Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Identifieur interne : 000359 ( Ncbi/Merge ); précédent : 000358; suivant : 000360Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Auteurs : Antonis C. Antoniou ; Amanda B. Spurdle ; Olga M. Sinilnikova ; Sue Healey ; Karen A. Pooley ; Rita K. Schmutzler ; Beatrix Versmold ; Christoph Engel ; Alfons Meindl ; Norbert Arnold ; Wera Hofmann ; Christian Sutter ; Dieter Niederacher ; Helmut Deissler ; Trinidad Caldes ; Kati K Mpj Rvi ; Heli Nevanlinna ; Jacques Simard ; Jonathan Beesley ; Xiaoqing Chen ; Susan L. Neuhausen ; Timothy R. Rebbeck ; Theresa Wagner ; Henry T. Lynch ; Claudine Isaacs ; Jeffrey Weitzel ; Patricia A. Ganz ; Mary B. Daly ; Gail Tomlinson ; Olufunmilayo I. Olopade ; Joanne L. Blum ; Fergus J. Couch ; Paolo Peterlongo ; Siranoush Manoukian ; Monica Barile ; Paolo Radice ; Csilla I. Szabo ; Lutecia H. Mateus Pereira ; Mark H. Greene ; Gad Rennert ; Flavio Lejbkowicz ; Ofra Barnett-Griness ; Irene L. Andrulis ; Hilmi Ozcelik ; Anne-Marie Gerdes ; Maria A. Caligo ; Yael Laitman ; Bella Kaufman ; Roni Milgrom ; Eitan Friedman ; Susan M. Domchek ; Katherine L. Nathanson ; Ana Osorio ; Gemma Llort ; Roger L. Milne ; Javier Benítez ; Ute Hamann ; Frans B. L. Hogervorst ; Peggy Manders ; Marjolijn J. L. Ligtenberg ; Ans M. W. Van Den Ouweland ; Susan Peock ; Margaret Cook ; Radka Platte ; D. Gareth Evans ; Rosalind Eeles ; Gabriella Pichert ; Carol Chu ; Diana Eccles ; Rosemarie Davidson ; Fiona Douglas ; Andrew K. Godwin ; Laure Barjhoux ; Sylvie Mazoyer ; Hagay Sobol ; Violaine Bourdon ; François Eisinger ; Agnès Chompret ; Corinne Capoulade ; Brigitte Bressac-De Paillerets ; Gilbert M. Lenoir ; Marion Gauthier-Villars ; Claude Houdayer ; Dominique Stoppa-Lyonnet ; Georgia Chenevix-Trench ; Douglas F. EastonSource :
- American Journal of Human Genetics [ 0002-9297 ] ; 2008.
Abstract
Germline mutations in
Url:
DOI: 10.1016/j.ajhg.2008.02.008
PubMed: 18355772
PubMed Central: 2427217
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> Mutation Carriers</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author><author><name sortKey="Hofmann, Wera" sort="Hofmann, Wera" uniqKey="Hofmann W" first="Wera" last="Hofmann">Wera Hofmann</name><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="aff12"></nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="aff13"></nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="aff14"></nlm:aff></affiliation></author><author><name sortKey="K Mpj Rvi, Kati" sort="K Mpj Rvi, Kati" uniqKey="K Mpj Rvi K" first="Kati" last="K Mpj Rvi">Kati K Mpj Rvi</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff16"></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. 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Hogervorst</name><affiliation><nlm:aff id="aff50"></nlm:aff></affiliation></author><author><name sortKey="Manders, Peggy" sort="Manders, Peggy" uniqKey="Manders P" first="Peggy" last="Manders">Peggy Manders</name><affiliation><nlm:aff id="aff51"></nlm:aff></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name><affiliation><nlm:aff id="aff52"></nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="aff53"></nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="aff54"></nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="aff55"></nlm:aff></affiliation></author><author><name sortKey="Pichert, Gabriella" sort="Pichert, Gabriella" uniqKey="Pichert G" first="Gabriella" last="Pichert">Gabriella Pichert</name><affiliation><nlm:aff id="aff56"></nlm:aff></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><nlm:aff id="aff57"></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="aff58"></nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="aff59"></nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="aff60"></nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="aff25"></nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnès" last="Chompret">Agnès Chompret</name><affiliation><nlm:aff id="aff62"></nlm:aff></affiliation></author><author><name sortKey="Capoulade, Corinne" sort="Capoulade, Corinne" uniqKey="Capoulade C" first="Corinne" last="Capoulade">Corinne Capoulade</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18355772</idno><idno type="pmc">2427217</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427217</idno><idno type="RBID">PMC:2427217</idno><idno type="doi">10.1016/j.ajhg.2008.02.008</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001C42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C42</idno><idno type="wicri:Area/Pmc/Curation">001B00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B00</idno><idno type="wicri:Area/Pmc/Checkpoint">002A30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002A30</idno><idno type="wicri:Area/Ncbi/Merge">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> Mutation Carriers</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author><author><name sortKey="Hofmann, Wera" sort="Hofmann, Wera" uniqKey="Hofmann W" first="Wera" last="Hofmann">Wera Hofmann</name><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="aff12"></nlm:aff></affiliation></author><author><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><affiliation><nlm:aff id="aff13"></nlm:aff></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation><nlm:aff id="aff14"></nlm:aff></affiliation></author><author><name sortKey="K Mpj Rvi, Kati" sort="K Mpj Rvi, Kati" uniqKey="K Mpj Rvi K" first="Kati" last="K Mpj Rvi">Kati K Mpj Rvi</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="aff16"></nlm:aff></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="aff18"></nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="aff19"></nlm:aff></affiliation></author><author><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name><affiliation><nlm:aff id="aff20"></nlm:aff></affiliation></author><author><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><affiliation><nlm:aff id="aff21"></nlm:aff></affiliation></author><author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><affiliation><nlm:aff id="aff22"></nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name><affiliation><nlm:aff id="aff23"></nlm:aff></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation><nlm:aff id="aff24"></nlm:aff></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><nlm:aff id="aff25"></nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><affiliation><nlm:aff id="aff26"></nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="aff27"></nlm:aff></affiliation></author><author><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L." last="Blum">Joanne L. Blum</name><affiliation><nlm:aff id="aff28"></nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="aff29"></nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="aff30"></nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="aff31"></nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="aff32"></nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="aff30"></nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="aff33"></nlm:aff></affiliation></author><author><name sortKey="Pereira, Lutecia H Mateus" sort="Pereira, Lutecia H Mateus" uniqKey="Pereira L" first="Lutecia H. Mateus" last="Pereira">Lutecia H. Mateus