Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Identifieur interne : 002705 ( Istex/Corpus ); précédent : 002704; suivant : 002706Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Auteurs : Frances M. K. Williams ; Angela M. Carter ; Pirro G. Hysi ; Gabriela Surdulescu ; Dylan Hodgkiss ; Nicole Soranzo ; Matthew Traylor ; Steve Bevan ; Martin Dichgans ; Peter M. W. Rothwell ; Cathie Sudlow ; Martin Farrall ; Kaisa Silander ; Mari Kaunisto ; Peter Wagner ; Olli Saarela ; Kari Kuulasmaa ; Jarmo Virtamo ; Veikko Salomaa ; Philippe Amouyel ; Dominique Arveiler ; Jean Ferrieres ; Per-Gunnar Wiklund ; M. Arfan Ikram ; Albert Hofman ; Giorgio B. Boncoraglio ; Eugenio A. Parati ; Anna Helgadottir ; Solveig Gretarsdottir ; Unnur Thorsteinsdottir ; Gudmar Thorleifsson ; Kari Stefansson ; Sudha Seshadri ; Anita Destefano ; Andreas Gschwendtner ; Bruce Psaty ; Will Longstreth ; Braxton D. Mitchell ; Yu-Ching Cheng ; Robert Clarke ; Marco Ferrario ; Joshua C. Bis ; Christopher Levi ; John Attia ; Elizabeth G. Holliday ; Rodney J. Scott ; Myriam Fornage ; Pankaj Sharma ; Karen L. Furie ; Jonathan Rosand ; Mike Nalls ; James Meschia ; Thomas H. Mosely ; Alun Evans ; Aarno Palotie ; Hugh S. Markus ; Peter J. Grant ; Tim D. SpectorSource :
- Annals of Neurology [ 0364-5134 ] ; 2013-01.
English descriptors
- KwdEn :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
- Teeft :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
Abstract
Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.
Url:
DOI: 10.1002/ana.23838
Links to Exploration step
ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ischemic stroke is associated with the ABO locus: The EuroCLOT study</title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: frances.williams@kcl.ac.uk</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</mods:affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation><mods:affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation><mods:affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation><mods:affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation><mods:affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Group Health Research Institute, Group Health, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington, WA</mods:affiliation></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, University of Maryland, Baltimore, MD</mods:affiliation></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><mods:affiliation>University of Insubria, Varese, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation><mods:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation><mods:affiliation>University of Newcastle, Callaghan, Australia</mods:affiliation></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><mods:affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation><mods:affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation><mods:affiliation>Queen's University of Belfast, Belfast, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/ana.23838</idno><idno type="url">https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002705</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002705</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en"><hi rend="italic">ABO</hi><ref type="note" target="#fn20"></ref><:t>Ischemic stroke is associated with the</:t><:t>locus: The EuroCLOT study</:t></title><author><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: frances.williams@kcl.ac.uk</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</mods:affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation><mods:affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation><mods:affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation><mods:affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation><mods:affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</mods:affiliation></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation><mods:affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><mods:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation><mods:affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation><mods:affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><mods:affiliation>DeCODE Genetics, Reykjavik, Iceland</mods:affiliation></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation><mods:affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Framingham Heart Study, Framingham, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Health Services, University of Washington, Seattlem WA</mods:affiliation></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation><mods:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Group Health Research Institute, Group Health, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Washington, WA</mods:affiliation></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation><mods:affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, University of Maryland, Baltimore, MD</mods:affiliation></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation><mods:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><mods:affiliation>University of Insubria, Varese, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation><mods:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</mods:affiliation></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation><mods:affiliation>University of Newcastle, Callaghan, Australia</mods:affiliation></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation><mods:affiliation>John Hunter Hospital, New Lambton Heights, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Hunter Medical Research Institute, New Lambton, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</mods:affiliation></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation><mods:affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation><mods:affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation><mods:affiliation>University of Mississippi Medical Center, Jackson, MS</mods:affiliation></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation><mods:affiliation>Queen's University of Belfast, Belfast, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><mods:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation><mods:affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation><mods:affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation><mods:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>ischemic</json:string><json:string>genetics</json:string><json:string>ischemic stroke</json:string><json:string>wellcome</json:string><json:string>cohort</json:string><json:string>coagulation</json:string><json:string>genotyping</json:string><json:string>wtccc2</json:string><json:string>morgam</json:string><json:string>consortium</json:string><json:string>phenotype</json:string><json:string>allele</json:string><json:string>snp</json:string><json:string>metastroke</json:string><json:string>fxiiia</json:string><json:string>isgs</json:string><json:string>fxiii</json:string><json:string>genotype</json:string><json:string>atherosclerosis</json:string><json:string>cardioembolic</json:string><json:string>genet</json:string><json:string>asgc</json:string><json:string>neurology</json:string><json:string>aric</json:string><json:string>cedir</json:string><json:string>gasros</json:string><json:string>rotterdam</json:string><json:string>college london</json:string><json:string>twinsuk</json:string><json:string>epidemiology</json:string><json:string>subunit</json:string><json:string>wellcome trust case control consortium</json:string><json:string>polymorphism</json:string><json:string>euroclot</json:string><json:string>atherosclerosis risk</json:string><json:string>independent snps</json:string><json:string>genome</json:string><json:string>fviii</json:string><json:string>cardioembolic stroke</json:string><json:string>stroke risk</json:string><json:string>wellcome trust</json:string><json:string>stroke subtype</json:string><json:string>supplementary table</json:string><json:string>edinburgh</json:string><json:string>national institute</json:string><json:string>thromb</json:string><json:string>human genetics</json:string><json:string>framingham</json:string><json:string>january</json:string><json:string>cardiovascular</json:string><json:string>wellcome trust centre</json:string><json:string>australian stroke genetics</json:string><json:string>risk factors</json:string><json:string>outcome study</json:string><json:string>ischemic stroke genetics study</json:string><json:string>locus</json:string><json:string>centre</json:string><json:string>fxiii activity</json:string><json:string>standard error</json:string><json:string>sample size</json:string><json:string>framingham heart study</json:string><json:string>vascular health</json:string><json:string>cardiovascular health study</json:string><json:string>willebrand factor</json:string><json:string>single nucleotide polymorphism</json:string><json:string>funding</json:string><json:string>fibrin</json:string><json:string>effect size</json:string><json:string>heart protection study</json:string><json:string>standard deviation</json:string><json:string>regression analysis</json:string><json:string>grant number</json:string><json:string>public health</json:string><json:string>genetic variants</json:string><json:string>wellcome trust genome campus</json:string><json:string>child health research</json:string><json:string>coagulation factors</json:string><json:string>communities study</json:string><json:string>monica risk</json:string><json:string>study design</json:string><json:string>arterioscler thromb vasc biol</json:string><json:string>subgroup analysis</json:string><json:string>assay</json:string><json:string>stroke</json:string><json:string>subtypes</json:string><json:string>beta</json:string><json:string>coronary artery disease</json:string><json:string>medical research</json:string><json:string>nhlbi contracts</json:string><json:string>morgam project</json:string><json:string>early onset stroke study</json:string><json:string>study group</json:string><json:string>research centre</json:string><json:string>additional support</json:string><json:string>foundation trust</json:string><json:string>health services</json:string><json:string>board membership</json:string><json:string>thromb haemost</json:string><json:string>cardiovascular disease</json:string><json:string>fviii levels</json:string><json:string>health partners</json:string><json:string>healthy volunteers</json:string><json:string>molecular medicine</json:string><json:string>euroclot study</json:string><json:string>molecular genetics</json:string><json:string>association