Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Identifieur interne : 004B55 ( Main/Merge ); précédent : 004B54; suivant : 004B56Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Auteurs : Frances M. K. Williams [Royaume-Uni] ; Angela M. Carter [Royaume-Uni] ; Pirro G. Hysi [Royaume-Uni] ; Gabriela Surdulescu [Royaume-Uni] ; Dylan Hodgkiss [Royaume-Uni] ; Nicole Soranzo [Royaume-Uni, États-Unis, Finlande] ; Matthew Traylor [Royaume-Uni] ; Steve Bevan [Royaume-Uni] ; Martin Dichgans [Allemagne] ; Peter M. W. Rothwell [Royaume-Uni] ; Cathie Sudlow [Royaume-Uni] ; Martin Farrall [Royaume-Uni] ; Kaisa Silander [Finlande] ; Mari Kaunisto [Finlande] ; Peter Wagner [Finlande] ; Olli Saarela [Finlande] ; Kari Kuulasmaa [Finlande] ; Jarmo Virtamo [Finlande] ; Veikko Salomaa [Finlande] ; Philippe Amouyel [France] ; Dominique Arveiler [France] ; Jean Ferrieres [France] ; Per-Gunnar Wiklund [Suède] ; M. Arfan Ikram [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Giorgio B. Boncoraglio [Italie] ; Eugenio A. Parati [Italie] ; Anna Helgadottir [Royaume-Uni, Islande] ; Solveig Gretarsdottir [Islande] ; Unnur Thorsteinsdottir [Islande] ; Gudmar Thorleifsson [Islande] ; Kari Stefansson [Islande] ; Sudha Seshadri [États-Unis] ; Anita Destefano [États-Unis] ; Andreas Gschwendtner [Allemagne] ; Bruce Psaty [États-Unis] ; Will Longstreth [États-Unis] ; Braxton D. Mitchell [Royaume-Uni] ; Yu-Ching Cheng [Royaume-Uni] ; Robert Clarke [Italie] ; Marco Ferrario [États-Unis] ; Joshua C. Bis [Australie] ; Christopher Levi [Australie, États-Unis] ; John Attia [Australie, États-Unis] ; Elizabeth G. Holliday [Australie, États-Unis] ; Rodney J. Scott [Australie, États-Unis] ; Myriam Fornage [Royaume-Uni] ; Pankaj Sharma [États-Unis] ; Karen L. Furie [États-Unis] ; Jonathan Rosand [États-Unis] ; Mike Nalls [États-Unis] ; James Meschia [États-Unis] ; Thomas H. Mosely [Royaume-Uni] ; Alun Evans ; Aarno Palotie [Royaume-Uni, États-Unis, Finlande] ; Hugh S. Markus [Royaume-Uni] ; Peter J. Grant [Royaume-Uni] ; Tim D. Spector [Royaume-Uni]Source :
- Annals of Neurology [ 0364-5134 ] ; 2013-01.
Descripteurs français
- Wicri :
- geographic : Finlande.
- topic : Maladie cardio-vasculaire, Consortium, épidémiologie, Génétique, Recherche médicale, Neurologie, Santé publique, Recherche scientifique.
English descriptors
- KwdEn :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
- Teeft :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
Abstract
Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.
Url:
- https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582024
DOI: 10.1002/ana.23838
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ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839Le document en format XML
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K." last="Williams">Frances M. K. Williams</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, University of Umeo̊, Umeo̊</wicri:regionArea><wicri:noRegion>Umeo̊</wicri:noRegion></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Neurology, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Callaghan</wicri:regionArea><wicri:noRegion>Callaghan</wicri:noRegion></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Cerebrovascular Research Unit, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University of Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term><term>Consortium</term><term>épidémiologie</term><term>Génétique</term><term>Recherche médicale</term><term>Neurologie</term><term>Santé publique</term><term>Recherche scientifique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</div></front></TEI><double doi="10.1002/ana.23838"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ischemic stroke is associated with the ABO locus: The EuroCLOT study</title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/ana.23838</idno><idno type="url">https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002705</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002705</idno><idno type="wicri:Area/Istex/Curation">002705</idno><idno type="wicri:Area/Istex/Checkpoint">000341</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000341</idno><idno type="wicri:doubleKey">0364-5134:2013:Williams F:ischemic:stroke:is</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en"><hi rend="italic">ABO</hi><ref type="note" target="#fn20"></ref><:t></:t><:t></:t></title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, University of Umeo̊, Umeo̊</wicri:regionArea><wicri:noRegion>Umeo̊</wicri:noRegion></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Neurology, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Callaghan</wicri:regionArea><wicri:noRegion>Callaghan</wicri:noRegion></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Cerebrovascular Research Unit, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University of Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term><term>Consortium</term><term>épidémiologie</term><term>Génétique</term><term>Recherche médicale</term><term>Neurologie</term><term>Santé publique</term><term>Recherche scientifique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ischemic Stroke Is Associated with the <italic>ABO</italic> Locus: The EuroCLOT Study</title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M K" last="Williams">Frances M K. Williams</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M" last="Carter">Angela M. Carter</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Division of Cardiovascular and Diabetes Research, University of Leeds</institution><addr-line>Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution><addr-line>Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard</institution><addr-line>Cambridge, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig-Maximilians-University</institution><addr-line>Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich</wicri:regionArea></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M W" last="Rothwell">Peter M W. Rothwell</name><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Division of Clinical Neurosciences, University of Edinburgh</institution><addr-line>Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Epidemiology and Public Health, Pasteur Institute of Lille</institution><addr-line>Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lille</wicri:regionArea></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Epidemiology and Public Health, University of Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><nlm:aff id="au15"><institution>Department of Epidemiology, Faculty of Medicine</institution><addr-line>Toulouse-Purpan, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Toulouse-Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Per Gunnar" sort="Wiklund, Per Gunnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Internal Medicine, University of