Pereira</name><affiliation><nlm:aff id="aff34"></nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="aff35"></nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="aff36"></nlm:aff></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><nlm:aff id="aff36"></nlm:aff></affiliation></author><author><name sortKey="Barnett Griness, Ofra" sort="Barnett Griness, Ofra" uniqKey="Barnett Griness O" first="Ofra" last="Barnett-Griness">Ofra Barnett-Griness</name><affiliation><nlm:aff id="aff36"></nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="aff37"></nlm:aff></affiliation><affiliation><nlm:aff id="aff38"></nlm:aff></affiliation><affiliation><nlm:aff id="aff39"></nlm:aff></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><nlm:aff id="aff38"></nlm:aff></affiliation><affiliation><nlm:aff id="aff39"></nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="aff40"></nlm:aff></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><nlm:aff id="aff41"></nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="aff42"></nlm:aff></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><nlm:aff id="aff43"></nlm:aff></affiliation></author><author><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name><affiliation><nlm:aff id="aff42"></nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="aff42"></nlm:aff></affiliation><affiliation><nlm:aff id="aff43"></nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="aff45"></nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="aff45"></nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="aff46"></nlm:aff></affiliation></author><author><name sortKey="Llort, Gemma" sort="Llort, Gemma" uniqKey="Llort G" first="Gemma" last="Llort">Gemma Llort</name><affiliation><nlm:aff id="aff47"></nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="aff48"></nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><nlm:aff id="aff46"></nlm:aff></affiliation><affiliation><nlm:aff id="aff48"></nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="aff49"></nlm:aff></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><nlm:aff id="aff50"></nlm:aff></affiliation></author><author><name sortKey="Manders, Peggy" sort="Manders, Peggy" uniqKey="Manders P" first="Peggy" last="Manders">Peggy Manders</name><affiliation><nlm:aff id="aff51"></nlm:aff></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name><affiliation><nlm:aff id="aff52"></nlm:aff></affiliation></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><affiliation><nlm:aff id="aff53"></nlm:aff></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><nlm:aff id="aff54"></nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="aff55"></nlm:aff></affiliation></author><author><name sortKey="Pichert, Gabriella" sort="Pichert, Gabriella" uniqKey="Pichert G" first="Gabriella" last="Pichert">Gabriella Pichert</name><affiliation><nlm:aff id="aff56"></nlm:aff></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><nlm:aff id="aff57"></nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="aff58"></nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="aff59"></nlm:aff></affiliation></author><author><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><affiliation><nlm:aff id="aff60"></nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="aff25"></nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name><affiliation><nlm:aff id="aff61"></nlm:aff></affiliation></author><author><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnès" last="Chompret">Agnès Chompret</name><affiliation><nlm:aff id="aff62"></nlm:aff></affiliation></author><author><name sortKey="Capoulade, Corinne" sort="Capoulade, Corinne" uniqKey="Capoulade C" first="Corinne" last="Capoulade">Corinne Capoulade</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name><affiliation><nlm:aff id="aff63"></nlm:aff></affiliation></author><author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="aff64"></nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Germline mutations in <italic>BRCA1</italic> and <italic>BRCA2</italic> confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in <italic>FGFR2</italic> (rs2981582), <italic>TNRC9</italic> (rs3803662), and <italic>MAP3K1</italic> (rs889312) are associated with increased breast cancer risks in the general population. To investigate whether these loci are also associated with breast cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, we genotyped these SNPs in a sample of 10,358 mutation carriers from 23 studies. The minor alleles of SNP rs2981582 and rs889312 were each associated with increased breast cancer risk in <italic>BRCA2</italic> mutation carriers (per-allele hazard ratio [HR] = 1.32, 95% CI: 1.20–1.45, p<sub>trend</sub> = 1.7 × 10<sup>−8</sup> and HR = 1.12, 95% CI: 1.02–1.24, p<sub>trend</sub> = 0.02) but not in <italic>BRCA1</italic> carriers. rs3803662 was associated with increased breast cancer risk in both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers (per-allele HR = 1.13, 95% CI: 1.06–1.20, p<sub>trend</sub> = 5 × 10<sup>−5</sup> in <italic>BRCA1</italic> and BRCA2 combined). These loci appear to interact multiplicatively on breast cancer risk in <italic>BRCA2</italic> mutation carriers. The differences in the effects of the <italic>FGFR2</italic> and <italic>MAP3K1</italic> SNPs between <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers point to differences in the biology of <italic>BRCA1</italic> and <italic>BRCA2</italic> breast cancer tumors and confirm the distinct nature of breast cancer in <italic>BRCA1</italic> mutation carriers.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<pmc-comment>ARTICLE</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Hum Genet</journal-id><journal-title>American Journal of Human Genetics</journal-title><issn pub-type="ppub">0002-9297</issn><issn pub-type="epub">1537-6605</issn><publisher><publisher-name>American Society of Human Genetics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18355772</article-id><article-id pub-id-type="pmc">2427217</article-id><article-id pub-id-type="publisher-id">AJHG106</article-id><article-id pub-id-type="doi">10.1016/j.ajhg.2008.02.008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> Mutation Carriers</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><email>antonis@srl.cam.ac.uk</email><xref rid="aff1" ref-type="aff">1</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Sinilnikova</surname><given-names>Olga M.</given-names></name><xref rid="aff3" ref-type="aff">3</xref><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Sue</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Pooley</surname><given-names>Karen A.