Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
Identifieur interne : 001F64 ( Ncbi/Checkpoint ); précédent : 001F63; suivant : 001F65Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
Auteurs : Mattias Johansson ; Anouar Fanidi ; David C. Muller ; Julie K. Bassett ; Ivind Midttun ; Stein Emil Vollset ; Ruth C. Travis ; Domenico Palli ; Amalia Mattiello ; Sabina Sieri ; Antonia Trichopoulou ; Pagona Lagiou ; Dimitrios Trichopoulos ; Börje Ljungberg ; Göran Hallmans ; Elisabete Weiderpass ; Guri Skeie ; Carlos A. González ; Miren Dorronsoro ; Petra H. Peeters ; H. B As Bueno-De-Mesquita ; Martine M. Ros ; Marie-Christine Boutron Ruault ; Guy Fagherazzi ; Françoise Clavel ; María-José Sánchez ; Aurelio Barricarte Gurrea ; Carmen Navarro ; J. Ramon Quiros ; Kim Overvad ; Anne Tj Nneland ; Krassimira Aleksandrova ; Paolo Vineis ; Marc J. Gunter ; Rudolf Kaaks ; Graham Giles ; Caroline Relton ; Elio Riboli ; Heiner Boeing ; Per Magne Ueland ; Gianluca Severi ; Paul BrennanSource :
- JNCI Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.
Descripteurs français
- KwdFr :
- Acide folique (sang), Adulte, Adulte d'âge moyen, Carbone (métabolisme), Estimation de Kaplan-Meier, Europe (épidémiologie), Femelle, Humains, Marqueurs biologiques (sang), Modèles de hasards proportionnels, Modèles logistiques, Mâle, Néphrocarcinome (mortalité), Néphrocarcinome (sang), Néphrocarcinome (épidémiologie), Odds ratio, Riboflavine (sang), Sujet âgé, Tumeurs du rein (mortalité), Tumeurs du rein (sang), Tumeurs du rein (épidémiologie), Vitamine B12 (sang), Vitamine B6 (sang), Vitamines (sang), Études cas-témoins, Évaluation des risques.
- MESH :
- mortalité : Néphrocarcinome, Tumeurs du rein.
- métabolisme : Carbone.
- sang : Acide folique, Marqueurs biologiques, Néphrocarcinome, Riboflavine, Tumeurs du rein, Vitamine B12, Vitamine B6, Vitamines.
- épidémiologie : Europe, Néphrocarcinome, Tumeurs du rein.
- Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Modèles de hasards proportionnels, Modèles logistiques, Mâle, Odds ratio, Sujet âgé, Études cas-témoins, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers (blood), Carbon (metabolism), Carcinoma, Renal Cell (blood), Carcinoma, Renal Cell (epidemiology), Carcinoma, Renal Cell (mortality), Case-Control Studies, Europe (epidemiology), Female, Folic Acid (blood), Humans, Kaplan-Meier Estimate, Kidney Neoplasms (blood), Kidney Neoplasms (epidemiology), Kidney Neoplasms (mortality), Logistic Models, Male, Middle Aged, Odds Ratio, Proportional Hazards Models, Riboflavin (blood), Risk Assessment, Vitamin B 12 (blood), Vitamin B 6 (blood), Vitamins (blood).
- MESH :
- chemical , blood : Biomarkers, Folic Acid, Riboflavin, Vitamin B 12, Vitamin B 6, Vitamins.
- chemical , metabolism : Carbon.
- geographic , epidemiology : Europe.
- blood : Carcinoma, Renal Cell, Kidney Neoplasms.
- epidemiology : Carcinoma, Renal Cell, Kidney Neoplasms.
- mortality : Carcinoma, Renal Cell, Kidney Neoplasms.
- Adult, Aged, Case-Control Studies, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Odds Ratio, Proportional Hazards Models, Risk Assessment.
Abstract
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.
The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided.
EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57,
Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR4vs1 = 0.47, 95% CI = 0.23 to 0.99,
Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.
