Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance
Identifieur interne : 001149 ( Ncbi/Curation ); précédent : 001148; suivant : 001150Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance
Auteurs : Serenella Salinari [Italie] ; Cyrille Debard [France] ; Alessandro Bertuzzi [Italie] ; Christine Durand [France] ; Paul Zimmet [Australie] ; Hubert Vidal [France] ; Geltrude Mingrone [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of
These findings show that jejunal proteins either from
Url:
DOI: 10.1371/journal.pone.0056258
PubMed: 23437106
PubMed Central: 3577828
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PMC:3577828Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Jejunal Proteins Secreted by <italic>db/db</italic>
Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance</title>
<author><name sortKey="Salinari, Serenella" sort="Salinari, Serenella" uniqKey="Salinari S" first="Serenella" last="Salinari">Serenella Salinari</name>
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<author><name sortKey="Debard, Cyrille" sort="Debard, Cyrille" uniqKey="Debard C" first="Cyrille" last="Debard">Cyrille Debard</name>
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<author><name sortKey="Durand, Christine" sort="Durand, Christine" uniqKey="Durand C" first="Christine" last="Durand">Christine Durand</name>
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<wicri:noRegion>Victoria</wicri:noRegion>
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<author><name sortKey="Vidal, Hubert" sort="Vidal, Hubert" uniqKey="Vidal H" first="Hubert" last="Vidal">Hubert Vidal</name>
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<author><name sortKey="Mingrone, Geltrude" sort="Mingrone, Geltrude" uniqKey="Mingrone G" first="Geltrude" last="Mingrone">Geltrude Mingrone</name>
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<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of <italic>db/db</italic>
or Swiss mice on glucose uptake <italic>in vivo</italic>
in Swiss mice and <italic>in vitro</italic>
in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p><italic>db/db</italic>
proteins induced massive IR either <italic>in vivo</italic>
or <italic>in vitro</italic>
, while Swiss proteins did not. In L6 cells, only <italic>db/db</italic>
proteins produced a noticeable increase in basal <sup>473</sup>
Ser-Akt phosphorylation, lack of GSK3β inhibition and a reduced basal <sup>389</sup>
Thr-p70-S6K1 phosphorylation. Human IR serum markedly increased basal <sup>473</sup>
Ser-Akt phosphorylation in a dose-dependent manner. Human CM IR proteins increased by about twofold both basal and insulin-stimulated <sup>473</sup>
Ser-Akt. Basal <sup>9</sup>
Ser-GSK3β phosphorylation was increased by IR subjects serum with a smaller potentiating effect of insulin.</p>
</sec>
<sec><title>Conclusions</title>
<p>These findings show that jejunal proteins either from <italic>db/db</italic>
mice or from insulin resistant subjects impair muscle insulin signaling, thus inducing insulin resistance.</p>
</sec>
</div>
</front>
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