</given-names></name><xref rid="aff1" ref-type="aff">1</xref><xref rid="aff5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Versmold</surname><given-names>Beatrix</given-names></name><xref rid="aff6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Engel</surname><given-names>Christoph</given-names></name><xref rid="aff7" ref-type="aff">7</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref rid="aff8" ref-type="aff">8</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Norbert</given-names></name><xref rid="aff9" ref-type="aff">9</xref></contrib><contrib contrib-type="author"><name><surname>Hofmann</surname><given-names>Wera</given-names></name><xref rid="aff10" ref-type="aff">10</xref></contrib><contrib contrib-type="author"><name><surname>Sutter</surname><given-names>Christian</given-names></name><xref rid="aff11" ref-type="aff">11</xref></contrib><contrib contrib-type="author"><name><surname>Niederacher</surname><given-names>Dieter</given-names></name><xref rid="aff12" ref-type="aff">12</xref></contrib><contrib contrib-type="author"><name><surname>Deissler</surname><given-names>Helmut</given-names></name><xref rid="aff13" ref-type="aff">13</xref></contrib><contrib contrib-type="author"><name><surname>Caldes</surname><given-names>Trinidad</given-names></name><xref rid="aff14" ref-type="aff">14</xref></contrib><contrib contrib-type="author"><name><surname>Kämpjärvi</surname><given-names>Kati</given-names></name><xref rid="aff15" ref-type="aff">15</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref rid="aff15" ref-type="aff">15</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref rid="aff16" ref-type="aff">16</xref></contrib><contrib contrib-type="author"><name><surname>Beesley</surname><given-names>Jonathan</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Xiaoqing</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><collab>the Kathleen Cuningham Consortium for Research into Familial Breast Cancer</collab><xref rid="aff17" ref-type="aff">17</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref rid="aff18" ref-type="aff">18</xref></contrib><contrib contrib-type="author"><name><surname>Rebbeck</surname><given-names>Timothy R.</given-names></name><xref rid="aff19" ref-type="aff">19</xref></contrib><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>Theresa</given-names></name><xref rid="aff20" ref-type="aff">20</xref></contrib><contrib contrib-type="author"><name><surname>Lynch</surname><given-names>Henry T.</given-names></name><xref rid="aff21" ref-type="aff">21</xref></contrib><contrib contrib-type="author"><name><surname>Isaacs</surname><given-names>Claudine</given-names></name><xref rid="aff22" ref-type="aff">22</xref></contrib><contrib contrib-type="author"><name><surname>Weitzel</surname><given-names>Jeffrey</given-names></name><xref rid="aff23" ref-type="aff">23</xref></contrib><contrib contrib-type="author"><name><surname>Ganz</surname><given-names>Patricia A.</given-names></name><xref rid="aff24" ref-type="aff">24</xref></contrib><contrib contrib-type="author"><name><surname>Daly</surname><given-names>Mary B.</given-names></name><xref rid="aff25" ref-type="aff">25</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Gail</given-names></name><xref rid="aff26" ref-type="aff">26</xref></contrib><contrib contrib-type="author"><name><surname>Olopade</surname><given-names>Olufunmilayo I.</given-names></name><xref rid="aff27" ref-type="aff">27</xref></contrib><contrib contrib-type="author"><name><surname>Blum</surname><given-names>Joanne L.</given-names></name><xref rid="aff28" ref-type="aff">28</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref rid="aff29" ref-type="aff">29</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref rid="aff31" ref-type="aff">31</xref></contrib><contrib contrib-type="author"><name><surname>Barile</surname><given-names>Monica</given-names></name><xref rid="aff32" ref-type="aff">32</xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><xref rid="aff30" ref-type="aff">30</xref></contrib><contrib contrib-type="author"><name><surname>Szabo</surname><given-names>Csilla I.</given-names></name><xref rid="aff33" ref-type="aff">33</xref></contrib><contrib contrib-type="author"><name><surname>Pereira</surname><given-names>Lutecia H. Mateus</given-names></name><xref rid="aff34" ref-type="aff">34</xref><xref rid="fn1" ref-type="fn">65</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H.</given-names></name><xref rid="aff35" ref-type="aff">35</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref rid="aff36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Lejbkowicz</surname><given-names>Flavio</given-names></name><xref rid="aff36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Barnett-Griness</surname><given-names>Ofra</given-names></name><xref rid="aff36" ref-type="aff">36</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref rid="aff37" ref-type="aff">37</xref><xref rid="aff38" ref-type="aff">38</xref><xref rid="aff39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><name><surname>Ozcelik</surname><given-names>Hilmi</given-names></name><xref rid="aff38" ref-type="aff">38</xref><xref rid="aff39" ref-type="aff">39</xref></contrib><contrib contrib-type="author"><collab>OCGN</collab><xref rid="aff37" ref-type="aff">37</xref></contrib><contrib contrib-type="author"><name><surname>Gerdes</surname><given-names>Anne-Marie</given-names></name><xref rid="aff40" ref-type="aff">40</xref></contrib><contrib contrib-type="author"><name><surname>Caligo</surname><given-names>Maria A.</given-names></name><xref rid="aff41" ref-type="aff">41</xref></contrib><contrib contrib-type="author"><name><surname>Laitman</surname><given-names>Yael</given-names></name><xref rid="aff42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Kaufman</surname><given-names>Bella</given-names></name><xref rid="aff43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><name><surname>Milgrom</surname><given-names>Roni</given-names></name><xref rid="aff42" ref-type="aff">42</xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Eitan</given-names></name><xref rid="aff42" ref-type="aff">42</xref><xref rid="aff43" ref-type="aff">43</xref></contrib><contrib contrib-type="author"><collab>The Swedish <italic>BRCA1</italic> and <italic>BRCA2</italic> study collaborators</collab><xref rid="aff44" ref-type="aff">44</xref></contrib><contrib contrib-type="author"><name><surname>Domchek</surname><given-names>Susan M.</given-names></name><xref rid="aff45" ref-type="aff">45</xref></contrib><contrib contrib-type="author"><name><surname>Nathanson</surname><given-names>Katherine L.</given-names></name><xref rid="aff45" ref-type="aff">45</xref></contrib><contrib contrib-type="author"><name><surname>Osorio</surname><given-names>Ana</given-names></name><xref rid="aff46" ref-type="aff">46</xref></contrib><contrib contrib-type="author"><name><surname>Llort</surname><given-names>Gemma</given-names></name><xref rid="aff47" ref-type="aff">47</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref rid="aff48" ref-type="aff">48</xref></contrib><contrib contrib-type="author"><name><surname>Benítez</surname><given-names>Javier</given-names></name><xref rid="aff46" ref-type="aff">46</xref><xref rid="aff48" ref-type="aff">48</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref rid="aff49" ref-type="aff">49</xref></contrib><contrib contrib-type="author"><name><surname>Hogervorst</surname><given-names>Frans B.L.</given-names></name><xref rid="aff50" ref-type="aff">50</xref></contrib><contrib contrib-type="author"><name><surname>Manders</surname><given-names>Peggy</given-names></name><xref rid="aff51" ref-type="aff">51</xref></contrib><contrib contrib-type="author"><name><surname>Ligtenberg</surname><given-names>Marjolijn J.L.