studies</json:string><json:string>confidence interval</json:string><json:string>odds ratio</json:string><json:string>association study</json:string><json:string>forest plot</json:string><json:string>factor viii</json:string><json:string>stroke subtyping</json:string><json:string>significant associations</json:string><json:string>finland</json:string><json:string>variant</json:string><json:string>genetic</json:string><json:string>complex disease genetics</json:string><json:string>significant association</json:string><json:string>effects model</json:string><json:string>clinical collections</json:string><json:string>positive results</json:string><json:string>body mass index</json:string><json:string>metastroke consortium</json:string><json:string>neurology table</json:string><json:string>study groups</json:string><json:string>pankaj sharma</json:string><json:string>stroke cases</json:string><json:string>fibrin clot phenotypes</json:string><json:string>turbidimetric assay</json:string><json:string>blood group</json:string><json:string>blood groups</json:string><json:string>myocardial infarction</json:string><json:string>wtccc2 controls</json:string><json:string>cerebral circulation</json:string><json:string>stroke subtypes</json:string><json:string>quality control</json:string><json:string>boehringer ingelheim</json:string><json:string>small effect</json:string><json:string>veterans affairs</json:string><json:string>candidate genes</json:string><json:string>wellcome trust sanger centre</json:string><json:string>health research</json:string><json:string>hospital genes</json:string><json:string>clinical neurosciences</json:string><json:string>stroke association</json:string><json:string>historical reasons</json:string><json:string>hemostatic factors</json:string><json:string>research facility</json:string><json:string>locus table</json:string><json:string>dementia research centre</json:string><json:string>grant numbers</json:string><json:string>morgam cohorts</json:string><json:string>ischemic stroke study</json:string><json:string>important contributions</json:string><json:string>project grant</json:string><json:string>research excellence</json:string><json:string>same region</json:string><json:string>intramural research program</json:string><json:string>rotterdam study</json:string><json:string>scientific research</json:string><json:string>ines barroso</json:string><json:string>telethon institute</json:string><json:string>diabetes research</json:string><json:string>western australia</json:string><json:string>cambridge institute</json:string><json:string>cambridge school</json:string><json:string>clinical medicine</json:string><json:string>queensland diamantina institute</json:string><json:string>aiden corvin</json:string><json:string>neuropsychiatric genetics research group</json:string><json:string>trinity college dublin</json:string><json:string>panos deloukas</json:string><json:string>ischemic stroke cases</json:string><json:string>brain imaging</json:string><json:string>genetic epidemiology</json:string><json:string>single nucleotide polymorphisms</json:string><json:string>twin research</json:string><json:string>systematic review</json:string><json:string>extensive phenotyping</json:string><json:string>coronary atherosclerosis</json:string><json:string>acute ischemic stroke</json:string><json:string>healthy families</json:string><json:string>atrial fibrillation</json:string></teeft></keywords><author><json:item><name>Frances M. K. Williams PhD, FRCP(E)</name><affiliations><json:string>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</json:string><json:string>E-mail: frances.williams@kcl.ac.uk</json:string><json:string>Correspondence address: Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</json:string></affiliations></json:item><json:item><name>Angela M. Carter PhD</name><affiliations><json:string>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</json:string></affiliations></json:item><json:item><name>Pirro G. Hysi PhD</name><affiliations><json:string>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Gabriela Surdulescu MSc</name><affiliations><json:string>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Dylan Hodgkiss MSc</name><affiliations><json:string>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Nicole Soranzo PhD</name><affiliations><json:string>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</json:string><json:string>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</json:string><json:string>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Matthew Traylor MSc</name><affiliations><json:string>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Steve Bevan PhD</name><affiliations><json:string>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Martin Dichgans MD, PhD</name><affiliations><json:string>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</json:string></affiliations></json:item><json:item><name>Peter M. W. Rothwell MD, PhD, FMedSci</name><affiliations><json:string>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</json:string></affiliations></json:item><json:item><name>Cathie Sudlow DPhil, FRCP(E)</name><affiliations><json:string>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</json:string></affiliations></json:item><json:item><name>Martin Farrall PhD, FRCPath</name><affiliations><json:string>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</json:string></affiliations></json:item><json:item><name>Kaisa Silander PhD</name><affiliations><json:string>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Mari Kaunisto PhD</name><affiliations><json:string>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Peter Wagner BSc</name><affiliations><json:string>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Olli Saarela PhD</name><affiliations><json:string>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Kari Kuulasmaa PhD</name><affiliations><json:string>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Jarmo Virtamo MD, PhD</name><affiliations><json:string>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Veikko Salomaa MD, PhD</name><affiliations><json:string>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Philippe Amouyel MD, PhD</name><affiliations><json:string>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Dominique Arveiler MD</name><affiliations><json:string>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</json:string></affiliations></json:item><json:item><name>Jean Ferrieres MD</name><affiliations><json:string>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</json:string></affiliations></json:item><json:item><name>Per‐Gunnar Wiklund MD, PhD</name><affiliations><json:string>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</json:string></affiliations></json:item><json:item><name>M. Arfan Ikram MD, PhD</name><affiliations><json:string>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</json:string></affiliations></json:item><json:item><name>Albert Hofman MD, PhD</name><affiliations><json:string>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</json:string></affiliations></json:item><json:item><name>Giorgio B. Boncoraglio MD</name><affiliations><json:string>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</json:string></affiliations></json:item><json:item><name>Eugenio A. Parati MD</name><affiliations><json:string>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</json:string></affiliations></json:item><json:item><name>Anna Helgadottir MD, PhD</name><affiliations><json:string>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</json:string><json:string>DeCODE Genetics, Reykjavik, Iceland</json:string></affiliations></json:item><json:item><name>Solveig Gretarsdottir PhD</name><affiliations><json:string>DeCODE Genetics, Reykjavik, Iceland</json:string></affiliations></json:item><json:item><name>Unnur Thorsteinsdottir PhD</name><affiliations><json:string>DeCODE Genetics, Reykjavik, Iceland</json:string></affiliations></json:item><json:item><name>Gudmar Thorleifsson PhD</name><affiliations><json:string>DeCODE Genetics, Reykjavik, Iceland</json:string></affiliations></json:item><json:item><name>Kari Stefansson PhD, Dr med</name><affiliations><json:string>DeCODE Genetics, Reykjavik, Iceland</json:string></affiliations></json:item><json:item><name>Sudha Seshadri MD</name><affiliations><json:string>Boston University Schools of Medicine and Public Health, Boston, MA</json:string><json:string>Framingham Heart Study, Framingham, MA</json:string><json:string>Departments of Health Services, University of Washington, Seattlem WA</json:string></affiliations></json:item><json:item><name>Anita DeStefano PhD</name><affiliations><json:string>Boston University Schools of Medicine and Public Health, Boston, MA</json:string><json:string>Framingham Heart Study, Framingham, MA</json:string><json:string>Departments of Health Services, University of Washington, Seattlem WA</json:string></affiliations></json:item><json:item><name>Andreas Gschwendtner Dr med</name><affiliations><json:string>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</json:string></affiliations></json:item><json:item><name>Bruce Psaty MD, PhD</name><affiliations><json:string>Epidemiology, Health Services, University of Washington, Seattle, WA</json:string><json:string>Medicine, and Health Services, University of Washington, Seattle, WA</json:string><json:string>Group Health Research Institute, Group Health, Seattle, WA</json:string><json:string>Department of Neurology, University of Washington, WA</json:string></affiliations></json:item><json:item><name>Will Longstreth MD</name><affiliations><json:string>Epidemiology, Health Services, University of Washington, Seattle, WA</json:string><json:string>Medicine, and Health Services, University of Washington, Seattle, WA</json:string><json:string>Department of Medicine, University of Maryland, Baltimore, MD</json:string></affiliations></json:item><json:item><name>Braxton D. Mitchell MPH, PhD</name><affiliations><json:string>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</json:string></affiliations></json:item><json:item><name>Yu‐Ching Cheng PhD</name><affiliations><json:string>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</json:string></affiliations></json:item><json:item><name>Robert Clarke MD</name><affiliations><json:string>University of Insubria, Varese, Italy</json:string></affiliations></json:item><json:item><name>Marco Ferrario MD</name><affiliations><json:string>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</json:string></affiliations></json:item><json:item><name>Joshua C. Bis