Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Identifieur interne : 000359 ( Ncbi/Checkpoint ); précédent : 000358; suivant : 000360Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Auteurs : Antonis C. Antoniou ; Amanda B. Spurdle ; Olga M. Sinilnikova ; Sue Healey ; Karen A. Pooley ; Rita K. Schmutzler ; Beatrix Versmold ; Christoph Engel ; Alfons Meindl ; Norbert Arnold ; Wera Hofmann ; Christian Sutter ; Dieter Niederacher ; Helmut Deissler ; Trinidad Caldes ; Kati K Mpj Rvi ; Heli Nevanlinna ; Jacques Simard ; Jonathan Beesley ; Xiaoqing Chen ; Susan L. Neuhausen ; Timothy R. Rebbeck ; Theresa Wagner ; Henry T. Lynch ; Claudine Isaacs ; Jeffrey Weitzel ; Patricia A. Ganz ; Mary B. Daly ; Gail Tomlinson ; Olufunmilayo I. Olopade ; Joanne L. Blum ; Fergus J. Couch ; Paolo Peterlongo ; Siranoush Manoukian ; Monica Barile ; Paolo Radice ; Csilla I. Szabo ; Lutecia H. Mateus Pereira ; Mark H. Greene ; Gad Rennert ; Flavio Lejbkowicz ; Ofra Barnett-Griness ; Irene L. Andrulis ; Hilmi Ozcelik ; Anne-Marie Gerdes ; Maria A. Caligo ; Yael Laitman ; Bella Kaufman ; Roni Milgrom ; Eitan Friedman ; Susan M. Domchek ; Katherine L. Nathanson ; Ana Osorio ; Gemma Llort ; Roger L. Milne ; Javier Benítez ; Ute Hamann ; Frans B. L. Hogervorst ; Peggy Manders ; Marjolijn J. L. Ligtenberg ; Ans M. W. Van Den Ouweland ; Susan Peock ; Margaret Cook ; Radka Platte ; D. Gareth Evans ; Rosalind Eeles ; Gabriella Pichert ; Carol Chu ; Diana Eccles ; Rosemarie Davidson ; Fiona Douglas ; Andrew K. Godwin ; Laure Barjhoux ; Sylvie Mazoyer ; Hagay Sobol ; Violaine Bourdon ; François Eisinger ; Agnès Chompret ; Corinne Capoulade ; Brigitte Bressac-De Paillerets ; Gilbert M. Lenoir ; Marion Gauthier-Villars ; Claude Houdayer ; Dominique Stoppa-Lyonnet ; Georgia Chenevix-Trench ; Douglas F. EastonSource :
- American Journal of Human Genetics [ 0002-9297 ] ; 2008.
Abstract
Germline mutations in
Url:
DOI: 10.1016/j.ajhg.2008.02.008
PubMed: 18355772
PubMed Central: 2427217
Affiliations:
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PMC:2427217Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
Mutation Carriers</title>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
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<author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name>
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<author><name sortKey="Pereira, Lutecia H Mateus" sort="Pereira, Lutecia H Mateus" uniqKey="Pereira L" first="Lutecia H. Mateus" last="Pereira">Lutecia H. Mateus Pereira</name>
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<affiliation><nlm:aff id="aff39"></nlm:aff>
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<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name>
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<author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name>
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<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
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</affiliation>
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<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name>
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</affiliation>
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<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name>
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</affiliation>
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<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
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<author><name sortKey="Llort, Gemma" sort="Llort, Gemma" uniqKey="Llort G" first="Gemma" last="Llort">Gemma Llort</name>
<affiliation><nlm:aff id="aff47"></nlm:aff>
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<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation><nlm:aff id="aff48"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
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</affiliation>
<affiliation><nlm:aff id="aff48"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:aff id="aff49"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name>
<affiliation><nlm:aff id="aff50"></nlm:aff>
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<author><name sortKey="Manders, Peggy" sort="Manders, Peggy" uniqKey="Manders P" first="Peggy" last="Manders">Peggy Manders</name>
<affiliation><nlm:aff id="aff51"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name>
<affiliation><nlm:aff id="aff52"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name>
<affiliation><nlm:aff id="aff53"></nlm:aff>
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<author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<affiliation><nlm:aff id="aff54"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation><nlm:aff id="aff55"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pichert, Gabriella" sort="Pichert, Gabriella" uniqKey="Pichert G" first="Gabriella" last="Pichert">Gabriella Pichert</name>
<affiliation><nlm:aff id="aff56"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name>
<affiliation><nlm:aff id="aff57"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation><nlm:aff id="aff58"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<affiliation><nlm:aff id="aff59"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name>
<affiliation><nlm:aff id="aff60"></nlm:aff>
</affiliation>
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<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:aff id="aff25"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name>
<affiliation><nlm:aff id="aff61"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name>
<affiliation><nlm:aff id="aff61"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name>
<affiliation><nlm:aff id="aff61"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnès" last="Chompret">Agnès Chompret</name>
<affiliation><nlm:aff id="aff62"></nlm:aff>
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</author>
<author><name sortKey="Capoulade, Corinne" sort="Capoulade, Corinne" uniqKey="Capoulade C" first="Corinne" last="Capoulade">Corinne Capoulade</name>
<affiliation><nlm:aff id="aff63"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<affiliation><nlm:aff id="aff63"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name>
<affiliation><nlm:aff id="aff63"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name>
<affiliation><nlm:aff id="aff64"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
<affiliation><nlm:aff id="aff64"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
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</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18355772</idno>
