Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
Identifieur interne : 002551 ( Pmc/Curation ); précédent : 002550; suivant : 002552Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
Auteurs : Mattias Johansson ; Anouar Fanidi ; David C. Muller ; Julie K. Bassett ; Ivind Midttun ; Stein Emil Vollset ; Ruth C. Travis ; Domenico Palli ; Amalia Mattiello ; Sabina Sieri ; Antonia Trichopoulou ; Pagona Lagiou ; Dimitrios Trichopoulos ; Börje Ljungberg ; Göran Hallmans ; Elisabete Weiderpass ; Guri Skeie ; Carlos A. González ; Miren Dorronsoro ; Petra H. Peeters ; H. B As Bueno-De-Mesquita ; Martine M. Ros ; Marie-Christine Boutron Ruault ; Guy Fagherazzi ; Françoise Clavel ; María-José Sánchez ; Aurelio Barricarte Gurrea ; Carmen Navarro ; J. Ramon Quiros ; Kim Overvad ; Anne Tj Nneland ; Krassimira Aleksandrova ; Paolo Vineis ; Marc J. Gunter ; Rudolf Kaaks ; Graham Giles ; Caroline Relton ; Elio Riboli ; Heiner Boeing ; Per Magne Ueland ; Gianluca Severi ; Paul BrennanSource :
- JNCI Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.
Abstract
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.
The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided.
EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57,
Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR4vs1 = 0.47, 95% CI = 0.23 to 0.99,
Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.
Url:
DOI: 10.1093/jnci/dju327
PubMed: 25376861
PubMed Central: 4273895
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Bassett</name></author><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name></author><author><name sortKey="Vollset, Stein Emil" sort="Vollset, Stein Emil" uniqKey="Vollset S" first="Stein Emil" last="Vollset">Stein Emil Vollset</name></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. 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Ros</name></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron Ruault">Marie-Christine Boutron Ruault</name></author><author><name sortKey="Fagherazzi, Guy" sort="Fagherazzi, Guy" uniqKey="Fagherazzi G" first="Guy" last="Fagherazzi">Guy Fagherazzi</name></author><author><name sortKey="Clavel, Francoise" sort="Clavel, Francoise" uniqKey="Clavel F" first="Françoise" last="Clavel">Françoise Clavel</name></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name></author><author><name sortKey="Gurrea, Aurelio Barricarte" sort="Gurrea, Aurelio Barricarte" uniqKey="Gurrea A" first="Aurelio Barricarte" last="Gurrea">Aurelio Barricarte Gurrea</name></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name></author><author><name sortKey="Quiros, J Ramon" sort="Quiros, J Ramon" uniqKey="Quiros J" first="J. Ramon" last="Quiros">J. Ramon Quiros</name></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></author><author><name sortKey="Aleksandrova, Krassimira" sort="Aleksandrova, Krassimira" uniqKey="Aleksandrova K" first="Krassimira" last="Aleksandrova">Krassimira Aleksandrova</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name></author><author><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name></author><author><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25376861</idno><idno type="pmc">4273895</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273895</idno><idno type="RBID">PMC:4273895</idno><idno type="doi">10.1093/jnci/dju327</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002701</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002701</idno><idno type="wicri:Area/Pmc/Curation">002551</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002551</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival</title><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name></author><author><name sortKey="Fanidi, Anouar" sort="Fanidi, Anouar" uniqKey="Fanidi A" first="Anouar" last="Fanidi">Anouar Fanidi</name></author><author><name sortKey="Muller, David C" sort="Muller, David C" uniqKey="Muller D" first="David C." last="Muller">David C. Muller</name></author><author><name sortKey="Bassett, Julie K" sort="Bassett, Julie K" uniqKey="Bassett J" first="Julie K." last="Bassett">Julie K. Bassett</name></author><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name></author><author><name sortKey="Vollset, Stein Emil" sort="Vollset, Stein Emil" uniqKey="Vollset S" first="Stein Emil" last="Vollset">Stein Emil Vollset</name></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></author><author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name></author><author><name sortKey="Hallmans, Goran" sort="Hallmans, Goran" uniqKey="Hallmans G" first="Göran" last="Hallmans">Göran Hallmans</name></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></author><author><name sortKey="Skeie, Guri" sort="Skeie, Guri" uniqKey="Skeie G" first="Guri" last="Skeie">Guri Skeie</name></author><author><name sortKey="Gonzalez, Carlos A" sort="Gonzalez, Carlos A" uniqKey="Gonzalez C" first="Carlos A." last="González">Carlos A. González</name></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name></author><author><name sortKey="Ros, Martine M" sort="Ros, Martine M" uniqKey="Ros M" first="Martine M." last="Ros">Martine M. Ros</name></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron Ruault">Marie-Christine