Url:
DOI: 10.1093/jnci/dju327
PubMed: 25376861
PubMed Central: 4273895
Affiliations:
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Muller</name></author><author><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K." last="Bassett">Julie K. Bassett</name></author><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name></author><author><name sortKey="Vollset, Stein Emil" sort="Vollset, Stein Emil" uniqKey="Vollset S" first="Stein Emil" last="Vollset">Stein Emil Vollset</name></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></author><author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></author><author><name sortKey="Skeie, Guri" sort="Skeie, Guri" uniqKey="Skeie G" first="Guri" last="Skeie">Guri Skeie</name></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="González">Carlos A. González</name></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name></author><author><name sortKey="Ros, Martine M" sort="Ros, Martine M" uniqKey="Ros M" first="Martine M." last="Ros">Martine M. Ros</name></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron Ruault">Marie-Christine Boutron Ruault</name></author><author><name sortKey="Fagherazzi, Guy" sort="Fagherazzi, Guy" uniqKey="Fagherazzi G" first="Guy" last="Fagherazzi">Guy Fagherazzi</name></author><author><name sortKey="Clavel, Francoise" sort="Clavel, Francoise" uniqKey="Clavel F" first="Françoise" last="Clavel">Françoise Clavel</name></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name></author><author><name sortKey="Gurrea, Aurelio Barricarte" sort="Gurrea, Aurelio Barricarte" uniqKey="Gurrea A" first="Aurelio Barricarte" last="Gurrea">Aurelio Barricarte Gurrea</name></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name></author><author><name sortKey="Quiros, J Ramon" sort="Quiros, J Ramon" uniqKey="Quiros J" first="J. Ramon" last="Quiros">J. Ramon Quiros</name></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></author><author><name sortKey="Aleksandrova, Krassimira" sort="Aleksandrova, Krassimira" uniqKey="Aleksandrova K" first="Krassimira" last="Aleksandrova">Krassimira Aleksandrova</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name></author><author><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name></author><author><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers (blood)</term><term>Carbon (metabolism)</term><term>Carcinoma, Renal Cell (blood)</term><term>Carcinoma, Renal Cell (epidemiology)</term><term>Carcinoma, Renal Cell (mortality)</term><term>Case-Control Studies</term><term>Europe (epidemiology)</term><term>Female</term><term>Folic Acid (blood)</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Kidney Neoplasms (blood)</term><term>Kidney Neoplasms (epidemiology)</term><term>Kidney Neoplasms (mortality)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Proportional Hazards Models</term><term>Riboflavin (blood)</term><term>Risk Assessment</term><term>Vitamin B 12 (blood)</term><term>Vitamin B 6 (blood)</term><term>Vitamins (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide folique (sang)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Carbone (métabolisme)</term><term>Estimation de Kaplan-Meier</term><term>Europe (épidémiologie)</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques (sang)</term><term>Modèles de hasards proportionnels</term><term>Modèles logistiques</term><term>Mâle</term><term>Néphrocarcinome (mortalité)</term><term>Néphrocarcinome (sang)</term><term>Néphrocarcinome (épidémiologie)</term><term>Odds ratio</term><term>Riboflavine (sang)</term><term>Sujet âgé</term><term>Tumeurs du rein (mortalité)</term><term>Tumeurs du rein (sang)</term><term>Tumeurs du rein (épidémiologie)</term><term>Vitamine B12 (sang)</term><term>Vitamine B6 (sang)</term><term>Vitamines (sang)</term><term>Études cas-témoins</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Folic Acid</term><term>Riboflavin</term><term>Vitamin B 12</term><term>Vitamin B 6</term><term>Vitamins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carbon</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carcinoma, Renal Cell</term><term>Kidney Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carcinoma, Renal Cell</term><term>Kidney Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Renal Cell</term><term>Kidney Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Néphrocarcinome</term><term>Tumeurs du rein</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carbone</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide folique</term><term>Marqueurs biologiques</term><term>Néphrocarcinome</term><term>Riboflavine</term><term>Tumeurs du rein</term><term>Vitamine B12</term><term>Vitamine B6</term><term>Vitamines</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Europe</term><term>Néphrocarcinome</term><term>Tumeurs du rein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Proportional Hazards Models</term><term>Risk Assessment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Études cas-témoins</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.