</given-names></name><xref rid="aff52" ref-type="aff">52</xref></contrib><contrib contrib-type="author"><name><surname>van den Ouweland</surname><given-names>Ans M.W.</given-names></name><xref rid="aff53" ref-type="aff">53</xref></contrib><contrib contrib-type="author"><collab>The DNA-HEBON collaborators</collab><xref rid="aff44" ref-type="aff">44</xref></contrib><contrib contrib-type="author"><name><surname>Peock</surname><given-names>Susan</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Margaret</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Platte</surname><given-names>Radka</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>D. Gareth</given-names></name><xref rid="aff54" ref-type="aff">54</xref></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind</given-names></name><xref rid="aff55" ref-type="aff">55</xref></contrib><contrib contrib-type="author"><name><surname>Pichert</surname><given-names>Gabriella</given-names></name><xref rid="aff56" ref-type="aff">56</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Carol</given-names></name><xref rid="aff57" ref-type="aff">57</xref></contrib><contrib contrib-type="author"><name><surname>Eccles</surname><given-names>Diana</given-names></name><xref rid="aff58" ref-type="aff">58</xref></contrib><contrib contrib-type="author"><name><surname>Davidson</surname><given-names>Rosemarie</given-names></name><xref rid="aff59" ref-type="aff">59</xref></contrib><contrib contrib-type="author"><name><surname>Douglas</surname><given-names>Fiona</given-names></name><xref rid="aff60" ref-type="aff">60</xref></contrib><contrib contrib-type="author"><collab>EMBRACE</collab><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Godwin</surname><given-names>Andrew K.</given-names></name><xref rid="aff25" ref-type="aff">25</xref></contrib><contrib contrib-type="author"><name><surname>Barjhoux</surname><given-names>Laure</given-names></name><xref rid="aff3" ref-type="aff">3</xref><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Mazoyer</surname><given-names>Sylvie</given-names></name><xref rid="aff4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Sobol</surname><given-names>Hagay</given-names></name><xref rid="aff61" ref-type="aff">61</xref></contrib><contrib contrib-type="author"><name><surname>Bourdon</surname><given-names>Violaine</given-names></name><xref rid="aff61" ref-type="aff">61</xref></contrib><contrib contrib-type="author"><name><surname>Eisinger</surname><given-names>François</given-names></name><xref rid="aff61" ref-type="aff">61</xref></contrib><contrib contrib-type="author"><name><surname>Chompret</surname><given-names>Agnès</given-names></name><xref rid="aff62" ref-type="aff">62</xref><xref rid="fn2" ref-type="fn">66</xref></contrib><contrib contrib-type="author"><name><surname>Capoulade</surname><given-names>Corinne</given-names></name><xref rid="aff63" ref-type="aff">63</xref></contrib><contrib contrib-type="author"><name><surname>Bressac-de Paillerets</surname><given-names>Brigitte</given-names></name><xref rid="aff63" ref-type="aff">63</xref></contrib><contrib contrib-type="author"><name><surname>Lenoir</surname><given-names>Gilbert M.</given-names></name><xref rid="aff63" ref-type="aff">63</xref></contrib><contrib contrib-type="author"><name><surname>Gauthier-Villars</surname><given-names>Marion</given-names></name><xref rid="aff64" ref-type="aff">64</xref></contrib><contrib contrib-type="author"><name><surname>Houdayer</surname><given-names>Claude</given-names></name><xref rid="aff64" ref-type="aff">64</xref></contrib><contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname><given-names>Dominique</given-names></name><xref rid="aff64" ref-type="aff">64</xref></contrib><contrib contrib-type="author"><collab>GEMO</collab></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><collab>on behalf of CIMBA</collab></contrib></contrib-group><aff id="aff1"><addr-line><sup>1</sup>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK</addr-line></aff><aff id="aff2"><addr-line><sup>2</sup>Queensland Institute of Medical Research, Brisbane, Australia</addr-line></aff><aff id="aff3"><addr-line><sup>3</sup>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, Lyon, France</addr-line></aff><aff id="aff4"><addr-line><sup>4</sup>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université Lyon 1, Lyon, France</addr-line></aff><aff id="aff5"><addr-line><sup>5</sup>Cancer Research UK, Human Cancer Genetics Group, Department of Oncology, University of Cambridge, UK</addr-line></aff><aff id="aff6"><addr-line><sup>6</sup>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Germany</addr-line></aff><aff id="aff7"><addr-line><sup>7</sup>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany</addr-line></aff><aff id="aff8"><addr-line><sup>8</sup>Department of Obstetrics and Gynaecology, Technical University, Munich, Germany</addr-line></aff><aff id="aff9"><addr-line><sup>9</sup>Department of Obstetrics and Gynaecology, University of Schleswig-Holstein, Campus Kiel, Germany</addr-line></aff><aff id="aff10"><addr-line><sup>10</sup>Institute of Human Genetics, Charite-University Medical Centre, Berlin, Germany</addr-line></aff><aff id="aff11"><addr-line><sup>11</sup>Institute of Human Genetics, University of Heidelberg, Germany</addr-line></aff><aff id="aff12"><addr-line><sup>12</sup>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Düsseldorf, Germany</addr-line></aff><aff id="aff13"><addr-line><sup>13</sup>Department of Obstetrics and Gynaecology, University of Ulm, Germany</addr-line></aff><aff id="aff14"><addr-line><sup>14</sup>Hospital Clinico San Carlos, Madrid, Spain</addr-line></aff><aff id="aff15"><addr-line><sup>15</sup>Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland</addr-line></aff><aff id="aff16"><addr-line><sup>16</sup>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec and Laval University</addr-line></aff><aff id="aff17"><addr-line><sup>17</sup>Peter MacCallum Cancer Institute, Melbourne, Australia</addr-line></aff><aff id="aff18"><addr-line><sup>18</sup>Department of Epidemiology, University of California, Irvine, CA, USA</addr-line></aff><aff id="aff19"><addr-line><sup>19</sup>Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA</addr-line></aff><aff id="aff20"><addr-line><sup>20</sup>University of Vienna, Vienna, Austria</addr-line></aff><aff id="aff21"><addr-line><sup>21</sup>Creighton University, Omaha, NE, USA</addr-line></aff><aff id="aff22"><addr-line><sup>22</sup>Fisher Center for Familial Cancer Research, Lombardi Cancer Center, Georgetown University, Washington, DC, USA</addr-line></aff><aff id="aff23"><addr-line><sup>23</sup>City of Hope National Medical Center, Duarte, CA, USA</addr-line></aff><aff id="aff24"><addr-line><sup>24</sup>UCLA Schools of Medicine & Public Health, and the UCLA Familial Cancer Registry of the Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, USA</addr-line></aff><aff id="aff25"><addr-line><sup>25</sup>Fox Chase Cancer Center, Philadelphia, PA, USA</addr-line></aff><aff id="aff26"><addr-line><sup>26</sup>University of Texas, Southwestern, Dallas, TX, USA</addr-line></aff><aff id="aff27"><addr-line><sup>27</sup>University of Chicago, Chicago, IL, USA</addr-line></aff><aff id="aff28"><addr-line><sup>28</sup>Baylor-Sammons Cancer Center, Dallas, Texas, USA</addr-line></aff><aff