PhD</name><affiliations><json:string>University of Newcastle, Callaghan, Australia</json:string></affiliations></json:item><json:item><name>Christopher Levi BSc, MBBS</name><affiliations><json:string>John Hunter Hospital, New Lambton Heights, Australia</json:string><json:string>Hunter Medical Research Institute, New Lambton, Australia</json:string><json:string>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</json:string></affiliations></json:item><json:item><name>John Attia MD, PhD</name><affiliations><json:string>John Hunter Hospital, New Lambton Heights, Australia</json:string><json:string>Hunter Medical Research Institute, New Lambton, Australia</json:string><json:string>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</json:string></affiliations></json:item><json:item><name>Elizabeth G. Holliday PhD</name><affiliations><json:string>John Hunter Hospital, New Lambton Heights, Australia</json:string><json:string>Hunter Medical Research Institute, New Lambton, Australia</json:string><json:string>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</json:string></affiliations></json:item><json:item><name>Rodney J. Scott PhD, FRCPath</name><affiliations><json:string>John Hunter Hospital, New Lambton Heights, Australia</json:string><json:string>Hunter Medical Research Institute, New Lambton, Australia</json:string><json:string>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</json:string></affiliations></json:item><json:item><name>Myriam Fornage PhD</name><affiliations><json:string>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Pankaj Sharma PhD, FRCP</name><affiliations><json:string>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Karen L. Furie MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</json:string></affiliations></json:item><json:item><name>Jonathan Rosand MD, MSc</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</json:string></affiliations></json:item><json:item><name>Mike Nalls PhD</name><affiliations><json:string>University of Mississippi Medical Center, Jackson, MS</json:string></affiliations></json:item><json:item><name>James Meschia MD</name><affiliations><json:string>University of Mississippi Medical Center, Jackson, MS</json:string></affiliations></json:item><json:item><name>Thomas H. Mosely PhD</name><affiliations><json:string>Queen's University of Belfast, Belfast, United Kingdom</json:string></affiliations></json:item><json:item><name>Alun Evans MD</name></json:item><json:item><name>Aarno Palotie MD, PhD</name><affiliations><json:string>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</json:string><json:string>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</json:string><json:string>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</json:string><json:string>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>Hugh S. Markus MD, FRCP</name><affiliations><json:string>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Peter J. Grant MD, FRCP</name><affiliations><json:string>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</json:string></affiliations></json:item><json:item><name>Tim D. Spector MD, FRCP</name><affiliations><json:string>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</json:string></affiliations></json:item></author><articleId><json:string>ANA23838</json:string></articleId><arkIstex>ark:/67375/WNG-DL9FTPZM-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</abstract><qualityIndicators><score>7.516</score><pdfWordCount>8461</pdfWordCount><pdfCharCount>60052</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>16</pdfPageCount><pdfPageSize>612 x 800.957 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>43</abstractWordCount><abstractCharCount>330</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Ischemic stroke is associated with the ABO locus: The EuroCLOT study</title><pmid><json:string>23381943</json:string></pmid><corporate><json:item><name>on Behalf of the EuroCLOT Investigators the Wellcome Trust Case Control Consortium 2 MOnica Risk, Genetics, Archiving and Monograph MetaStroke and the International Stroke Genetics Consortium</name></json:item></corporate><genre><json:string>article</json:string></genre><host><title>Annals of Neurology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8249</json:string></doi><issn><json:string>0364-5134</json:string></issn><eissn><json:string>1531-8249</json:string></eissn><publisherId><json:string>ANA</json:string></publisherId><volume>73</volume><issue>1</issue><pages><first>16</first><last>31</last><total>16</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Rapid Communication</value></json:item></subject></host><namedEntities><unitex><date><json:string>1958</json:string><json:string>2013</json:string></date><geogName></geogName><orgName><json:string>Department Epidemiology and Population</json:string><json:string>Department of Twin Research and Genetic Epidemiology</json:string><json:string>University of Cambridge Dept Clinical Neurosciences</json:string><json:string>NINDS</json:string><json:string>Department of Neurology, Research Hospital of the Neurological Institute</json:string><json:string>Netherlands Organisation for Scientific Research</json:string><json:string>Broad Institute of Massachusetts Institute of Technology and Harvard</json:string><json:string>National Institute of Health Research</json:string><json:string>Netherlands Genomics Initiative</json:string><json:string>NIHR</json:string><json:string>University of Insubria</json:string><json:string>Division of Adult</json:string><json:string>Obesity Research Center</json:string><json:string>National Institute for Volume</json:string><json:string>UK and German</json:string><json:string>Steering Committee for YODA</json:string><json:string>University of Edinburgh</json:string><json:string>NIA</json:string><json:string>Vascular Dementia Research Foundation</json:string><json:string>University of Oxford</json:string><json:string>Telethon Institute for Child Health Research, Child Health Research, University of Western Australia, Subiaco, Australia and Cambridge</json:string><json:string>University of Edinburgh, Edinburgh, United Kingdom</json:string><json:string>NIH National Institute of Neurological Disorders and Stroke</json:string><json:string>Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland</json:string><json:string>Institute for Stroke and Dementia</json:string><json:string>Wellcome Trust Case Control Consortium, German</json:string><json:string>Neurology Research Council, Stroke Association, Dunhill Medical Trust, NIHR, and the NIHR Biomedical Research Centre, Oxford</json:string><json:string>NHS</json:string><json:string>John Hunter Hospital, New Lambton Heights, Australia</json:string><json:string>Dementia Research Centre, St George</json:string><json:string>Hunter Medical Research Institute, New Lambton, Australia</json:string><json:string>Department of Epidemiology and Public Health</json:string><json:string>Research and Development, Medical Research Service, and Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs</json:string><json:string>University of Belfast</json:string><json:string>Johns Hopkins University</json:string><json:string>NHS Foundation Trust, London, United Kingdom</json:string><json:string>National Blood Service</json:string><json:string>Wellcome Trust Clinical Research Facility and part</json:string><json:string>Department of Oncology, University of Oxford</json:string><json:string>Municipality of Rotterdam</json:string><json:string>European Commission</json:string><json:string>Synaptic Systems</json:string><json:string>Intramural Research Program of the NIA, NIH</json:string><json:string>Finland, Center of Excellence</json:string><json:string>Southern California Diabetes Endocrinology Research Center</json:string><json:string>Affymetrix</json:string><json:string>Massachusetts General Hospital Genes Affecting Stroke Risk and Outcome</json:string><json:string>Ministry of Health</json:string><json:string>National Institutes of Health Genes, Environment, and Health Initiative</json:string><json:string>Erasmus Medical Center</json:string><json:string>Diabetes Research, University of Leeds, Leeds, United Kingdom</json:string><json:string>and National Institute of Diabetes and Digestive</json:string><json:string>Hospital Campus</json:string><json:string>Ministry of Education, Culture and Science</json:string><json:string>International Stroke Genetics Consortium Objective</json:string><json:string>Netherlands Organization for the Health Research and Development</json:string><json:string>Division of Clinical Neurosciences</json:string><json:string>Netherlands Heart Foundation</json:string><json:string>Genetics Core Laboratory of the Wellcome Trust Clinical Research Facility, Western General Hospital, Edinburgh</json:string><json:string>Foundation, Jackstaedt Foundation, Corona Foundation</json:string><json:string>Human Genetics and Department of Statistics, University of Oxford</json:string><json:string>Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health</json:string><json:string>Northern Sweden, and Northern Ireland</json:string><json:string>Australian National Health and Medical Research</json:string><json:string>University of Mississippi Medical Center</json:string><json:string>NWO</json:string><json:string>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</json:string><json:string>University of Queensland Diamantina Institute, Brisbane, Australia</json:string><json:string>Stroke Prevention Research Unit, University Department of Clinical Neurology</json:string><json:string>Department of Epidemiology, Faculty of Medicine, Toulouse-Purpan, Toulouse, France</json:string><json:string>Foundation Trust and King</json:string><json:string>Addenbrooke’s Hospital, Cambridge, United Kingdom</json:string><json:string>Australian National Heart Foundation</json:string><json:string>Research Excellence</json:string><json:string>Erasmus University</json:string><json:string>Queen Mary University</json:string><json:string>Scottish Funding Council Brain Imaging Research Centre</json:string><json:string>Division of Cardiovascular</json:string><json:string>Bugher Foundation Centers for Stroke Prevention Research</json:string><json:string>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</json:string><json:string>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</json:string><json:string>Guy’s Hospital, London, United Kingdom</json:string><json:string>British Heart Foundation Centre for Research Excellence</json:string><json:string>Netherlands Organisation of Scientific Research NWO Investments</json:string><json:string>Department of