Boutron Ruault</name></author><author><name sortKey="Fagherazzi, Guy" sort="Fagherazzi, Guy" uniqKey="Fagherazzi G" first="Guy" last="Fagherazzi">Guy Fagherazzi</name></author><author><name sortKey="Clavel, Francoise" sort="Clavel, Francoise" uniqKey="Clavel F" first="Françoise" last="Clavel">Françoise Clavel</name></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name></author><author><name sortKey="Gurrea, Aurelio Barricarte" sort="Gurrea, Aurelio Barricarte" uniqKey="Gurrea A" first="Aurelio Barricarte" last="Gurrea">Aurelio Barricarte Gurrea</name></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name></author><author><name sortKey="Quiros, J Ramon" sort="Quiros, J Ramon" uniqKey="Quiros J" first="J. Ramon" last="Quiros">J. Ramon Quiros</name></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></author><author><name sortKey="Aleksandrova, Krassimira" sort="Aleksandrova, Krassimira" uniqKey="Aleksandrova K" first="Krassimira" last="Aleksandrova">Krassimira Aleksandrova</name></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></author><author><name sortKey="Giles, Graham" sort="Giles, Graham" uniqKey="Giles G" first="Graham" last="Giles">Graham Giles</name></author><author><name sortKey="Relton, Caroline" sort="Relton, Caroline" uniqKey="Relton C" first="Caroline" last="Relton">Caroline Relton</name></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name></author><author><name sortKey="Ueland, Per Magne" sort="Ueland, Per Magne" uniqKey="Ueland P" first="Per Magne" last="Ueland">Per Magne Ueland</name></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.</p></sec><sec sec-type="methods"><title>Methods</title><p>The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided.</p></sec><sec><title>Results</title><p>EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (OR<sub>4vs1</sub>) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, <italic>P</italic><sub>trend</sub> < .001. We found similar results after adjusting for potential confounders (adjusted <italic>P</italic><sub>trend</sub> < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (HR<sub>4vs1</sub>) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, <italic>P</italic><sub>trend</sub> < .001).</p><p>Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR<sub>4vs1</sub> = 0.47, 95% CI = 0.23 to 0.99, <italic>P</italic><sub>trend</sub> = .07) and all-cause mortality (HR<sub>4vs1</sub> = 0.56, 95% CI = 0.27 to 1.17, <italic>P</italic><sub>trend</sub> = .02). No association was evident for the other measured biomarkers.</p></sec><sec><title>Conclusion</title><p>Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chow, Wh" uniqKey="Chow W">WH Chow</name></author><author><name sortKey="Dong, Lm" uniqKey="Dong L">LM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Natl Cancer Inst</journal-id><journal-id journal-id-type="iso-abbrev">J. Natl. Cancer Inst</journal-id><journal-id journal-id-type="hwp">jnci</journal-id><journal-id journal-id-type="publisher-id">jnci</journal-id><journal-title-group><journal-title>JNCI Journal of the National Cancer Institute</journal-title></journal-title-group><issn pub-type="ppub">0027-8874</issn><issn pub-type="epub">1460-2105</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25376861</article-id><article-id pub-id-type="pmc">4273895</article-id><article-id pub-id-type="doi">10.1093/jnci/dju327</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Mattias</given-names></name><xref ref-type="corresp" rid="c2">*</xref><xref ref-type="corresp" rid="c3">†</xref></contrib><contrib contrib-type="author"><name><surname>Fanidi</surname><given-names>Anouar</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Muller</surname><given-names>David C.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Bassett</surname><given-names>Julie K.</given-names></name><xref ref-type="corresp" rid="c2">*</xref></contrib><contrib contrib-type="author"><name><surname>Midttun</surname><given-names>Øivind</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vollset</surname><given-names>Stein Emil</given-names></name></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Palli</surname><given-names>Domenico</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mattiello</surname><given-names>Amalia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sieri</surname><given-names>Sabina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Trichopoulou</surname><given-names>Antonia</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lagiou</surname><given-names>Pagona</given-names></name></contrib><contrib contrib-type="author"><name><surname>Trichopoulos</surname><given-names>Dimitrios</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ljungberg</surname><given-names>Börje</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hallmans</surname><given-names>Göran</given-names></name></contrib><contrib contrib-type="author"><name><surname>Weiderpass</surname><given-names>Elisabete</given-names></name></contrib><contrib contrib-type="author"><name><surname>Skeie</surname><given-names>Guri</given-names></name></contrib><contrib contrib-type="author"><name><surname>González</surname><given-names>Carlos A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dorronsoro</surname><given-names>Miren</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H. B(as).