id="aff29"><addr-line><sup>29</sup>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</addr-line></aff><aff id="aff30"><addr-line><sup>30</sup>Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori and IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</addr-line></aff><aff id="aff31"><addr-line><sup>31</sup>Medical Genetics Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</addr-line></aff><aff id="aff32"><addr-line><sup>32</sup>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</addr-line></aff><aff id="aff33"><addr-line><sup>33</sup>Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA</addr-line></aff><aff id="aff34"><addr-line><sup>34</sup>Laboratory of Population Genetics, US National Cancer Institute, National Institutes of Health, Rockville, MD, USA</addr-line></aff><aff id="aff35"><addr-line><sup>35</sup>Clinical Genetics Branch, National Cancer Institute, Rockville, MD, USA</addr-line></aff><aff id="aff36"><addr-line><sup>36</sup>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel</addr-line></aff><aff id="aff37"><addr-line><sup>37</sup>Ontario Cancer Genetics Network, Cancer Care Ontario, and Department of Molecular Genetics, University of Toronto, Ontario, Canada</addr-line></aff><aff id="aff38"><addr-line><sup>38</sup>Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada</addr-line></aff><aff id="aff39"><addr-line><sup>39</sup>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Canada</addr-line></aff><aff id="aff40"><addr-line><sup>40</sup>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark</addr-line></aff><aff id="aff41"><addr-line><sup>41</sup>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy</addr-line></aff><aff id="aff42"><addr-line><sup>42</sup>The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical center, Tel-Hashomer, Israel</addr-line></aff><aff id="aff43"><addr-line><sup>43</sup>Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel</addr-line></aff><aff id="aff44"><addr-line><sup>44</sup>See Acknowledgments</addr-line></aff><aff id="aff45"><addr-line><sup>45</sup>Department of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA</addr-line></aff><aff id="aff46"><addr-line><sup>46</sup>Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre, Madrid, Spain</addr-line></aff><aff id="aff47"><addr-line><sup>47</sup>Genetic Counselling Unit, Prevention and Cancer Control Service, Institut Català d'Oncologia, Barcelona, Spain</addr-line></aff><aff id="aff48"><addr-line><sup>48</sup>Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre, Madrid, Spain</addr-line></aff><aff id="aff49"><addr-line><sup>49</sup>Deutsches Krebsforschungszentrum, Heidelberg, Germany</addr-line></aff><aff id="aff50"><addr-line><sup>50</sup>Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></aff><aff id="aff51"><addr-line><sup>51</sup>Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands</addr-line></aff><aff id="aff52"><addr-line><sup>52</sup>Department of Human Genetics and Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</addr-line></aff><aff id="aff53"><addr-line><sup>53</sup>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</addr-line></aff><aff id="aff54"><addr-line><sup>54</sup>Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK</addr-line></aff><aff id="aff55"><addr-line><sup>55</sup>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, United Kingdom</addr-line></aff><aff id="aff56"><addr-line><sup>56</sup>Clinical Genetics, Guy's Hospital, London, UK</addr-line></aff><aff id="aff57"><addr-line><sup>57</sup>Yorkshire Regional Genetics Service, Leeds, UK</addr-line></aff><aff id="aff58"><addr-line><sup>58</sup>Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK</addr-line></aff><aff id="aff59"><addr-line><sup>59</sup>Ferguson-Smith Centre for Clinical Genetics, Glasgow, UK</addr-line></aff><aff id="aff60"><addr-line><sup>60</sup>Institute of Human Genetics, Centre for Life, Newcastle upon Tyne, UK</addr-line></aff><aff id="aff61"><addr-line><sup>61</sup>INSERM UMR599, Institut Paoli-Calmettes, Département d'Oncologie Génétique, Marseille 13275, France</addr-line></aff><aff id="aff62"><addr-line><sup>62</sup>Oncological Genetics, Department of Medicine, Institut Gustave Roussy, Villejuif, France</addr-line></aff><aff id="aff63"><addr-line><sup>63</sup>CNRS FRE2939, Department of Genetics, Institut Gustave Roussy, Villejuif, France</addr-line></aff><aff id="aff64"><addr-line><sup>64</sup>Institut Curie, Genetics Department, Université Paris-Descartes, France</addr-line></aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author <email>antonis@srl.cam.ac.uk</email></corresp><fn id="fn1"><label>65</label><p>Present address: University of Miami, Sylvester Cancer Center, Miami, FL, USA.</p></fn><fn id="fn2"><label>66</label><p>Deceased.</p></fn></author-notes><pub-date pub-type="ppub"><day>11</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>04</day><month>4</month><year>2008</year></pub-date><volume>82</volume><issue>4</issue><fpage>937</fpage><lpage>948</lpage><history><date date-type="received"><day>21</day><month>12</month><year>2007</year></date><date date-type="rev-recd"><day>11</day><month>2</month><year>2008</year></date><date date-type="accepted"><day>13</day><month>2</month><year>2008</year></date></history><permissions><copyright-statement>© 2008 The American Society of Human Genetics. Published by Elsevier Ltd. All right reserved..</copyright-statement><copyright-year>2008</copyright-year><copyright-holder>The American Society of Human Genetics</copyright-holder><license><p>This document may be redistributed and reused, subject to <ext-link ext-link-type="uri" xlink:href="http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0">certain conditions</ext-link>.</p></license></permissions><abstract><p>Germline mutations in <italic>BRCA1</italic> and <italic>BRCA2</italic> confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in <italic>FGFR2</italic> (rs2981582), <italic>TNRC9</italic> (rs3803662), and <italic>MAP3K1</italic> (rs889312) are associated with increased breast cancer risks in the general population. To investigate whether these loci are also associated with breast cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, we genotyped these SNPs in a sample of 10,358 mutation carriers from 23 studies. The minor alleles of SNP rs2981582 and rs889312 were each associated with increased breast cancer risk in <italic>BRCA2</italic> mutation carriers (per-allele hazard ratio [HR] = 1.32, 95% CI: 1.20–1.45, p<sub>trend</sub> = 1.7 × 10<sup>−8</sup> and HR = 1.12, 95% CI: 1.02–1.24, p<sub>trend</sub> = 0.02) but not in <italic>BRCA1</italic> carriers. rs3803662 was associated with increased breast cancer risk in both <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers (per-allele HR = 1.13, 95% CI: 1.06–1.20, p<sub>trend</sub> = 5 × 10<sup>−5</sup> in <italic>BRCA1</italic> and BRCA2 combined). These loci appear to interact multiplicatively on breast cancer risk in <italic>BRCA2</italic> mutation carriers. The differences in the effects of the <italic>FGFR2</italic> and <italic>MAP3K1</italic> SNPs between <italic>BRCA1</italic> and <italic>BRCA2</italic> carriers point to differences in the biology of <italic>BRCA1</italic> and <italic>BRCA2</italic> breast cancer tumors and confirm the distinct nature of breast cancer in <italic>BRCA1</italic> mutation carriers.