Medicine, University of Maryland, Baltimore, MD</json:string><json:string>Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology, London, United Kingdom</json:string><json:string>Department of Neurology, University of Washington, WA</json:string><json:string>NIH National Institute on Aging</json:string><json:string>Oxford University</json:string><json:string>National Human Genome Research Institute</json:string><json:string>National Institute for Health and Welfare</json:string><json:string>NIH National Heart, Lung, and Blood Institute</json:string><json:string>Institute of Psychiatry, London, United Kingdom</json:string><json:string>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</json:string><json:string>Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</json:string><json:string>US Department of Veterans Affairs</json:string><json:string>Human Genetics and Department of Statistics, University of Oxford, Oxford, United Kingdom</json:string><json:string>American Neurological Association</json:string><json:string>Institute of Psychiatry, King</json:string><json:string>NHLBI</json:string><json:string>Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom</json:string><json:string>GENEVA Coordinating Center</json:string><json:string>Sigrid Juselius Foundation, Finland</json:string><json:string>Department of Medical and Molecular Genetics</json:string><json:string>University of London</json:string><json:string>University of Cambridge School of Clinical Medicine</json:string><json:string>University of San Francisco</json:string><json:string>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</json:string><json:string>Academy of Finland Center of Excellence</json:string><json:string>Department of Internal Medicine, University of Umea, Umea, Sweden</json:string><json:string>Vincent Fairfax Family Foundation</json:string><json:string>NGI</json:string><json:string>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</json:string><json:string>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</json:string><json:string>Annual Research Funding</json:string><json:string>National Health Service</json:string><json:string>Yale University</json:string><json:string>University of Washington</json:string><json:string>University of Newcastle</json:string><json:string>Biomedical Research Centre, Ninewells Hospital and Medical School</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Per-Gunnar Wiklund</json:string><json:string>Emma Gray</json:string><json:string>Arfan Ikram</json:string><json:string>Matti Pirinen</json:string><json:string>London Social</json:string><json:string>Marco Ferrario</json:string><json:string>Academy</json:string><json:string>Yu-Ching Cheng</json:string><json:string>Mari Kaunisto</json:string><json:string>Dylan Hodgkiss</json:string><json:string>Pankaj Sharma</json:string><json:string>Drs C. Jackson</json:string><json:string>Elvira Bramon</json:string><json:string>Naomi Hammond</json:string><json:string>Bruce S. Weir</json:string><json:string>Karen L. Furie</json:string><json:string>Pamela Whittaker</json:string><json:string>Eugenio A. Parati</json:string><json:string>Giorgio B. Boncoraglio</json:string><json:string>J. Wardlaw</json:string><json:string>Philippe Amouyel</json:string><json:string>Analysis</json:string><json:string>T. Tuovinen</json:string><json:string>Smith Charity</json:string><json:string>Simon C. Potter</json:string><json:string>Jennifer Liddle</json:string><json:string>J. Bumpstead</json:string><json:string>Line Repository</json:string><json:string>Grant Codes</json:string><json:string>Serge Dronov</json:string><json:string>Aiden Corvin</json:string><json:string>Cathie Sudlow</json:string><json:string>M.Fa</json:string><json:string>Jean Ferrieres</json:string><json:string>Garrett Hele</json:string><json:string>Nicole Soranzo</json:string><json:string>A. Farrall</json:string><json:string>Gabriela Surdulescu</json:string><json:string>M. W. Rothwell</json:string><json:string>Christopher G. Mathew</json:string><json:string>Christopher Levi</json:string><json:string>A. Vikman</json:string><json:string>Matthew Gillman</json:string><json:string>Juan P. Casas</json:string><json:string>C. Viswanathan</json:string><json:string>M. Dennis</json:string><json:string>Sarah Edkins</json:string><json:string>MOnica Risk</json:string><json:string>Jonathan Rosand</json:string><json:string>Peter Donnelly</json:string><json:string>C. A. Spencer</json:string><json:string>Robert Plomin</json:string><json:string>London School</json:string><json:string>Veikko Salomaa</json:string><json:string>M. Boothby</json:string><json:string>K. Kristiansson</json:string><json:string>M. McDowall</json:string><json:string>G. Potter</json:string><json:string>Sarah E. Hunt</json:string><json:string>N. A. Palmer</json:string><json:string>Will Longstreth</json:string><json:string>Martin Dichgans</json:string><json:string>J. Surr</json:string><json:string>W. Kohlhammer</json:string><json:string>Grant Code</json:string><json:string>Anna Rautanen</json:string><json:string>Richard Pearson</json:string><json:string>Thomas H. Mosely</json:string><json:string>Hugh S. Markus</json:string><json:string>Wing Block</json:string><json:string>P. Sandercock</json:string><json:string>Locus</json:string><json:string>Bruce Psaty</json:string><json:string>Min Max</json:string><json:string>Albert Hofman</json:string><json:string>Amy Strange</json:string><json:string>M.Fe</json:string><json:string>K. Kaliva</json:string><json:string>Tim D. Spector</json:string><json:string>Michelle Ricketts</json:string><json:string>S. Keir</json:string><json:string>J. C. Hopewell</json:string><json:string>A. Hutchison</json:string><json:string>C. Warlow</json:string><json:string>S. Hart</json:string><json:string>Matthew Traylor</json:string><json:string>Solveig Gretarsdottir</json:string><json:string>Audrey Duncanson</json:string><json:string>Gavin Band</json:string><json:string>Angela M. Carter</json:string><json:string>Anita DeStefano</json:string><json:string>John Attia</json:string><json:string>Richard C. Trembath</json:string><json:string>James Meschia</json:string><json:string>J. Armitage</json:string><json:string>Eleni Giannoulatou</json:string><json:string>Ines Barroso</json:string><json:string>Dominique Arveiler</json:string><json:string>Myriam Fornage</json:string><json:string>Grant Numbers</json:string><json:string>K.St</json:string><json:string>S. Parish</json:string><json:string>L. Foley</json:string><json:string>Matthew Waller</json:string><json:string>Nicholas W. Wood</json:string><json:string>R. Collins</json:string><json:string>Matthew A. Brown</json:string><json:string>Alun Evans</json:string><json:string>Olli Saarela</json:string><json:string>Aarno Palotie</json:string><json:string>Unnur Thorsteinsdottir</json:string><json:string>Anna Helgadottir</json:string><json:string>Williams</json:string><json:string>Sara Widaa</json:string><json:string>G. Hysi</json:string><json:string>M. Blackwell</json:string><json:string>Stephen J. Sawcer</json:string><json:string>Paul Weston</json:string><json:string>Owen T. McCann</json:string><json:string>Braxton D. Mitchell</json:string><json:string>M. Suvela</json:string><json:string>Andreas Gschwendtner</json:string><json:string>Kari Stefansson</json:string><json:string>Carlo Besta</json:string><json:string>Jarmo Virtamo</json:string><json:string>Rodney J. Scott</json:string><json:string>Gudmar Thorleifsson</json:string><json:string>Mike Nalls</json:string><json:string>Peter Wagner</json:string><json:string>Kaisa Silander</json:string><json:string>K.Si</json:string></persName><placeName><json:string>MS</json:string><json:string>San Diego</json:string><json:string>Bristol</json:string><json:string>Germany</json:string><json:string>Varese</json:string><json:string>St Thomas</json:string><json:string>Blackburn</json:string><json:string>Munich</json:string><json:string>Finland</json:string><json:string>Australia</json:string><json:string>Santa Clara</json:string><json:string>UK</json:string><json:string>Edinburgh</json:string><json:string>Helsinki</json:string><json:string>London</json:string><json:string>Boston</json:string><json:string>Dundee</json:string><json:string>Seattle</json:string><json:string>Jackson</json:string><json:string>Belfast</json:string><json:string>Europe</json:string><json:string>Milan</json:string><json:string>Strasbourg</json:string><json:string>Baltimore</json:string><json:string>Leeds</json:string><json:string>Toulouse</json:string><json:string>Rotterdam</json:string><json:string>Westminster Bridge</json:string><json:string>United Kingdom</json:string><json:string>CA</json:string><json:string>MA</json:string><json:string>France</json:string><json:string>European Union</json:string><json:string>Iceland</json:string><json:string>WA</json:string><json:string>Cambridge</json:string><json:string>Reykjavik</json:string><json:string>Italy</json:string><json:string>Lille</json:string><json:string>Oxford</json:string><json:string>Netherlands</json:string></placeName><ref_url><json:string>http://www.chs-nhlbi.org/pi.htm</json:string><json:string>http://www.ktl.fi/publications/morgam/cohorts</json:string><json:string>http://www.b</json:string><json:string>http://ccr.coriell.org/ninds</json:string><json:string>http://biowulf.nih.gov</json:string><json:string>http://www.helmholtz-muenchen.de/en/kora-en/kora-homepage/index.html</json:string></ref_url><ref_bibl><json:string>Williams et al</json:string><json:string>Wu et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-DL9FTPZM-W</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - clinical neurology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1002/ana.23838</json:string></doi><id>D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en"><hi rend="italic">ABO</hi><ref type="note" target="#fn20"></ref><:t>Ischemic stroke is associated with the</:t><:t>locus: The EuroCLOT study</:t></title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 2012 American Neurological Association</licence></availability><date type="published" when="2013-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en"><hi rend="italic">ABO</hi><ref type="note" target="#fn20"></ref><:t>Ischemic stroke is associated with the</:t><:t>locus: The EuroCLOT study</:t></title><title level="a" type="short" xml:lang="en">Ischemic Stroke and ABO Locus</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Frances M. K.</forename><surname>Williams</surname><roleName type="degree">PhD, FRCP(E)</roleName></persName><email>frances.williams@kcl.ac.uk</email><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom<address><country key="GB"></country></address></affiliation><affiliation>Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Angela M.