Umeå</institution><addr-line>Umeå, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M" last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Department of Epidemiology, Erasmus University Medical Center</institution><addr-line>Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Department of Epidemiology, Erasmus University Medical Center</institution><addr-line>Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B" last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A" last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="au20"><institution>Boston University Schools of Medicine and Public Health</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au21"><institution>Framingham Heart Study</institution><addr-line>Framingham, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham</wicri:cityArea></affiliation><affiliation><nlm:aff id="au22"><institution>Departments of Health Services, University of Washington</institution><addr-line>Seattlem WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><nlm:aff id="au20"><institution>Boston University Schools of Medicine and Public Health</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au21"><institution>Framingham Heart Study</institution><addr-line>Framingham, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham</wicri:cityArea></affiliation><affiliation><nlm:aff id="au22"><institution>Departments of Health Services, University of Washington</institution><addr-line>Seattlem WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig-Maximilians-University</institution><addr-line>Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><nlm:aff id="au23"><institution>Epidemiology, Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au24"><institution>Medicine, and Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au25"><institution>Group Health Research Institute, Group Health</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="au26"><institution>Department of Neurology, University of Washington</institution><addr-line>WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><nlm:aff id="au23"><institution>Epidemiology, Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au24"><institution>Medicine, and Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au27"><institution>Department of Medicine, University of Maryland</institution><addr-line>Baltimore, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Clinical Trial Service Unit, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Yu Ching" sort="Cheng, Yu Ching" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Clinical Trial Service Unit, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>University of Insubria</institution><addr-line>Varese, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Varese</wicri:regionArea></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><nlm:aff id="au30"><institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>University of Newcastle</institution><addr-line>Callaghan, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Callaghan</wicri:regionArea></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><nlm:aff id="au35"><institution>Imperial College Cerebrovascular Research Unit, Imperial College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><nlm:aff id="au36"><institution>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L" last="Furie">Karen L. Furie</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Jacksonville, FL, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Jacksonville, FL, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>University of Mississippi Medical Center</institution><addr-line>Jackson, MS</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>University of Mississippi Medical Center</institution><addr-line>Jackson, MS</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H" last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><nlm:aff id="au39"><institution>Queen's University of Belfast</institution><addr-line>Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution><addr-line>Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard</institution><addr-line>Cambridge, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S" last="Markus">Hugh S. Markus</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J" last="Grant">Peter J. Grant</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Division of Cardiovascular and Diabetes Research, University of Leeds</institution><addr-line>Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23381943</idno><idno type="pmc">3582024</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582024</idno><idno type="RBID">PMC:3582024</idno><idno type="doi">10.1002/ana.23838</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002239</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002239</idno><idno type="wicri:Area/Pmc/Curation">002089</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002089</idno><idno type="wicri:Area/Pmc/Checkpoint">001A38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A38</idno><idno type="wicri:Area/Ncbi/Merge">001122</idno><idno type="wicri:Area/Ncbi/Curation">001122</idno><idno type="wicri:Area/Ncbi/Checkpoint">001122</idno><idno type="wicri:doubleKey">0364-5134:2013:Williams F:ischemic:stroke:is</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ischemic Stroke Is Associated with the <italic>ABO</italic> Locus: The EuroCLOT Study</title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M K" last="Williams">Frances M K. Williams</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M" last="Carter">Angela M. Carter</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Division of Cardiovascular and Diabetes Research, University of Leeds</institution><addr-line>Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution><addr-line>Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard</institution><addr-line>Cambridge, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig-Maximilians-University</institution><addr-line>Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich</wicri:regionArea></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M W" last="Rothwell">Peter M W. Rothwell</name><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Division of Clinical Neurosciences, University of Edinburgh</institution><addr-line>Edinburgh, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Epidemiology and Public Health, Pasteur Institute of Lille</institution><addr-line>Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lille</wicri:regionArea></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Epidemiology and Public Health, University of Strasbourg</institution><addr-line>Strasbourg, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><nlm:aff id="au15"><institution>Department of Epidemiology, Faculty of Medicine</institution><addr-line>Toulouse-Purpan, Toulouse, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Toulouse-Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Per