</p></abstract></article-meta></front><floats-wrap><fig id="fig1"><label>Figure 1</label><caption><p>Study-Specific Estimates of the Per-Allele Hazard Ratio for SNP rs2981582 in <italic>FGFR2</italic></p><p>The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines represent the 95% confidence intervals.</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Study-Specific Estimates of the Per-Allele Hazard Ratio for SNP rs3803662 in <italic>TNRC9</italic></p><p>The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines represent the 95% confidence intervals.</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="fig3"><label>Figure 3</label><caption><p>Study-Specific Estimates of the Per-Allele Hazard Ratio for SNP rs889312 in <italic>MAP3K1</italic></p><p>The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines represent the 95% confidence intervals.</p></caption><graphic xlink:href="gr3"></graphic></fig><fig id="fig4"><label>Figure 4</label><caption><p>Cumulative Risk of Breast Cancer among <italic>BRCA2</italic> Mutation Carriers by Combined <italic>FGFR2</italic> and <italic>TNRC9</italic> Genotype under a Multiplicative Model for the Joint Effects of the Loci</p><p>The combined <italic>FGFR2</italic> and <italic>TNRC9</italic> genotypes are as follows: <italic>FGFR2</italic> = GG, GA, or AA; <italic>TNRC9</italic> = CC, CT, or TT. “Average” represents the cumulative breast cancer risk over all possible modifying effects among <italic>BRCA2</italic> mutation carriers born after 1950. The minor allele frequencies for the <italic>FGFR2</italic> and <italic>TNRC9</italic> SNPs were assumed to be 0.39 and 0.26, respectively.</p></caption><graphic xlink:href="gr4"></graphic></fig><table-wrap position="float" id="tbl1"><label>Table 1</label><caption><p>Number of <italic>BRCA1</italic> and <italic>BRCA2</italic> Mutation Carriers by Study</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Study</th><th>Country<xref rid="tblfn1" ref-type="table-fn">a</xref></th><th>BRCA1</th><th>BRCA2</th><th>BRCA1 and BRCA2</th><th>Genotyping platform</th></tr></thead><tbody><tr><td>EMBRACE</td><td>U.K. and Eire</td><td>658</td><td>471</td><td>3</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>Spanish National Cancer Centre (CNIO)</td><td>Spain</td><td>167</td><td>205</td><td>0</td><td>Taqman</td></tr><tr><td>Deutsches Krebsforschungszentrum (DKFZ)</td><td>Germany</td><td>122</td><td>50</td><td>0</td><td>Taqman, MALDI-TOF MS, Biplex</td></tr><tr><td>Fox Chase Cancer Center (FCCC)</td><td>U.S.A.</td><td>50</td><td>41</td><td>1</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers (GEMO)</td><td>France</td><td>1102</td><td>554</td><td>0</td><td>Taqman</td></tr><tr><td>German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)</td><td>Germany</td><td>568</td><td>280</td><td>3</td><td>BIORAD iCycler</td></tr><tr><td>Hospital Clinico San Carlos (HCSC)</td><td>Spain</td><td>90</td><td>78</td><td>0</td><td>Taqman</td></tr><tr><td>Helsinki Breast Cancer Study (HBCS)</td><td>Finland</td><td>102</td><td>104</td><td>0</td><td>Taqman</td></tr><tr><td><italic>In</italic>terdisciplinary <italic>He</italic>alth <italic>R</italic>esearch <italic>I</italic>nternational <italic>T</italic>eam <italic>Br</italic>east <italic>Ca</italic>ncer <italic>S</italic>usceptibility (INHERIT BRCAs)</td><td>Quebec-Canada</td><td>72</td><td>82</td><td>0</td><td>Taqman</td></tr><tr><td>kConFab</td><td>Australia</td><td>426</td><td>353</td><td>0</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>Modifiers and Genetics in Cancer (MAGIC)</td><td>U.S.A.</td><td>683</td><td>378</td><td>1</td><td>Taqman</td></tr><tr><td>MAYO</td><td>U.S.A.</td><td>108</td><td>54</td><td>0</td><td>Taqman</td></tr><tr><td>Milan Breast Cancer Study Group (MBCSG)</td><td>Italy</td><td>251</td><td>135</td><td>0</td><td>Taqman</td></tr><tr><td>National Cancer Institute (NCI)</td><td>U.S.A.</td><td>147</td><td>50</td><td>0</td><td>Taqman</td></tr><tr><td>National Israeli Cancer Control Center (NICCC)</td><td>Israel</td><td>283</td><td>160</td><td>1</td><td>Taqman</td></tr><tr><td>Ontario Cancer Genetics Network (OCGN)</td><td>Canada</td><td>195</td><td>143</td><td>0</td><td>Taqman</td></tr><tr><td>Odense University Hospital(OUH)</td><td>Denmark</td><td>106</td><td>0</td><td>0</td><td>Taqman</td></tr><tr><td>Pisa Breast Cancer Study (PBCS)</td><td>Italy</td><td>54</td><td>30</td><td>0</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>Sheeba Medical Centre (SMC)-Tel Hashomer</td><td>Israel</td><td>283</td><td>101</td><td>0</td><td>Taqman</td></tr><tr><td>SWE-BRCA</td><td>Sweden</td><td>426</td><td>127</td><td>0</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>Mod-SQuaD</td><td>Czech Republic</td><td>138</td><td>37</td><td>0</td><td></td></tr><tr><td>University of Pennsylvania (UPENN)</td><td>U.S.A.</td><td>271</td><td>124</td><td>1</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td>HEriditary Breast and Ovarian study Netherlands (DNA-HEBON)</td><td>The Netherlands</td><td>489</td><td>0</td><td>0</td><td>iPLEX<xref rid="tblfn2" ref-type="table-fn">b</xref></td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td>Total</td><td></td><td>6791</td><td>3557</td><td>10</td><td></td></tr></tbody></table><table-wrap-foot><fn id="tblfn1"><label>a</label><p>Coordinating center.</p></fn></table-wrap-foot><table-wrap-foot><fn id="tblfn2"><label>b</label><p>Indicates that samples were genotyped at a central location (Queensland Institute of Medical Research).</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="tbl2"><label>Table 2</label><caption><p>Patient Characteristics</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th></th><th colspan="2"><italic>BRCA1</italic><xref rid="tblfn3" ref-type="table-fn">a</xref><hr></hr></th><th colspan="2"><italic>BRCA2</italic><hr></hr></th></tr><tr><th>Characteristic</th><th>Total</th><th>Unaffected</th><th>Breast Cancer</th><th>Unaffected</th><th>Breast Cancer</th></tr></thead><tbody><tr><td>Number</td><td>10,358</td><td>3300</td><td>3501</td><td>1574</td><td>1983</td></tr><tr><td>Person-years follow-up</td><td>440,252</td><td>140,541</td><td>14,2734</td><td>69,778</td><td>87,199</td></tr><tr><td>Median age at censure (IQR)</td><td>41 (34–49)</td><td>41 (33–50)</td><td>40 (34–46)</td><td>43 (34–52)</td><td>43 (37–50)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td colspan="6">Age at Censure, N (%)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td><30</td><td align="char">1222 (10.8)</td><td align="char">499 (15.1)</td><td align="char">320 (9.1)</td><td align="char">196 (12.5)</td><td align="char">107 (5.4)</td></tr><tr><td>30–39</td><td align="char">3436 (33.2)</td><td align="char">958 (29.0)</td><td align="char">1416 (40.5)</td><td align="char">443 (28.1)</td><td align="char">619 (31.2)</td></tr><tr><td>40–49</td><td align="char">3305 (31.9)</td><td align="char">946 (28.7)</td><td align="char">1200 (12.1)</td><td align="char">428 (27.2)</td><td align="char">731 (36.9)</td></tr><tr><td>50–59</td><td align="char">1683 (16.3)</td><td align="char">584 (17.7)</td><td align="char">423 (12.1)</td><td