Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Identifieur interne : 002705 ( Istex/Curation ); précédent : 002704; suivant : 002706Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Auteurs : Frances M. K. Williams [Royaume-Uni] ; Angela M. Carter [Royaume-Uni] ; Pirro G. Hysi [Royaume-Uni] ; Gabriela Surdulescu [Royaume-Uni] ; Dylan Hodgkiss [Royaume-Uni] ; Nicole Soranzo [Royaume-Uni, États-Unis, Finlande] ; Matthew Traylor [Royaume-Uni] ; Steve Bevan [Royaume-Uni] ; Martin Dichgans [Allemagne] ; Peter M. W. Rothwell [Royaume-Uni] ; Cathie Sudlow [Royaume-Uni] ; Martin Farrall [Royaume-Uni] ; Kaisa Silander [Finlande] ; Mari Kaunisto [Finlande] ; Peter Wagner [Finlande] ; Olli Saarela [Finlande] ; Kari Kuulasmaa [Finlande] ; Jarmo Virtamo [Finlande] ; Veikko Salomaa [Finlande] ; Philippe Amouyel [France] ; Dominique Arveiler [France] ; Jean Ferrieres [France] ; Per-Gunnar Wiklund [Suède] ; M. Arfan Ikram [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Giorgio B. Boncoraglio [Italie] ; Eugenio A. Parati [Italie] ; Anna Helgadottir [Royaume-Uni, Islande] ; Solveig Gretarsdottir [Islande] ; Unnur Thorsteinsdottir [Islande] ; Gudmar Thorleifsson [Islande] ; Kari Stefansson [Islande] ; Sudha Seshadri [États-Unis] ; Anita Destefano [États-Unis] ; Andreas Gschwendtner [Allemagne] ; Bruce Psaty [États-Unis] ; Will Longstreth [États-Unis] ; Braxton D. Mitchell [Royaume-Uni] ; Yu-Ching Cheng [Royaume-Uni] ; Robert Clarke [Italie] ; Marco Ferrario [États-Unis] ; Joshua C. Bis [Australie] ; Christopher Levi [Australie, États-Unis] ; John Attia [Australie, États-Unis] ; Elizabeth G. Holliday [Australie, États-Unis] ; Rodney J. Scott [Australie, États-Unis] ; Myriam Fornage [Royaume-Uni] ; Pankaj Sharma [États-Unis] ; Karen L. Furie [États-Unis] ; Jonathan Rosand [États-Unis] ; Mike Nalls [États-Unis] ; James Meschia [États-Unis] ; Thomas H. Mosely [Royaume-Uni] ; Alun Evans ; Aarno Palotie [Royaume-Uni, États-Unis, Finlande] ; Hugh S. Markus [Royaume-Uni] ; Peter J. Grant [Royaume-Uni] ; Tim D. Spector [Royaume-Uni]Source :
- Annals of Neurology [ 0364-5134 ] ; 2013-01.
Descripteurs français
- Wicri :
- geographic : Finlande.
- topic : Maladie cardio-vasculaire, Consortium, épidémiologie, Génétique, Recherche médicale, Neurologie, Santé publique, Recherche scientifique.
English descriptors
- KwdEn :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
- Teeft :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
Abstract
Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.
Url:
DOI: 10.1002/ana.23838
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Rothwell</name><affiliation wicri:level="1"><mods:affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="1"><mods:affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin 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Kaunisto</name><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, University of Umeo̊, Umeo̊</wicri:regionArea></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="1"><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Group Health Research Institute, Group Health, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, University of Washington, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Neurology, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, University of Maryland, Baltimore, MD</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="1"><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><mods:affiliation>University of Insubria, Varese, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><mods:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><mods:affiliation>University of Newcastle, Callaghan, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Callaghan</wicri:regionArea></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><mods:affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Cerebrovascular Research Unit, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><mods:affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><mods:affiliation>Queen's University of Belfast, Belfast, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University of Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation wicri:level="1"><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation wicri:level="1"><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/ana.23838</idno><idno type="url">https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002705</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002705</idno><idno type="wicri:Area/Istex/Curation">002705</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en"><hi rend="italic">ABO</hi><ref type="note" target="#fn20"></ref><:t>Ischemic stroke is associated with the</:t><:t>locus: The EuroCLOT study</:t></title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: frances.williams@kcl.ac.uk</mods:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation><mods:affiliation>Correspondence address: Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</mods:affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation wicri:level="1"><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="1"><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="1"><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="1"><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation wicri:level="1"><mods:affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="1"><mods:affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, University of Umeo̊, Umeo̊</wicri:regionArea></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="1"><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Group Health Research Institute, Group Health, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, University of Washington, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Neurology, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Department of Medicine, University of Maryland, Baltimore, MD</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="1"><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="1"><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><mods:affiliation>University of Insubria, Varese, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Insubria, Varese</wicri:regionArea></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><mods:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><mods:affiliation>University of Newcastle, Callaghan, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Callaghan</wicri:regionArea></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><mods:affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Cerebrovascular Research Unit, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><mods:affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><mods:affiliation>Queen's University of Belfast, Belfast, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University of Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation wicri:level="1"><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation wicri:level="1"><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="1"><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term><term>Consortium</term><term>épidémiologie</term><term>Génétique</term><term>Recherche médicale</term><term>Neurologie</term><term>Santé publique</term><term>Recherche scientifique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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