</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ros</surname><given-names>Martine M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boutron Ruault</surname><given-names>Marie-Christine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fagherazzi</surname><given-names>Guy</given-names></name></contrib><contrib contrib-type="author"><name><surname>Clavel</surname><given-names>Françoise</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sánchez</surname><given-names>María-José</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gurrea</surname><given-names>Aurelio Barricarte</given-names></name></contrib><contrib contrib-type="author"><name><surname>Navarro</surname><given-names>Carmen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Quiros</surname><given-names>J. Ramon</given-names></name></contrib><contrib contrib-type="author"><name><surname>Overvad</surname><given-names>Kim</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tjønneland</surname><given-names>Anne</given-names></name></contrib><contrib contrib-type="author"><name><surname>Aleksandrova</surname><given-names>Krassimira</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vineis</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gunter</surname><given-names>Marc J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kaaks</surname><given-names>Rudolf</given-names></name></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham</given-names></name></contrib><contrib contrib-type="author"><name><surname>Relton</surname><given-names>Caroline</given-names></name></contrib><contrib contrib-type="author"><name><surname>Riboli</surname><given-names>Elio</given-names></name></contrib><contrib contrib-type="author"><name><surname>Boeing</surname><given-names>Heiner</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ueland</surname><given-names>Per Magne</given-names></name><xref ref-type="corresp" rid="c3">†</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="corresp" rid="c3">†</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="corresp" rid="c3">†</xref></contrib><aff id="AF0001"><bold>Affiliations of authors:</bold><institution>International Agency for Research on Cancer</institution>,<addr-line>Lyon</addr-line>,<country>France</country> (MJ, AF, DCM, PB);<institution>Cancer Epidemiology Centre, The Cancer Council Victoria</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country> (JKB, GG, GiS);<institution>Bevital AS</institution>,<addr-line>Bergen</addr-line>,<country>Norway</country> (ØM);<institution>Norwegian Institute of Public Health and Department of Global Public Health and Primary Care, University of Bergen</institution>,<addr-line>Bergen</addr-line>,<country>Norway</country> (SEV);<institution>Nuffield Department of Clinical Medicine, University of Oxford</institution>,<addr-line>Oxford</addr-line>,<country>UK</country> (RCT);<institution>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO)</institution>,<addr-line>Florence</addr-line>,<country>Italy</country> (DP);<institution>Dipartimento di Medicina Clinica e Chirurgia, Federico II University</institution>,<addr-line>Naples</addr-line>,<country>Italy</country> (AM);<institution>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori</institution>,<addr-line>Milano</addr-line>,<country>Italy</country> (SS);<institution>Hellenic Health Foundation</institution>,<addr-line>Athens</addr-line>,<country>Greece</country> (AT, DT);<institution>World Health Organization Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</institution>,<addr-line>Athens</addr-line>,<country>Greece</country> (AT, PL);<institution>Department of Epidemiology, Harvard School of Public Health</institution>,<addr-line>Boston, MA</addr-line> (PL, DT);<institution>Bureau of Epidemiologic Research, Academy of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country> (PL, DT);<institution>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country> (BL);<institution>Department of Biobank Research, Umeå University</institution>,<addr-line>Umeå</addr-line>,<country>Sweden</country> (GH);<institution>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø</institution>,<addr-line>Tromsø</addr-line>,<country>Norway</country> (EW, GuS);<institution>Department of Research, Cancer Registry of Norway</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country> (EW);<institution>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</institution>,<addr-line>Stockholm</addr-line>,<country>Sweden</country> (EW);<institution>Samfundet Folkhälsan</institution>,<addr-line>Helsinki</addr-line>,<country>Finland</country> (EW);<institution>Catalan Institute of Oncology (ICO)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country> (CAG);<institution>Public Health Direction, Basque regional Health Department</institution>,<addr-line>San Sebastian</addr-line>,<country>Spain</country> (MD);<institution>Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) - Health Research Institute (BIODONOSTIA)</institution>,<country>Spain</country> (HBBdM, MMR);<institution>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center</institution>,<addr-line>Utrecht</addr-line>,<country>the