align="char">295 (18.7)</td><td align="char">381 (19.2)</td></tr><tr><td>60–69</td><td align="char">562 (5.4)</td><td align="char">208 (6.3)</td><td align="char">109 (3.1)</td><td align="char">135 (8.6)</td><td align="char">110 (5.5)</td></tr><tr><td>70+</td><td align="char">250 (2.4)</td><td align="char">105 (3.2)</td><td align="char">33 (0.9)</td><td align="char">77 (4.9)</td><td align="char">35 (1.8)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td colspan="6">Year of Birth, N (%)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td><1920</td><td align="char">92 (0.9)</td><td align="char">25 (0.8)</td><td align="char">32 (0.9)</td><td align="char">20 (1.3)</td><td align="char">15 (0.8)</td></tr><tr><td>1920–1929</td><td align="char">383 (3.7)</td><td align="char">93 (2.8)</td><td align="char">140 (4.0)</td><td align="char">48 (3.0)</td><td align="char">102 (5.1)</td></tr><tr><td>1930–1939</td><td align="char">963 (9.3)</td><td align="char">246 (7.4)</td><td align="char">335 (9.6)</td><td align="char">138 (8.8)</td><td align="char">244 (12.3)</td></tr><tr><td>1940–1949</td><td align="char">2066 (20.0)</td><td align="char">511 (15.5)</td><td align="char">836 (23.9)</td><td align="char">228 (14.5)</td><td align="char">491 (24.8)</td></tr><tr><td>1950–1959</td><td align="char">2913 (28.1)</td><td align="char">804 (24.4)</td><td align="char">1,122 (32.0)</td><td align="char">368 (23.4)</td><td align="char">619 (31.2)</td></tr><tr><td>1960+</td><td align="char">3741 (38.0)</td><td align="char">1,621 (49.1)</td><td align="char">1,036 (29.6)</td><td align="char">772 (49.0)</td><td align="char">512 (25.8)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td colspan="6">Risk-Reducing Salpingo-Oophorectomy (RRSO)</td></tr><tr><td colspan="6"><hr></hr></td></tr><tr><td>No RRSO</td><td align="char">6613 (63.8)</td><td align="char">2,032 (61.6)</td><td align="char">2369 (67.7)</td><td align="char">928 (59.0)</td><td align="char">1284 (64.7)</td></tr><tr><td>RRSO</td><td align="char">577 (5.6)</td><td align="char">318 (9.6)</td><td align="char">85 (2.4)</td><td align="char">119 (7.6)</td><td align="char">55 (2.8)</td></tr><tr><td>Missing</td><td align="char">3168 (30.6)</td><td align="char">950 (28.8)</td><td align="char">1047 (29.9)</td><td align="char">527 (33.4)</td><td align="char">644 (32.5)</td></tr></tbody></table><table-wrap-foot><fn><p>IQR: Interquartile range.</p></fn></table-wrap-foot><table-wrap-foot><fn id="tblfn3"><label>a</label><p>Includes the ten females who have mutations in both BRCA1 and BRCA2.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="tbl3"><label>Table 3</label><caption><p>Genotype Frequencies by Mutation and Disease Status and Hazard-Ratio Estimates</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th></th><th>Unaffected (%)</th><th>Affected (%)</th><th>HR<xref rid="tblfn4" ref-type="table-fn">a</xref></th><th>95% CI</th><th>p Value</th></tr></thead><tbody><tr><td colspan="7"><italic>FGFR2</italic> rs2981582</td></tr><tr><td colspan="7"><hr></hr></td></tr><tr><td><italic>BRCA1</italic> and <italic>BRCA2</italic></td><td>GG</td><td align="char">1547 (36.0)</td><td align="char">1647 (33.0)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>GA</td><td align="char">2051 (47.7)</td><td align="char">2407 (48.2)</td><td align="char">1.10</td><td align="char">1.01–1.20</td><td></td></tr><tr><td></td><td>AA</td><td align="char">703 (16.3)</td><td align="char">936 (18.8)</td><td align="char">1.24</td><td align="char">1.11–1.38</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.00045</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.11</td><td align="char">1.05–1.17</td><td>0.000095</td></tr><tr><td><italic>BRCA1</italic></td><td>GG</td><td align="char">1021 (35.5)</td><td align="char">1114 (35.3)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>GA</td><td align="char">1376 (47.9)</td><td align="char">1487 (47.2)</td><td align="char">0.99</td><td align="char">0.89–1.10</td><td></td></tr><tr><td></td><td>AA</td><td align="char">477 (16.6)</td><td align="char">553 (17.5)</td><td align="char">1.05</td><td align="char">0.92–1.20</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.65</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.02</td><td align="char">0.95–1.09</td><td>0.60</td></tr><tr><td><italic>BRCA2</italic></td><td>GG</td><td align="char">526 (36.9)</td><td align="char">533 (29.0)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>GA</td><td align="char">675 (47.3)</td><td align="char">920 (50.1)</td><td align="char">1.35</td><td align="char">1.17–1.57</td><td></td></tr><tr><td></td><td>AA</td><td align="char">226 (15.8)</td><td align="char">383 (20.9)</td><td align="char">1.72</td><td align="char">1.41–2.09</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>9.9 × 10<sup>−8</sup></td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.32</td><td align="char">1.20–1.45</td><td>1.7 × 10<sup>−8</sup></td></tr><tr><td colspan="7"><hr></hr></td></tr><tr><td colspan="7"><italic>TNRC9</italic> rs3803662</td></tr><tr><td colspan="7"><hr></hr></td></tr><tr><td>BRCA1 and BRCA2</td><td>CC</td><td align="char">2244 (50.3)</td><td align="char">2422 (47.6)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>CT</td><td align="char">1831 (41.1)</td><td align="char">2173 (42.7)</td><td align="char">1.13</td><td align="char">1.04–1.22</td><td></td></tr><tr><td></td><td>TT</td><td align="char">382 (8.6)</td><td align="char">497 (9.7)</td><td align="char">1.28</td><td align="char">1.11–1.46</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.00027</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.13</td><td align="char">1.06–1.20</td><td>5 × 10<sup>−5</sup></td></tr><tr><td><italic>BRCA1</italic></td><td>CC</td><td align="char">1542 (50.9)</td><td align="char">1571 (48.2)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>CT</td><td align="char">1238 (40.8)</td><td align="char">1384 (42.4)</td><td align="char">1.11</td><td align="char">1.01–1.22</td><td></td></tr><tr><td></td><td>TT</td><td align="char">251 (8.3)</td><td align="char">308 (9.4)</td><td align="char">1.24</td><td align="char">1.04–1.46</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.017</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.11</td><td align="char">1.03–1.19</td><td>0.0043</td></tr><tr><td><italic>BRCA2</italic></td><td>CC</td><td align="char">702 (49.2)</td><td align="char">851 (46.5)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>CT</td><td align="char">593 (41.6)</td><td align="char">789 (43.2)</td><td align="char">1.15</td><td align="char">1.00–1.32</td><td></td></tr><tr><td></td><td>TT</td><td align="char">131 (9.2)</td><td align="char">189 (10.3)</td><td align="char">1.32</td><td>1.04-1.67</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.033</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.15</td><td align="char">1.03–1.27</td><td>0.009</td></tr><tr><td colspan="7"><hr></hr></td></tr><tr><td colspan="7"><italic>MAP3K1</italic> rs889312</td></tr><tr><td colspan="7"><hr></hr></td></tr><tr><td><italic>BRCA1</italic> and <italic>BRCA2</italic></td><td>AA</td><td align="char">2440 (50.5)</td><td align="char">2711 (49.9)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>AC</td><td