<idno type="pmc">2427217</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427217</idno>
<idno type="RBID">PMC:2427217</idno>
<idno type="doi">10.1016/j.ajhg.2008.02.008</idno>
<date when="2008">2008</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
Mutation Carriers</title>
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<affiliation><nlm:aff id="aff20"></nlm:aff>
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<affiliation><nlm:aff id="aff21"></nlm:aff>
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<affiliation><nlm:aff id="aff32"></nlm:aff>
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<author><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name>
<affiliation><nlm:aff id="aff61"></nlm:aff>
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</analytic>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>Germline mutations in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in <italic>FGFR2</italic>
(rs2981582), <italic>TNRC9</italic>
(rs3803662), and <italic>MAP3K1</italic>
(rs889312) are associated with increased breast cancer risks in the general population. To investigate whether these loci are also associated with breast cancer risk in <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers, we genotyped these SNPs in a sample of 10,358 mutation carriers from 23 studies. The minor alleles of SNP rs2981582 and rs889312 were each associated with increased breast cancer risk in <italic>BRCA2</italic>
mutation carriers (per-allele hazard ratio [HR] = 1.32, 95% CI: 1.20–1.45, p<sub>trend</sub>
= 1.7 × 10<sup>−8</sup>
and HR = 1.12, 95% CI: 1.02–1.24, p<sub>trend</sub>
= 0.02) but not in <italic>BRCA1</italic>
carriers. rs3803662 was associated with increased breast cancer risk in both <italic>BRCA1</italic>
and <italic>BRCA2</italic>
mutation carriers (per-allele HR = 1.13, 95% CI: 1.06–1.20, p<sub>trend</sub>
= 5 × 10<sup>−5</sup>
in <italic>BRCA1</italic>
and BRCA2 combined). These loci appear to interact multiplicatively on breast cancer risk in <italic>BRCA2</italic>
mutation carriers. The differences in the effects of the <italic>FGFR2</italic>
and <italic>MAP3K1</italic>
SNPs between <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers point to differences in the biology of <italic>BRCA1</italic>
and <italic>BRCA2</italic>
breast cancer tumors and confirm the distinct nature of breast cancer in <italic>BRCA1</italic>
mutation carriers.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name>
<name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name>
<name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name>
<name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name>
<name sortKey="Barnett Griness, Ofra" sort="Barnett Griness, Ofra" uniqKey="Barnett Griness O" first="Ofra" last="Barnett-Griness">Ofra Barnett-Griness</name>
<name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name>
<name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L." last="Blum">Joanne L. Blum</name>
<name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name>
<name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name>
<name sortKey="Capoulade, Corinne" sort="Capoulade, Corinne" uniqKey="Capoulade C" first="Corinne" last="Capoulade">Corinne Capoulade</name>
<name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnès" last="Chompret">Agnès Chompret</name>
<name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name>
<name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name>
<name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name>
<name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name>
<name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name>
<name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name>
<name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name>
<name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name>
<name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
<name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name>
<name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name>
<name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name>
<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<name sortKey="Hofmann, Wera" sort="Hofmann, Wera" uniqKey="Hofmann W" first="Wera" last="Hofmann">Wera Hofmann</name>
<name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name>
<name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
<name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<name sortKey="K Mpj Rvi, Kati" sort="K Mpj Rvi, Kati" uniqKey="K Mpj Rvi K" first="Kati" last="K Mpj Rvi">Kati K Mpj Rvi</name>
<name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name>
<name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name>
<name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name>
<name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name>
<name sortKey="Llort, Gemma" sort="Llort, Gemma" uniqKey="Llort G" first="Gemma" last="Llort">Gemma Llort</name>
<name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name>
<name sortKey="Manders, Peggy" sort="Manders, Peggy" uniqKey="Manders P" first="Peggy" last="Manders">Peggy Manders</name>
<name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
<name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name>
<name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name>
<name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name>
<name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name>
<name sortKey="Pereira, Lutecia H Mateus" sort="Pereira, Lutecia H Mateus" uniqKey="Pereira L" first="Lutecia H. Mateus" last="Pereira">Lutecia H. Mateus Pereira</name>
<name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<name sortKey="Pichert, Gabriella" sort="Pichert, Gabriella" uniqKey="Pichert G" first="Gabriella" last="Pichert">Gabriella Pichert</name>
<name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name>
<name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name>
<name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name>
<name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name>
<name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name>
<name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name>
<name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name>
<name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name>
<name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name>
<name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name>
<name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name>
<name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name>
</noCountry>
</tree>
</affiliations>
</record>
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