></author><author><name sortKey="Her, Z" uniqKey="Her Z">Z Her</name></author><author><name sortKey="Ong, Ek" uniqKey="Ong E">EK Ong</name></author><author><name sortKey="Chen, Jm" uniqKey="Chen J">JM Chen</name></author><author><name sortKey="Dimatatac, F" uniqKey="Dimatatac F">F Dimatatac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuzzocrea, S" uniqKey="Cuzzocrea S">S Cuzzocrea</name></author><author><name sortKey="Chatterjee, Pk" uniqKey="Chatterjee P">PK Chatterjee</name></author><author><name sortKey="Mazzon, E" uniqKey="Mazzon E">E Mazzon</name></author><author><name sortKey="Dugo, L" uniqKey="Dugo L">L Dugo</name></author><author><name sortKey="De Sarro, A" uniqKey="De Sarro A">A De Sarro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genovese, T" uniqKey="Genovese T">T Genovese</name></author><author><name sortKey="Cuzzocrea, S" uniqKey="Cuzzocrea S">S Cuzzocrea</name></author><author><name sortKey="Di Paola, R" uniqKey="Di Paola R">R Di Paola</name></author><author><name sortKey="Failla, M" uniqKey="Failla M">M Failla</name></author><author><name sortKey="Mazzon, E" uniqKey="Mazzon E">E Mazzon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeidler, Pc" uniqKey="Zeidler P">PC Zeidler</name></author><author><name sortKey="Millecchia, Lm" uniqKey="Millecchia L">LM Millecchia</name></author><author><name sortKey="Castranova, V" uniqKey="Castranova V">V Castranova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orvedahl, A" uniqKey="Orvedahl A">A Orvedahl</name></author><author><name sortKey="Macpherson, S" uniqKey="Macpherson S">S MacPherson</name></author><author><name sortKey="Sumpter, R" uniqKey="Sumpter R">R Sumpter</name></author><author><name sortKey="Talloczy, Z" uniqKey="Talloczy Z">Z Talloczy</name></author><author><name sortKey="Zou, Z" uniqKey="Zou Z">Z Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stetson, Db" uniqKey="Stetson D">DB Stetson</name></author><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R Medzhitov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, Jy" uniqKey="Jeong J">JY Jeong</name></author><author><name sortKey="Kwon, Hb" uniqKey="Kwon H">HB Kwon</name></author><author><name sortKey="Ahn, Jc" uniqKey="Ahn J">JC Ahn</name></author><author><name sortKey="Kang, D" uniqKey="Kang D">D Kang</name></author><author><name sortKey="Kwon, Sh" uniqKey="Kwon S">SH Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murooka, Tt" uniqKey="Murooka T">TT Murooka</name></author><author><name sortKey="Deruaz, M" uniqKey="Deruaz M">M Deruaz</name></author><author><name sortKey="Marangoni, F" uniqKey="Marangoni F">F Marangoni</name></author><author><name sortKey="Vrbanac, Vd" uniqKey="Vrbanac V">VD Vrbanac</name></author><author><name sortKey="Seung, E" uniqKey="Seung E">E Seung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sewald, X" uniqKey="Sewald X">X Sewald</name></author><author><name sortKey="Gonzalez, Dg" uniqKey="Gonzalez D">DG Gonzalez</name></author><author><name sortKey="Haberman, Am" uniqKey="Haberman A">AM Haberman</name></author><author><name sortKey="Mothes, W" uniqKey="Mothes W">W Mothes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hickman, Hd" uniqKey="Hickman H">HD Hickman</name></author><author><name sortKey="Reynoso, Gv" uniqKey="Reynoso G">GV Reynoso</name></author><author><name sortKey="Ngudiankama, Bf" uniqKey="Ngudiankama B">BF Ngudiankama</name></author><author><name sortKey="Rubin, Ej" uniqKey="Rubin E">EJ Rubin</name></author><author><name sortKey="Magadan, Jg" uniqKey="Magadan J">JG Magadán</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Levraud, Jp" uniqKey="Levraud J">JP Levraud</name></author><author><name sortKey="Colucci Guyon, E" uniqKey="Colucci Guyon E">E Colucci-Guyon</name></author><author><name sortKey="Redd, Mj" uniqKey="Redd M">MJ Redd</name></author><author><name sortKey="Lutfalla, G" uniqKey="Lutfalla G">G Lutfalla</name></author><author><name