Netherlands</country> (PHP);<institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line>,<country>the Netherlands</country> (HBBdM, MMR);<institution>Department of Gastroenterology and Hepatology, University Medical Centre</institution>,<addr-line>Utrecht</addr-line>,<country>the Netherlands</country> (HBBdM);<institution>Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team</institution>,<addr-line>Villejuif</addr-line>,<country>France</country> (MCBR, GF, FC);<institution>Université Paris Sud</institution>,<addr-line>UMRS 1018, Villejuif</addr-line>,<country>France</country> (MCBR, GF, FC);<institution>Institut Gustave-Roussy (IGR)</institution>,<addr-line>Villejuif</addr-line>,<country>France</country> (MCBR, GF, FC);<institution>Andalusian School of Public Health</institution>,<addr-line>Granada</addr-line>,<country>Spain</country> (MJS);<institution>Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)</institution>,<country>Spain</country> (MJS, ABG, CN);<institution>Navarra Public Health Institute</institution>,<addr-line>Pamplona</addr-line>,<country>Spain</country> (ABG);<institution>Department of Epidemiology, Regional Health Authority</institution>,<addr-line>Murcia</addr-line>,<country>Spain</country> (CN);<institution>Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia</institution>,<country>Spain</country> (CN);<institution>Public Health Directorate</institution>,<addr-line>Asturias</addr-line>,<country>Spain</country> (JRQ);<institution>Section for Epidemiology, Department of Public Health, Aarhus University</institution>,<addr-line>Aarhus</addr-line>,<country>Denmark</country> (KO);<institution>Danish Cancer Society Research Center</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country> (AT);<institution>Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke</institution>,<addr-line>Nuthetal</addr-line>,<country>Germany</country> (HB, KA);<institution>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College</institution>,<addr-line>London</addr-line>,<country>UK</country> (PV, MJG, ER);<institution>HuGeF Foundation</institution>,<addr-line>Torino</addr-line>,<country>Italy</country> (PV, GiS);<institution>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country> (RK);<institution>Institute of Genetic Medicine, Newcastle University</institution>,<addr-line>Newcastle</addr-line>,<country>UK</country> (CR);<institution>Section for Pharmacology, Institute of Medicine, University of Bergen</institution>,<addr-line>Bergen</addr-line>,<country>Norway</country> (PMU);<institution>Laboratory of Clinical Biochemistry, Haukeland University Hospital</institution>,<addr-line>Bergen</addr-line>,<country>Norway</country> (PMU);<institution>Centre for Epidemiology and Biostatistics, University of Melbourne, Australia (GG</institution>, GiS).</aff></contrib-group><author-notes><corresp id="c2">* Authors contributed equally to this work.</corresp><corresp id="c3">† Senior authors.</corresp><corresp id="c1"><bold>Correspondence to:</bold> Mattias Johansson, PhD, Genetic Epidemiology Group, International Agency for Research on Cancer (IARC/WHO), 150 cours Albert Thomas, 69008 Lyon, France (e-mail: <email>JohanssonM@iarc.fr</email>).</corresp></author-notes><pub-date pub-type="collection"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>5</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>11</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>106</volume><issue>12</issue><elocation-id>dju327</elocation-id><history><date date-type="received"><day>31</day><month>12</month><year>2013</year></date><date date-type="rev-recd"><day>11</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>3</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press.</copyright-statement><copyright-year>2014</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><abstract><sec><title>Background</title><p>The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.</p></sec><sec sec-type="methods"><title>Methods</title><p>The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided.</p></sec><sec><title>Results</title><p>EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (OR<sub>4vs1</sub>) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, <italic>P</italic><sub>trend</sub> < .001. We found similar results after adjusting for potential confounders (adjusted <italic>P</italic><sub>trend</sub> < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4<sup>th</sup> and 1<sup>st</sup> quartiles (HR<sub>4vs1</sub>) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, <italic>P</italic><sub>trend</sub> < .001).</p><p>Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR<sub>4vs1</sub> = 0.47, 95% CI = 0.23 to 0.99, <italic>P</italic><sub>trend</sub> = .07) and all-cause mortality (HR<sub>4vs1</sub> = 0.56, 95% CI = 0.27 to 1.17, <italic>P</italic><sub>trend</sub> = .02). No association was evident for the other measured biomarkers.</p></sec><sec><title>Conclusion</title><p>Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.</p></sec></abstract><counts><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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