</forename><surname>Carter</surname><roleName type="degree">PhD</roleName></persName><affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Pirro G.</forename><surname>Hysi</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Gabriela</forename><surname>Surdulescu</surname><roleName type="degree">MSc</roleName></persName><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Dylan</forename><surname>Hodgkiss</surname><roleName type="degree">MSc</roleName></persName><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Nicole</forename><surname>Soranzo</surname><roleName type="degree">PhD</roleName></persName><affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom<address><country key="GB"></country></address></affiliation><affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA<address><country key="US"></country></address></affiliation><affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Matthew</forename><surname>Traylor</surname><roleName type="degree">MSc</roleName></persName><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Steve</forename><surname>Bevan</surname><roleName type="degree">PhD</roleName></persName><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Martin</forename><surname>Dichgans</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Peter M. W.</forename><surname>Rothwell</surname><roleName type="degree">MD, PhD, FMedSci</roleName></persName><affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Cathie</forename><surname>Sudlow</surname><roleName type="degree">DPhil, FRCP(E)</roleName></persName><affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Martin</forename><surname>Farrall</surname><roleName type="degree">PhD, FRCPath</roleName></persName><affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0012"><persName><forename type="first">Kaisa</forename><surname>Silander</surname><roleName type="degree">PhD</roleName></persName><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0013"><persName><forename type="first">Mari</forename><surname>Kaunisto</surname><roleName type="degree">PhD</roleName></persName><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0014"><persName><forename type="first">Peter</forename><surname>Wagner</surname><roleName type="degree">BSc</roleName></persName><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0015"><persName><forename type="first">Olli</forename><surname>Saarela</surname><roleName type="degree">PhD</roleName></persName><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0016"><persName><forename type="first">Kari</forename><surname>Kuulasmaa</surname><roleName type="degree">PhD</roleName></persName><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0017"><persName><forename type="first">Jarmo</forename><surname>Virtamo</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0018"><persName><forename type="first">Veikko</forename><surname>Salomaa</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0019"><persName><forename type="first">Philippe</forename><surname>Amouyel</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0020"><persName><forename type="first">Dominique</forename><surname>Arveiler</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0021"><persName><forename type="first">Jean</forename><surname>Ferrieres</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0022"><persName><forename type="first">Per‐Gunnar</forename><surname>Wiklund</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden<address><country key="SE"></country></address></affiliation></author><author xml:id="author-0023"><persName><forename type="first">M.</forename><surname>Arfan Ikram</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0024"><persName><forename type="first">Albert</forename><surname>Hofman</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0025"><persName><forename type="first">Giorgio B.</forename><surname>Boncoraglio</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0026"><persName><forename type="first">Eugenio A.</forename><surname>Parati</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0027"><persName><forename type="first">Anna</forename><surname>Helgadottir</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom<address><country key="GB"></country></address></affiliation><affiliation>DeCODE Genetics, Reykjavik, Iceland<address><country key="IS"></country></address></affiliation></author><author xml:id="author-0028"><persName><forename type="first">Solveig</forename><surname>Gretarsdottir</surname><roleName type="degree">PhD</roleName></persName><affiliation>DeCODE Genetics, Reykjavik, Iceland<address><country key="IS"></country></address></affiliation></author><author xml:id="author-0029"><persName><forename type="first">Unnur</forename><surname>Thorsteinsdottir</surname><roleName type="degree">PhD</roleName></persName><affiliation>DeCODE Genetics, Reykjavik, Iceland<address><country key="IS"></country></address></affiliation></author><author xml:id="author-0030"><persName><forename type="first">Gudmar</forename><surname>Thorleifsson</surname><roleName type="degree">PhD</roleName></persName><affiliation>DeCODE Genetics, Reykjavik, Iceland<address><country key="IS"></country></address></affiliation></author><author xml:id="author-0031"><persName><forename type="first">Kari</forename><surname>Stefansson</surname><roleName type="degree">PhD, Dr med</roleName></persName><affiliation>DeCODE Genetics, Reykjavik, Iceland<address><country key="IS"></country></address></affiliation></author><author xml:id="author-0032"><persName><forename type="first">Sudha</forename><surname>Seshadri</surname><roleName type="degree">MD</roleName></persName><affiliation>Boston University Schools of Medicine and Public Health, Boston, MA<address><country key="US"></country></address></affiliation><affiliation>Framingham Heart Study, Framingham, MA<address><country key="US"></country></address></affiliation><affiliation>Departments of Health Services, University of Washington, Seattlem WA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0033"><persName><forename type="first">Anita</forename><surname>DeStefano</surname><roleName type="degree">PhD</roleName></persName><affiliation>Boston University Schools of Medicine and Public Health, Boston, MA<address><country key="US"></country></address></affiliation><affiliation>Framingham Heart Study, Framingham, MA<address><country key="US"></country></address></affiliation><affiliation>Departments of Health Services, University of Washington, Seattlem WA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0034"><persName><forename type="first">Andreas</forename><surname>Gschwendtner</surname><roleName type="degree">Dr med</roleName></persName><affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany<address><country key="DE"></country></address></affiliation></author><author xml:id="author-0035"><persName><forename type="first">Bruce</forename><surname>Psaty</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA<address><country key="US"></country></address></affiliation><affiliation>Medicine, and Health Services, University of Washington, Seattle, WA<address><country key="US"></country></address></affiliation><affiliation>Group Health Research Institute, Group Health, Seattle, WA<address><country key="US"></country></address></affiliation><affiliation>Department of Neurology, University of Washington, WA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0036"><persName><forename type="first">Will</forename><surname>Longstreth</surname><roleName type="degree">MD</roleName></persName><affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA<address><country key="US"></country></address></affiliation><affiliation>Medicine, and Health Services, University of Washington, Seattle, WA<address><country key="US"></country></address></affiliation><affiliation>Department of Medicine, University of Maryland, Baltimore, MD<address><country key="US"></country></address></affiliation></author><author xml:id="author-0037"><persName><forename type="first">Braxton D.</forename><surname>Mitchell</surname><roleName type="degree">MPH, PhD</roleName></persName><affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0038"><persName><forename type="first">Yu‐Ching</forename><surname>Cheng</surname><roleName type="degree">PhD</roleName></persName><affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0039"><persName><forename type="first">Robert</forename><surname>Clarke</surname><roleName type="degree">MD</roleName></persName><affiliation>University of Insubria, Varese, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0040"><persName><forename type="first">Marco</forename><surname>Ferrario</surname><roleName type="degree">MD</roleName></persName><affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0041"><persName><forename type="first">Joshua C.</forename><surname>Bis</surname><roleName type="degree">PhD</roleName></persName><affiliation>University of Newcastle, Callaghan, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0042"><persName><forename type="first">Christopher</forename><surname>Levi</surname><roleName type="degree">BSc, MBBS</roleName></persName><affiliation>John Hunter Hospital, New Lambton Heights, Australia<address><country key="AU"></country></address></affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia<address><country key="AU"></country></address></affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX<address><country key="US"></country></address></affiliation></author><author xml:id="author-0043"><persName><forename type="first">John</forename><surname>Attia</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>John Hunter Hospital, New Lambton Heights, Australia<address><country key="AU"></country></address></affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia<address><country key="AU"></country></address></affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX<address><country key="US"></country></address></affiliation></author><author xml:id="author-0044"><persName><forename type="first">Elizabeth G.</forename><surname>Holliday</surname><roleName type="degree">PhD</roleName></persName><affiliation>John Hunter Hospital, New Lambton Heights, Australia<address><country key="AU"></country></address></affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia<address><country key="AU"></country></address></affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX<address><country key="US"></country></address></affiliation></author><author xml:id="author-0045"><persName><forename type="first">Rodney J.