Gunnar" sort="Wiklund, Per Gunnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Internal Medicine, University of Umeå</institution><addr-line>Umeå, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M" last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Department of Epidemiology, Erasmus University Medical Center</institution><addr-line>Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Department of Epidemiology, Erasmus University Medical Center</institution><addr-line>Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B" last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A" last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>DeCODE Genetics</institution><addr-line>Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="au20"><institution>Boston University Schools of Medicine and Public Health</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au21"><institution>Framingham Heart Study</institution><addr-line>Framingham, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham</wicri:cityArea></affiliation><affiliation><nlm:aff id="au22"><institution>Departments of Health Services, University of Washington</institution><addr-line>Seattlem WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><nlm:aff id="au20"><institution>Boston University Schools of Medicine and Public Health</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au21"><institution>Framingham Heart Study</institution><addr-line>Framingham, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham</wicri:cityArea></affiliation><affiliation><nlm:aff id="au22"><institution>Departments of Health Services, University of Washington</institution><addr-line>Seattlem WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig-Maximilians-University</institution><addr-line>Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Munich</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><nlm:aff id="au23"><institution>Epidemiology, Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au24"><institution>Medicine, and Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au25"><institution>Group Health Research Institute, Group Health</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation><nlm:aff id="au26"><institution>Department of Neurology, University of Washington</institution><addr-line>WA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><nlm:aff id="au23"><institution>Epidemiology, Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au24"><institution>Medicine, and Health Services, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au27"><institution>Department of Medicine, University of Maryland</institution><addr-line>Baltimore, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Clinical Trial Service Unit, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Yu Ching" sort="Cheng, Yu Ching" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Clinical Trial Service Unit, University of Oxford</institution><addr-line>Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>University of Insubria</institution><addr-line>Varese, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Varese</wicri:regionArea></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><nlm:aff id="au30"><institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution><addr-line>Seattle, WA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>University of Newcastle</institution><addr-line>Callaghan, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Callaghan</wicri:regionArea></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>John Hunter Hospital</institution><addr-line>New Lambton Heights, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au33"><institution>Hunter Medical Research Institute</institution><addr-line>New Lambton, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center</institution><addr-line>Houston, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><nlm:aff id="au35"><institution>Imperial College Cerebrovascular Research Unit, Imperial College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><nlm:aff id="au36"><institution>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L" last="Furie">Karen L. Furie</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Jacksonville, FL, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Jacksonville, FL, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>University of Mississippi Medical Center</institution><addr-line>Jackson, MS</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>University of Mississippi Medical Center</institution><addr-line>Jackson, MS</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H" last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><nlm:aff id="au39"><institution>Queen's University of Belfast</institution><addr-line>Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution><addr-line>Hinxton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard</institution><addr-line>Cambridge, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Institute for Molecular Medicine Finland, University of Helsinki</institution><addr-line>Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S" last="Markus">Hugh S. Markus</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Stroke and Dementia Research Centre, St George's University of London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J" last="Grant">Peter J. Grant</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Division of Cardiovascular and Diabetes Research, University of Leeds</institution><addr-line>Leeds, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Twin Research and Genetic Epidemiology, King's College London</institution><addr-line>London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Neurology</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</p></sec><sec><title>Methods</title><p>Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).</p></sec><sec><title>Results</title><p>Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (<italic>p</italic> < 5 × 10<sup>–8</sup>) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (<italic>p</italic> = 2.6 × 10<sup>–186</sup>), rs10665 with FVII (<italic>p</italic> = 2.4 × 10<sup>–47</sup>), and rs505922 in the <italic>ABO</italic> gene with both von Willebrand factor (<italic>p</italic> = 4.7 × 10<sup>–57</sup>) and factor VIII (<italic>p</italic> = 1.2 × 10<sup>–36</sup>). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88–0.99, <italic>p</italic> = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), <italic>p</italic> = 0.001, a finding specific to large-vessel and cardioembolic stroke (<italic>p</italic> = 0.001 and <italic>p</italic> = < 0.001, respectively) but not seen with small-vessel stroke (<italic>p</italic> = 0.811).</p></sec><sec><title>Interpretation</title><p><italic>ABO</italic> gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. 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