sortKey="Herbomel, P" uniqKey="Herbomel P">P Herbomel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traver, D" uniqKey="Traver D">D Traver</name></author><author><name sortKey="Paw, Bh" uniqKey="Paw B">BH Paw</name></author><author><name sortKey="Poss, Kd" uniqKey="Poss K">KD Poss</name></author><author><name sortKey="Penberthy, Wt" uniqKey="Penberthy W">WT Penberthy</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Hc" uniqKey="Park H">HC Park</name></author><author><name sortKey="Kim, Ch" uniqKey="Kim C">CH Kim</name></author><author><name sortKey="Bae, Yk" uniqKey="Bae Y">YK Bae</name></author><author><name sortKey="Yeo, Sy" uniqKey="Yeo S">SY Yeo</name></author><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernardos, Rl" uniqKey="Bernardos R">RL Bernardos</name></author><author><name sortKey="Raymond, Pa" uniqKey="Raymond P">PA Raymond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Pd" uniqKey="Dong P">PD Dong</name></author><author><name sortKey="Munson, Ca" uniqKey="Munson C">CA Munson</name></author><author><name sortKey="Norton, W" uniqKey="Norton W">W Norton</name></author><author><name sortKey="Crosnier, C" uniqKey="Crosnier C">C Crosnier</name></author><author><name sortKey="Pan, X" uniqKey="Pan X">X Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renshaw, Sa" uniqKey="Renshaw S">SA Renshaw</name></author><author><name sortKey="Loynes, Ca" uniqKey="Loynes C">CA Loynes</name></author><author><name sortKey="Trushell, Dm" uniqKey="Trushell D">DM Trushell</name></author><author><name sortKey="Elworthy, S" uniqKey="Elworthy S">S Elworthy</name></author><author><name sortKey="Ingham, Pw" uniqKey="Ingham P">PW Ingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellett, F" uniqKey="Ellett F">F Ellett</name></author><author><name sortKey="Pase, L" uniqKey="Pase L">L Pase</name></author><author><name sortKey="Hayman, Jw" uniqKey="Hayman J">JW Hayman</name></author><author><name sortKey="Andrianopoulos, A" uniqKey="Andrianopoulos A">A Andrianopoulos</name></author><author><name sortKey="Lieschke, Gj" uniqKey="Lieschke G">GJ Lieschke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suster, Ml" uniqKey="Suster M">ML Suster</name></author><author><name sortKey="Kikuta, H" uniqKey="Kikuta H">H Kikuta</name></author><author><name sortKey="Urasaki, A" uniqKey="Urasaki A">A Urasaki</name></author><author><name sortKey="Asakawa, K" uniqKey="Asakawa K">K Asakawa</name></author><author><name sortKey="Kawakami, K" uniqKey="Kawakami K">K Kawakami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellett, F" uniqKey="Ellett F">F Ellett</name></author><author><name sortKey="Lieschke, Gj" uniqKey="Lieschke G">GJ Lieschke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svoboda, Kr" uniqKey="Svoboda K">KR Svoboda</name></author><author><name sortKey="Linares, Ae" uniqKey="Linares A">AE Linares</name></author><author><name sortKey="Ribera, Ab" uniqKey="Ribera A">AB Ribera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greiser Wilke, I" uniqKey="Greiser Wilke I">I Greiser-Wilke</name></author><author><name sortKey="Moenning, V" uniqKey="Moenning V">V Moenning</name></author><author><name sortKey="Kaaden, Or" uniqKey="Kaaden O">OR Kaaden</name></author><author><name sortKey="Figueiredo, Lt" uniqKey="Figueiredo L">LT Figueiredo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Covassin, L" uniqKey="Covassin L">L Covassin</name></author><author><name sortKey="Amigo, Jd" uniqKey="Amigo J">JD Amigo</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Teplyuk, V" uniqKey="Teplyuk V">V Teplyuk</name></author><author><name sortKey="Straubhaar, J" uniqKey="Straubhaar J">J Straubhaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thisse, C" uniqKey="Thisse C">C Thisse</name></author><author><name sortKey="Thisse, B" uniqKey="Thisse B">B Thisse</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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