</forename><surname>Scott</surname><roleName type="degree">PhD, FRCPath</roleName></persName><affiliation>John Hunter Hospital, New Lambton Heights, Australia<address><country key="AU"></country></address></affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia<address><country key="AU"></country></address></affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX<address><country key="US"></country></address></affiliation></author><author xml:id="author-0046"><persName><forename type="first">Myriam</forename><surname>Fornage</surname><roleName type="degree">PhD</roleName></persName><affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0047"><persName><forename type="first">Pankaj</forename><surname>Sharma</surname><roleName type="degree">PhD, FRCP</roleName></persName><affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0048"><persName><forename type="first">Karen L.</forename><surname>Furie</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0049"><persName><forename type="first">Jonathan</forename><surname>Rosand</surname><roleName type="degree">MD, MSc</roleName></persName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0050"><persName><forename type="first">Mike</forename><surname>Nalls</surname><roleName type="degree">PhD</roleName></persName><affiliation>University of Mississippi Medical Center, Jackson, MS<address><country key="US"></country></address></affiliation></author><author xml:id="author-0051"><persName><forename type="first">James</forename><surname>Meschia</surname><roleName type="degree">MD</roleName></persName><affiliation>University of Mississippi Medical Center, Jackson, MS<address><country key="US"></country></address></affiliation></author><author xml:id="author-0052"><persName><forename type="first">Thomas H.</forename><surname>Mosely</surname><roleName type="degree">PhD</roleName></persName><affiliation>Queen's University of Belfast, Belfast, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0053"><persName><forename type="first">Alun</forename><surname>Evans</surname><roleName type="degree">MD</roleName></persName></author><author xml:id="author-0054"><persName><forename type="first">Aarno</forename><surname>Palotie</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom<address><country key="GB"></country></address></affiliation><affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA<address><country key="US"></country></address></affiliation><affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland<address><country key="FI"></country></address></affiliation><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0055"><persName><forename type="first">Hugh S.</forename><surname>Markus</surname><roleName type="degree">MD, FRCP</roleName></persName><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0056"><persName><forename type="first">Peter J.</forename><surname>Grant</surname><roleName type="degree">MD, FRCP</roleName></persName><affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0057"><persName><forename type="first">Tim D.</forename><surname>Spector</surname><roleName type="degree">MD, FRCP</roleName></persName><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0058"><author><orgName>on Behalf of the EuroCLOT Investigators the Wellcome Trust Case Control Consortium 2 MOnica Risk, Genetics, Archiving and Monograph MetaStroke and the International Stroke Genetics Consortium</orgName></author></author><idno type="istex">D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</idno><idno type="ark">ark:/67375/WNG-DL9FTPZM-W</idno><idno type="DOI">10.1002/ana.23838</idno><idno type="unit">ANA23838</idno><idno type="toTypesetVersion">file:ANA.ANA23838.pdf</idno></analytic><monogr><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="book-DOI">10.1002/(ISSN)1531-8249</idno><idno type="book-part-DOI">10.1002/ana.v73.1</idno><idno type="product">ANA</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.<hi rend="bold">Objective</hi></p><p>: Common genetic variants identified through genome‐wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).<hi rend="bold">Methods</hi></p><p><hi rend="bold">Results</hi><hi rend="italic">p</hi><hi rend="superscript">–8</hi><hi rend="italic">p</hi><hi rend="superscript">–186</hi><hi rend="italic">p</hi><hi rend="superscript">–47</hi><hi rend="italic">ABO</hi><hi rend="italic">p</hi><hi rend="superscript">–57</hi><hi rend="italic">p</hi><hi rend="superscript">–36</hi><hi rend="italic">p</hi><hi rend="italic">p</hi><hi rend="italic">p</hi><hi rend="italic">p</hi><hi rend="italic">p</hi><:t>: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (</:t><:t>< 5 × 10</:t><:t>) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (</:t><:t>= 2.6 × 10</:t><:t>), rs10665 with FVII (</:t><:t>= 2.4 × 10</:t><:t>), and rs505922 in the</:t><:t>gene with both von Willebrand factor (</:t><:t>= 4.7 × 10</:t><:t>) and factor VIII (</:t><:t>= 1.2 × 10</:t><:t>). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88–0.99,</:t><:t>= 0.023). Independent replication in Meta‐Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02),</:t><:t>= 0.001, a finding specific to large‐vessel and cardioembolic stroke (</:t><:t>= 0.001 and</:t><:t>= < 0.001, respectively) but not seen with small‐vessel stroke (</:t><:t>= 0.811).</:t></p><p><hi rend="bold">Interpretation</hi><hi rend="italic">ABO</hi><:t>:</:t><:t>gene variants are associated with large‐vessel and cardioembolic stroke but not small‐vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. Ann Neurol 2013</:t></p></abstract><textClass><keywords rend="articleCategory"><term>Rapid Communication</term></keywords><keywords rend="tocHeading1"><term>Rapid Communication</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change>undefined</change><change>[object Object]</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/ana.v73.1</doi><numberingGroup><numbering type="journalVolume" number="73">73</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2013-01">January 2013</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="80" status="forIssue" accessType="open"><doi origin="wiley" registered="yes">10.1002/ana.23838</doi><idGroup><id type="unit" value="ANA23838"></id></idGroup><countGroup><count type="pageTotal" number="16"></count></countGroup><titleGroup><title type="articleCategory">Rapid Communication</title><title type="tocHeading1">Rapid Communication</title></titleGroup><copyright ownership="publisher">Copyright © 2012 American Neurological Association</copyright><eventGroup><event type="manuscriptReceived" date="2012-04-27"></event><event type="manuscriptRevised" date="2012-09-21"></event><event type="manuscriptAccepted" date="2012-10-29"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.2.0 mode:FullText" date="2013-03-13"></event><event type="publishedOnlineAccepted" date="2012-12-13"></event><event type="publishedOnlineFinalForm" date="2013-02-04"></event><event type="firstOnline" date="2013-02-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">16</numbering><numbering type="pageLast">31</numbering></numberingGroup><correspondenceTo>Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA23838.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="7"></count><count type="referenceTotal" number="41"></count><count type="wordTotal" number="8906"></count></countGroup><titleGroup><title type="main" xml:lang="en">Ischemic stroke is associated with the <i>ABO</i> locus: The EuroCLOT study<link href="#fn20"></link></title><title type="short" xml:lang="en">Ischemic Stroke and <fi>ABO</fi> Locus</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Frances M. K.</givenNames><familyName>Williams</familyName><degrees>PhD, FRCP(E)</degrees></personName><contactDetails><email>frances.williams@kcl.ac.uk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Angela M.</givenNames><familyName>Carter</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Pirro G.</givenNames><familyName>Hysi</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Gabriela</givenNames><familyName>Surdulescu</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dylan</givenNames><familyName>Hodgkiss</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Nicole</givenNames><familyName>Soranzo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Matthew</givenNames><familyName>Traylor</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Steve</givenNames><familyName>Bevan</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Martin</givenNames><familyName>Dichgans</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Peter M. W.</givenNames><familyName>Rothwell</familyName><degrees>MD, PhD, FMedSci</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Cathie</givenNames><familyName>Sudlow</familyName><degrees>DPhil, FRCP(E)</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Martin</givenNames><familyName>Farrall</familyName><degrees>PhD, FRCPath</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Kaisa</givenNames><familyName>Silander</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Mari</givenNames><familyName>Kaunisto</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Peter</givenNames><familyName>Wagner</familyName><degrees>BSc</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Olli</givenNames><familyName>Saarela</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Kari</givenNames><familyName>Kuulasmaa</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Jarmo</givenNames><familyName>Virtamo</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Veikko</givenNames><familyName>Salomaa</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af13"><personName><givenNames>Philippe</givenNames><familyName>Amouyel</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af14"><personName><givenNames>Dominique</givenNames><familyName>Arveiler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au22" creatorRole="author" affiliationRef="#af15"><personName><givenNames>Jean</givenNames><familyName>Ferrieres</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au23" creatorRole="author" affiliationRef="#af16"><personName><givenNames>Per‐Gunnar</givenNames><familyName>Wiklund</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au24" creatorRole="author" affiliationRef="#af17"><personName><givenNames>M.</givenNames><familyName>Arfan Ikram</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au25" creatorRole="author" affiliationRef="#af17"><personName><givenNames>Albert</givenNames><familyName>Hofman</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au26" creatorRole="author" affiliationRef="#af18"><personName><givenNames>Giorgio B.