</p></sec><sec sec-type="methods"><title>Methods</title><p>The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided.</p></sec><sec><title>Results</title><p>EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (OR<sub>4vs1</sub>) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, <italic>P</italic><sub>trend</sub> < .001. We found similar results after adjusting for potential confounders (adjusted <italic>P</italic><sub>trend</sub> < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (HR<sub>4vs1</sub>) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, <italic>P</italic><sub>trend</sub> < .001).</p><p>Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR<sub>4vs1</sub> = 0.47, 95% CI = 0.23 to 0.99, <italic>P</italic><sub>trend</sub> = .07) and all-cause mortality (HR<sub>4vs1</sub> = 0.56, 95% CI = 0.27 to 1.17, <italic>P</italic><sub>trend</sub> = .02). No association was evident for the other measured biomarkers.</p></sec><sec><title>Conclusion</title><p>Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chow, Wh" uniqKey="Chow W">WH Chow</name></author><author><name sortKey="Dong, Lm" uniqKey="Dong L">LM Dong</name></author><author><name sortKey="Devesa, Ss" uniqKey="Devesa S">SS Devesa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scelo, G" uniqKey="Scelo G">G Scelo</name></author><author><name sortKey="Brennan, P" uniqKey="Brennan P">P Brennan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purdue, Mp" uniqKey="Purdue M">MP Purdue</name></author><author><name sortKey="Johansson, M" uniqKey="Johansson M">M Johansson</name></author><author><name sortKey="Zelenika, D" uniqKey="Zelenika D">D Zelenika</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name></author><author><name sortKey="Mannisto, S" uniqKey="Mannisto S">S Mannisto</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiseman, M" uniqKey="Wiseman M">M Wiseman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchner, Fl" uniqKey="Buchner F">FL Buchner</name></author><author><name sortKey="Bueno De Mesquita, Hb" uniqKey="Bueno De Mesquita H">HB Bueno-de-Mesquita</name></author><author><name sortKey="Linseisen, J" uniqKey="Linseisen J">J Linseisen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchner, Fl" uniqKey="Buchner F">FL Buchner</name></author><author><name sortKey="Bueno De Mesquita, Hb" uniqKey="Bueno De Mesquita H">HB Bueno-de-Mesquita</name></author><author><name sortKey="Ros, Mm" uniqKey="Ros M">MM Ros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Yi" uniqKey="Kim Y">YI Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name></author><author><name sortKey="Mannisto, S" uniqKey="Mannisto S">S Mannisto</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Tm" uniqKey="Gibson T">TM Gibson</name></author><author><name sortKey="Weinstein, Sj" uniqKey="Weinstein S">SJ Weinstein</name></author><author><name sortKey="Mayne, St" uniqKey="Mayne S">ST Mayne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riboli, E" uniqKey="Riboli E">E Riboli</name></author><author><name sortKey="Hunt, Kj" uniqKey="Hunt K">KJ Hunt</name></author><author><name sortKey="Slimani, N" uniqKey="Slimani N">N Slimani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name></author><author><name sortKey="English, Dr" uniqKey="English D">DR English</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Dc" uniqKey="Muller D">DC Muller</name></author><author><name 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Schafer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Kj" uniqKey="Lee K">KJ Lee</name></author><author><name sortKey="Carlin, Jb" uniqKey="Carlin J">JB Carlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Royston, P" uniqKey="Royston P">P Royston</name></author><author><name sortKey="Parmar, Mk" uniqKey="Parmar M">MK Parmar</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lao, O" uniqKey="Lao O">O Lao</name></author><author><name sortKey="Lu, Tt" uniqKey="Lu