align="char">1963 (40.7)</td><td align="char">2195 (40.4)</td><td align="char">1.02</td><td align="char">0.94–1.10</td><td></td></tr><tr><td></td><td>CC</td><td align="char">426 (8.8)</td><td align="char">530 (9.8)</td><td align="char">1.08</td><td align="char">0.95–1.22</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.53</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.03</td><td align="char">0.97–1.09</td><td>0.29</td></tr><tr><td><italic>BRCA1</italic></td><td>AA</td><td align="char">1637 (50.0)</td><td align="char">1743 (50.2)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>AC</td><td align="char">1329 (40.6)</td><td align="char">1394 (40.2)</td><td align="char">1.00</td><td align="char">0.91–1.09</td><td></td></tr><tr><td></td><td>CC</td><td align="char">306 (9.4)</td><td align="char">332 (9.6)</td><td align="char">0.98</td><td align="char">0.84–1.15</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.98</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">0.99</td><td align="char">0.93–1.06</td><td>0.86</td></tr><tr><td><italic>BRCA2</italic></td><td>AA</td><td align="char">803 (51.6)</td><td align="char">968 (49.2)</td><td align="char">1.00</td><td></td><td></td></tr><tr><td></td><td>AC</td><td align="char">634 (40.7)</td><td align="char">801 (40.7)</td><td align="char">1.08</td><td align="char">0.94–1.24</td><td></td></tr><tr><td></td><td>CC</td><td align="char">120 (7.7)</td><td align="char">198 (10.1)</td><td align="char">1.32</td><td align="char">1.05–1.66</td><td></td></tr><tr><td></td><td>2-df test</td><td></td><td></td><td></td><td></td><td>0.049</td></tr><tr><td></td><td>Per allele</td><td></td><td></td><td align="char">1.12</td><td align="char">1.02–1.24</td><td>0.020</td></tr></tbody></table><table-wrap-foot><fn id="tblfn4"><label>a</label><p>In all cases, where significant, the effect is consistent with a multiplicative model in which each copy of the disease allele confers the estimated, per-allele HR.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="tbl4"><label>Table 4</label><caption><p>HR Estimates for the Combined Genotypes of SNPs in <italic>FGFR2</italic> and <italic>TNRC9</italic> among <italic>BRCA2</italic> Carriers under a Multiplicative Model and under a Fully Saturated Model</p></caption><table frame="hsides" rules="groups"><tbody><tr><td>FGFR2/TNRC9 Genotype</td><td>HR Multiplicative Model<xref rid="tblfn5" ref-type="table-fn">a</xref></td><td>HR Fully Saturated Model</td><td>Predicted Genotype Distribution<xref rid="tblfn6" ref-type="table-fn">b</xref> (%)</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td>GG/CC</td><td align="char">1.00</td><td align="char">1.00</td><td align="char">20.4</td></tr><tr><td>GG/CT</td><td align="char">1.16</td><td align="char">1.05</td><td align="char">14.3</td></tr><tr><td>GG/TT</td><td align="char">1.35</td><td align="char">1.23</td><td align="char">2.5</td></tr><tr><td>GA/CC</td><td align="char">1.29</td><td align="char">1.25</td><td align="char">26.1</td></tr><tr><td>GA/CT</td><td align="char">1.50</td><td align="char">1.44</td><td align="char">18.3</td></tr><tr><td>GA/TT</td><td align="char">1.75</td><td align="char">1.72</td><td align="char">3.2</td></tr><tr><td>AA/CC</td><td align="char">1.67</td><td align="char">1.41</td><td align="char">8.3</td></tr><tr><td>AA/CT</td><td align="char">1.94</td><td align="char">2.08</td><td align="char">5.9</td></tr><tr><td>AA/TT</td><td align="char">2.26</td><td align="char">2.08</td><td align="char">1.0</td></tr></tbody></table><table-wrap-foot><fn id="tblfn5"><label>a</label><p>Multiplicative model, per-allele HRs. <italic>FGFR2</italic>: 1.29 (95%CI: 1.17–1.43); <italic>TNRC9</italic>: 1.16 (95%CI: 1.04–1.30).</p></fn></table-wrap-foot><table-wrap-foot><fn id="tblfn6"><label>b</label><p>Assuming a minor allele frequency of 0.39 for <italic>FGFR2</italic> (rs rs2981582) and 0.26 for <italic>TNRC9</italic> (rs rs3803662).<xref rid="bib10" ref-type="bibr"><sup>10</sup></xref></p></fn></table-wrap-foot></table-wrap></floats-wrap></pmc><affiliations><list></list><tree><noCountry><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><name sortKey="Barnett Griness, Ofra" sort="Barnett Griness, Ofra" uniqKey="Barnett Griness O" first="Ofra" last="Barnett-Griness">Ofra Barnett-Griness</name><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><name sortKey="Blum, Joanne L" sort="Blum, Joanne L" uniqKey="Blum J" first="Joanne L." last="Blum">Joanne L. Blum</name><name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><name sortKey="Capoulade, Corinne" sort="Capoulade, Corinne" uniqKey="Capoulade C" first="Corinne" last="Capoulade">Corinne Capoulade</name><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnès" last="Chompret">Agnès Chompret</name><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><name sortKey="Deissler, Helmut" sort="Deissler, Helmut" uniqKey="Deissler H" first="Helmut" last="Deissler">Helmut Deissler</name><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><name sortKey="Douglas, Fiona" sort="Douglas, Fiona" uniqKey="Douglas F" first="Fiona" last="Douglas">Fiona Douglas</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><name sortKey="Hofmann, Wera" sort="Hofmann, Wera" uniqKey="Hofmann W" first="Wera" last="Hofmann">Wera Hofmann</name><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name><name sortKey="K Mpj Rvi, Kati" sort="K Mpj Rvi, Kati" uniqKey="K Mpj Rvi K" first="Kati" last="K Mpj Rvi">Kati K Mpj Rvi</name><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name><name sortKey="Ligtenberg, Marjolijn J L" sort="Ligtenberg, Marjolijn J L" uniqKey="Ligtenberg M" first="Marjolijn J. L." last="Ligtenberg">Marjolijn J. L. Ligtenberg</name><name sortKey="Llort, Gemma" sort="Llort, Gemma" uniqKey="Llort G" first="Gemma" last="Llort">Gemma Llort</name><name sortKey="Lynch, Henry T" sort="Lynch, Henry T" uniqKey="Lynch H" first="Henry T." last="Lynch">Henry T. Lynch</name><name sortKey="Manders, Peggy" sort="Manders, Peggy" uniqKey="Manders P" first="Peggy" last="Manders">Peggy Manders</name><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><name sortKey="Milgrom, Roni" sort="Milgrom, Roni" uniqKey="Milgrom R" first="Roni" last="Milgrom">Roni Milgrom</name><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><name sortKey="Pereira, Lutecia H Mateus" sort="Pereira, Lutecia H Mateus" uniqKey="Pereira L" first="Lutecia H. Mateus" last="Pereira">Lutecia H. Mateus Pereira</name><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><name sortKey="Pichert, Gabriella" sort="Pichert, Gabriella" uniqKey="Pichert G" first="Gabriella" last="Pichert">Gabriella Pichert</name><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><name sortKey="Tomlinson, Gail" sort="Tomlinson, Gail" uniqKey="Tomlinson G" first="Gail" last="Tomlinson">Gail Tomlinson</name><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><name sortKey="Wagner, Theresa" sort="Wagner, Theresa" uniqKey="Wagner T" first="Theresa" last="Wagner">Theresa Wagner</name><name sortKey="Weitzel, Jeffrey" sort="Weitzel, Jeffrey" uniqKey="Weitzel J" first="Jeffrey" last="Weitzel">Jeffrey Weitzel</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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