</givenNames><familyName>Boncoraglio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au27" creatorRole="author" affiliationRef="#af18"><personName><givenNames>Eugenio A.</givenNames><familyName>Parati</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au28" creatorRole="author" affiliationRef="#af10 #af19"><personName><givenNames>Anna</givenNames><familyName>Helgadottir</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au29" creatorRole="author" affiliationRef="#af19"><personName><givenNames>Solveig</givenNames><familyName>Gretarsdottir</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au30" creatorRole="author" affiliationRef="#af19"><personName><givenNames>Unnur</givenNames><familyName>Thorsteinsdottir</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au31" creatorRole="author" affiliationRef="#af19"><personName><givenNames>Gudmar</givenNames><familyName>Thorleifsson</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au32" creatorRole="author" affiliationRef="#af19"><personName><givenNames>Kari</givenNames><familyName>Stefansson</familyName><degrees>PhD, Dr med</degrees></personName></creator><creator xml:id="au33" creatorRole="author" affiliationRef="#af20 #af21 #af22"><personName><givenNames>Sudha</givenNames><familyName>Seshadri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au34" creatorRole="author" affiliationRef="#af20 #af21 #af22"><personName><givenNames>Anita</givenNames><familyName>DeStefano</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au35" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Andreas</givenNames><familyName>Gschwendtner</familyName><degrees>Dr med</degrees></personName></creator><creator xml:id="au36" creatorRole="author" affiliationRef="#af23 #af24 #af25 #af26"><personName><givenNames>Bruce</givenNames><familyName>Psaty</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au37" creatorRole="author" affiliationRef="#af23 #af24 #af27"><personName><givenNames>Will</givenNames><familyName>Longstreth</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au38" creatorRole="author" affiliationRef="#af28"><personName><givenNames>Braxton D.</givenNames><familyName>Mitchell</familyName><degrees>MPH, PhD</degrees></personName></creator><creator xml:id="au39" creatorRole="author" affiliationRef="#af28"><personName><givenNames>Yu‐Ching</givenNames><familyName>Cheng</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au40" creatorRole="author" affiliationRef="#af29"><personName><givenNames>Robert</givenNames><familyName>Clarke</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au41" creatorRole="author" affiliationRef="#af30"><personName><givenNames>Marco</givenNames><familyName>Ferrario</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au42" creatorRole="author" affiliationRef="#af31"><personName><givenNames>Joshua C.</givenNames><familyName>Bis</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au43" creatorRole="author" affiliationRef="#af32 #af33 #af34"><personName><givenNames>Christopher</givenNames><familyName>Levi</familyName><degrees>BSc, MBBS</degrees></personName></creator><creator xml:id="au44" creatorRole="author" affiliationRef="#af32 #af33 #af34"><personName><givenNames>John</givenNames><familyName>Attia</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au45" creatorRole="author" affiliationRef="#af32 #af33 #af34"><personName><givenNames>Elizabeth G.</givenNames><familyName>Holliday</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au46" creatorRole="author" affiliationRef="#af32 #af33 #af34"><personName><givenNames>Rodney J.</givenNames><familyName>Scott</familyName><degrees>PhD, FRCPath</degrees></personName></creator><creator xml:id="au47" creatorRole="author" affiliationRef="#af35"><personName><givenNames>Myriam</givenNames><familyName>Fornage</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au48" creatorRole="author" affiliationRef="#af36"><personName><givenNames>Pankaj</givenNames><familyName>Sharma</familyName><degrees>PhD, FRCP</degrees></personName></creator><creator xml:id="au49" creatorRole="author" affiliationRef="#af37"><personName><givenNames>Karen L.</givenNames><familyName>Furie</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au50" creatorRole="author" affiliationRef="#af37"><personName><givenNames>Jonathan</givenNames><familyName>Rosand</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au51" creatorRole="author" affiliationRef="#af38"><personName><givenNames>Mike</givenNames><familyName>Nalls</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au52" creatorRole="author" affiliationRef="#af38"><personName><givenNames>James</givenNames><familyName>Meschia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au53" creatorRole="author" affiliationRef="#af39"><personName><givenNames>Thomas H.</givenNames><familyName>Mosely</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au54" creatorRole="author"><personName><givenNames>Alun</givenNames><familyName>Evans</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au55" creatorRole="author" affiliationRef="#af3 #af4 #af5 #af11"><personName><givenNames>Aarno</givenNames><familyName>Palotie</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au56" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Hugh S.</givenNames><familyName>Markus</familyName><degrees>MD, FRCP</degrees></personName></creator><creator xml:id="au57" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Peter J.</givenNames><familyName>Grant</familyName><degrees>MD, FRCP</degrees></personName></creator><creator xml:id="au58" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Tim D.</givenNames><familyName>Spector</familyName><degrees>MD, FRCP</degrees></personName></creator><creator xml:id="au59" creatorRole="author"><groupName>on Behalf of the EuroCLOT Investigators the Wellcome Trust Case Control Consortium 2 MOnica Risk, Genetics, Archiving and Monograph MetaStroke and the International Stroke Genetics Consortium</groupName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FI" type="organization"><unparsedAffiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="GB" type="organization"><unparsedAffiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="DE" type="organization"><unparsedAffiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="GB" type="organization"><unparsedAffiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="GB" type="organization"><unparsedAffiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="GB" type="organization"><unparsedAffiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="FI" type="organization"><unparsedAffiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="FI" type="organization"><unparsedAffiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="FR" type="organization"><unparsedAffiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="FR" type="organization"><unparsedAffiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="FR" type="organization"><unparsedAffiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="SE" type="organization"><unparsedAffiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="NL" type="organization"><unparsedAffiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af18" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af19" countryCode="IS" type="organization"><unparsedAffiliation>DeCODE Genetics, Reykjavik, Iceland</unparsedAffiliation></affiliation><affiliation xml:id="af20" countryCode="US" type="organization"><unparsedAffiliation>Boston University Schools of Medicine and Public Health, Boston, MA</unparsedAffiliation></affiliation><affiliation xml:id="af21" countryCode="US" type="organization"><unparsedAffiliation>Framingham Heart Study, Framingham, MA</unparsedAffiliation></affiliation><affiliation xml:id="af22" countryCode="US" type="organization"><unparsedAffiliation>Departments of Health Services, University of Washington, Seattlem WA</unparsedAffiliation></affiliation><affiliation xml:id="af23" countryCode="US" type="organization"><unparsedAffiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af24" countryCode="US" type="organization"><unparsedAffiliation>Medicine, and Health Services, University of Washington, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af25" countryCode="US" type="organization"><unparsedAffiliation>Group Health Research Institute, Group Health, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af26" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, University of Washington, WA</unparsedAffiliation></affiliation><affiliation xml:id="af27" countryCode="US" type="organization"><unparsedAffiliation>Department of Medicine, University of Maryland, Baltimore, MD</unparsedAffiliation></affiliation><affiliation xml:id="af28" countryCode="GB" type="organization"><unparsedAffiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af29" countryCode="IT" type="organization"><unparsedAffiliation>University of Insubria, Varese, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af30" countryCode="US" type="organization"><unparsedAffiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</unparsedAffiliation></affiliation><affiliation xml:id="af31" countryCode="AU" type="organization"><unparsedAffiliation>University of Newcastle, Callaghan, Australia</unparsedAffiliation></affiliation><affiliation xml:id="af32" countryCode="AU" type="organization"><unparsedAffiliation>John Hunter Hospital, New Lambton Heights, Australia</unparsedAffiliation></affiliation><affiliation xml:id="af33" countryCode="AU" type="organization"><unparsedAffiliation>Hunter Medical Research Institute, New Lambton, Australia</unparsedAffiliation></affiliation><affiliation xml:id="af34" countryCode="US" type="organization"><unparsedAffiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</unparsedAffiliation></affiliation><affiliation xml:id="af35" countryCode="GB" type="organization"><unparsedAffiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af36" countryCode="US" type="organization"><unparsedAffiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</unparsedAffiliation></affiliation><affiliation xml:id="af37" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</unparsedAffiliation></affiliation><affiliation xml:id="af38" countryCode="US" type="organization"><unparsedAffiliation>University of Mississippi Medical Center, Jackson, MS</unparsedAffiliation></affiliation><affiliation xml:id="af39" countryCode="GB" type="organization"><unparsedAffiliation>Queen's University of Belfast, Belfast, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><supportingInformation><p>
Additional supporting information can be found in the online version of this article.