T">TT Lu</name></author><author><name sortKey="Nothnagel, M" uniqKey="Nothnagel M">M Nothnagel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palo, Ju" uniqKey="Palo J">JU Palo</name></author><author><name sortKey="Ulmanen, I" uniqKey="Ulmanen I">I Ulmanen</name></author><author><name sortKey="Lukka, M" uniqKey="Lukka M">M Lukka</name></author><author><name sortKey="Ellonen, P" uniqKey="Ellonen P">P Ellonen</name></author><author><name sortKey="Sajantila, A" uniqKey="Sajantila A">A Sajantila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Midttun, O" uniqKey="Midttun O">O Midttun</name></author><author><name sortKey="Ulvik, A" uniqKey="Ulvik A">A Ulvik</name></author><author><name sortKey="Ringdal Pedersen, E" uniqKey="Ringdal Pedersen E">E Ringdal Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Platten, M" uniqKey="Platten M">M Platten</name></author><author><name sortKey="Wick, W" uniqKey="Wick W">W Wick</name></author><author><name sortKey="Van Den Eynde, Bj" uniqKey="Van Den Eynde B">BJ Van den Eynde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakakeeny, L" uniqKey="Sakakeeny L">L Sakakeeny</name></author><author><name sortKey="Roubenoff, R" uniqKey="Roubenoff R">R Roubenoff</name></author><author><name sortKey="Obin, M" uniqKey="Obin M">M Obin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsubara, K" uniqKey="Matsubara K">K Matsubara</name></author><author><name sortKey="Komatsu, S" uniqKey="Komatsu S">S Komatsu</name></author><author><name sortKey="Oka, T" uniqKey="Oka T">T Oka</name></author><author><name sortKey="Kato, N" uniqKey="Kato N">N Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giovannucci, E" uniqKey="Giovannucci E">E Giovannucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, E" uniqKey="Cho E">E Cho</name></author><author><name sortKey="Giovannucci, El" uniqKey="Giovannucci E">EL Giovannucci</name></author><author><name sortKey="Joh, Hk" uniqKey="Joh H">HK Joh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosetti, C" uniqKey="Bosetti C">C Bosetti</name></author><author><name sortKey="Scotti, L" uniqKey="Scotti L">L Scotti</name></author><author><name sortKey="Maso, Ld" uniqKey="Maso L">LD Maso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Xy" uniqKey="Wu X">XY Wu</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bairoch, A" uniqKey="Bairoch A">A Bairoch</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aleksandrova, Krassimira" sort="Aleksandrova, Krassimira" uniqKey="Aleksandrova K" first="Krassimira" last="Aleksandrova">Krassimira Aleksandrova</name><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K." last="Bassett">Julie K. Bassett</name><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron Ruault">Marie-Christine Boutron Ruault</name><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name><name sortKey="Clavel, Francoise" sort="Clavel, Francoise" uniqKey="Clavel F" first="Françoise" last="Clavel">Françoise Clavel</name><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><name sortKey="Fagherazzi, Guy" sort="Fagherazzi, Guy" uniqKey="Fagherazzi G" first="Guy" last="Fagherazzi">Guy Fagherazzi</name><name sortKey="Fanidi, Anouar" sort="Fanidi, Anouar" uniqKey="Fanidi A" first="Anouar" last="Fanidi">Anouar Fanidi</name><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="González">Carlos A. González</name><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><name sortKey="Gurrea, Aurelio Barricarte" sort="Gurrea, Aurelio Barricarte" uniqKey="Gurrea A" first="Aurelio Barricarte" last="Gurrea">Aurelio Barricarte Gurrea</name><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C." last="Muller">David C. Muller</name><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><name sortKey="Quiros, J Ramon" sort="Quiros, J Ramon" uniqKey="Quiros J" first="J. Ramon" last="Quiros">J. Ramon Quiros</name><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><name sortKey="Ros, Martine M" sort="Ros, Martine M" uniqKey="Ros M" first="Martine M." last="Ros">Martine M. Ros</name><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><name sortKey="Skeie, Guri" sort="Skeie, Guri" uniqKey="Skeie G" first="Guri" last="Skeie">Guri Skeie</name><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><name sortKey="Vollset, Stein Emil" sort="Vollset, Stein Emil" uniqKey="Vollset S" first="Stein Emil" last="Vollset">Stein Emil Vollset</name><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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