</p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana23838:ANA_23838_sm_SuppTab"></mediaResource><caption>Supporting Information Table</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Objective</b>: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</p><p><b>Methods</b>: Common genetic variants identified through genome‐wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).</p><p><b>Results</b>: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (<i>p</i> < 5 × 10<sup>–8</sup>) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (<i>p</i> = 2.6 × 10<sup>–186</sup>), rs10665 with FVII (<i>p</i> = 2.4 × 10<sup>–47</sup>), and rs505922 in the <i>ABO</i> gene with both von Willebrand factor (<i>p</i> = 4.7 × 10<sup>–57</sup>) and factor VIII (<i>p</i> = 1.2 × 10<sup>–36</sup>). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88–0.99, <i>p</i> = 0.023). Independent replication in Meta‐Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), <i>p</i> = 0.001, a finding specific to large‐vessel and cardioembolic stroke (<i>p</i> = 0.001 and <i>p</i> = < 0.001, respectively) but not seen with small‐vessel stroke (<i>p</i> = 0.811).</p><p><b>Interpretation</b>: <i>ABO</i> gene variants are associated with large‐vessel and cardioembolic stroke but not small‐vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. Ann Neurol 2013</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn20"><p>Wellcome Trust Case Control Consortium 2 members are listed in the Appendix on page 29.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ischemic stroke is associated with the ABO locus: The EuroCLOT study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Ischemic Stroke and ABO Locus</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ischemic stroke is associated with the ABO locus: The EuroCLOT study</title></titleInfo><name type="personal"><namePart type="given">Frances M. K.</namePart><namePart type="family">Williams</namePart><namePart type="termsOfAddress">PhD, FRCP(E)</namePart><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</affiliation><affiliation>E-mail: frances.williams@kcl.ac.uk</affiliation><affiliation>Correspondence address: Address correspondence to Dr Williams, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block 8, Westminster Bridge Road, London, SE1 7EH.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angela M.</namePart><namePart type="family">Carter</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pirro G.</namePart><namePart type="family">Hysi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gabriela</namePart><namePart type="family">Surdulescu</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dylan</namePart><namePart type="family">Hodgkiss</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicole</namePart><namePart type="family">Soranzo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</affiliation><affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</affiliation><affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthew</namePart><namePart type="family">Traylor</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Steve</namePart><namePart type="family">Bevan</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Dichgans</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter M. W.</namePart><namePart type="family">Rothwell</namePart><namePart type="termsOfAddress">MD, PhD, FMedSci</namePart><affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cathie</namePart><namePart type="family">Sudlow</namePart><namePart type="termsOfAddress">DPhil, FRCP(E)</namePart><affiliation>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Farrall</namePart><namePart type="termsOfAddress">PhD, FRCPath</namePart><affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kaisa</namePart><namePart type="family">Silander</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mari</namePart><namePart type="family">Kaunisto</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Wagner</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olli</namePart><namePart type="family">Saarela</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kari</namePart><namePart type="family">Kuulasmaa</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jarmo</namePart><namePart type="family">Virtamo</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Veikko</namePart><namePart type="family">Salomaa</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Amouyel</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dominique</namePart><namePart type="family">Arveiler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean</namePart><namePart type="family">Ferrieres</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Per‐Gunnar</namePart><namePart type="family">Wiklund</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Internal Medicine, University of Umeo̊, Umeo̊, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Arfan Ikram</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Albert</namePart><namePart type="family">Hofman</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgio B.</namePart><namePart type="family">Boncoraglio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugenio A.</namePart><namePart type="family">Parati</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna</namePart><namePart type="family">Helgadottir</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom</affiliation><affiliation>DeCODE Genetics, Reykjavik, Iceland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Solveig</namePart><namePart type="family">Gretarsdottir</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>DeCODE Genetics, Reykjavik, Iceland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Unnur</namePart><namePart type="family">Thorsteinsdottir</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>DeCODE Genetics, Reykjavik, Iceland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gudmar</namePart><namePart type="family">Thorleifsson</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>DeCODE Genetics, Reykjavik, Iceland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kari</namePart><namePart type="family">Stefansson</namePart><namePart type="termsOfAddress">PhD, Dr med</namePart><affiliation>DeCODE Genetics, Reykjavik, Iceland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sudha</namePart><namePart type="family">Seshadri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</affiliation><affiliation>Framingham Heart Study, Framingham, MA</affiliation><affiliation>Departments of Health Services, University of Washington, Seattlem WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anita</namePart><namePart type="family">DeStefano</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Boston University Schools of Medicine and Public Health, Boston, MA</affiliation><affiliation>Framingham Heart Study, Framingham, MA</affiliation><affiliation>Departments of Health Services, University of Washington, Seattlem WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Gschwendtner</namePart><namePart type="termsOfAddress">Dr med</namePart><affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruce</namePart><namePart type="family">Psaty</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</affiliation><affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</affiliation><affiliation>Group Health Research Institute, Group Health, Seattle, WA</affiliation><affiliation>Department of Neurology, University of Washington, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Will</namePart><namePart type="family">Longstreth</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Epidemiology, Health Services, University of Washington, Seattle, WA</affiliation><affiliation>Medicine, and Health Services, University of Washington, Seattle, WA</affiliation><affiliation>Department of Medicine, University of Maryland, Baltimore, MD</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Braxton D.</namePart><namePart type="family">Mitchell</namePart><namePart type="termsOfAddress">MPH, PhD</namePart><affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu‐Ching</namePart><namePart type="family">Cheng</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Clarke</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Insubria, Varese, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marco</namePart><namePart type="family">Ferrario</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joshua C.</namePart><namePart type="family">Bis</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Newcastle, Callaghan, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christopher</namePart><namePart type="family">Levi</namePart><namePart type="termsOfAddress">BSc, MBBS</namePart><affiliation>John Hunter Hospital, New Lambton Heights, Australia</affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia</affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Attia</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>John Hunter Hospital, New Lambton Heights, Australia</affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia</affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elizabeth G.</namePart><namePart type="family">Holliday</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>John Hunter Hospital, New Lambton Heights, Australia</affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia</affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rodney J.</namePart><namePart type="family">Scott</namePart><namePart type="termsOfAddress">PhD, FRCPath</namePart><affiliation>John Hunter Hospital, New Lambton Heights, Australia</affiliation><affiliation>Hunter Medical Research Institute, New Lambton, Australia</affiliation><affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Myriam</namePart><namePart type="family">Fornage</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Imperial College Cerebrovascular Research Unit, Imperial College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pankaj</namePart><namePart type="family">Sharma</namePart><namePart type="termsOfAddress">PhD, FRCP</namePart><affiliation>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen L.</namePart><namePart type="family">Furie</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan</namePart><namePart type="family">Rosand</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mike</namePart><namePart type="family">Nalls</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Mississippi Medical Center, Jackson, MS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James</namePart><namePart type="family">Meschia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Mississippi Medical Center, Jackson, MS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas H.</namePart><namePart type="family">Mosely</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Queen's University of Belfast, Belfast, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alun</namePart><namePart type="family">Evans</namePart><namePart type="termsOfAddress">MD</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aarno</namePart><namePart type="family">Palotie</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom</affiliation><affiliation>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA</affiliation><affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</affiliation><affiliation>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hugh S.</namePart><namePart type="family">Markus</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Stroke and Dementia Research Centre, St George's University of London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter J.</namePart><namePart type="family">Grant</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tim D.</namePart><namePart type="family">Spector</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on Behalf of the EuroCLOT Investigators the Wellcome Trust Case Control Consortium 2 MOnica Risk, Genetics, Archiving and Monograph MetaStroke and the International Stroke Genetics Consortium</namePart><description>Department of Twin Research and Genetic Epidemiology, King's College London, London, United KingdomDivision of Cardiovascular and Diabetes Research, University of Leeds, Leeds, United KingdomWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United KingdomProgram in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MADepartment of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, FinlandStroke and Dementia Research Centre, St George's University of London, London, United KingdomInstitute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich, GermanyStroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford, United KingdomDivision of Clinical Neurosciences, University of Edinburgh, Edinburgh, United KingdomWellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford, United KingdomInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, FinlandChronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, FinlandDepartment of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, FranceDepartment of Epidemiology and Public Health, University of Strasbourg, Strasbourg, FranceDepartment of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse, FranceDepartment of Internal Medicine, University of Umeo̊, Umeo̊, SwedenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan, ItalyDeCODE Genetics, Reykjavik, IcelandBoston University Schools of Medicine and Public Health, Boston, MAFramingham Heart Study, Framingham, MADepartments of Health Services, University of Washington, Seattlem WAEpidemiology, Health Services, University of Washington, Seattle, WAMedicine, and Health Services, University of Washington, Seattle, WAGroup Health Research Institute, Group Health, Seattle, WADepartment of Neurology, University of Washington, WADepartment of Medicine, University of Maryland, Baltimore, MDClinical Trial Service Unit, University of Oxford, Oxford, United KingdomUniversity of Insubria, Varese, ItalyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WAUniversity of Newcastle, Callaghan, AustraliaJohn Hunter Hospital, New Lambton Heights, AustraliaHunter Medical Research Institute, New Lambton, AustraliaHuman Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TXImperial College Cerebrovascular Research Unit, Imperial College London, London, United KingdomCenter for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MADepartment of Neurology, Mayo Clinic, Jacksonville, FL, USAUniversity of Mississippi Medical Center, Jackson, MSQueen's University of Belfast, Belfast, United Kingdom</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2013-01</dateIssued><dateCaptured encoding="w3cdtf">2012-04-27</dateCaptured><dateValid encoding="w3cdtf">2012-10-29</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">7</extent><extent unit="references">41</extent><extent unit="words">8906</extent></physicalDescription><abstract>Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</abstract><abstract>Methods: Common genetic variants identified through genome‐wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3).</abstract><abstract>Results: Stage 1 identified 524 single nucleotide polymorphisms (SNPs) from 23 linkage disequilibrium blocks having significant association (p < 5 × 10–8) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 × 10–186), rs10665 with FVII (p = 2.4 × 10–47), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 × 10–57) and factor VIII (p = 1.2 × 10–36). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88–0.99, p = 0.023). Independent replication in Meta‐Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large‐vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small‐vessel stroke (p = 0.811).</abstract><abstract>Interpretation: ABO gene variants are associated with large‐vessel and cardioembolic stroke but not small‐vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. Ann Neurol 2013</abstract><note type="content">*Wellcome Trust Case Control Consortium 2 members are listed in the Appendix on page 29.</note><relatedItem type="host"><titleInfo><title>Annals of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Additional supporting information can be found in the online version of this article.Supporting Info Item: Supporting Information Table - </note><subject><genre>article-category</genre><topic>Rapid Communication</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>16</start><end>31</end><total>16</total></extent></part></relatedItem><identifier type="istex">D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839</identifier><identifier type="ark">ark:/67375/WNG-DL9FTPZM-W</identifier><identifier type="DOI">10.1002/ana.23838</identifier><identifier type="ArticleID">ANA23838</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 American Neurological Association</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002705 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002705 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839
|texte= Ischemic stroke is associated with the ABO locus: The EuroCLOT study
}}
| This area was generated with Dilib version V0.6.33. |  |